Synthetic peptides in biotechnology:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York
Liss
1988
|
| Schriftenreihe: | Advances in biotechnological processes
10 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XI, 239 S. Ill. |
| ISBN: | 0845132091 |
Internformat
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| 650 | 2 | |a Peptides - synthèse chimique | |
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Datensatz im Suchindex
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| adam_text | V ADVANCES IN BIOTECHNOLOGICAL PROCESSES VOLUME 10 SYNTHETIC PEPTIDES IN
BIOTECHNOLOGY EDITOR AVSHALOM MIZRAHI ISRAEL INSTITUTE FOR BIOLOGICAL
RESEARCH NESS ZIONA, ISRAEL ALAN R. LISS, INC., NEW YORK CONTENTS
CONTRIBUTORS IX PREFACE AVSHALOM MIZRAHI XI AUTOMATION OF PEPTIDE
SYNTHESIS RAYMOND NEWTON AND JOHN E. FOX I. THE CHEMISTRY OF PEPTIDE
SYNTHESIS 2 . II. INSTRUMENTATION FOR SOLID-PHASE PEPTIDE SYNTHESIS 9 A.
BASIC REQUIREMENTS 9 B. REAGENT DELIVERY SYSTEMS 10 C. REACTION VESSELS
12 D. GENERAL OPERATION OF AUTOMATIC SYNTHESIZERS 17 1. SEMIAUTOMATIC
INSTRUMENTS 17 2. FULLY AUTOMATIC SYNTHESIZERS 18 3. AUTOMATIC
SYNTHESIZERS DESIGNED SPECIFICALLY FOR USE WITH FMOC CHEMISTRY 20 E.
SOFTWARE FOR CONTROL OF PEPTIDE SYNTHESIZERS 21 1. SEMIAUTOMATIC
SYNTHESIZERS 21 2. SOFTWARE FOR FULLY AUTOMATIC SYNTHESIZERS 22 III.
FUTURE DEVELOPMENTS 23 POSSIBILITIES AND LIMITATIONS OF SYNTHETIC
PEPTIDE VACCINES S.J. BARTELING I. CONSTRUCTED IMMUNOGENS, A NEW
GENERATION OF VACCINES 28 A. CONSTRUCTED MONO- AND POLYVALENT MODIFIED
LIVE-VIRUS VACCINES 28 B. BIOSYNTHETIC VACCINES . . . . 29 C.
SYNTHETIC PEPTIDE VACCINES 29 II. PROGRESS IN THE PREPARATION OF
SYNTHETIC PEPTIDE VACCINES 30 A. ANTIBACTERIAL AND ANTITOXOID VACCINES
30 B. ANTIPARASITIC VACCINES 31 C. ANTIVIRAL VACCINES 31 III. ANTIGENS
AND IMMUNOGENS 35 A. ANTIGENICITY VERSUS IMMUNOGENICITY . . 35 B.
EPITOPES, PARATOPES, ANTIGENIC SITES, AND ANTIGENIC DOMAINS 35 C.
STRUCTURAL ASPECTS OF EPITOPES 36 IV. PREDICTION OF EPITOPES 37 A.
ACCESSIBILITY 37 B. HYDROPHILICITY, SECONDARY STRUCTURE, AND MOBILITY 38
V. USE OF ANTIBODIES TO DETECT EPITOPES 39 A. ISOLATION OF VIRUS MUTANTS
RESISTANT TO MONOCLONAL ANTIBODIES 39 B. RECOGNITION OF RANDOM PROTEIN
FRAGMENTS AND SYSTEMATIC TRUNCATED PROTEINS . 39 VI 0 CONTENTS C.
PEPSCAN ANALYSIS 40 D. MULTIPLE T-BAG PEPTIDE SYNTHESIS 41 E. MIMOTOPE
ANALYSIS 42 VI. REQUIREMENTS FOR IMMUNOGENICITY OF PEPTIDES 43 VII.
ADJUVANTS AND CARRIERS 44 A. ADJUVANTS 44 B. CARRIERS 45 VIII.
