The endothelins:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Berlin [u.a.]
Springer
1990
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Literaturverz. S. [165] - 177 |
| Beschreibung: | XIII, 183 S. Ill., graph. Darst. |
| ISBN: | 3540528563 0387528563 |
Internformat
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| 245 | 1 | 0 | |a The endothelins |c Winifred G. Nayler |
| 264 | 1 | |a Berlin [u.a.] |b Springer |c 1990 | |
| 300 | |a XIII, 183 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 500 | |a Literaturverz. S. [165] - 177 | ||
| 650 | 4 | |a Polypeptides | |
| 650 | 4 | |a Endothelins | |
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Datensatz im Suchindex
| _version_ | 1804118285184139264 |
|---|---|
| adam_text | Winifred G Nayler
The Endothelins
With 69 Figures and 55 Tables
Springer-Verlag
Berlin Heidelberg New York London
Paris Tokyo Hong Kong Barcelona
Contents
Chapter 1 The Discovery and General Properties of the Endothelins
- The Endothelins 2
- The Discovery of the Endothelins 3
• - General Properties of Endothelin-1 5
- Summary 8
Chapter 2 The Chemistry of the Endothelins
- Endothelin-1 (or Porcine Endothelin, or ET-1) 10
- Endothelin-2 (ET-2) 11
- Endothelin-3 (Rat Endothelin, or IiT-3) 14
- VIC [(Mouse) (3 Endothelin) 16
- Nomenclature 16
- Endothelin-1 17
- Endothelin-2 17
- Endothelin-3 17
- VIC [(Mouse) (3 Endothelin] 18
- Molecular Manipulations Which Modify the Contractile
Activity of Endothelin-1 18
- The Relative Vasoconstrictor Activities of the Various
Endothelins 19
- Summary 19
Chapter 3 The Biosynthesis of the Endothelins
- The Biosynthesis of the Endothelins 21
- Endothelin-1 (Porcine and Human I 22
- Porcine Endothelin-1 22
- Human Endothelin-1 24
- Endothelin-2 and Endothelin-3 25
- Vasoactive Intestinal Contractor Endothelin (VIC) 27
- The Biological Significance of the Conversion of the Big
Endothelins to Mature Endothelins 28
- Summary 29
X Contents
Chapter 4 Other Chemically-Related Toxins
- The Sarafotoxins 31
- Apamin 35
- Atrotoxin 37
- Summary 37
Chapter 5 The Contractile Effect of Endothelin-1
- Endothelin-1: Evidence of its Contractile Effect on Smooth
Muscle 39
- Characterization of Endothelin-1 Induced Contraction of
Vascular and Non Vascular Smooth Muscle 42
- The Positive Inotropic Effect of Endothelin-1 on Cardiac
Muscle 46
- Does Endothelin-1 Exert a Positive Chronotropic Effect on
the Heart? 47
- Summary 48
Chapter 6 The Biochemical Events Involved in the Contractile
and Positive Inotropic Activity of Endothelin-1
- Endothelin - and Vascular Smooth Muscle 50
- Enhanced Slow Channel Ca2+ Entry 56
- Endothelin-1 Induced Increase in Cytosolic Ca2+ in Cardiac
Myocytes 60
- Summary 61
Chapter 7 Endothelin Receptors: Their Distribution and Properties
- Tissue Distribution of the Endothelin Binding Sites 63
- Characterization of Endothelin Binding Sites 65
- Evidence of Multiple Endothelin Receptors 70
- The Biochemical Analysis of the Endothelin Receptors 70
- Are the Endothelin Binding Sites Functional? 71
- Up and Down Regulation of the Endothelin Receptors 71
- The Density of Endothelin-1 Binding Sites in Various Tissues 73
- Summary 73
Chapter 8 Metabolism and Clearance of the Endothelins
- Time Course of Endothelin-1 Removal 75
- Comparison With Other Vasoactive Polypeptides 77
- Mechanisms Involved in the Removal of Endothelin-1 77
- Dissociation between the Disappearance of Endothelin-1
From the Bloodstream and It s Constrictor Effect 78
- Summary 78
Contents XI
Chapter 9 Plasma, Tissue and Urine Endothelin-1
- Tissue Levels of Endothelin-1 81
- Sites of Endothelin Synthesis 85
- Factors Which Stimulate the Expression of
Preproendothelin mRNA 86
- Conditions which Stimulate Endothelin Secretion 87
- Clearance of Endothelin from the Circulation 89
- Summary 89
Chapter 10 Effect of Various Pathological Conditions
on Plasma Endothelin
- Plasma Levels of Immunoreactive Endothelin-1 in Various
Pathological Conditions 93
- Experimental Conditions Which Provoke Raised Plasma
Levels of Endothelin-1 96
- Cold Provocation 96
- Other Changes 96
- Summary 97
Chapter 11 Endothelin and the Kidney
- The Hypersensitivy of Renal Arteries to Endothelin-1 98
- The Heterogeneity of the Renal Vascular Effects of
Endothelin-1 101
- The Distribution and Properties of Endothelin-1 Receptors
in the Kidney 102
- Endothelin-1 Binding Sites in Renal Glomerular Mesangial
Cells 104
- Effect of Endothelin-1 on Renal Tubular Epithelial Function 105
- The in Situ Production of Endothelin in the Kidney: Is It a
Local Hormone? 105
- Endothelin-1 and Renal Failure: Is There a Link? 105
- Summary 106
Chapter 12 Endothelin and the Brain
- Evidence of a Direct Central Effect of Endothelin
(Endothelin-1) 107
- Evidence of the Local Production of Endothelins in the Brain 108
