Psychoactive drugs: tolerance and sensitization
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Clifton, NJ
Humana Pr.
1989
|
| Schriftenreihe: | Contemporary neuroscience
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XV, 600 S. |
| ISBN: | 0896031489 |
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Datensatz im Suchindex
| _version_ | 1804118014428184576 |
|---|---|
| adam_text | PSYCHOACTIVE DRUGS TOLERANCE AND SENSITIZATION EDITED BY A. J. GOUDIE
UNIVERSITY OF LIVERPOOL, LIVERPOOL, ENGLAND AND M. W. EMMETT-OGLESBY
TEXAS COLLEGE OF OSTEOPATHIC MEDICINE, FORT WORTH, TEXAS HUMANA PRESS *
CLIFTON, NEW JERSEY CONTENTS LIST OF CONTRIBUTORS XI PREFACE XIII
TOLERANCE AND SENSITIZATION: OVERVIEW ANDREW J. GOUDIE AND MICHAEL W.
EMMETT-OGLESBY REFERENCES 12 PART 1: BEHAVIORAL MECHANISMS THE ROLE OF
INSTRUMENTAL LEARNING IN BEHAVIORAL TOLERANCE TO DRUGS DAVID L. WOLGIN
1. INTRODUCTION 17 2. REVIEW OF THE LITERATURE 20 2.1. STIMULANTS 22
2.2. ALCOHOL 50 2.3. MORPHINE 67 2.4. ANXIOLYTICS 76 2.5. MARIJUANA 84
3. WHAT IS LEARNED? 88 3.1. HOW DOES AMPHETAMINE SUPPRESS FEEDING? 89
3.2. CONTINGENT SUPPRESSION OF STEREOTYPY 91 3.3. IMPLICATIONS OF THE
THEORY 94 4. SUMMARY AND CONCLUSIONS 95 REFERENCES 97 PHARMACOLOGICAL
CONDITIONING AND DRUG EFFECTS SHEPARD SIEGEL 1. NONPHARMACOLOGICAL
CONTRIBUTIONS TO DRUG EFFECTS 115 2. THE PAVLOVIAN CONDITIONING
SITUATION 117 2.1. DRUGS AS UNCONDITIONAL STIMULI 118 V VI CONTENTS 2.2.
THE PHARMACOLOGICAL CONDITIONAL RESPONSE 118 2.3. DETERMINATION OF
PHARMACOLOGICAL CR TOPOGRAPHY 119 2.4. PAVLOVIAN CONDITIONING AND DRUG
TOLERANCE 121 3. EVIDENCE FOR THE CONDITIONING ANALYSIS OF TOLERANCE 121
3.1. ENVIROMENTAL SPECIFICITY OF TOLERANCE 122 3.2. RETARDATION OF
TOLERANCE 129 3.3. DISRUPTION OF ESTABLISHED TOLERANCE 133 3.4.
ASSOCIATIVE INHIBITION OF TOLERANCE 138 3.5. DRUG TOLERANCE AND COMPOUND
PREDRUG CUES 139 3.6. PHARMACOLOGICAL CUES FOR DRUGS 145 4. PRACTICAL
IMPLICATIONS OF THE CONDITIONING ANALYSIS OF TOLERANCE 151 4.1.
CROSS-DRUG EFFECTS 152 4.2. CONTROL OF TOLERANCE 153 4.3. OPIATE
OVERDOSE 153 5. PHARMACOLOGICAL CONDITIONING AND DRUG DEPENDENCE 158 6.
UNRESOLVED ISSUES AND ALTERNATIVE FORMULATIONS 158 6.1. DETECTION OF THE
DRUG-COMPENSATORY CR 158 6.2. TOLERANCE AS HABITUATION 164 7.
NONCOMPENSATORY PHARMACOLOGICAL CONDITIONAL RESPONSES 166 7.1. DRUG-LIKE
CRS AND DRUG SENSITIZATION 166 7.2. DRUG-LIKE CRS AND DRUG INTERACTIONS
167 8. CONCLUSIONS 168 REFERENCES 169 BEHAVIORAL AND PHARMACOLOGICAL
HISTORY AS DETERMINANTS OF TOLERANCE- AND SENSITIZATION-LIKE PHENOMENA
IN DRUG ACTION JAMES E. BARRETT, JOHN R. GLOWA, AND MICHAEL A. NADER 1.
