Verfügbarkeit: Natural history of the major histocompatibility complex

Natural history of the major histocompatibility complex:

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1. Verfasser:	Klein, Jan (VerfasserIn)
Format:	Buch
Sprache:	English
Veröffentlicht:	New York u.a. Wiley 1986
Schlagworte:	Complexe majeur d'histocompatibilité Genes, MHC Class II HLA histocompatibility antigens Histocompatibility Major Histocompatibility Complex Major histocompatibility complex MHC
Online-Zugang:	Inhaltsverzeichnis
Beschreibung:	XIX, 775 S. Ill., Kt.
ISBN:	0471809535

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MARC


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Datensatz im Suchindex

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adam_text	NATURAL HISTORY OF THE MAJOR HISTOCOMPATIBILITY COMPLEX Jan Klein Abteilung Immungenetik, Max-Planck-lnstitut fur Biologie, Tubingen, Federal Republic of Germany A WILEY-INTERSCIENCE PUBLICATION JOHN WILEY amp; SONS New York • Chichester * Brisbane * Toronto * Singapore CONTENTS A NOTE ABOUT REFERENCES AND ABBREVIATIONS JOURNAL ABBREVIATIONS OTHER ABBREVIATIONS 1 THE STORY At the Elms Development of Inbred Strains Beginning of Tumor Transplantation Beginning of Blood Group Research Discovery of Antigen II Inauguration of Histogenetic Methods and the Baptism of the H-2 Complex Discovery of the B Complex Discovery of the HLA Complex Discovery of ^-Microglobulin Discovery of Class II Molecules Discovery of the Mhc Function What Is Mhc? 2 THE GENE: ORGANISMIC APPROACH Chromosomes and Crossing-over Linkage and Genetic Maps Example of Genetic Analysis Intragenic Recombination Gene Mapping in Humans Alternative Ways of Gene Mapping Mhc in Vertebrates HLA Complex xv XVII XIX H-2 Complex 50 Mhc of Primates Other Than the Human 74 Mhc of Rodents Other Than the Mouse 76 Mhc of Lagomorphs 79 Mhc of Carnivores 80 Mhc of Ungulates 80 Mhc of Birds 82 Mhc of Amphibians 83 THE GENE: MOLECULAR APPROACH 87 Review of Nucleic Acid and Chromosome Structure 87 Gene Activation 89 DNA Transcription 94 RNA Modification 95 Translation of RNA 97 Isolation of Mhc Genes 98 In Vitro Translation 99 Cloning of Mhc Genes 100 Restriction Endonucleases—The Molecular Scissors 103 Tinker Tailor: Joining of DNA Molecules 104 Transfer of DNA into Host Cells 105 Selection for Mhc DNA 107 DNA Libraries 110 Screening of Libraries With a Probe 111 Use of Synthetic Oligodeoxynucleotides for Identification of Mhc Genes 112 Mapping of Mhc Genes 113 Sequencing of Mhc Genes 114 XI Expression of Cloned Genes in Mammalian Cells Counting the Genes Organizing the Genes Mhc Genes Alternative Splicing Pseudogenes and Secreted Molecules Molecular Map of the HLA Region Molecular Map of the H-2 Region Molecular Studies in Other Species Methylation and Regulation of Gene Expression 4 THE PROTEIN Structure of Plasma Membrane Cytoskeleton Topography of the Cell Surface Passive Diffusion Induced Redistribution Membrane Recycling Cell Cycle and Mhc Expression Tissue Distribution Isolation of Mhc Molecules Characterization Orientation in the Membrane Structure of the Class I a Chain /^-Microglobulin ~~ Structure of Class II Molecules Mutations in H-2E Loci Third Class of Mhc Molecules? Class II y Chain Biosynthesis of Mhc Molecules Degradation and Shedding Mhc Molecules in Liposomes 5 THE ANTIBODY Immunoglobulins Production and Characterization of Antibodies Methods of Antibody Detection Principles of Serological Analysis - Interpretation of Serological Data Idiotypy Crossreactivities 256 Topography of Mhc Molecules 263 Summaries of Mhc Serology in Different Species 275 Praise of Serology 289 THE CELL 291 T Lymphocyte 292 Lymphocyte Activation 297 T-Cell Receptor 300 T-Cell