Early phase drug evaluation in man:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Boca Raton u.a.
CRC Pr.
1990
|
| Ausgabe: | 1. publ. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | X, 737 S. |
| ISBN: | 0849377080 |
Internformat
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| 245 | 1 | 0 | |a Early phase drug evaluation in man |c ed. by John O'Grady ... |
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Datensatz im Suchindex
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| adam_text | HI - EARLY PHASE DRUG EVALUATION IN MAN EDITED BY JOHN O GRADY, MD, FRCP
MEDICAL DIRECTOR MAY AND BAKER PHARMACEUTICALS RHONE-POULENC LTD
DAGENHAM RM10 7XS, UK AND VISITING PROFESSOR OF CLINICAL PHARMACOLOGY
UNIVERSITY OF VIENNA, AUSTRIA AND OTTO I. LINET, MD,PIID DIRECTOR OF
CLINICAL DEVELOPMENT UNIT 1 THE UPJOHN COMPANY KALAMAZOO, MI 49001, USA
M MACMILLAN PRESS SCIENTIFIC & MEDICAL CONTENTS FOREWORD SIR JOHN VANE
IX PREFACE X I. PRELIMINARIES TO TESTING OF DRUGS IN MAN 1 1. THE
PHARMACEUTICAL BACKGROUND 3 5. C. VALVANI 2. THE PHARMACOLOGICAL
BACKGROUND 14 B. J. R. WHITTLE, J. A. SALMON ANDR. M. FERRIS 3. THE
METABOLIC BACKGROUND 25 W. J. ADAMS 4. THE TOXICOLOGICAL BACKGROUND 39
A. DAY AN 5. ANIMAL TESTS AS PREDICTORS OF HUMAN RESPONSE 63 P. I. FOLB
6. INTERNATIONAL REGULATORY REQUIREMENTS 83 F. W. TEATHER 7. REGULATORY
REQUIREMENTS IN JAPAN 89 Y. YOSHINO II. ORGANISATION AND DECISION MAKING
97 8. THE ORGANISATION OF NEW DRUG EVALUATION IN THE PHARMACEUTICAL
INDUSTRY 99 Y. CHAMPEY 9. THE ROLE OF CONTRACT RESEARCH UNITS 110 A. P.
FLETCHER 10. DECISION POINTS IN HUMAN DRUG DEVELOPMENT 121 R. D. MAMELOK
AND J . N. LESSEM 11. GOOD CLINICAL RESEARCH PRACTICE AND QUALITY
ASSURANCE 127 B. GENNERY III. ETHICAL AND LEGAL CONSIDERATIONS 137 12.
ETHICAL ASPECTS OF RESEARCH IN HEALTHY VOLUNTEERS 139 S. /. WARRINGTON
VI CONTENTS 13. ETHICAL ASPECTS OF RESEARCH IN PATIENTS 150 F. WELLS 14.
LEGAL LIABILITIES IN CLINICAL TRIALS 161 /. C. DODDS-SMITH IV. MEASURING
DRUG ACTIVITY IN MAN 193 15. THE ASSESSMENT OF TOLERANCE AND
SIDE-EFFECTS IN NON-PATIENT VOLUNTEERS 195 D. JACKSON 16. DESIGN OF
FIRST-ADMINISTRATION STUDIES IN HEALTHY MAN 207 C. BROOM 17. THE
DETECTION AND ASSESSMENT OF ADVERSE REACTIONS IN EARLY PHASE PATIENT
TRIALS 214 /. N. LESSEM AND R. D. MAMELOK 18. THE ASSESSMENT OF
PHARMACODYNAMIC EFFECTS 220 J. D. HARRY 19. THE ASSESSMENT OF
PHARMACOKINETICS 229 5. TOON 20. RADIOLABELLED METABOLISM STUDIES IN MAN
243 J. MCEWEN AND I. H. STEVENSON V. ASSESSMENT OF DRUG EFFECTS ON THE
CARDIOVASCULAR SYSTEM 251 21. NON-INVASIVE MEASUREMENT OF CARDIOVASCULAR
RESPONSE 253 /. D. HARRY 22. ANTI-ANGINAL DRUGS 265 E. ROLAND 23.
ANTI-ARRHYTHMIC AGENTS 288 P. K. MARROTT 24. PHASE I TRIALS ON
ANTI-HYPERTENSIVE DRUGS ; 302 /. R. COCKCROFTAND D. J. WEBB 25. DRUGS
FOR HEART FAILURE 313 /. E. RUSH AND M. JESSUP 26. ANTITHROMBOTIC AND
THROMBOLYTIC DRUGS 326 /. RITTER 27. MONITORING OF ANTITHROMBOTIC
ACTIVITY BY PLATELET LABELLING 337 H. SINZINGER AND P. FITSCHA VI.
ASSESSMENT OF DRUG EFFECTS ON THE RESPIRATORY SYSTEM 349 28. ASSESSMENT
OF RESPIRATORY RESPONSES 351 T. W. EVANS AND P. J. BARNES 29.
ANTI-ASTHMATIC DRUGS 362 A. M. EDWARDS CONTENTS VII VII. ASSESSMENT OF
DRUG EFFECTS ON THE CENTRAL NERVOUS SYSTEM 377 30. MEASUREMENT OF CNS
EFFECTS 379 B. MUSCH, I. HINDMARCH AND B. SALETU 31. DRUGS IN EPILEPSY
395 /. /. MORROW AND A. RICHENS 32. ANXIOLYTICS 407 B. MUSCH 33.