INTRODUCTION 181 1.1. GENERAL DETERMINANTS OF THE BEHAVIORAL EFFECTS OF
DRUGS: RELATIONSHIP TO TOLERANCE AND SENSITIZATION 183 1.2. HISTORICAL
INFLUENCES ON BEHAVIOR: RELEVANCE TO TOLERANCE .. 188 2. BEHAVIORAL
HISTORY AND DRUG ACTION 191 2.1. EARLY STUDIES 191 2.2. RECENT STUDIES
196 3. PHARMACOLOGICAL HISTORY AS A DETERMINANT OF DRUG ACTION 201 3.1.
HISTORY WITH ACUTELY ADMINISTERED DRUGS 202 3.2. DRUG
SELF-ADMINISTRATION 204 4. DRUG-BEHAVIOR INTERACTION HISTORIES 206 5.
SUMMARY AND CONCLUSIONS 210 REFERENCES 214 CONTENTS VII TOLERANCE TO
DRUG DISCRIMINATIVE STIMULI ALICE M. YOUNG AND CHRISTINE A. SANNERUD 1.
INTRODUCTION : 221 2. ESTABLISHMENT AND MAINTENANCE OF DRUG STIMULUS
CONTROL 222 3. CHARACTERISTICS OF DRUG STIMULUS CONTROL 229 3.1. TESTS
FOR GENERALIZATION OF STIMULUS CONTROL 230 3.2. DOSE DEPENDENCE 232 3.3.
PHARMACOLOGICAL SPECIFICITY 234 4. MODIFICATION OF THE SENSITIVITY OF
THE DISCRIMINATIVE ASSAY 235 4.1. ROLE OF TRAINING DOSE 236 4.2. ROLE OF
BEHAVIORAL CONTINGENCIES 239 4.3. MODULATION OF GENERALIZATION PROFILES
241 5. DEVELOPMENT OF TOLERANCE TO DRUG STIMULUS CONTROL 242 5.1. DOES
EXTENDED EXPOSURE TO A DRUG DISCRIMINATION TASK, AND THUS TO A DRUG,
CONFER TOLERANCE TO DRUG STIMULUS CONTROL? 243 5.2. DOES SUPPLEMENTAL
DRUG ADMINISTRATION CONFER TOLERANCE TO DRUG STIMULUS CONTROL? 250 6.
CONCLUSIONS 267 REFERENCES 270 PART 2: MOLECULAR MECHANISMS
DISPOSITIONAL MECHANISMS IN DRUG TOLERANCE AND SENSITIZATION A. D. LE
AND JATINDER M. KHANNA 1. INTRODUCTION 281 2. SCOPE OF THIS REVIEW 282
3. MECHANISMS OF DISPOSITIONAL TOLERANCE 283 3.1. CHANGE IN ABSORPTION
283 3.2. CHANGE IN VOLUME OF DISTRIBUTION 285 3.3. BIOTRANSFORMATION OR
CHANGE IN RATE OF METABOLISM 286 3.4. CHANGE IN EXCRETION 288 3.5.
SUMMARY 288 4. DISPOSITIONAL FACTORS IN TOLERANCE AND SENSITIZATION TO
VARIOUS DRUG CLASSES 289 4.1. DISPOSITIONAL TOLERANCE TO ETHANOL 289
4.2. DISPOSITIONAL TOLERANCE TO BARBITURATES 294 4.3. DISPOSITIONAL
TOLERANCE TO BENZODIAZEPINES 301 4.4. DISPOSITIONAL TOLERANCE TO OPIATES
(MORPHINE) 305 4.5. CENTRAL STIMULANTS: AMPHETAMINE AND COCAINE 310
VIII CONTENTS 5. CROSS-TOLERANCE AND CROSS-SENSITIZATION: DISPOSITIONAL
MECHANISMS 314 5.1. DEFINITION 314 5.2. DISPOSITIONAL CROSS-TOLERANCE
AND SENSITIZATION 315 6. VARIABLES OR FACTORS THAT INFLUENCE
DISPOSITIONAL TOLERANCE AND SENSITIZATION 320 6.1. BEHAVIORAL
MANIPULATIONS 320 6.2. AGING 325 6.3. NUTRITION/DIET 326 6.4. OTHERS 327
7. SUMMARY AND CONCLUSION 328 REFERENCES 331 DOPAMINE RECEPTOR CHANGES
DURING CHRONIC DRUG ADMINISTRATION ANDREW J. GREENSHAW, GLEN B. BAKER,
AND THOMAS B. WISHART 1. THE PARAMETRIC ESTIMATION OF NEURAL RECEPTORS:
BASIC PRINCIPLES AND CLINICAL RELEVANCE 353 2. EMERGENT CHANGES IN
RECEPTOR NUMBER AND AFFINITY 356 3. DOPAMINE FUNCTION IN BIOLOGICAL
PSYCHIATRY 357 4. DOPAMINE RECEPTOR SUBTYPES 357 5. EFFECTS OF CHRONIC
DOPAMINE AGONISTS 359 5.1. CHRONIC AMPHETAMINE ADMINISTRATION 359 5.2.
