Pharmaceutical chemicals in perspective:
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Format: | Buch |
| Sprache: | Undetermined |
| Veröffentlicht: |
New York u.a.
Wiley
1989
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XVIII, 517 S. |
| ISBN: | 0471843636 |
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Datensatz im Suchindex
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|---|---|
| adam_text | Pharmaceutical
Chemicals
in Perspective
Bryan G Reuben
South Bank Polytechnic
London, England
Harold A Wittcoff
The Chem Systems Group
Tarrytown, New York
WILEY
A WILEY-INTERSCIENCE PUBLICATION
John Wiley amp; Sons
NEW YORK / CHICHESTER / BRISBANE / TORONTO / SINGAPORE
Contents
PART I THE BACKGROUND TO PHARMACEUTICALS
1 History 3
2 The Characteristics of die Pharmaceutical Industry 18
2 1 The World Pharmaceutical Industry / 18
2 2 The Pharmaceutical Industry in the U S Economy /22
2 3 Profitability / 23
2 4 Capital Investment / 24
2 5 Research Expenditure / 25
2 6 Employment / 28
2 7 Patent Protection / 29
2 8 Competition and Promotion / 30
2 9 Manufacture of Products / 30
2 10 Drug Testing / 32
2 11 Drug Nomenclature and Generic Drugs / 36
2 11 1 Generic versus Branded Pharmaceuticals / 38
3 Patterns of Illness and Health Care 41
3 1 Ethical and Over-the-Counter Drugs / 41
3 2 Physicians / 42
3 3 Patients / 44
331 Mortality / 44
332 Disability / 48
xi
xii CONTENTS
333 Visits to the Physician / 50
334 Prescribing Drugs / 52
335 Correlation / 55
4 Pharmacological Concepts 56
4 1 Receptor Theory / 56
411 Enzymes / 57
412 Nucleic Acids / 58
413 Permeases / 60
4 2 Radioligands / 61
421 Receptor Geometry / 64
4 3 Replacements, Redesigned Agonists, and Antagonists / 65
431 Agonists / 65
432 Antagonists / 66
433 Drug Design / 69
434 Structure-Activity Relations / 70
4 4 What Happens to Drugs in the Body / 7 2
4 5 Drug Absorption and Dosage Forms / 74
451 Enteral Dosage / 74
452 Percutaneous Dosage / 76
453 Inhalation / 77
454 Parenteral Dosage / 78
455 Other Dosage Forms / 79
4 6 Drug Distribution / 81
461 Binding to Plasma Protein and Blood Cells /81
462 Physical Properties of the Drug / 82
463 Other Factors / 82
4 7 Biotransformation of Drugs / 83
4 8 Excretion / 88
4 9 Bioavailability and the Digoxin Affair / 88
4 10 Properties of an Ideal Drug / 91
4 11 Conclusion / 93
PART II: THE TOP-100 DRUGS
5 The Production of Pharmaceuticals 97
5 1 The Top-100 Drugs / 97
5 2 Classification of Drugs / 101
5 3 Sources of Drugs / 104
CONTENTS xiii
5 4 Manufacturing Processes / 106
541 Quality Control / 106
542 Choice of Reagents / 108
543 Plant Design / 108
544 Cost Structure / 109
6 Antibacterials and Antibiotics 111
6 1 Classification of Bacteria / 113
6 2 Sulfonamides / 115
6 3 Penicillins / 120
631 Penicillin Manufacture / 126
632 Improving Penicillins / 128
633 Semisynthetic Penicillins / 130
634 Production of 6-Aminopenicillanic Acid / 132
635 Production of Ampicillin and Amoxycillin /133
636 Penicillin Esters / 134
637 B-Lactamase Inhibitors / 138
638 The Future of Penicillins / 139
6 4 Cephalosporins / 142
641 Manufacture of Cephalosporins / 145
642 7-Oximinoacylcephalosporins / 148
643 Cephamycin C Derivatives / 151
644 Cephalosporins in Hospitals / 152
6 5 Tetracyclines / 152
657 Manufacture of Tetracyclines / 154
652 Rolitetracycline / 156
6 6 Macrolide Antibiotics / 157
6 7 Aminoglycosides and Antituberculosis Drugs / 158
671 Tuberculosis Therapy / 159
6 8 Peptide Antibiotics / 162
6 9 Quinolone Antibacterials / 163
6 10 Miscellaneous Antibacterials / 164
6 10 1 Chloramphenicol and Nitrofurantoin / 164
6 10 2 Lincomycin and Clindamycin / 167
6 10 3 Vancomycin / 168
6 11 Antifungals / 168
6 12 The Future / 170
7 Cardiovascular Drugs 174
7 1 The Functioning of the Heart / 174
711 Diseases of the Heart / 177
XiV CONTENTS
7 2 Cardiac Glycosides / 179
7 3 Antiarrhythmics / 180
7 4 Diuretics / 182
