Histamine and histamine antagonists:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Berlin [u.a.]
Springer
1991
|
| Schriftenreihe: | Handbook of experimental pharmacology
97 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Literaturangaben |
| Beschreibung: | XXVI, 763 S. Ill., graph. Darst. |
| ISBN: | 3540528032 0387528032 |
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| 245 | 1 | 0 | |a Histamine and histamine antagonists |c contributors J.-M. Arrang ... Ed. Börje Uvnäs |
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Datensatz im Suchindex
| _version_ | 1804118528417071104 |
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| adam_text | HISTAMINE AND HISTAMINE ANTAGONISTS CONTRIBUTORS J.-M. ARRANG, K.E.
BARRETT, A. BAST, M.A. BEAVEN, M.L. BOUTHENET A.F. CASY, L.A. CHAHL, W.
DIETZ, A. DOENICKE, M. ENNIS, W.A. FOGEL J.C. FOREMAN, M. GARBARG, B.D.
GOMPERTS, G. GRANERUS, J.P. GREEN S.S. GROSS, R. HAKANSON, N. INAGAKI,
N. ITOWI, M.A. KALINER, J.J. KEYZER R. LEVI, R. LINDLAR, W. LORENZ, K.
MAEYAMA, P.F. MANNAIONI, C. MASLINSKI P.T. MCBRIDE, E. NEUGEBAUER, K.J.
OBRINK, E. OOSTING, P. PANULA F.L. PEARCE, H. POLLARD, G.D. PRELL, M.
RUAT, LISA E. RUBIN, J. SATTLER U. SCHAFER, J.-C. SCHWARTZ, S.A.
SLORACH, B. STINNER, F. SUNDLER, Y. TAGUCHI K. TASAKA, H. TIMMERMANN, B.
UVNAS, H. VAN DER GOOT, H. WADA T. WATANABE, J. WATKINS, A. YAMATODANI
EDITOR BORJE UVNAS SPRINGER-VERLAG BERLIN HEIDELBERG NEW YORK LONDON
PARIS TOKYO HONG KONG BARCELONA CONTENTS CHAPTER 1 CURRENT TECHNIQUES OF
HISTAMINE DETERMINATION A. SUGGESTIONS TO THOSE WHO HAVE BECOME
HISTAMINOLOGISTS AT A TIME OF OVERFLOODING AND BIASED INFORMATION W.
LORENZ 1 INTRODUCTION 1 REFERENCES 2 B. BIOASSAYS P.F. MANNAIONI 3 I.
INTRODUCTION 3 II. DESCRIPTION 3 III. PRACTICABILITY 4 IV. RELIABILITY 5
V. COMMENTS 7 REFERENCES 7 C. FLUOROMETRIC ASSAYS W. LORENZ AND E.
NEUGEBAUER. WITH 6 FIGURES 9 I. INTRODUCTION 9 II. MODIFICATIONS OF THE
FLUOROMETRIC ASSAY : * . 9 III. STRATEGY FOR SELECTING A MODIFIED
FLUOROMETRIC ASSAY FOR SOLVING A SPECIFIC ANALYTICAL PROBLEM 13 IV.
COMBINED METHOD AS A STANDARD TECHNIQUE FOR HISTAMINE ASSAYS IN TISSUES,
BODY FLUIDS AND ISOLATED CELLS 15 1. SAMPLE-TAKING AND PREPARATION 15 2.
HOMOGENIZATION AND CENTRIFUGATION 15 3. ION-EXCHANGE CHROMATOGRAPHY ON
DOWEX 50W-X8 16 4. EXTRACTION BY SOLVENT PARTITION 16 XII CONTENTS 5.
CONDENSATION STEP 17 6. MEASUREMENT AND CALCULATION OF HISTAMINE
CONTENTS 18 V. RELIABILITY AND PRACTICABILITY OF THE FLUOROMETRIC
METHODS 18 1. DETECTABILITY (SENSITIVITY) 19 2. SPECIFICITY 19 3.
PRECISION 22 4. ACCURACY 24 5. PRACTICABILITY 26 VI. CONCLUSIONS 26
REFERENCES 26 D. AUTOMATED FLUOROMETRIC ASSAYS M. ENNIS. WITH 1 FIGURE
31 I. INTRODUCTION 31 II. CHEMISTRY OF THE REACTIONS 31 III. CHEMICAL
SYSTEM IN USE IN THE AUTHOR S LABORATORY 32 IV. CARRY-OVER 34 V.
DETECTABILITY 34 VI. SPECIFICITY 34 VII. WITH-RUN IMPRECISION 35 VIII.
PRACTICABILITY 35 IX. GLASS MICROFIBRE-BASED HISTAMINE ASSAY 35 X.