CHRONIC ADMINISTRATION OF DIRECT DOPAMINE AGONISTS 363 5.3. EFFECTS OF
CHRONIC COCAINE 367 6. EFFECTS OF CHRONIC DOPAMINE ANTAGONISTS 368 6.1.
SHORT-TERM ANTAGONIST ADMINISTRATION 368 6.2. LONG-TERM ANTAGONIST
ADMINISTRATION 369 6.3. ANALYSES OF PRESYNAPTIC DOPAMINE RECEPTOR
CHANGES INDUCED BY CHRONIC DOPAMINE ANTAGONISTS 375 6.4. LITHIUM
INTERACTIONS WITH CHRONIC DOPAMINE ANTAGONIST EFFECTS 378 6.5. EFFECTS
OF CHRONIC ANTIDEPRESSANT TREATMENT ON DOPAMINE RECEPTOR BINDING 379 7.
EFFECTS OF CHRONIC DRUG ADMINISTRATION ON DOPAMINE RECEPTORS IN HUMANS
379 7.1. POSTMORTEM AND IN VIVO BINDING STUDIES 380 7.2. CENTRAL VS
PERIPHERAL RECEPTOR ESTIMATIONS*THE PROBLEM OF ASSESSING LONG-TERM
CHANGES IN RECEPTOR FUNCTION IN THE CLINICAL CONTEXT 387 CONTENTS IX 8.
SUMMARY 389 REFERENCES 390 SENSITIZATION TO THE ACTIONS OF
ANTIDEPRESSANT DRUGS PAUL WILLNER 1. WHY ARE ANTIDEPRESSANTS SLOW TO
ACT? 407 2. SLOW CHANGES IN MONOAMINE RECEPTOR FUNCTION 411 2.1.
BETA-RECEPTOR DOWNREGULATION 411 2.2. DESENSITIZATION OF ALPHA 2
RECEPTORS 415 2.3. SENSITIZATION OF ALPHA! RECEPTORS 418 2.4.
SENSITIZATION OF DOPAMINE RECEPTORS 420 2.5. SENSITIZATION OF 5-HT
RECEPTORS? 422 3. SENSITIZATION TO THE BEHAVIORAL EFFECTS OF
ANTIDEPRESSANTS 425 3.1. THE BEHAVIORAL DESPAIR MODEL 426 3.2. THE
LEARNED HELPLESSNESS MODEL 431 3.3. THE CHRONIC MILD STRESS MODEL 433
3.4. OTHER MODELS 434 4. SOME METHODOLOGICAL COMMENTS 437 REFERENCES 441
ADAPTATION IN NEURONAL CALCIUM CHANNELS AS A COMMON BASIS FOR PHYSICAL
DEPENDENCE ON CENTRAL DEPRESSANT DRUGS JOHN M. LITTLETON AND HILARY J.