741 Carbonic Anhydrase Inhibitors / 184
742 Low-Ceiling Diuretics / 184
743 High-Ceiling (Loop) Diuretics / 187
744 Potassium-Sparing Diuretics / 188
745 Potassium Replenishers / 192
7 5 Coronary Vasodilators and jS-Adrenergic Agents /192
751 Nitrates and Nitrites / 193
752 Calcium Antagonists / 194
753 Hemorheologic Agent / 196
754 Mode of Action of B-Adrenergic Agents /197
755 B-Adrenergic Drugs / 200
756 B-Adrenergic Blocking Drugs / 203
757 a- and B-Adrenergic Drug / 207
7 6 Antihypertensive Agents / 207
761 Centrally Acting Antihypertensioes / 207
762 Vasodilators / 211
763 Adrenergic Neuron Blockers / 212
764 Angiotensin-Converting Enzyme Inhibitors / 212
7 7 Anticoagulants / 214
7 8 Thrombolytic Agents / 218
7 9 Hypolipemics / 219
7 10 Conclusion / 222
8 Drugs Affecting the Central Nervous System 224
8 1 Hypnotics and Sedatives / 227
811 Barbiturates / 227
812 Nonbarbiturate Hypnotics and Sedatives / 229
813 Anticonvulsants / 231
8 2 Major Tranquilizers (Neuroleptics) / 233
8 3 Anxiolytics (Minor Tranquilizers) / 238
831 Benzodiazepines / 240
832 Benzodiazepine Syntheses / 243
833 Meprobamate, Hydroxyzine, and Buspirone / 248
834 Benzodiazepine Antagonists and Mode of Action / 249
8 4 Antidepressants / 253
841 Monoamine Oxidase Inhibitors / 253
842 Tricyclic Antidepressants / 255
843 Tetracyclic Antidepressants / 258
844 Serotonin Reuptake Inhibitors / 261
CONTENTS xv
8 5 Stimulants and Appetite Suppressants / 263
55/ Amphetamine-like Anorectics / 264
852 Caffeine and Cocaine / 266
8 6 Psychotomimetics / 268
8 7 Use and Abuse / 270
9 Antihistamines 274
9 1 Allergy / 274
9 2 Antiallergy and Antinausea Compounds / 276
9 3 Nonsoporific Antihistamines / 279
9 4 Syntheses of Hi Blockers / 280
9 5 Cold Cures / 282
9 6 H2-Blocking Antihistamines and Antiulcer Drugs / 284
961 Syntheses of H2 Blockers / 289
962 Other Antiulcer Drugs / 289
10 Analgesics 292
10 1 Narcotic Analgesics / 292
10 1 1 Antidiarrhea Drugs / 294
10 1 2 Methadone and Propoxyphene / 297
10 1 3 Morphine Antagonists / 300
10 1 4 Opioid Receptors / 301
10 1 5 Etorphine / 301
10 1 6 Buprenorphine / 303
10 1 7 Oxycodone, Hydrocodone, Dihydrocodeine,
and Dextromethorphan / 304
10 2 Nonnarcotic Pain Relievers / 305
10 2 1 Aspirin / 307
10 2 2 Acetaminophen (Paracetamol) / 308
10 3 Endorphins and Enkephalins / 310
11 Steroid Drugs 314
11 1 Natural Steroids / 314
11 2 Conjugated Estrogenic Hormone / 317
11 3 Oral Contraceptives / 318
11 3 1 Progesterone Antagonist / 320
11 3 2 Risks of Oral Contraceptives / 321
11 4 Anti-inflammatory Steroids / 323
11 5 Other Applications of Steroids / 325
11 6 Manufacture of Steroids / 325
11 6 1 Steroids from Diosgenin / 327
XVi CONTENTS
11 6 2 Steroids from Stigmasterol / 328
11 6 3 Steroids from Sitosterol / 330
12 Nonsteroid Anti-inflammatory Agents 334
12 1 a-Arylpropionic Acids / 336
12 1 1 Syntheses of Ibuprofen / 337
12 1 2 Syntheses of Naproxen / 342
12 1 3 Synthesis of Fenoprofen / 345
12 2 Substituted Acetic Acid Derivatives / 346
12 3 Enolic 0-Diketones / 346
12 4 Anthranilic/Salicylic Acid Derivatives / 350
12 5 Other Anti-inflammatories / 350
12 6 Conclusion / 351
13 Hypoglycemics 353
13 1 Replacement Therapy / 354
13 2 Insulin via Recombinant DNA / 354
13 3 Oral Hypoglycemics / 357
13 3 1 Syntheses of Oral Hypoglycemics / 359
13 4 Recent Developments / 361
14 Anticholinergic Drugs 363
14 1 The Solanaceous Alkaloids / 366
14 2 Dicyclomine / 366
14 3 Clidinium Bromide / 367
15 Antiasthma Drugs 369
15 1 /J-Adrenergic Agonists / 370
15 1 1 Syntheses of B2 Agonists / 373
15 2 Methylxanthine Bronchodilators / 375
15 3 Disodium Cromoglycate / 377
15 3 1 Dosage Forms / 378
15 4 Steroids / 379
15 5 Leukotriene Inhibitors / 379
16 Parkinson s Disease 380
16 1 Asymmetric Synthesis of Levodopa / 381
16 2 Effects of Levodopa / 383
16 3 Other Drugs / 384
16 4 Huntingdon s Chorea / 385
CONTENTS xvii