CONCLUSIONS 37 REFERENCES 37 E. RADIOENZYMATIC ASSAYS IN BIOLOGICAL
FLUIDS M.A. BEAVEN. WITH 1 FIGURE .39 I. INTRODUCTION 39 II. ASSAY
PROCEDURES 40 III. APPLICATIONS 42 IV. PRECISION, ACCURACY AND
SPECIFICITY 43 V. SENSITIVITY 43 REFERENCES 45 F. DETERMINATION BY
HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY G. GRANERUS. WITH 1 FIGURE 49 I.
TECHNIQUES 49 II. DETECTION AND DERIVATIZATION 50 III. PERFORMANCE
CHARACTERISTICS 51 1. PRECISION 51 2. ACCURACY AND SPECIFICITY 51
CONTENTS XIII 3. DETECTABILITY 52 IV. COANALYSIS OF RELATED COMPOUNDS 53
V. PRACTICABILITY 56 VI. CONCLUSIONS 56 REFERENCES 57 G. DETERMINATION
IN BIOLOGICAL SAMPLES BY GAS CHROMATOGRAPHY-MASS SPECTROMETRY J.J.
KEYZER AND E. OOSTING. WITH 1 FIGURE 59 I. INTRODUCTION 59 II.
DESCRIPTION 60 1. MATERIALS 60 2. SAMPLE HANDLING 60 3. EXTRACTION
PROCEDURE 61 4. PREPARATION OF STANDARDS 61 5. DERIVATIZATION 61 6. GAS
CHROMATOGRAPHY-MASS SPECTROMETRY 61 7. QUANTIFICATION 62 III.
PRACTICABILITY 63 IV. PRECISION, ACCURACY AND SPECIFICITY 63 REFERENCES
64 H. IMMUNOLOGIC METHODS P.T. MCBRIDE AND M.A. KALINER. WITH 3 FIGURES
67 I. INTRODUCTION 67 II. DESCRIPTION 68 III. PRACTICABILITY . . . 69
IV. PRECISION 70 V. ACCURACY AND SPECIFICITY 70 VI. DETECTABILITY 72
VII. FORMAT OF THE ASSESSMENT REPORT 73 REFERENCES 73 J. MEASUREMENT OF
HISTAMINE METABOLITES J.P. GREEN AND G.D. PRELL 77 I. INTRODUCTION 77
II. ENHANCEMENT OF INSIGHTS INTO THE PHYSIOLOGICAL AND
PATHOPHYSIOLOGICAL ROLES OF HISTAMINE BY MEASURING ITS METABOLITES 77
REFERENCES 78 XIV CONTENTS K. MUNICH CONSENSUS DEVELOPMENT CONFERENCE ON
HISTAMINE DETERMINATION W. LORENZ, E. NEUGEBAUER, B. UVNAS, M.A. BEAVEN,
M. ENNIS, G. GRANERUS, J.P. GREEN, J.J. KEYZER, P.T. MCBRIDE, P.F.
MANNAIONI, F.L. PEARCE, AND J. WATKINS. WITH 2 FIGURES 81 I. CONSENSUS
DEVELOPMENT CONFERENCE: A NEW STRATEGY FOR SOLVING PROBLEMS NOT ONLY IN
CLINICAL MEDICINE BUT ALSO IN BIOMEDICINE IN A FORMALIZED WAY 81 II.
RESULTS: THE CONSENSUS STATEMENT 83 1. WHAT CRITERIA SHOULD BE USED TO
ANALYSE THE RELIABILITY OF A HISTAMINE ASSAY? 84 A) DETECTABILITY
(SENSITIVITY) 84 B) SPECIFICITY 84 C) PRECISION 84 D) ACCURACY 86 2. HOW
RELIABLE AT PRESENT ARE THE PRINCIPAL ASSAYS FOR MEASURING HISTAMINE IN
STANDARD SOLUTIONS WITH AUTHENTIC HISTAMINE 86 3. HOW RELIABLE AT
PRESENT ARE THE PRINCIPAL ASSAYS FOR MEASURING HISTAMINE IN HUMAN
PLASMA? 86 4. IS THE USEFULNESS OF THE PRINCIPAL ASSAYS FOR OBTAINING
RELIABLE HISTAMINE VALUES DEMONSTRATED FOR A SERIES OF BIOMEDICAL
CONDITIONS AND FOR SOME MORE COMPLEX SITUATIONS? 90 III. CONCLUSION 90
REFERENCES 91 CHAPTER 2 HETEROGENEITY OF MAST CELLS K.E. BARRETT AND
F.L. PEARCE. WITH 3 FIGURES 93 A. INTRODUCTION: ROLE AND DISTRIBUTION OF
MAST CELLS 93 B. ASPECTS OF MAST CELL HETEROGENEITY . * . 94 I.
HISTOCHEMICAL DIFFERENCES BETWEEN MAST CELLS 94 II. ULTRASTRUCTURAL
DIFFERENCES BETWEEN MAST CELLS 96 III. DIFFERENCES IN PREFORMED AND
NEWLY SYNTHESIZED MAST CELL MEDIATORS 99 IV. FUNCTIONAL DIFFERENCES:
VARIATIONS IN RESPONSE TO SECRETORY STIMULI AND ANTI-ALLERGIC DRUGS 104
CONTENTS XV C. ORIGINS OF MAST CELL HETEROGENEITY 107 D. SUMMARY AND
CONCLUSIONS 110 I. IMPLICATIONS OF MAST CELL HETEROGENEITY 110 II.