- Endothelin-1 and Endothelin- 3 Distribution in the Brain 108
- The Occurence and Distribution of Specific High Affinity
Binding Sites for Endothelin (Endothelin-1) in the Brain 110
- What is the Functional Significance of Endothelin Binding in
the Brain? Ill
XII Contents
- Mode of Action 112
- Endothelin-1 and the Cerebral Arteries 113
- Summary 114
Chapter 13 Endothelin and the Coronary Circulation
- The Coronary Constrictor Effect of Endothelin-1 116
- The Biochemical Basis of the Coronary Constrictor Effect of
Endothelin-1 121
- Endothelin-1 Receptors in the Coronary Vasculature 123
- The Relative Sensitivity of Coronary Arteries and Veins to
the Constrictor Effect of Endothelin-1 124
- The Transient Endothelin-1 Coronary Vasodilation 125
- The Effect of Endothelin-1 Induced Coronary
Vasoconstriction on Myocardial Function „ 126
- Is Endothelin-1 Involved in the Development of Coronary
Vasospasm? 127
- Summary 127
Chapter 14 Endothelin-1 and the Heart
- The Characteristics of the Endothelin-1 induced Positive
Inotropic Response 129
- The Mechanisms Involved in the Positive Inotropic Effect of
Endothelin-1 131
- The Positive Chronotropic Effect of Endothelin-1 133
- Endothelin-1 and the Release of Atrionatriuretic Peptide
(ANP) 133
- Endothelin and the Ischaemic Heart 134
- Summary 137
Chapter 15 Endothelin, Cell Proliferation and Atherosclerosis
- Endothelin-1 and the Atherosclerotic Process 140
- The Mitogenic Effect of Endothelin-1 on Rat Vascular
Smooth Muscle Cells 141
- Effect of Growth Factors on the Endothelin-1 Induced
Increase in [3H]thymidi tie Uptake 142
- Factors Which Exacerbate the Effect of Endothelin-1 on
Vascular Smooth Muscle Cell Proliferation 144
- The Ability of Calcium Antagonists to Attenuate
Endothelin-1 Induced Cell Proliferation 145
- Summary 146
Contents XIII
Chapter 16 The Constrictor Effect of the Endothelins on Bronchiolar
and Tracheal Smooth Muscle
- The Relative Sensitivity of Bronchiolar and Tracheal Smooth
Muscle to the Constrictor Effect of the Endothelins 150
- The Local Production of Endothelin-1 and Endothelin-3 151
- Mode of Action 152
¥
- The Role of the Endothelins in Respiratory Disorders 152
- Summary 152
Chapter 17 Endothelin and Hypertension
- Plasma Endothelin-1 in Hypertensives 155
- Endothelin-1 Binding Site Density in Spontaneously
Hypertensive Rats 156
- Is a Central Effect of the Endothelins Involved in
Hypertension 156
- Is There a Vasodilator-Vasoconstrictor Imbalance? 157
- Is the Vasoconstrictor Effect of Endothelin Due to its Effect
on Large Capacitance or Small Resistance Vessels? 157
- Mode of Action 158
- Agents Which Overcome the Vasoconstrictor Effect of
Endothelin-1 158
- Endothelin-1, Hypertension and the Renal Vasculature 158
- Summary 158
Chapter 18 The Endothelins and Platelet Aggregation
- The Inhibitory Effect of Endothelin-1 on Platelet
Aggregation 160
- The Fibrinolytic Activity of Endothelin-3 162
- Summary 162
Chapter 19 Do the Endothelins have a Future? 163
References 165
Subject Index 179
|
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| id | DE-604.BV004054277 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T16:07:52Z |
| institution | BVB |
| isbn | 3540528563 0387528563 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-002535554 |
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| physical | XIII, 183 S. Ill., graph. Darst. |
| publishDate | 1990 |
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| publishDateSort | 1990 |
| publisher | Springer |
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| spelling | Nayler, Winifred G. Verfasser aut The endothelins Winifred G. Nayler Berlin [u.a.] Springer 1990 XIII, 183 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Literaturverz. S. [165] - 177 Polypeptides Endothelins Endothel (DE-588)4014675-3 gnd rswk-swf Endothelin (DE-588)4255702-1 gnd rswk-swf Endothel (DE-588)4014675-3 s DE-604 Endothelin (DE-588)4255702-1 s HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=002535554&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Nayler, Winifred G. The endothelins Polypeptides Endothelins Endothel (DE-588)4014675-3 gnd Endothelin (DE-588)4255702-1 gnd |
| subject_GND | (DE-588)4014675-3 (DE-588)4255702-1 |
| title | The endothelins |
| title_auth | The endothelins |
| title_exact_search | The endothelins |
| title_full | The endothelins Winifred G. Nayler |
| title_fullStr | The endothelins Winifred G. Nayler |
| title_full_unstemmed | The endothelins Winifred G. Nayler |
| title_short | The endothelins |
| title_sort | the endothelins |
| topic | Polypeptides Endothelins Endothel (DE-588)4014675-3 gnd Endothelin (DE-588)4255702-1 gnd |
| topic_facet | Polypeptides Endothelins Endothel Endothelin |
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