Biology of mammalian germ cell mutagenesis:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Cold Spring Harbor, NY
Cold Spring Harbor Laboratory Press
1990
|
| Schriftenreihe: | Banbury report
34 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XVIII, 461 S. Ill. |
| ISBN: | 0879692340 |
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| 245 | 1 | 0 | |a Biology of mammalian germ cell mutagenesis |c ed. by James W. Allen |
| 264 | 1 | |a Cold Spring Harbor, NY |b Cold Spring Harbor Laboratory Press |c 1990 | |
| 300 | |a XVIII, 461 S. |b Ill. | ||
| 336 | |b txt |2 rdacontent | ||
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| 650 | 4 | |a Cellules germinales - Congrès | |
| 650 | 4 | |a Mutagénicité - Congrès | |
| 650 | 4 | |a Mutation (Biologie) - Congrès | |
| 650 | 4 | |a Chromosome Aberrations |v Congresses | |
| 650 | 4 | |a Germ Cells |v Congresses | |
| 650 | 4 | |a Germ cells |v Congresses | |
| 650 | 4 | |a Mutagenicity Tests |v Congresses | |
| 650 | 4 | |a Mutagenicity testing |v Congresses | |
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Datensatz im Suchindex
| _version_ | 1804118425732120576 |
|---|---|
| adam_text | Biology of Mammalian
Germ Cell Mutagenesis
Edited by
JAMES W ALLEN
Genetic Toxicology Division
U S Environmental Protection Agency
BRYN A BRIDGES
MRC Cell Mutation Unit
University of Sussex
MARY F LYON
MRC Radiobiology Unit
MONTROSE J MOSES
Duke University Medical Center
LIANE B RUSSELL
Biology Division
Oak Ridge National Laboratory
n
COLD SPRING HARBOR LABORATORY PRESS
Contents
Participants, ix
Preface, xlli
SECTION 1: GERM-LINE PROPERTIES AFFECTING INDUCTION
AND RECOVERY
Barriers to Entry of Substances Into Seminiferous Tubules:
Compatibility of Morphological and Physiological
Evidence / Lonnie D Russell 3
Cell-Cell Interactions In the Testis: A Guide for the Perplexed /
Irving Bamdas Fritz 19
Correlation between Prollferative Activity of Mouse
Spermatogonlal Stem Cells and Their Sensitivity for Cell
Killing and Induction of Reciprocal Translocations by
Irradiation / Dirk G de Rooij, Yvonne van der Meer,
Ans M M van Pelt, and Paul P W van Buul 35
Use of Heritable Mutations In the Analysis of Meiosis /
Mary Ann Handel 51
Regulation of Testicular Postmelotlc Genes / Norman B Hecht 67
Molecular Targets, DNA Breakage, and DNA Repair: Their Roles
in Mutation Induction In Mammalian Germ Cells /
Gary A Sega 79
Detecting Specific-locus Mutations In Human Sperm /
Andrew J Wyrobek, Marge Currie, Jackie L Stilwell,
Rod Balhorn, and Larry H Stanker 93
SECTION 2: ABERRANT CHROMOSOME STRUCTURE / BEHAVIOR
Clastogenlc Effects of Acrylamlde in Different Germ-cell Stages
of Male Mice / Ilse-Dore Adler 115
xv
xvi / Contents
The Synaptonemal Complex as an Indicator of Induced
Chromosome Damage / Montrose J Moses, Patricia
Poorman-Allen, James H Tepperberg, James B Gibson,
Lorraine C Backer, and James W Allen 133
Synaptonemal Complex Analysis of Mutagen Effects on Meiotic
Chromosome Structure and Behavior / James W Allen,
Patricia Poorman-Allen, Lorraine C Backer, Barbara
Westbrook-Collins, and Montrose J Moses 155
Meiosis and Experimentation jn the Yeast Saccharomyces
cerevislae I Michael E Dresser 171
Human Sperm Cytogenetics and the One-cell Zygote /
Brigitte F Brandriff and Laurie A Gordon 183
Chromosome Aberrations Associated with Induced Mutations:
Effect on Mapping New Mutations / Muriel T Davisson and
Susan E Lewis 195
SECTION 3: VARIABLES AFFECTING THE RATE AND NATURE
OF MUTATIONS
Factors Affecting Mutation Induction by X-rays in the
Spermatogonial Stem Cells of Mice of Strain 101/H /
Bruce M Cattanach, Carol Rasberry, and Colin Beechey 209
Toward an Understanding of the Mechanisms of Mutation
Induction by Ethyinitrosourea In Germ Cells of the Mouse /
Jack Favor 221
Mosaic Mutants Induced by Ethyinitrosourea In Late Germ Cells
of Mice / Susan E Lewis, Lois B Barnett, and Raymond A Popp 237
Analysis of Eiectrophoreticaiiy Detected Mutations Induced in
Mouse Germ Cells by Ethyinitrosourea /Josephine Peters,
Janet Jones, Simon T Ball, and John B Clegg 247
Investigating Inborn Errors of Phenylalanine Metabolism by
Efficient Mutagenesis of the Mouse Germ Line /
J David McDonald, AlexandraShedlovsky, and William F Dove 259
Contents / xvil
• Factors Affecting the Nature of Induced Mutations /
Liane B Russell, William L Russell, Eugene M Rinchik, and
Patricia R Hunsicker 271
SECTION 4: NONMUTATIONAL GENETIC EFFECTS ON EARLY
DEVELOPMENT
Effect of Imprinting on Analysis of Genetic Mutations /
Julie DeLoia and Davor Solter 293
What Is the Radiosensitive Target of Mammalian Gametes and
Embryos at Low Doses of Radiation? / Lynn M Wiley 299
Developmental Anomalies: Mutatlonal Consequence of Mouse *
Zygote Exposure / Walderico M Generoso, Joe C Rutledge,
and John Aronson 311