PROBLEMS OF NOMENCLATURE ILL III. CONCLUSIONS 112 REFERENCES 112 CHAPTER
3 CONTROL OF THE EXOCYTOTIC MECHANISM IN RAT MAST CELLS B.D. GOMPERTS.
WITH 9 FIGURES 119 A. THE MAST CELL AND EXOCYTOTIC SECRETION 119 B.
STIMULUS-SECRETION COUPLING 121 I. ROLE OF CA 2+ 121 II. ROLE OF ATP 122
III. CELL PERMEABILISATION 122 IV. SECRETION INDUCED BY CA 2+ FROM ATP 4
-PERMEABILISED MAST CELLS 123 1. SECRETION INDUCED BY CA 2+ FROM OTHER
SECRETORY CELLS . . . 123 2. CONTROL OF CA 2+ AFFINITY BY GTP IN
PERMEABILISED PLATELETS . 124 V. CALCIUM ION INDEPENDENT SECRETION
INDUCED BY GTP FROM PERMEABILISED NEUTROPHILS 125 C. ESSENTIAL ROLE FOR
GTP IN EXOCYTOSIS FROM MAST CELLS 125 I. ESSENTIAL SYNERGY FOR CA 2+ AND
GTP FOR SECRETION FROM PERMEABILISED MAST CELLS 125 1. ENHANCEMENT OF
AFFINITY FOR CA 2+ AND GUANINE NUCLEOTIDE BY ATP , . . 126 2.
ENHANCEMENT OF AFFINITY FOR GTP BY ATP 127 3. ROLE OF ATP IN
STIMULUS-SECRETION COUPLING 127 4. ROLE OF PROTEIN KINASE C IN THE
MAINTENANCE OF EFFECTOR AFFINITY 127 5. RESTORATION OF RESPONSIVENESS BY
ATP TO CELLS RENDERED REFRACTORY FOLLOWING PERMEABILISATION 128 II. ROLE
OF POLYPHOSPHOINOSITIDE METABOLITES IN EXOCYTOSIS? . . . 129 1.
G-PROTEIN CONTROL OF EXOCYTOSIS: G E 130 2. INVOLVEMENT OF G E IN OTHER
SECRETORY CELLS 131 3. RECEPTOR CONTROL OF G E IN MAST CELLS? 131 III.
SUMMARY 132 D. KINETICS OF EXOCYTOSIS 132 I. EFFECT OF VARYING GTP-Y-S
132 II. EFFECT OF VARYING CA 2+ 133 XVI CONTENTS III. RATE OF
ARACHIDONATE PRODUCTION PARALLELING EXOCYTOSIS . . . . 133 IV.
INHIBITION OF ONSET OF EXOCYTOSIS BY ATP 134 1. A PROTEIN
DEPHOSPHORYLATION MECHANISM OF EXOCYTOTIC SECRETION 135 V. SUMMARY 136
E. MEASUREMENT OF MEMBRANE CAPACITANCE 137 I. UNIT EXOCYTOTIC EVENTS 137
1. CAPACITANCE FLICKER 137 2. BEIGE MOUSE MAST CELLS 137 F. CONCLUSION
138 REFERENCES 139 CHAPTER 4 FORMATION OF HISTAMINE: HISTIDINE
DECARBOXYLASE T. WATANABE, Y. TAGUCHI, K. MAEYAMA, AND H. WADA. WITH 2
FIGURES 145 A. INTRODUCTION 145 B. DISTRIBUTION 145 I. STOMACH 146 II.
MAST CELLS 146 III. BRAIN 146 IV. MISCELLANEOUS TISSUES . 147 C.
PURIFICATION 147 D. PROPERTIES 148 E. INHIBITORS 150 I. IN VITRO STUDIES
ON HDC INHIBITION BY FMH 150 II. IN VIVO INACTIVATION OF HDC AND
DEPLETION OF HISTAMINE BY FMH ADMINISTRATION 153 III. EFFECT OF
HISTAMINE DEPLETION BY FMH ON PHYSIOLOGICAL PARAMETERS AND POSSIBLE USE
OF FMH AS A DRUG 154 F. CHANGES IN HDC ACTIVITY WITH VARIOUS TREATMENTS
154 G. ANTIBODIES 154 REFERENCES 156 CHAPTER 5 CATABOLISM OF HISTAMINE
C. MASLINSKI AND W.A. FOGEL. WITH 5 FIGURES 165 A. INTRODUCTION 165 B.
METHYLATION OF HISTAMINE 167 I. RING N-METHYLATION 167 1. ASSAY OF
HISTAMINE N-METHYLTRANSFERASE 168 2. PROPERTIES OF HISTAMINE
N-METHYLTRANSFERASE 169 CONTENTS XVII 3. INHIBITORS OF HISTAMINE
N-METHYLTRANSFERASE ACTIVITY . . . . 170 4. OCCURRENCE AND DISTRIBUTION
171 5. METABOLITES 172 II. SIDE-CHAIN METHYLATION 174 C. OXIDATIVE
DEAMINATION OF HISTAMINE 174 I. ASSAY OF DIAMINE OXIDASE 176 II.