POSSIBILITIES AND LIMITATIONS OF VACCINE CONSTRUCTION 46 IX. FUTURE
ASPECTS: NONPROPHYLACTIC APPLICATIONS 48 ANTI-PEPTIDE ANTIBODIES TO
ONCOPROTEINS: THE PREDETERMINED SPECIFICITY AND DETECTION OF GENE
PRODUCTS PREDICTED BY NUCLEOTIDE SEQUENCE ANALYSES TAKEO TANAKA AND
MARTIN J. CLINE I. GENERATION OF ANTIPEPTIDE ANTIBODIES 62 II. DETECTION
OF RAS GENE PRODUCTS PREDICTED FROM NUCLEIC ACID SEQUENCES 68 A.
DETECTION OF C-RAS P2 IS IN NORMAL RAT TISSUES 71 B. DETECTION OF P21
RAS ONCOPROTEINS IN HUMAN CANCERS 73 III. CLINICAL APPLICATION OF THE
ANTIBODIES 73 APPLICATION OF CHEMICALLY SYNTHETIC PEPTIDES IN CLINICAL
DIAGNOSIS OF VIRUSES: THEORETICAL AND PRACTICAL CONSIDERATIONS NAOMI
ARIEL, DAVID KATZ, AND EYTAN ALHANATY I. DETECTION OF VIRUSES AND VIRAL
ANTIGENS 82 II. DETECTION OF ANTIVIRAL ANTIBODIES 82 III. LOCALIZATION
AND CHARACTERIZATION OF ANTIGENIC EPITOPES IN PROTEINS*FROM INTACT
PROTEINS TO SYNTHETIC PEPTIDES 83 IV. NOVEL MULTIPEPTIDE SYNTHETIC
METHODS FOR EPITOPE LOCALIZATION 85 V. THE USE OF SYNTHETIC PEPTIDES FOR
VIRAL DIAGNOSIS 87 A. ACQUIRED IMMUNE DEFICIENCY SYNDROME (AIDS) 87 B.
EPSTEIN-BARR VIRUS (EBV) 88 C. MALARIA 89 D. HEPATITIS B 89 VI.
SYNTHETIC PEPTIDES AS IMMUNOGENS FOR THE PRODUCTION OF SPECIFIC
ANTIBODIES . . . . 90 VII. PROSPECTIVE DEVELOPMENTS . . . 91 SYNTHETIC
FLUOROPEPTIDES AS PHARMACOLOGICALLY USEFUL COMPOUNDS BARBARA IMPERIALI
I. BACKGROUND 97 II. FLUORINATED INHIBITORS OF PROTEOLYTIC ENZYMES 99 A.
SERINE PROTEASES . 100 1. IRREVERSIBLE INHIBITORS . 100 2. REVERSIBLE
INHIBITORS 107 B. SULFHYDRYL PROTEASES 113 C. METALLOPROTEASES 113 D.
ASPARTYL PROTEASES 114 III. FLUORINATED ANALOGS OF PEPTIDE HORMONES AND
MISCELLANEOUS PEPTIDES 117 A. 4,4-DIFLUOROPROLINE 118 B.
P-FLUOROPHENYLALANINE * 120 CONTENTS 0 VII C. /3-FLUORO-L-ALANINE 121 D.
FLUORINATED HISTIDINE ANALOGS 121 E. FLUOROLYSINE 123 F.