17 Miscellaneous Drugs 387
17 1 Thyroid Hormones / 387
17 2 Muscle Relaxants / 389
17 3 Allopurinol / 390
17 4 Antismoking Drug / 391
17 5 Acne Treatment / 391
17 6 Metoclopramide / 392
17 7 Vitamins / 393
17 7 1 Vitamin C / 393
17 7 2 Vitamin A / 396
17 7 3 Vitamin B12 / 397
PART III DRUG GROUPS OUTSIDE THE TOP-100
18 Tropical Diseases 401
18 1 Insecticides / 403
18 2 Antiprotozoals / 404
18 2 1 Malaria / 404
18 2 2 Trypansomiasis and Leishmaniasis / 410
18 2 3 Amebiasis and Trichomoniasis / 411
18 3 Helminth Infections / 413
18 3 1 Drugs against Nematodes / 414
18 3 2 Drugs against Trematodes / 416
18 4 Tuberculosis, Cholera, Typhoid Fever, Leprosy / 418
18 5 Yellow Fever and Hepatitis / 420
18 6 Conclusion / 421
19 Prostaglandins 422
19 1 The Arachidonic Acid Cascade / 423
19 1 1 Prostaglandin Endoperoxides and Prostaglandins / 426
19 1 2 Thromboxanes / 429
19 1 3 Prostacyclin / 430
19 1 4 Leukotrienes / 431
19 2 Prostaglandin Syntheses / 434
19 3 Novel Nonnarcotic Analgesics / 434
19 4 Steroids and Prostaglandins / 436
XViii CONTENTS
20 Antiviral Drugs 438
20 1 Replication of Viruses / 439
20 2 Virus Infections / 441
20 3 Pyrimidine and Purine Antimetabolites / 442
20 4 Amantadine / 444
20 5 Drugs against AIDS / 445
20 6 Other Antiviral Drugs / 446
21 Anticancer Drugs 448
21 1 Origins of Cancer / 448
21 2 Prevention and Treatment / 451
21 3 Steroids / 452
21 4 Alkylating Agents / 453
21 5 Antimetabolites / 454
21 6 Antibiotics / 456
21 7 Platinum Complexes / 457
21 8 Miscellaneous Drugs / 458
22 Orphan Drugs 460
23 Innovations and Issues 463
23 1 New Chemical Entities 1986-1988 / 463
23 2 The Achievement of the Pharmaceutical Industry / 467
23 3 The Problems of the Pharmaceutical Industry /468
23 3 1 Adverse Drug Reactions / 468
23 3 2 Overprescribing / 469
23 3 3 Are Profits Excessive? / 469
23 A Drugs of the Future / 471
23 5 Conclusion / 472
Appendixes
1 The Most Widely Prescribed Drugs by Chemical Entity /475
2 International Classification of Diseases / 478
3 Bibliography and Notes / 482
Index 499
|
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| spelling | Reuben, Bryan G. Verfasser aut Pharmaceutical chemicals in perspective Bryan G. Leuben ; Harold A. Wittcoff New York u.a. Wiley 1989 XVIII, 517 S. txt rdacontent n rdamedia nc rdacarrier Geschichte (DE-588)4020517-4 gnd rswk-swf Arzneimittel (DE-588)4003115-9 gnd rswk-swf Pharmazeutische Industrie (DE-588)4045696-1 gnd rswk-swf USA (DE-588)4078704-7 gnd rswk-swf USA (DE-588)4078704-7 g Pharmazeutische Industrie (DE-588)4045696-1 s Geschichte (DE-588)4020517-4 s DE-604 Arzneimittel (DE-588)4003115-9 s Wittcoff, Harold A. Verfasser aut HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=001904942&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Reuben, Bryan G. Wittcoff, Harold A. Pharmaceutical chemicals in perspective Geschichte (DE-588)4020517-4 gnd Arzneimittel (DE-588)4003115-9 gnd Pharmazeutische Industrie (DE-588)4045696-1 gnd |
| subject_GND | (DE-588)4020517-4 (DE-588)4003115-9 (DE-588)4045696-1 (DE-588)4078704-7 |
| title | Pharmaceutical chemicals in perspective |
| title_auth | Pharmaceutical chemicals in perspective |
| title_exact_search | Pharmaceutical chemicals in perspective |
| title_full | Pharmaceutical chemicals in perspective Bryan G. Leuben ; Harold A. Wittcoff |
| title_fullStr | Pharmaceutical chemicals in perspective Bryan G. Leuben ; Harold A. Wittcoff |
| title_full_unstemmed | Pharmaceutical chemicals in perspective Bryan G. Leuben ; Harold A. Wittcoff |
| title_short | Pharmaceutical chemicals in perspective |
| title_sort | pharmaceutical chemicals in perspective |
| topic | Geschichte (DE-588)4020517-4 gnd Arzneimittel (DE-588)4003115-9 gnd Pharmazeutische Industrie (DE-588)4045696-1 gnd |
| topic_facet | Geschichte Arzneimittel Pharmazeutische Industrie USA |
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