OCCURRENCE OF DIAMINE OXIDASE 177 III. PROPERTIES OF DIAMINE OXIDASE 179
IV. INHIBITORS 180 D. OTHER CATABOLIC PATHWAYS OF HISTAMINE 180 I.
GLUTAMYLATION OF HISTAMINE 180 II. ACETYLATION OF HISTAMINE 181
REFERENCES 182 CHAPTER 6 HISTAMINE RECEPTORS IN BRAIN J.-C. SCHWARTZ,
J.-M. ARRANG, M.-L. BOUTHENET, M. GARBARG, H. POLLARD, AND M. RUAT. WITH
16 FIGURES 191 A. INTRODUCTION 191 B. HISTAMINE H! RECEPTORS 192 I.
MOLECULAR PROPERTIES 192 II. DISTRIBUTION IN THE CNS 194 III. INOSITOL
PHOSPHOLIPID HYDROLYSIS 199 IV. POTENTIATION OF CYCLIC AMP ACCUMULATION
202 V. GLYCOGENOLYSIS 204 VI. CYCLIC GMP ACCUMULATION AND OTHER
BIOCHEMICAL RESPONSES . 204 VII. ELECTROPHYSIOLOGICAL RESPONSES 205 C.
HISTAMINE H 2 RECEPTORS : . . 207 I. MOLECULAR PROPERTIES 207 II.
ADENYLATE CYCLASE ACTIVATION 208 III. PHOSPHOLIPID METHYLATION 210 IV.
LOCALIZATION 210 V. ELECTROPHYSIOLOGICAL RESPONSES 212 D. HISTAMINE H 3
RECEPTORS 214 I. PHARMACOLOGICAL DEFINITION AND STRUCTURE-ACTIVITY
RELATIONSHIPS 214 II. MEDIATION OF ACTIONS 221 III. RADIOLABELLING 222
IV. DISTRIBUTION IN THE CNS 224 E. CONCLUSIONS 226 REFERENCES 227 XVIII
CONTENTS CHAPTER 7 STRUCTURE AND FUNCTIONS OF THE HISTAMINERGIC NEURONE
SYSTEM A. YAMATODANI, N. INAGAKI, P. PANULA, N. ITOWI, T. WATANABE, AND
H. WADA. WITH 3 FIGURES 243 A. INTRODUCTION 243 B. LOCATION AND
DISTRIBUTION OF THE HISTAMINERGIC NEURONE SYSTEM 243 I. NEUROCHEMICAL
STUDIES 243 II. IMMUNOHISTOCHEMICAL STUDIES 249 1. HISTAMINERGIC SYSTEM
IN RAT BRAIN 249 A) HISTIDINE DECARBOXYLASE AS A MARKER 249 B) HISTAMINE
AS A MARKER 249 C) HISTAMINERGIC NEURONES IN THE TUBEROMAMMILLARY
NUCLEUS OF RAT HYPOTHALAMUS 251 D) ORGANIZATION OF HISTAMINERGIC NERVE
FIBRES IN RAT BRAIN 253 2. CENTRAL HISTAMINERGIC SYSTEM IN OTHER SPECIES
253 III. AUTORADIOGRAPHIC STUDIES 254 C. PHYSIOLOGICAL FUNCTIONS OF THE
HISTAMINERGIC NEURONE SYSTEM . . . 255 I. GENERAL CONSIDERATIONS 255 II.
A-FLUOROMETHYLHISTIDINE AS A PHARMACOLOGICAL TOOL . . . . . . . 257 III.
POSSIBLE PHYSIOLOGICAL FUNCTIONS DEDUCED FROM NEUROPHARMACOLOGICAL
STUDIES 257 1. BEHAVIOURS 258 A) MOTOR ACTIVITY 258 B) CONDITIONED
BEHAVIOUR 258 C) AGGRESSION AND DEPRESSION 258 D) CATALEPTIC BEHAVIOUR
258 E) FEEDING BEHAVIOUR 259 F) DRINKING BEHAVIOUR 259 2.
SLEEP-WAKEFULNESS 259 3. ANTINOCICEPTION AND ANALGESIA 260 4.
