Tin-based antitumour drugs: [proceedings of the NATO Advanced Research Workshop on the Effect of Tin upon Malignant Cell Growth held in Brussels, Belgium, July 16 - 20, 1989]
Gespeichert in:
| Format: | Tagungsbericht Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Berlin u.a.
Springer
1990
|
| Schriftenreihe: | NATO: [Nato ASI series / H]
37 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | VIII, 226 S. Ill. |
| ISBN: | 3540504176 0387504176 |
Internformat
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Datensatz im Suchindex
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| adam_text |
TIN-BASED ANTITUMOUR DRUGS EDITED BY M. GIELEN VRIJE UNIVERSITEIT
BRUSSEL, ROOM 8G512, PLEINLAAN 2, B-1050 BRUSSELS, BELGIUM
SPRINGER-VERLAG BERLIN HEIDELBERG NEWYORK LONDON PARIS TOKYO HONG KONG
PUBLISHED IN COOPERATION WITH NATO SCIENTIFIC AFFAIRS DIVISION CONTENTS
THE ROLE OF NON-PLATINUM COMPLEXES IN CANCER THERAPY 1 BERNHARD K.
KEPPLER TUMOR-INHIBITING METAL COMPLEXES AND THE DEVELOPMENT OF
CISPLATIN 1 THE DEVELOPMENT OF NEW TUMOR-INHIBITING METAL COMPLEXES 9
FUNDAMENTAL STRATEGIES 9 METHODS 9 SYNTHESIS OF DIRECT DERIVATIVES OF
CISPLATIN 15 BASIC IDEAS 15 THE DEVELOPMENT OF NON-PLATINUM COMPLEXES 17
NON-PLATINUM COMPLEXES IN PRECLINICAL TRIALS 17 TUMOR-INHIBITING
RUTHENIUM COMPLEXES 24 NON-PLATINUM COMPLEXES IN CLINICAL STUDIES 39
GALLIUM AND GERMANIUM COMPOUNDS IN CLINICAL STUDIES 40 PRECLINICAL AND
CLINICAL DEVELOPMENT OF BUDOTITANE 41 STRUCTURE-ACTIVITY RELATION OF
TUMOR-INHIBITING BIS(P'-DIKETONATO) METAL COMPLEXES 43 VARIATION OF THE
(P-DIKETONATO) LIGAND 44 VARIATION OF THE CENTRAL METAL 47 VARIATION OF
THE GROUP X 48 ANTITUMOR ACTIVITY IN OTHER TRANSPLANTABLE TUMOR MODELS
50 THERAPY RESULTS ON AUTOCHTONOUS, AMMN-LNDUCED, COLORECTAL TUMORS WITH
BUDOTITANE 51 TOXICITY OF BUDOTITANE 53 BUDOTITANE CLINICAL PHASE I
STUDY 54 DRUG TARGETING 55 PERSPECTIVES 58 REFERENCES 60 TIN COMPOUNDS
AND THEIR POTENTIAL AS PHARMACEUTICAL AGENTS 69 ALAN CROWE INTRODUCTION
69 TIN PROTOPORPHYRIN FOR THE TREATMENT OF NEONATAL JAUNDICE 72
ANTITUMOUR PROPERTIES OF TIN CHEMICALS 80 MODE OF ACTION 91 THE USE OF
TIN DERIVATIVES IN THE PHOTODYNAMIC THERAPY OF CANCER 95 TIN DERIVATIVES
AS ANTIVIRAL AGENTS 102 OTHER PHARMACEUTICAL USES 104 CONCLUSION 105
ACKNOWLEDGEMENTS ' 108 REFERENCES 108 VII THE ROLE OF NATURAL TIN
HORMONES IN SENESCENCE: A HYPOTHESIS 115 NATE F. CARDARELLI BACKGROUND:
