Topical drug delivery formulations:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York u.a.
Dekker
1990
|
| Schriftenreihe: | Drugs and the pharmaceutical sciences
42 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XII, 420 S. Ill. |
| ISBN: | 082478183X |
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Datensatz im Suchindex
| _version_ | 1804117021088022528 |
|---|---|
| adam_text | TOPICAL DRUG DELIVERY FORMULATIONS EDITED BY DAVID W. OSBORNE ANTON H.
AMANN THE UPJOHN COMPANY KALAMAZOO, MICHIGAN MARCEL DEKKER, INC. NEW
YORK AND BASEL CONTENTS PREFACE HI CONTRIBUTORS XI PART I: PRINCIPLES OF
SKIN AND FORMULATION INTERACTIONS 1 PRACTICAL CONSIDERATIONS FOR TOPICAL
DRUG FORMULATIONS WITH AND WITHOUT ENHANCERS 1 EUGENE R. COOPER AND
DINESH C. PATEL I. INTRODUCTION 1 II. VEHICLE DESIGN , 1 III. EVALUATION
OF VEHICLE PERFORMANCE 7 IV. FORMULATION EXAMPLE: DESONIDE 10 REFERENCES
11 2 THE IMPORTANCE OF EPIDERMAL LIPIDS FOR THE STRATUM CORNEUM BARRIER
13 PETER M. ELIAS I. EVOLUTION OF CURRENT CONCEPTS OF STRATUM CORNEUM
STRUCTURE 13 II. EPIDERMAL DIFFERENTIATION 15 III. COMPOSITION OF
STRATUM CORNEUM LIPIDS 17 IV. LIPID BIOSYNTHETIC GRADIENTS IN THE
EPIDERMIS 19 V. CLINICAL AND PATHOPHYSIOLOGIC IMPLICATIONS OF THE
TWO-COMPARTMENT MODEL 24 REFERENCES 26 VI CONTENTS 3 STRATUM CORNEUM
STRUCTURE AND TRANSPORT PROPERTIES 29 STIG E. FRIBERG, IBRAHIM H.
KAYALI, MARION MARGOSIAK, DAVID W. OSBORNE, AND ANTHONY J. I. WARD I.
INTRODUCTION 29 II. LIPID ORGANIZATION 29 III. SUMMARY 44 REFERENCES 44
4 PENETRATION ENHANCER INCORPORATION IN BILAYERS 47 ANTHONY J. I. WARD
AND REGINA TALLON I. INTRODUCTION 47 II. EXPERIMENTAL BACKGROUND 48 III.
EXPERIMENTAL 53 IV. RESULTS AND DISCUSSION 54 REFERENCES 66 5 THE
INFLUENCE OF SKIN SURFACE LIPIDS ON TOPICAL FORMULATIONS 69 DAVID W.
OSBORNE AND DOUGLAS A HATZENBUHLER I. INTRODUCTION 69 II. SKIN AND
SURFACE LIPID EXCRETION 70 III. COMPOSITION OF SKIN SURFACE LIPIDS 73
IV. FALLACIES CONCERNING SKIN SURFACE LIPIDS 77 V. MODEL SKIN SURFACE
LIPIDS 78 VI. INTERACTIONS BETWEEN SKIN SURFACE LIPIDS AND TOPICAL
FORMULATIONS 82 VII. CONCLUDING REMARKS 83 REFERENCES 84 6 IMMUNOLOGY OF
THE SKIN 87 DAVID H. LYNCH AND LEE K. ROBERTS I. INTRODUCTION 87 II.
STRUCTURE AND HISTOLOGICAL ORGANIZATION OF THE SKIN 88 III. INFLAMMATION
AND IMMUNE RESPONSES IN THE SKIN 90 IV. SKIN-ASSOCIATED LYMPHOID TISSUES
92 V. IMMUNOCOMPETENT CELLS WITHIN THE SKIN 94 VI. EFFECTS OF AGENTS
THAT DEPLETE SKIN OF LANGERHANS CELLS ON IMMUNE RESPONSES TO ANTIGENS
ENCOUNTERED THROUGH THE SKIN 101 VII. CONCLUSION 102 REFERENCES 104
CONTENTS VII PART II: DRUG FORMULATION SELECTION AND TESTING FOR TOPICAL
USE 7 COMPUTATIONAL METHODS FOR PRODRUG OR DRUG ANALOGUE SELECTION
OPTIMIZED FOR PERCUTANEOUS DELIVERY 109 DAVID W. OSBORNE I. II. III. IV.
V. VI. INTRODUCTION DESCRIPTION OF THE MODELS COMPARISON OF PREDICTED
AND EXPERIMENTAL FLUX VALUES USE OF THE PREDICTIVE MODELS CONTOUR PLOTS
ADDITIONAL CONSIDERATIONS REFERENCES 109 110 112 112 113 124 125 8
KINETIC CONSIDERATIONS IN THE DESIGN OF SURFACTANT- BASED TOPICAL
FORMULATIONS 127 ANTHONY J. I. WARD I. INTRODUCTION 127 II. EXPERIMENTAL
BACKGROUND 128 III. RESULTS AND DISCUSSION 129 IV. SUMMARY 139
REFERENCES 140 9 THE USE OF PHASE BEHAVIOR AND LABORATORY ROBOTICS FOR
THE OPTIMIZATION OF PHARMACEUTICAL TOPICAL FORMULATIONS 143 DAVID W.