NEUROENDOCRINE SYSTEM 260 A) CORTICOTROPIN 260 B) SOMATOTROPIN 261 C)
GONADOTROPIN 261 D) PROLACTIN 262 E) THYROTROPIN 262 F) VASOPRESSIN 263
5. BLOOD PRESSURE 263 6. THERMOREGULATION 264 D. CONCLUSION 265
REFERENCES . 265 CONTENTS XIX CHAPTER 8 HISTAMINE H 2 RECEPTORS AND LUNG
FUNCTION J.C. FOREMAN. WITH 4 FIGURES 285 A. INTRODUCTION 285 B. H 2
RECEPTORS AND AIRWAY SMOOTH MUSCLE 286 C. H 2 RECEPTORS AND PULMONARY
VASCULATURE 294 D. H 2 RECEPTORS AND MUCUS SECRETION 296 E. H 2
RECEPTORS AND INFLAMMATORY MEDIATOR RELEASE FROM LUNG . . . 297 F. H 2
RECEPTORS AND THE CONTROL OF LUNG FUNCTION IN VIVO 298 G. CONCLUDING
REMARKS 299 REFERENCES 300 CHAPTER 9 HISTAMINE AND THE PARIETAL CELL
K.J. OBRINK 305 A. INTRODUCTION 305 I. HISTORICAL NOTES 305 II.
EXPERIMENTAL MODELS 306 1. INTACT ANIMALS 306 2. ISOLATED STOMACHS 306
3. ISOLATED GLANDS 307 4. ISOLATED CELLS 307 5. SUBCELLULAR PREPARATIONS
307 B. STIMULATORY PROCESSES AT THE PARIETAL CELL 307 I. RECEPTORS 307
1. HISTAMINE 308 2. GASTRIN . 309 3. ACETYLCHOLINE . 310 4. ADENOSINE
310 5. OTHER RECEPTORS 310 II. MODE OF ACTION OF SECRETAGOGUES. SECOND
MESSENGERS 310 1. HISTAMINE 310 2. GASTRIN 310 3. ACETYLCHOLINE 311 HI.
HISTAMINE AS THE FINAL COMMON MEDIATOR OR JUST A COOPERATIVE
SECRETAGOGUE 311 1. THE TRANSMISSION HYPOTHESIS 311 2. THE PERMISSION
HYPOTHESIS 312 3. HISTAMINE-CONTAINING CELLS 313 IV. MODE OF ACTION BY
SOME GASTRIC ACID INHIBITORS 314 XX CONTENTS 1. ADENOSINE 315 2.
SOMATOSTATIN 315 3. PROSTAGLANDINS 315 V. A DIFFERENT HYPOTHESIS 316 C.
EFFECTS ON THE PARIETAL CELL 316 I. THE BLACK BOX 316 II. THE PROTON
TRANSLOCATION SYSTEM. MORPHOLOGICAL TRANSFORMATION 316 D. CONCLUSIONS
318 REFERENCES 318 CHAPTER 10 DO HISTAMINE-STORING CELLS IN THE GASTRIC
MUCOSA MEDIATE THE ACID-STIMULATING ACTION OF GASTRIN? R. HAKANSON AND
F. SUNDLER. WITH 8 FIGURES 325 A. INTRODUCTION 325 B. THE HISTAMINE AS
MEDIATOR HYPOTHESIS 326 C. THE INTERACTION HYPOTHESIS 327 D. CRITICAL
EVALUATION OF PREVAILING MODELS 328 E. THE TRANSDUCER HYPOTHESIS 331 F.
GASTRIC HISTAMINE STORES 334 I. ENTEROCHROMAFFIN-LIKE CELLS 336 II. MAST
CELLS 339 III. HISTAMINE-CONTAINING NEURONS 339 G. CONCLUDING REMARKS
342 REFERENCES 343 CHAPTER 11 HISTAMINE IN CARDIOVASCULAR FUNCTION AND
DYSFUNCTION: RECENT DEVELOPMENTS R. LEVI, L.E. RUBIN, AND S.S. GROSS.
WITH 1 FIGURE 347 A. EFFECTS OF HISTAMINE ON THE HEART 347 I.
INTRODUCTION *. . 347 II. SINOATRIAL RATE 348 III. ATRIOVENTRICULAR
CONDUCTION 350 IV. AUTOMATICITY AND TRIGGERED ACTIVITY 352 V.
CONTRACTILITY 353 B. EFFECTS OF HISTAMINE ON VASCULATURE 355 I.
OVERVIEW: EFFECTS AND MECHANISMS 355 CONTENTS XXI II. CORONARY VESSELS
362 III. CEREBRAL VESSELS 363 IV. PULMONARY VESSELS 364 V. AORTA 365 VI.
MESENTERIC ARTERY 366 VII. RENAL ARTERY 367 VIII. VEINS 367 C. ROLE OF
HISTAMINE IN CARDIOVASCULAR PATHOPHYSIOLOGY 368 I. LOCALIZATION AND
RELEASE 368 II. IMMEDIATE HYPERSENSITIVITY 369 III. MYOCARDIAL ISCHEMIA
370 IV. ATHEROSCLEROSIS AND DIABETES 371 D. A PHYSIOLOGICAL ROLE FOR
HISTAMINE IN THE CARDIOVASCULAR SYSTEM? . 372 REFERENCES 374 CHAPTER 12
HISTAMINE IN ANAESTHESIA AND SURGERY: CAUSALITY ANALYSIS W. LORENZ, W.