LITTLE 1. INTRODUCTION 461 1.1. DECREMENTAL AND OPPOSITIONAL TOLERANCE
462 1.2. CROSS-TOLERANCE AND CROSS-DEPENDENCE 466 1.3. AIMS OF THE
PRESENT CHAPTER 467 2. MECHANISM OF ACTION OF CENTRAL DEPRESSANTS 469
2.1. ALCOHOL AND GENERAL ANESTHETICS 469 2.2. BARBITURATES , 477 2.3.
BENZODIAZEPINES 482 2.4. OPIATES 487 3. ACUTE EFFECTS OF CENTRAL
DEPRESSANT DRUGS*SUMMARY 489 4. BEHAVIORAL INTERACTIONS OF CA 2+ CHANNEL
INHIBITORS WITH CNS DEPRESSANTS 491 4.1. INTERACTIONS WITH ALCOHOLS AND
ANESTHETICS 492 4.2. INTERACTIONS WITH BARBITURATES AND BENZODIAZEPINES
500 4.3. INTERACTIONS WITH OPIATES 502 4.4. CONCLUSIONS 503. 5. OVERALL
CONCLUSIONS 504 REFERENCES 505 X CONTENTS PART 3: SUMMARY CHAPTERS
BEHAVIORAL TOLERANCE AND SENSITIZATION DEFINITIONS AND EXPLANATIONS
DEREK E. BLACKMAN 1. THE DEFINITION OF TOLERANCE AND SENSITIZATION 522
2. THE EXPLANATION OF TOLERANCE/SENSITIZATION 532 3. CONCLUDING COMMENTS
539 REFERENCES 544 DRUG TOLERANCE AND SENSITIZATION A PHARMACOLOGICAL
OVERVIEW HAROLD KALANT 1. DEFINITIONS OF TOLERANCE AND SENSITIZATION 549
2. MAJOR IDENTIFIED INFLUENCES ON TOLERANCE AND SENSITIZATION 554 3.
PHARMACOKINETIC FACTORS 555 4. INSTRUMENTAL LEARNING 558 5. PAVLOVIAN
CONDITIONING 564 6. TASK-SPECIFICITY OF TOLERANCE 567 7. POSSIBLE
BIOLOGICAL MECHANISMS UNDERLYING PHARMACODYNAMIC TOLERANCE 568 8.
CONCLUSION 572 REFERENCES 573 CONTRIBUTING AUTHORS 579 INDEX 585
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| id | DE-604.BV003667405 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-09T16:03:34Z |
| institution | BVB |
| isbn | 0896031489 |
| language | English |
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| physical | XV, 600 S. |
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| series2 | Contemporary neuroscience |
| spelling | Psychoactive drugs tolerance and sensitization ed. by A. J. Goudie ... Clifton, NJ Humana Pr. 1989 XV, 600 S. txt rdacontent n rdamedia nc rdacarrier Contemporary neuroscience Antidepressiva gtt Drogas larpcal Psychofarmaca gtt Psychotropes Tolerantie (farmacologie) gtt Tolérance aux médicaments Antidepressive Agents pharmacology Behavior drug effects Drug Tolerance Drug tolerance Psychotropic Drugs pharmacology Psychotropic drugs Psychopharmakon (DE-588)4047729-0 gnd rswk-swf Dosis-Wirkungs-Beziehung (DE-588)4130752-5 gnd rswk-swf Psychopharmakon (DE-588)4047729-0 s Dosis-Wirkungs-Beziehung (DE-588)4130752-5 s DE-604 Goudie, A. J. Sonstige (DE-588)1038564085 oth GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=002335281&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Psychoactive drugs tolerance and sensitization Antidepressiva gtt Drogas larpcal Psychofarmaca gtt Psychotropes Tolerantie (farmacologie) gtt Tolérance aux médicaments Antidepressive Agents pharmacology Behavior drug effects Drug Tolerance Drug tolerance Psychotropic Drugs pharmacology Psychotropic drugs Psychopharmakon (DE-588)4047729-0 gnd Dosis-Wirkungs-Beziehung (DE-588)4130752-5 gnd |
| subject_GND | (DE-588)4047729-0 (DE-588)4130752-5 |
| title | Psychoactive drugs tolerance and sensitization |
| title_auth | Psychoactive drugs tolerance and sensitization |
| title_exact_search | Psychoactive drugs tolerance and sensitization |
| title_full | Psychoactive drugs tolerance and sensitization ed. by A. J. Goudie ... |
| title_fullStr | Psychoactive drugs tolerance and sensitization ed. by A. J. Goudie ... |
| title_full_unstemmed | Psychoactive drugs tolerance and sensitization ed. by A. J. Goudie ... |
| title_short | Psychoactive drugs |
| title_sort | psychoactive drugs tolerance and sensitization |
| title_sub | tolerance and sensitization |
| topic | Antidepressiva gtt Drogas larpcal Psychofarmaca gtt Psychotropes Tolerantie (farmacologie) gtt Tolérance aux médicaments Antidepressive Agents pharmacology Behavior drug effects Drug Tolerance Drug tolerance Psychotropic Drugs pharmacology Psychotropic drugs Psychopharmakon (DE-588)4047729-0 gnd Dosis-Wirkungs-Beziehung (DE-588)4130752-5 gnd |
| topic_facet | Antidepressiva Drogas Psychofarmaca Psychotropes Tolerantie (farmacologie) Tolérance aux médicaments Antidepressive Agents pharmacology Behavior drug effects Drug Tolerance Drug tolerance Psychotropic Drugs pharmacology Psychotropic drugs Psychopharmakon Dosis-Wirkungs-Beziehung |
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