IMMUNE INVOLVEMENT 115 BACKGROUND: GEROPROTECTIVE EFFECTS OF TIN 120
CAPITULATION 121 ONTOGENY OF THE IMMUNE SYSTEM 121 IMMUNE THEORY OF
AGING 123 THYMUS-PINEAL AXIS 124 LIFE PATTERN HYPOTHESIS 127 TIN
DEPRIVATION AND LIFE SPAN 129 TIN AND THE LIFE PATTERN 131 SUMMARY 136
REFERENCES 139 THE SPECIATION AND BIOAVAILABILITY OF TIN IN BIOFLUIDS
147 J.R. DUFFIELD, C.R. MORRIS, D.M. MORRISH, J.A. VESEY AND DAVID R.
WILLIAMS INTRODUCTION 147 HISTORICAL OUTLINE 147 SPECIATION STUDIES 149
EXPERIMENTAL 150 MATERIALS 150 PROCEDURE 150 RESULTS 153 FORMATION
CONSTANTS MEASUREMENT 153 REGRESSION ANALYSIS 155 SPECIATION MODELLING \
155 DISCUSSION \ 158 TIN IN CANNED FOOD 158 BIOAVAILABILITY 160 TOXICITY
AND ESSENTIALITY 161 CONCLUSIONS 163 ACKNOWLEDGEMENTS 164 REFERENCES 164
CELLULAR INTERACTIONS OF ORGANOTIN COMPOUNDS IN RELATION TO THEIR
ANTITUMOR ACTIVITY 169 ANDRE PENNINKS INTRODUCTION 169 DIRECT CYTOTOXIC
EFFECTS 170 DISTURBANCES OF MITOCHONDRIAL ENERGETICS IN VITRO 173 VIII
DISTURBANCES OF CELLULAR ENERGETICS IN VITRO 176 DISTURBANCES OF
MACROMOLECULAR SYNTHESIS IN VITRO 178 SUMMARY AND CONCLUSIONS ON THE
CELLULAR EFFECTS OF ORGANOTINS 180 VIVO-VITRO RELATION OF ANTITUMOUR
ACTIVITY OF ORGANOTINS 182 MODE OF ACTION OF ORGANOTINS IN RELATION TO
THEIR ANTITUMOR ACTIVITY 184 REFERENCES 186 SELECTIVITY OF
ANTIPROLIFERATIVE EFFECTS OF DIALKYLTIN COMPOUNDS IN VITRO AND IN VIVO
191 GERHARD HENNIGHAUSEN AND STANISLAW SZYMANIEC COMPUTER ASSISTED
STRUCTURE-ACTIVITY CORRELATIONS OF ORGANOTIN COMPOUNDS AS POTENTIAL
ANTICANCER AND ANTI-HIV AGENTS 201 VEN NARAYANAN, MOHAMED NASR AND
KENNETH D. PAULL INTRODUCTION 201 RESULTS 201 DISCUSSION 203 CONCLUSIONS
216 REFERENCES 216 ROUTE OF ADMINISTRATION IS A DETERMINANT OF THE
TISSUE DISPOSITION AND EFFECTS OF TBTO ON CYTOCHROME P-450-DEPENDENT
DRUG METABOLISM 219 DANIEL W. ROSENBERG INTRODUCTION 219 MATERIALS AND
METHODS 219 RESULTS AND DISCUSSION 221 ACKNOWLEDGEMENTS 224 REFERENCES
225 |
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| discipline | Medizin |
| format | Conference Proceeding Book |
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| spelling | Tin-based antitumour drugs [proceedings of the NATO Advanced Research Workshop on the Effect of Tin upon Malignant Cell Growth held in Brussels, Belgium, July 16 - 20, 1989] ed. by M. Gielen Berlin u.a. Springer 1990 VIII, 226 S. Ill. txt rdacontent n rdamedia nc rdacarrier NATO: [Nato ASI series / H] 37 Cytostatikum (DE-588)4068347-3 gnd rswk-swf Zinnverbindungen (DE-588)4190914-8 gnd rswk-swf Zinn (DE-588)4190888-0 gnd rswk-swf (DE-588)1071861417 Konferenzschrift 1989 Brüssel gnd-content Zinnverbindungen (DE-588)4190914-8 s Cytostatikum (DE-588)4068347-3 s DE-604 Zinn (DE-588)4190888-0 s Gielen, Marcel Sonstige oth Advanced Research Workshop on the Effect of Tin upon Malignant Cell Growth 1989 Brüssel Sonstige (DE-588)2110464-5 oth H] NATO: [Nato ASI series 37 (DE-604)BV000023246 37 GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=002543732&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Tin-based antitumour drugs [proceedings of the NATO Advanced Research Workshop on the Effect of Tin upon Malignant Cell Growth held in Brussels, Belgium, July 16 - 20, 1989] Cytostatikum (DE-588)4068347-3 gnd Zinnverbindungen (DE-588)4190914-8 gnd Zinn (DE-588)4190888-0 gnd |
| subject_GND | (DE-588)4068347-3 (DE-588)4190914-8 (DE-588)4190888-0 (DE-588)1071861417 |
| title | Tin-based antitumour drugs [proceedings of the NATO Advanced Research Workshop on the Effect of Tin upon Malignant Cell Growth held in Brussels, Belgium, July 16 - 20, 1989] |
| title_auth | Tin-based antitumour drugs [proceedings of the NATO Advanced Research Workshop on the Effect of Tin upon Malignant Cell Growth held in Brussels, Belgium, July 16 - 20, 1989] |
| title_exact_search | Tin-based antitumour drugs [proceedings of the NATO Advanced Research Workshop on the Effect of Tin upon Malignant Cell Growth held in Brussels, Belgium, July 16 - 20, 1989] |
| title_full | Tin-based antitumour drugs [proceedings of the NATO Advanced Research Workshop on the Effect of Tin upon Malignant Cell Growth held in Brussels, Belgium, July 16 - 20, 1989] ed. by M. Gielen |
| title_fullStr | Tin-based antitumour drugs [proceedings of the NATO Advanced Research Workshop on the Effect of Tin upon Malignant Cell Growth held in Brussels, Belgium, July 16 - 20, 1989] ed. by M. Gielen |
| title_full_unstemmed | Tin-based antitumour drugs [proceedings of the NATO Advanced Research Workshop on the Effect of Tin upon Malignant Cell Growth held in Brussels, Belgium, July 16 - 20, 1989] ed. by M. Gielen |
| title_short | Tin-based antitumour drugs |
| title_sort | tin based antitumour drugs proceedings of the nato advanced research workshop on the effect of tin upon malignant cell growth held in brussels belgium july 16 20 1989 |
| title_sub | [proceedings of the NATO Advanced Research Workshop on the Effect of Tin upon Malignant Cell Growth held in Brussels, Belgium, July 16 - 20, 1989] |
| topic | Cytostatikum (DE-588)4068347-3 gnd Zinnverbindungen (DE-588)4190914-8 gnd Zinn (DE-588)4190888-0 gnd |
| topic_facet | Cytostatikum Zinnverbindungen Zinn Konferenzschrift 1989 Brüssel |
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| volume_link | (DE-604)BV000023246 |
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