DIETZ, M. ENNIS, B. STINNER, AND A. DOENICKE WITH 15 FIGURES 385 A.
INTRODUCTION 385 B. NETWORKS OF EXPERIMENTAL AND CLINICAL EVIDENCE
SUGGESTING THAT HISTAMINE IS SIGNIFICANTLY INVOLVED IN ADVERSE REACTIONS
DURING ANAESTHESIA AND SURGERY 385 I. HYPNOTIC AGENTS AND THE CRITERIA
FOR CAUSAL ASSOCIATIONS . . 386 1. KOCH-DALE CRITERIA 387 2. HILL
CRITERIA 389 II. CLINICAL EPIDEMIOLOGY OF ADVERSE REACTIONS 390 III.
CLASSIFICATION OF THE REACTIONS BY MECHANISMS . . . . : . . 391 IV.
PLASMA SUBSTITUTES . 391 V. NARCOTICS AND MUSCLE RELAXANTS 395 VI.
CONTRAST MEDIA DURING OPERATIONS 402 VII. SURGICAL MANOEUVRES AND OTHER
PHYSICAL AND CHEMICAL MEASURES DURING OPERATIONS 408 1. DISEASES WITH
ELEVATED PLASMA HISTAMINE LEVELS . . . . . 409 2. PREOPERATIVE MEASURES
413 3. SURGICAL PROCEDURES 413 4. POSTOPERATIVE RECOVERY AND CARE 417 C.
PHILOSOPHY OF HISTAMINE IN ANAESTHESIA AND SURGERY: H, + H 2 PROPHYLAXIS
AS A PRACTICAL APPROACH . . 421 REFERENCES 425 XXII CONTENTS CHAPTER 13
HISTAMINE IN DUODENAL ULCER, STRESS-INDUCED LESIONS, AND UPPER
GASTROINTESTINAL BLEEDING: CAUSALITY ANALYSIS J. SATTLER, W. LORENZ, R.
LINDLAR, AND U. SCHAFER. WITH 14 FIGURES . 441 A. INTRODUCTION 441 B.
METHODS FOR ASSESSING CAUSAL ASSOCIATIONS OF HISTAMINE AS A MEDIATOR OF
GASTROINTESTINAL DISEASES AMONG OTHER CANDIDATES . . 442 I. DECISION
TREE: META-ANALYSIS 442 II. KOCH-DALE AND HILL CRITERIA: UNICAUSAL
ANALYSIS 443 III. CONDITIONAL PROBABILITIES AND CAUSAL NETWORKS:
MULTICAUSAL ANALYSIS 443 C. DUODENAL ULCER 446 I. META-ANALYSIS 447 II.
UNICAUSAL ANALYSIS 448 III. MULTICAUSAL ANALYSIS 450 D. STRESS-INDUCED
LESIONS 453 I. META-ANALYSIS 453 1. TRAUMA 454 2. MAJOR SURGERY 455 3.
CEREBRAL INJURY 456 4. HEMORRHAGIC SHOCK . 456 5. RESPIRATORY
INSUFFICIENCY 457 6. FAT EMBOLISM 457 7. RENAL INSUFFICIENCY 457 8.
SEPSIS AND SEPTIC SHOCK 458 9. IMMOBILIZATION 459 10. PSYCHOLOGICAL
STRESS 459 11. BURNS 459 12. ULCEROGENIC DRUGS 459 II. CAUSALITY
ANALYSIS 460 E. UPPER GASTROINTESTINAL BLEEDING . . . 461 I.
META-ANALYSIS 462 II. CAUSALITY ANALYSIS 464 F. CONCLUSION 466
REFERENCES 467 CHAPTER 14 HISTAMINE AND THE BLOOD K. TASAKA. WITH 1
FIGURE 473 A. INTRODUCTION 473 B. AMOUNT OF HISTAMINE IN THE BLOOD 473
C. DISTRIBUTION OF HISTAMINE IN THE BLOOD 478 CONTENTS XXIII I. PLASMA
AND SERUM 478 II. GRANULAR SERIES OF LEUCOCYTES (BASOPHILS, NEUTROPHILS
AND EOSINOPHILS) 479 III. NON-GRANULAR SERIES OF LEUCOCYTES (LYMPHOCYTES
AND MONOCYTES) 480 IV. PLATELETS 481 D. METABOLISM OF HISTAMINE IN THE
BLOOD 481 I. LEUCOCYTES 482 II. CHANGES IN METABOLISM 483 E. RELEASE OF
HISTAMINE FROM BLOOD CELLS 484 I. BASOPHILS 484 II. EOSINOPHILS 488 III.
NEUTROPHILS 489 IV. LYMPHOCYTES 489 F. EFFECTS OF HISTAMINE ON BLOOD
CELLS 490 I. NEUTROPHILS 490 .-. II. EOSINOPHILS 491 III. IMMUNOLOGICAL
REACTIONS 493 1. HISTAMINE AS AN IMMUNOSUPPRESSIVE FACTOR 493 2.