Manipulation of the Mouse Genome by Homologous
Recombination / Oliver Smithies and Beverly H Kolier 321
SECTION 5: UTILIZATION OF DNA TECHNIQUES IN THE
DETECTION OF GERM-LINE MUTATIONS
Molecular Approaches to the Estimation of Germinal Gene
Mutation Rates / Harvey W Mohrenweiser, Brian A Perry,
and Stephen A Judd 335
Quantitation and Characterization of Human Germinal Mutations
at Hypervariable Loci / Bruce W Kovacs, Bejan Shahbahrami,
and David E Comings 351
VAnalysis of DNA Sequences In Individual Human Sperm
Using PCR / Norman Arnheim 363
Insertional Mutagenesis in Transgenic Mice / Richard P Woychik,
Barbara R Beatty, William L McKinney, Debra K Andreadis,
Anne J Chang, and P Eugene Barker 377
xvlll / Contents
SECTION 6: GENETIC RISK ESTIMATION
IT Problems and Possibilities in Genetic Risk Estimation /
William L Russell 385
f
Quantification of Germ-cell Risk Associated with the Induction of
Heritable Translocations / Vicki L Dellarco and Lorenz R Rhomberg 397
^ Use of Germ-cell Mutagenicity Testing by the U S Environmental
Protection Agency Office of Toxic Substances /
Michael C Cimino and Angela E Auletta 413
/ Mammalian Heritable Effects Research in the National Toxicology
Program / Jack B Bishop and Michael D Shelby 425
- The Importance of the Direct Method of Genetic Risk Estimation
and Ways to Improve It / Paul B Selby 437
VAspects of Germ Cells Relevant to Mutagenic Risk Evaluations:
Some Concluding Remarks / Bryn A Bridges 451
Author Index 455
Subject Index 457
|
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| dewey-ones | 599 - Mammalia |
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| dewey-tens | 590 - Animals |
| discipline | Biologie |
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| spelling | Biology of mammalian germ cell mutagenesis ed. by James W. Allen Cold Spring Harbor, NY Cold Spring Harbor Laboratory Press 1990 XVIII, 461 S. Ill. txt rdacontent n rdamedia nc rdacarrier Banbury report 34 Cellules germinales - Congrès Mutagénicité - Congrès Mutation (Biologie) - Congrès Chromosome Aberrations Congresses Germ Cells Congresses Germ cells Congresses Mutagenicity Tests Congresses Mutagenicity testing Congresses Mutation (Biology) Congresses Mutation Congresses Risk Factors Congresses Säugetiere (DE-588)4051253-8 gnd rswk-swf Gamet (DE-588)4157017-0 gnd rswk-swf Mutagenese (DE-588)4170881-7 gnd rswk-swf (DE-588)1071861417 Konferenzschrift 1989 Cold Spring Harbor NY gnd-content (DE-588)1071861417 Konferenzschrift 1989 New York, NY gnd-content Säugetiere (DE-588)4051253-8 s Gamet (DE-588)4157017-0 s Mutagenese (DE-588)4170881-7 s DE-604 Allen, James W. Sonstige oth Banbury report 34 (DE-604)BV000005169 34 HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=002631164&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Biology of mammalian germ cell mutagenesis Banbury report Cellules germinales - Congrès Mutagénicité - Congrès Mutation (Biologie) - Congrès Chromosome Aberrations Congresses Germ Cells Congresses Germ cells Congresses Mutagenicity Tests Congresses Mutagenicity testing Congresses Mutation (Biology) Congresses Mutation Congresses Risk Factors Congresses Säugetiere (DE-588)4051253-8 gnd Gamet (DE-588)4157017-0 gnd Mutagenese (DE-588)4170881-7 gnd |
| subject_GND | (DE-588)4051253-8 (DE-588)4157017-0 (DE-588)4170881-7 (DE-588)1071861417 |
| title | Biology of mammalian germ cell mutagenesis |
| title_auth | Biology of mammalian germ cell mutagenesis |
| title_exact_search | Biology of mammalian germ cell mutagenesis |
| title_full | Biology of mammalian germ cell mutagenesis ed. by James W. Allen |
| title_fullStr | Biology of mammalian germ cell mutagenesis ed. by James W. Allen |
| title_full_unstemmed | Biology of mammalian germ cell mutagenesis ed. by James W. Allen |
| title_short | Biology of mammalian germ cell mutagenesis |
| title_sort | biology of mammalian germ cell mutagenesis |
| topic | Cellules germinales - Congrès Mutagénicité - Congrès Mutation (Biologie) - Congrès Chromosome Aberrations Congresses Germ Cells Congresses Germ cells Congresses Mutagenicity Tests Congresses Mutagenicity testing Congresses Mutation (Biology) Congresses Mutation Congresses Risk Factors Congresses Säugetiere (DE-588)4051253-8 gnd Gamet (DE-588)4157017-0 gnd Mutagenese (DE-588)4170881-7 gnd |
| topic_facet | Cellules germinales - Congrès Mutagénicité - Congrès Mutation (Biologie) - Congrès Chromosome Aberrations Congresses Germ Cells Congresses Germ cells Congresses Mutagenicity Tests Congresses Mutagenicity testing Congresses Mutation (Biology) Congresses Mutation Congresses Risk Factors Congresses Säugetiere Gamet Mutagenese Konferenzschrift 1989 Cold Spring Harbor NY Konferenzschrift 1989 New York, NY |
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