Clones 308 Mixed Lymphocyte Reaction 309 Cell-Mediated Lymphocytotoxicity (CML) 331 Graft-Versus-Host Reaction 368 Delayed-Type Hypersensitivity and Contact Sensitivity 377 Allograft Reaction 382 Transplantation Tolerance 400 Nature of Alloreactivity 417 FUNCTION 423 Avant-propos 424 The Bumpy Roads Leading to Mhc Restriction 425 Antigen Presentation in the Context of Class I Molecules 441 Presentation of Viral Antigens in the Context of Class I Molecules 445 Presentation of Hapten-Modifed Molecules in the Context of Class I Molecules 461 Presentation of Minor Histocompatibility Antigens in the Context of Class I Molecules 468 Presentation of Particulate Antigens in the Context of Class II Molecules 472 Recognition of Soluble Antigens in the Context of Class II Molecules 474 Tc Cell 492 Th Cell 518 Ts Cell 552 Nature of Nonresponsiveness 576 Individualization of the T-Cell Repertoire 581 T-Cell Subsets, Mhc Context, and Lymphocyte Function 589 What Purpose Does the Mhc Serve? 596 Nonimmune Functions of the Mhc? 597 Contents Contents XIII THE POPULATION 609 Genes in Populations 609 Human Populations and the HLA Complex 615 Polymorphism of the Mouse H-2 Complex 627 Mhc Polymorphism in Other Species 633 Associations Between HLA and Noninfectious Diseases 635 Associations Between Infectious Diseases and Mhc 651 Some Explanations of Polymorphism 656 SOCIOLOGY 659 Mhc Chromosome 660 Genes Coding for Complement Components 660 Steroid 21-Hydroxylase (Cytochrome P-450) 679 t Complex 683 Enzyme-Encoding Loci 705 Other Loci Linked to the Mhc 711 10 EVOLUTION 715 Whence the Mhc? 716 Relatives of the Mhc 732 Homologies Among the Mhc Genes 740 Evolution of Mhc and of Associated Loci 742 Forces Propelling the Evolution of Mhc Genes 747 Rate at Which Mhc Evolution Takes Place 754 Chromosome Evolution 757 INDEX 763
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spelling	Klein, Jan Verfasser aut Natural history of the major histocompatibility complex New York u.a. Wiley 1986 XIX, 775 S. Ill., Kt. txt rdacontent n rdamedia nc rdacarrier Complexe majeur d'histocompatibilité Genes, MHC Class II HLA histocompatibility antigens Histocompatibility Major Histocompatibility Complex Major histocompatibility complex MHC (DE-588)4169760-1 gnd rswk-swf MHC (DE-588)4169760-1 s DE-604 HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=002536947&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis
spellingShingle	Klein, Jan Natural history of the major histocompatibility complex Complexe majeur d'histocompatibilité Genes, MHC Class II HLA histocompatibility antigens Histocompatibility Major Histocompatibility Complex Major histocompatibility complex MHC (DE-588)4169760-1 gnd
subject_GND	(DE-588)4169760-1
title	Natural history of the major histocompatibility complex
title_auth	Natural history of the major histocompatibility complex
title_exact_search	Natural history of the major histocompatibility complex
title_full	Natural history of the major histocompatibility complex
title_fullStr	Natural history of the major histocompatibility complex
title_full_unstemmed	Natural history of the major histocompatibility complex
title_short	Natural history of the major histocompatibility complex
title_sort	natural history of the major histocompatibility complex
topic	Complexe majeur d'histocompatibilité Genes, MHC Class II HLA histocompatibility antigens Histocompatibility Major Histocompatibility Complex Major histocompatibility complex MHC (DE-588)4169760-1 gnd
topic_facet	Complexe majeur d'histocompatibilité Genes, MHC Class II HLA histocompatibility antigens Histocompatibility Major Histocompatibility Complex Major histocompatibility complex MHC
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