LYMPHOCYTES 493 G. HISTAMINE-INDUCED LEUCOCYTOSIS 498 I.
HISTAMINE-RELATED LEUCOCYTOSIS IN EXPERIMENTAL ANIMALS . . 498 II.
EFFECT ON NEUTROPHIL PRECURSORS 499 III. HISTAMINE AND CELL
PROLIFERATION 500 IV. EFFECT ON LEUKAEMIC CELLS 500 REFERENCES 501
CHAPTER 15 HISTAMINE IN FOOD S.A. SLORACH 511 A. INTRODUCTION 511 B.
FORMATION AND LEVELS OF HISTAMINE IN FOODS 511 I. FORMATION 511 II.
LEVELS 513 1. FISH AND FISH PRODUCTS 513 2. MILK AND CHEESE 513 3. WINE
AND BEER 514 4. OTHER FOODS 514 III. MEASURES TO CONTROL HISTAMINE
FORMATION 514 C. HISTAMINE ( SCOMBROID ) FOOD POISONING 515 I. SYMPTOMS
515 II. DIAGNOSIS AND TREATMENT 516 XXIV CONTENTS III. EPIDEMIOLOGY 516
IV. ROLE OF HISTAMINE 517 REFERENCES 519 CHAPTER 16 ROLE OF HISTAMINE IN
THE ACTIONS OF NEUROPEPTIDES AND LOCAL HORMONES L.A. CHAHL. WITH 1
FIGURE 521 A. INTRODUCTION 521 B. MAST CELL HETEROGENEITY 521 C. RELEASE
OF HISTAMINE BY THE TACHYKININS 522 I. SUBSTANCE P 523 1. STUDIES ON RAT
PERITONEAL MAST CELLS 523 A) TACHYKININ ANTAGONISTS 524 B) BENZALKONIUM
CHLORIDE 525 C) NEURAMINIDASE 525 D) MECHANISM OF ACTION OF SUBSTANCE P
ON MAST CELLS . . . 525 2. IN VIVO STUDIES IN ANIMALS 527 3. STUDIES ON
HUMAN MAST CELLS AND HUMAN SKIN 527 II. NEUROKININS 529 D. RELEASE OF
HISTAMINE BY OTHER NEUROPEPTIDES 529 I. NEUROTENSIN 529 II. SOMATOSTATIN
531 III. VASOACTIVE INTESTINAL POLYPEPTIDE 532 IV. OPIOID PEPTIDES 533
V. CALCITONIN GENE-RELATED PEPTIDES 534 E. RELEASE OF HISTAMINE BY LOCAL
HORMONES 534 I. BRADYKININ AND RELATED PEPTIDES. . . . I 534 II.
PROSTANOIDS ^ 535 F. ROLE OF HISTAMINE IN THE ACTIONS OF NEUROPEPTIDES
536 I. AXON REFLEXES, ANTIDROMIC VASODILATATION AND NEUROGENIC
INFLAMMATION 536 1. NATURE OF THE NEURONES 536 2. SENSITIVITY TO
CAPSAICIN 537 3. NEUROPEPTIDES IN PRIMARY AFFERENT NEURONES 537 II.
FUNCTIONAL RELATIONSHIP BETWEEN SENSORY NEURONES AND MAST CELLS 538 III.
INTERACTIONS BETWEEN HISTAMINE AND NEUROPEPTIDES 538 G. CONCLUSION 540
REFERENCES 540 CONTENTS XXV CHAPTER 17 ANTAGONISTS OF H, RECEPTORS OF
HISTAMINE: RECENT DEVELOPMENTS A.F. CASY 549 A. INTRODUCTION 549 B.
CHEMICAL TYPES OF H,-ANTIHISTAMINIC AGENT 550 I. TERTIARY AMINOALKYL
ETHERS 550 II. CYCLIZINES 551 III. L,L-DIARYL-3-AMINOPROPENES 552 IV.
TERFENADINE 553 V. ASTEMIZOLE 555 VI. TRICYCLIC DERIVATIVES 557 VII.
MISCELLANEOUS TYPES 559 C. BINDING STUDIES 563 D. STERIC ASPECTS 564 I.
ISOMERIC POTENCY AND AFFINITY RATIOS 566 E. FINAL REMARKS . 567
REFERENCES 567 CHAPTER 18 STRUCTURAL REQUIREMENTS FOR HISTAMINE H 2
AGONISTS AND H 2 ANTAGONISTS H. VAN DER GOOT, A. BAST, AND H. TIMMERMAN.
WITH 4 FIGURES . . . . 573 A. INTRODUCTION 573 B. STRUCTURAL
REQUIREMENTS FOR H 2 AGONISM 573 I. INTRODUCTION 573 II. HISTAMINE
ANALOGUES 574 III. DIMAPRIT ANALOGUES 582 IV. IMPROMIDINE ANALOGUES ; .