OSBORNE I. INTRODUCTION 143 II. DETERMINATION OF COMPONENT RANGES 145
III. OPTIMIZATION TECHNIQUES . 188 IV. CLOSING REMARKS 193 REFERENCES
194 10 GENERAL CONSIDERATIONS FOR STABILITY TESTING OF TOPICAL
PHARMACEUTICAL FORMULATIONS 197 GARY R. DUKES I. INTRODUCTION 197 II.
PREFORMULATION STAGE 199 III. FORMULATION DEVELOPMENT STAGE 201 IV.
PROPOSED PRODUCT 206 V. NEW PRODUCT STAGE 208 VI. ESTABLISHED PRODUCT
STAGE 208 VII. PRODUCT REVISION STAGE 209 VIII. CONCLUSION 210
REFERENCES 210 VIII CONTENTS 11 IN VITRO TESTING OF TOPICAL
PHARMACEUTICAL FORMULATIONS 213 RONALD C. WESTER AND HOWARD I. MAIBACH
I. INTRODUCTION 213 II. BASIC STUDY DESIGN 213 III. FACTORS 214 IV.
CONCLUSIONS 220 REFERENCES 220 12 DRUG DELIVERY FROM TOPICAL
FORMULATIONS: THEORETICAL PREDICTION AND EXPERIMENTAL ASSESSMENT 221
WILLIAM J. ADDICKS, GORDON L, FLYNN, NORMAN D. WEINER, AND RANE L. CURL
I. INTRODUCTION 221 II. IN VITRO RELEASE FROM VEHICLES 222 III.
APPLICATIONS OF THEORY: IN VITRO RELEASE STUDIES 232 IV. DIFFUSION
STUDIES INVOLVING SKIN 237 REFERENCES 242 13 THE USE OF SOLUBILITY
PARAMETERS OF DRUG AND VEHICLE TO DESCRIBE SKIN TRANSPORT 245 KENNETH B.