HYPNOTICS 421 G. R. MCCLELLAND AND P. J. SUMMERFIELD 34. ANTIDEPRESSANTS
433 J. L. SIEGEL, Z. E. DZIEWANOWSKA AND H. LAINE 35. ANTIPSYCHOTIC
AGENTS 443 T. H. CORN ANDJ. R. M. HAIGH VIII. ASSESSMENT OF DRUG EFFECTS
ON THE GASTRO-INTESTINAL SYSTEM 455 36. MEASUREMENT OF GASTRO-INTESTINAL
EFFECTS 457 K. H. ANTONIN AND P. R. BIECK 37. ANTI-ULCER DRUGS 481 C.
BROOM IX. ASSESSMENT OF DRUG EFFECTS ON THE KIDNEY 493 38. DIURETICS 495
J. MCMURRAY AND J. MCEWEN 39. MEASUREMENT OF RENAL SIDE-EFFECTS 508 A.
DAWNAY X. ASSESSMENT OF THE EFFECTS OF DRUGS USED IN OBSTETRICS AND
GYNAECOLOGY 519 40. ABORTIFACIENT DRUGS 521 M. BYGDEMAN 41. OXYTOCIC
DRUGS 532 M . BAMBER AND M. G. ELDER XL ASSESSMENT OF DRUG ACTIVITY IN
THE SKIN 551 42. MEASUREMENT OF SKIN RESPONSE TO DRUGS 553 S. SHUSTER,
P. M. FAN AND C. M. LAWRENCE 43. DRUGS FOR ECZEMA 566 /. R. GIBSON AND
V. K. MANNA 44. DRUGS AFFECTING HAIR GROWTH 586 E. NOVAK VIII CONTENTS
XII. ASSESSMENT OF DRUGS USED FOR THE TREATMENT OF METABOLIC DISORDERS
599 45. HYPOLIPIDAEMIC DRUGS 601 R. H. JAY AND D. J. BETTERIDGE 46.
ANTIDIABETIC DRUGS 611 D. C. HOWEY XIII. ASSESSMENT OF THE EFFECTS OF
CHEMOTHERAPEUTIC AGENTS 625 47. ANTIBACTERIAL DRUGS 627 A. PICKUP 48.
ANTIVIRAL DRUGS 631 W.SOO 49. ANTICANCER DRUGS 644 L. SCHACTER, M.
ROZENCWEIG, C. NICAISE, R. CANETTA, S. KELLY AND L. SMALDONE XIV.
ASSESSMENT OF DRUGS AFFECTING THE INFLAMMATORY PROCESS AND PAIN 655 50.
DRUGS AFFECTING THE IMMUNE RESPONSE 657 M. ROONEY AND G. DUFF 51.
ANTI-INFLAMMATORY DRUGS 674 P. S. HELLIWELLAND V. WRIGHT 52. ANALGESICS
689 R. L. HOLLAND INDEX 703
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| isbn | 0849377080 |
| language | English |
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| physical | X, 737 S. |
| publishDate | 1990 |
| publishDateSearch | 1990 |
| publishDateSort | 1990 |
| publisher | CRC Pr. |
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| spelling | Early phase drug evaluation in man ed. by John O'Grady ... 1. publ. Boca Raton u.a. CRC Pr. 1990 X, 737 S. txt rdacontent n rdamedia nc rdacarrier Médicaments - Essais cliniques Clinical trials Drug Evaluation Drugs Testing Medizinische Ethik (DE-588)4074672-0 gnd rswk-swf Methode (DE-588)4038971-6 gnd rswk-swf Klinische Prüfung (DE-588)4031192-2 gnd rswk-swf Klinische Prüfung (DE-588)4031192-2 s Medizinische Ethik (DE-588)4074672-0 s DE-604 Methode (DE-588)4038971-6 s O'Grady, John Sonstige oth GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=002597903&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Early phase drug evaluation in man Médicaments - Essais cliniques Clinical trials Drug Evaluation Drugs Testing Medizinische Ethik (DE-588)4074672-0 gnd Methode (DE-588)4038971-6 gnd Klinische Prüfung (DE-588)4031192-2 gnd |
| subject_GND | (DE-588)4074672-0 (DE-588)4038971-6 (DE-588)4031192-2 |
| title | Early phase drug evaluation in man |
| title_auth | Early phase drug evaluation in man |
| title_exact_search | Early phase drug evaluation in man |
| title_full | Early phase drug evaluation in man ed. by John O'Grady ... |
| title_fullStr | Early phase drug evaluation in man ed. by John O'Grady ... |
| title_full_unstemmed | Early phase drug evaluation in man ed. by John O'Grady ... |
| title_short | Early phase drug evaluation in man |
| title_sort | early phase drug evaluation in man |
| topic | Médicaments - Essais cliniques Clinical trials Drug Evaluation Drugs Testing Medizinische Ethik (DE-588)4074672-0 gnd Methode (DE-588)4038971-6 gnd Klinische Prüfung (DE-588)4031192-2 gnd |
| topic_facet | Médicaments - Essais cliniques Clinical trials Drug Evaluation Drugs Testing Medizinische Ethik Methode Klinische Prüfung |
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