/3-FLUOROASPARAGINE 124 IV. CONCLUSIONS AND PERSPECTIVES 125
SYNTHETIC-PEPTIDE-BASED IMMUNODIAGNOSIS OF RETROVIRUS INFECTIONS:
CURRENT STATUS AND FUTURE PROSPECTS CHANG YI WANG I. RETROVIRUS
STRUCTURE AND GENETIC ORGANIZATION 132 II. RETROVIRAL POLYPEPTIDES OF
SERODIAGNOSTIC IMPORTANCE 133 III. DYNAMICS OF THE ANTIBODY RESPONSE TO
HIV-1 INFECTION 134 IV. CURRENT STATUS IN SERODIAGNOSIS OF RETROVIRUS
INFECTIONS 135 V. SYNTHETIC-PEPTIDE APPROACH TO HIV-ANTIBODY SCREENING
137 A. INCREASED SPECIFICITY 139 B. INCREASED SENSITIVITY 139 C. EARLIER
DETECTION OF HIV-SPECIFIC ANTIBODIES 140 D. DECREASE IN TIME REQUIRED
FOR COMPLETION OF TEST RESULTING FROM AN ACCELERATION OF IMMUNOASSAY
REACTION KINETICS AS MIGHT BE PREDICTED BY THE LAW OF MASS ACTION 140 E.
ABSOLUTE CORRELATION WITH SEROPOSITIVITY DETERMINED BY WESTERN BLOT
ANALYSIS 140 F. A HIGH DEGREE OF LOT-TO-LOT REPRODUCIBILITY OF TEST
RESULTS 141 VI. EIAS FOR THE DETECTION OF HTLV-1 AND HIV-2 ANTIBODIES
141 VII. FUTURE PROSPECTS 144 OVERVIEW ON THE USE OF SYNTHETIC PEPTIDES
IN HUMAN IMMUNODEFICIENCY VIRUS INFECTION RONALD C. KENNEDY, TRAN C.
CHANH, JONATHAN S. ALLAN, GORDON R. DREESMAN, JORG W. EICHBERG, ROBERTO
CAUDA, AND PATRICK KANDA I. SYNTHETIC PEPTIDES DEFINE NATIVE HIV-1
EPITOPES 152 II. SYNTHETIC PEPTIDES RECOGNIZE ANTIBODIES FROM
HIV-SEROPOSITIVE INDIVIDUALS . . . . 156 III. SYNTHETIC PEPTIDES DEFINE
T-CELL DETERMINANTS 158 IV. HIV-1 ENVELOPE SYNTHETIC PEPTIDES ARE
IMMUNOSUPPRESSIVE 159 V. ANTIBODIES TO SYNTHETIC PEPTIDES EXHIBIT
ANTIBODY-DEPENDENT CELLULAR CYTOTOXICITY 160 VI. STUDIES INVOLVING
COMPLEMENTARY PEPTIDES SPECIFIED BY COMPLEMENTARY NUCLEIC ACID SEQUENCES
160 VII. PARTIAL SEQUENCE HOMOLOGY BETWEEN HIV AND NEUROLEUKIN 161 VIII.
STUDIES INVOLVING THE OCTAPEPTIDE DESIGNATED PEPTIDE T 162 IX. STUDIES
WITH SYNTHETIC PEPTIDES THAT REPRESENT PUTATIVE VACCINE CANDIDATES . . .
. 163 X. CONCLUDING REMARKS AND FUTURE CONSIDERATIONS 166 RECENT
DEVELOPMENTS IN ENZYMATIC SYNTHESIS OF PEPTIDE KAZUHIRO NAKANISHI AND
RYUICHI MATSUNO I. CHARACTERISTICS OF ENZYMATIC METHODS 174 A. GENERAL
ASPECTS OF ENZYMATIC SYNTHESIS 174 B. ADVANTAGES AND DISADVANTAGES OF
THE ^ENZYMATIC METHOD 175 C. EQUILIBRIUM OF PEPTIDE SYNTHESIS 176 II.
WAYS TO SHIFT THE EQUILIBRIUM TOWARD PEPTIDE SYNTHESIS 178 A. PRODUCT
PRECIPITATION METHOD 179 VIII 0 CONTENTS B. REACTION BY THE ADDITION OF
ORGANIC COSOLVENT 179 C. AQUEOUS/ORGANIC BIPHASIC REACTIONS 183 D.
REACTION WITH IMMOBILIZED ENZYME IN AN ORGANIC SOLVENT 186 E. REACTION
IN A REVERSED MICELLE 187 F. MISCELLANEOUS 188 III. KINETICS OF
AQUEOUS/ORGANIC BIPHASIC SYSTEM 189 IV. INDUSTRIAL APPLICATIONS 193 A.