SLOAN I. INTRODUCTION 245 II. GENERAL APPLICATIONS OF REGULAR SOLUTION
THEORY TO PARTITIONING PROCESSES 247 III. APPLICATION OF REGULAR
SOLUTION THEORY TO PERCUTANEOUS ABSORPTION PROCESSES 249 IV. CONCLUSION
268 REFERENCES 269 14 USE OF AN EPIDERMAL CULTURE FOR CUTANEOUS TOXICITY
STUDIES 271 F. L. VAUGHAN I. INTRODUCTION 271 II. DEVELOPING CULTIVATION
PROCEDURES 274 III. STRATIFICATION AND DIFFERENTIATION OF KERATINOCYTES
CULTURED ON NYLON MEMBRANES 282 IV. EXPERIMENTATION WITH SULFUR MUSTARD
IN CUTANEOUS TOXICITY STUDIES USING THE EPIDERMAL CULTURE 286 V. SUMMARY
AND CONCLUSIONS 295 REFERENCES 296 CONTENTS IX PART III: NONTRADITIONAL
TOPICAL DRUG DELIVERY FORMULATIONS 15 THE MICROSPONGE: A NOVEL TOPICAL
PROGRAMMABLE DELIVERY SYSTEM 299 SERGIO NACHT AND MARTIN KATZ I. THE
NEED FOR BETTER SKIN DELIVERY SYSTEMS 299 II. MICROSPONGE TECHNOLOGY 300
III. MICROSPONGE SYNTHESIS 301 IV. PHYSICAL CHARACTERIZATION OF
MICROSPONGES 307 V. PROGRAMMABLE PARAMETERS 308 VI. RELEASE MECHANISMS
310 VII. SAFETY SUBSTANTIATION 312 VIII. INCREASED EFFICACY AND
AESTHETIC APPEAL OF DRUG FORMULATIONS 317 IX. POSSIBLE APPLICATIONS FOR
MICROSPONGE SYSTEMS 322 X. ADVANTAGES FOR INDUSTRY . 324 REFERENCES 324
16 LIPOSOME-BASED VEHICLES FOR TOPICAL DELIVERY 327 PAUL S. VSTER I.
INTRODUCTION 327 II. LIPOSOMOLOGY 327 III. FORMULATING TOPICAL
PRODUCTS WITH LIPOSOMES 332 IV. RESEARCH STUDIES 337 V. FUTURE
DIRECTIONS 344 REFERENCES 346 17 SURFACTANT ASSOCIATION COLLOIDS AS
TOPICAL DRUG DELIVERY VEHICLES 349 DAVID W. OSBORNE, ANTHONY J, 1. WARD,
AND KILIAN J, O NEILL I. INTRODUCTION 349 II. DESCRIPTION OF
SURFACTANT ASSOCIATION COLLOIDS 350 III. FORMULATION OF TOPICAL
SURFACTANT ASSOCIATION COLLOIDS 355 IV. DRUG DELIVERY FROM TOPICAL
SURFACTANT ASSOCIATION COLLOIDS 372 V. CONCLUDING REMARKS 376 REFERENCES
377 X CONTENTS 18 GEL DOSAGE FORMS: THEORY, FORMULATION, AND PROCESSING
381 LORRAINE E. PENA I. THEORY 381 II. FORMULATION 382 III. PROCESSING
387 REFERENCES 388 19 USING SILICONES IN TOPICAL PRODUCTS 389 MICHAEL S.
STARCH I. INTRODUCTION 389 II. TYPES OF SILICONES USED IN TOPICAL
PRODUCTS AND THEIR PROPERTIES 390 III. FORMULATING SILICONES INTO
CONVENTIONAL TOPICAL FORMULATIONS 397 IV. NONTRADITIONAL TOPICAL
FORMULATIONS BASED ON SILICONES 406 REFERENCES 408 INDEX 411
|
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| dewey-ones | 615 - Pharmacology and therapeutics |
| dewey-raw | 615/.6 |
| dewey-search | 615/.6 |
| dewey-sort | 3615 16 |
| dewey-tens | 610 - Medicine and health |
| discipline | Chemie / Pharmazie Medizin |
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| spelling | Topical drug delivery formulations ed. by David W. Osborne ... New York u.a. Dekker 1990 XII, 420 S. Ill. txt rdacontent n rdamedia nc rdacarrier Drugs and the pharmaceutical sciences 42 Excipients - Congrès Médicaments - Administration par voie transdermique - Congrès Peau - Physiologie - Congrès Administration, Cutaneous Congresses Biological Transport Congresses Drug Carriers Congresses Excipients Congresses Skin Physiology Congresses Skin metabolism Congresses Transdermal medication Congresses Haut (DE-588)4023838-6 gnd rswk-swf Wirkstofffreisetzung (DE-588)4190018-2 gnd rswk-swf Dermatikum (DE-588)4011488-0 gnd rswk-swf Hautresorption (DE-588)4023861-1 gnd rswk-swf Transdermales therapeutisches System (DE-588)4194948-1 gnd rswk-swf (DE-588)1071861417 Konferenzschrift gnd-content Dermatikum (DE-588)4011488-0 s Wirkstofffreisetzung (DE-588)4190018-2 s DE-604 Hautresorption (DE-588)4023861-1 s Transdermales therapeutisches System (DE-588)4194948-1 s Haut (DE-588)4023838-6 s Osborne, David W. Sonstige oth Drugs and the pharmaceutical sciences 42 (DE-604)BV000002008 42 GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=001694551&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Topical drug delivery formulations Drugs and the pharmaceutical sciences Excipients - Congrès Médicaments - Administration par voie transdermique - Congrès Peau - Physiologie - Congrès Administration, Cutaneous Congresses Biological Transport Congresses Drug Carriers Congresses Excipients Congresses Skin Physiology Congresses Skin metabolism Congresses Transdermal medication Congresses Haut (DE-588)4023838-6 gnd Wirkstofffreisetzung (DE-588)4190018-2 gnd Dermatikum (DE-588)4011488-0 gnd Hautresorption (DE-588)4023861-1 gnd Transdermales therapeutisches System (DE-588)4194948-1 gnd |
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| title | Topical drug delivery formulations |
| title_auth | Topical drug delivery formulations |
| title_exact_search | Topical drug delivery formulations |
| title_full | Topical drug delivery formulations ed. by David W. Osborne ... |
| title_fullStr | Topical drug delivery formulations ed. by David W. Osborne ... |
| title_full_unstemmed | Topical drug delivery formulations ed. by David W. Osborne ... |
| title_short | Topical drug delivery formulations |
| title_sort | topical drug delivery formulations |
| topic | Excipients - Congrès Médicaments - Administration par voie transdermique - Congrès Peau - Physiologie - Congrès Administration, Cutaneous Congresses Biological Transport Congresses Drug Carriers Congresses Excipients Congresses Skin Physiology Congresses Skin metabolism Congresses Transdermal medication Congresses Haut (DE-588)4023838-6 gnd Wirkstofffreisetzung (DE-588)4190018-2 gnd Dermatikum (DE-588)4011488-0 gnd Hautresorption (DE-588)4023861-1 gnd Transdermales therapeutisches System (DE-588)4194948-1 gnd |
| topic_facet | Excipients - Congrès Médicaments - Administration par voie transdermique - Congrès Peau - Physiologie - Congrès Administration, Cutaneous Congresses Biological Transport Congresses Drug Carriers Congresses Excipients Congresses Skin Physiology Congresses Skin metabolism Congresses Transdermal medication Congresses Haut Wirkstofffreisetzung Dermatikum Hautresorption Transdermales therapeutisches System Konferenzschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=001694551&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000002008 |
| work_keys_str_mv | AT osbornedavidw topicaldrugdeliveryformulations |