. 586 C. STRUCTURAL REQUIREMENTS FOR H 2 ANTAGONISM . 605 I.
INTRODUCTION 605 II. CIMETIDINE ANALOGUES 607 III. RANITIDINE ANALOGUES
631 IV. TIOTIDINE ANALOGUES 646 V. LAMTIDINE ANALOGUES . 661 VI. DIARYL
ANALOGUES 695 VII. MISCELLANEOUS 712 D. STRUCTURAL CHARACTERISTICS OF H
2 ANTAGONISTS IN CYTOCHROME P-450 INACTIVATION 723 I. INTRODUCTION 723
II. INTERACTION WITH CYTOCHROME P-450 724 XXVI CONTENTS III. LIGAND
INTERACTIONS OF CIMETIDINE 725 IV. EFFECT OF RANITIDINE; STRUCTURAL
REQUIREMENTS IN GENERAL . . . 727 V. EFFECTS OF H 2 ANTAGONISTS ON THE
OXIDASE ACTIVITY OF CYTOCHROME P-450 733 VI. PREVENTION OF TOXICITY OF
XENOBIOTICS BY H 2 ANTAGONISTS . . . 733 VII. CONCLUSION 733 REFERENCES
734 SUBJECT INDEX. 749
|
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| bvnumber | BV004343349 |
| classification_rvk | XI 1701 |
| classification_tum | CHE 834f CHE 820f MED 308f |
| ctrlnum | (OCoLC)260139192 (DE-599)BVBBV004343349 |
| dewey-full | 612.01575 615.1 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 612 - Human physiology 615 - Pharmacology and therapeutics |
| dewey-raw | 612.01575 615.1 |
| dewey-search | 612.01575 615.1 |
| dewey-sort | 3612.01575 |
| dewey-tens | 610 - Medicine and health |
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| id | DE-604.BV004343349 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T16:11:44Z |
| institution | BVB |
| isbn | 3540528032 0387528032 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-002699200 |
| oclc_num | 260139192 |
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| owner | DE-19 DE-BY-UBM DE-12 DE-355 DE-BY-UBR DE-20 DE-11 DE-188 DE-578 |
| owner_facet | DE-19 DE-BY-UBM DE-12 DE-355 DE-BY-UBR DE-20 DE-11 DE-188 DE-578 |
| physical | XXVI, 763 S. Ill., graph. Darst. |
| publishDate | 1991 |
| publishDateSearch | 1991 |
| publishDateSort | 1991 |
| publisher | Springer |
| record_format | marc |
| series | Handbook of experimental pharmacology |
| series2 | Handbook of experimental pharmacology |
| spelling | Histamine and histamine antagonists contributors J.-M. Arrang ... Ed. Börje Uvnäs Berlin [u.a.] Springer 1991 XXVI, 763 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Handbook of experimental pharmacology 97 Literaturangaben Pharmacology cabt Histamine cabt Antihistaminics cabt Stoffwechsel (DE-588)4057699-1 gnd rswk-swf Antihistaminikum (DE-588)4002284-5 gnd rswk-swf Histamin (DE-588)4025082-9 gnd rswk-swf Histamin (DE-588)4025082-9 s DE-604 Stoffwechsel (DE-588)4057699-1 s Antihistaminikum (DE-588)4002284-5 s Uvnäs, Börje 1913-2003 Sonstige (DE-588)115780750X oth Arrang, J.-M. Sonstige oth Handbook of experimental pharmacology 97 (DE-604)BV002390716 97 GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=002699200&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Histamine and histamine antagonists Handbook of experimental pharmacology Pharmacology cabt Histamine cabt Antihistaminics cabt Stoffwechsel (DE-588)4057699-1 gnd Antihistaminikum (DE-588)4002284-5 gnd Histamin (DE-588)4025082-9 gnd |
| subject_GND | (DE-588)4057699-1 (DE-588)4002284-5 (DE-588)4025082-9 |
| title | Histamine and histamine antagonists |
| title_auth | Histamine and histamine antagonists |
| title_exact_search | Histamine and histamine antagonists |
| title_full | Histamine and histamine antagonists contributors J.-M. Arrang ... Ed. Börje Uvnäs |
| title_fullStr | Histamine and histamine antagonists contributors J.-M. Arrang ... Ed. Börje Uvnäs |
| title_full_unstemmed | Histamine and histamine antagonists contributors J.-M. Arrang ... Ed. Börje Uvnäs |
| title_short | Histamine and histamine antagonists |
| title_sort | histamine and histamine antagonists |
| topic | Pharmacology cabt Histamine cabt Antihistaminics cabt Stoffwechsel (DE-588)4057699-1 gnd Antihistaminikum (DE-588)4002284-5 gnd Histamin (DE-588)4025082-9 gnd |
| topic_facet | Pharmacology Histamine Antihistaminics Stoffwechsel Antihistaminikum Histamin |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=002699200&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV002390716 |
| work_keys_str_mv | AT uvnasborje histamineandhistamineantagonists AT arrangjm histamineandhistamineantagonists |