SEMISYNTHESIS OF HUMAN INSULIN 194 B. SYNTHESIS OF ASPARTAME 195 V.
FINAL REMARKS 199 SYNTHETIC ENKEPHALIN ANALOGS: DESIGNING NEW DRUGS OF
PHARMACOLOGICAL INTEREST YASUYUKI SHIMOHIGASHI, CHARLES H. STAMMER, AND
TOMMASO COSTA I. RECEPTOR-SELECTIVE ENKEPHALIN ANALOGS 204 II.
ENKEPHALIN ANALOGS WITH CONFORMATIONAL RESTRICTIONS 205 A.
CONFORMATIONAL RESTRICTIONS 205 B. RIGIDIFICATION OF POSSIBLE /3-TURN
STRUCTURE IN ENKEPHALIN 206 C. CYCLIZATION OF ENKEPHALIN PEPTIDES 207 D.
INCORPORATION OF STRUCTURALLY CONSTRAINED AMINO ACIDS 210 III. DIMERIC
ENKEPHALIN ANALOGS 213 IV. CONCLUDING REMARKS 219 INDEX 225 CONTENTS OF
PREVIOUS VOLUMES 235
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| id | DE-604.BV004062867 |
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| indexdate | 2024-07-09T16:08:00Z |
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| isbn | 0845132091 |
| language | English |
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| physical | XI, 239 S. Ill. |
| publishDate | 1988 |
| publishDateSearch | 1988 |
| publishDateSort | 1988 |
| publisher | Liss |
| record_format | marc |
| series | Advances in biotechnological processes |
| series2 | Advances in biotechnological processes |
| spelling | Synthetic peptides in biotechnology ed.: Avshalom Mizrahi New York Liss 1988 XI, 239 S. Ill. txt rdacontent n rdamedia nc rdacarrier Advances in biotechnological processes 10 Biotechnologie Biotechnologie ram Peptides - synthèse chimique Peptides ram Biotechnology Peptides Synthesis Peptides chemical synthesis Vaccines Biotechnologie (DE-588)4069491-4 gnd rswk-swf Synthetische Peptide (DE-588)4271831-4 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Synthetische Peptide (DE-588)4271831-4 s Biotechnologie (DE-588)4069491-4 s DE-604 Mizrāḥî, Avšālôm Sonstige oth Advances in biotechnological processes 10 (DE-604)BV000833972 10 GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=002540633&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Synthetic peptides in biotechnology Advances in biotechnological processes Biotechnologie Biotechnologie ram Peptides - synthèse chimique Peptides ram Biotechnology Peptides Synthesis Peptides chemical synthesis Vaccines Biotechnologie (DE-588)4069491-4 gnd Synthetische Peptide (DE-588)4271831-4 gnd |
| subject_GND | (DE-588)4069491-4 (DE-588)4271831-4 (DE-588)4143413-4 |
| title | Synthetic peptides in biotechnology |
| title_auth | Synthetic peptides in biotechnology |
| title_exact_search | Synthetic peptides in biotechnology |
| title_full | Synthetic peptides in biotechnology ed.: Avshalom Mizrahi |
| title_fullStr | Synthetic peptides in biotechnology ed.: Avshalom Mizrahi |
| title_full_unstemmed | Synthetic peptides in biotechnology ed.: Avshalom Mizrahi |
| title_short | Synthetic peptides in biotechnology |
| title_sort | synthetic peptides in biotechnology |
| topic | Biotechnologie Biotechnologie ram Peptides - synthèse chimique Peptides ram Biotechnology Peptides Synthesis Peptides chemical synthesis Vaccines Biotechnologie (DE-588)4069491-4 gnd Synthetische Peptide (DE-588)4271831-4 gnd |
| topic_facet | Biotechnologie Peptides - synthèse chimique Peptides Biotechnology Peptides Synthesis Peptides chemical synthesis Vaccines Synthetische Peptide Aufsatzsammlung |
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