Neurobiology of glycoconjugates:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York u.a.
Plenum Press
1989
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XVII, 453 S. Ill. |
| ISBN: | 0306431289 |
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| 650 | 2 | |a Glycoconjugués - Métabolisme | |
| 650 | 4 | |a Glycolipides | |
| 650 | 4 | |a Glycoprotéines | |
| 650 | 2 | |a Neurobiologie | |
| 650 | 4 | |a Neurochimie | |
| 650 | 2 | |a Neurochimie | |
| 650 | 4 | |a Glycoconjuages | |
| 650 | 4 | |a Glycoconjugates |x metabolism | |
| 650 | 4 | |a Glycolipids | |
| 650 | 4 | |a Glycoproteins | |
| 650 | 4 | |a Neurobiology | |
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Datensatz im Suchindex
| _version_ | 1804117007169224704 |
|---|---|
| adam_text | Neurobiology of
Glycoconjugates
Edited by
Richard U Margolis
New York University Medical Center
New York, New York
and
Renee K Margolis
State University of New York
Health Science Center at Brooklyn
Brooklyn, New York
Plenum Press • New York and London
Contents
Chapter 1
Structure and Localization of Gangliosides
Robert K Yu and Megumi Saito
1 Introduction 1
2 Structures 1
2 1 Ganglio Series 20
2 2 Hemato and Gala Series 20
2 3 Lacto Series 20
2 4 Globo and Isoglobo Series 21
3 Localization 21
3 1 Whole Nerve Tissues 21
3 2 Nerve Cells 21
3 3 Subcellular Fractions 31
4 References 34
Chapter 2
Biosynthesis, Metabolism, and Biological Effects of Gangliosides
Robert W Ledeefv
1 Introduction and Overview 43
2 Ganglioside Biosynthesis 44
2 1 In Vitro Studies Establishing the Major Pathways 44
2 2 Site of Biosynthesis 47
2 3 Regulation of Biosynthesis 48
3 Metabolism 50
3 1 In Vivo Studies 50
3 2 Catabolism: Localization 51
3 3 Transport and Transfer 54
4 Function 57
4 1 Gangliosides and Receptors 57
4 2 Receptor Modulators 58
ix
X CONTENTS
4 3 Enzyme Modulation 60
4 4 Neuritogenic and Neuronotrophic Activity 62
5 References 69
Chapter 3
Structure and Localization of Glycoproteins and Proteoglycans
Renee K Margolis and Richard U Margolis
1 Introduction 85
2 Structure 86
2 1 Glycoproteins 86
2 2 Glycosaminoglycans and Proteoglycans 90
3 Localization and Properties of Specific Nervous Tissue Glycoproteins
and Proteoglycans 94
3 1 The NILE Glycoprotein (LI Antigen, Ng-CAM) 94
3 2 Brain Thy-1 Glycoprotein 95
3 3 The F3-87-8 Glycoprotein 99
3 4 Hyaluronic Acid and the Chondroitin Sulfate Proteoglycans of
Brain 100
3 5 Heparan Sulfate Proteoglycans of Nervous Tissue 105
3 6 Retina Proteoglycans 110
3 7 Glycoproteins and Proteoglycans of Chromaffin Granules and
Large Dense-Cored Vesicles Ill
4 Biological Function of the Carbohydrate Units in Glycoproteins and
Proteoglycans 115
5 Appendix 116
6 References 118
Chapter 4
Biosynthesis of Glycoproteins
Charles J Waechter ~~
1 Introduction and Background 127
2 Dolichol Pathway for Protein N-Glycosylation 128
2 1 Enzymatic Synthesis of a Dolichol-Linked Oligosaccharide
Intermediate in the Rough Endoplasmic Reticulum 128
2 2 Enzymatic Transfer of Glucosylated Precursor Oligosaccharide
from Dolichyl Pyrophosphate to Asparagine Residues of Nascent
Polypeptide Acceptors 129
3 Processing of N-Linked Oligosaccharide Chains 130
3 1 Effect of Inhibitors of Processing Glycosidases on N-Linked
Oligosaccharide Assembly in Nervous Tissue 132
3 2 Sugar Nucleotide:Glycoprotein Glycosyltransferases Involved in
the Biosynthesis of N-Linked Oligosaccharide Chains 133
CONTENTS xi
3 3 Sugar Nucleotide:Glycoprotein Glycosyltransferases Involved in
the Biosynthesis of O-Linked Oligosaccharide Chains 134
4 Enzymes Involved in Dolichyl Phosphate Metabolism 134
4 1 Dolichol Kinase 135
4 2 Polyisoprenyl Phosphate Phosphatase 136
4 3 Dolichyl Pyrophosphate Phosphatase 137
4 4 Dolichyl Ester Hydrolase 137
4 5 Subcellular Locations of Enzymes Involved in Dolichyl Phosphate
Metabolism 137
5 Developmental Changes in Dolichol Pathway 138
5 1 Metabolic Labeling Studies on Protein N-Glycosylation Activity 138
5 2 Developmental Changes in Enzyme Activities Related to the Lipid
Intermediate Pathway 139
5 3 Developmental Changes in Dolichyl Phosphate Metabolism 139
6 Content of Dolichol, Dolichyl Esters, and Dolichyl Phosphate in
Nervous Tissue 140
7 Consequences of Blocking N-Glycosylation of Membrane Glycoproteins
Performing Specific Neurobiological Functions 141
7 1 Acetylcholine Receptors 141
7 2 Voltage-Sensitive Sodium Channels 142
7 3 Opiate Receptors 143
7 4 Rhodopsin 143
7 5 P0of PNS Myelin 143
7 6 Other Neurobiological Processes 143
8 Summary and Prospectus 144
9 References 145
Chapter 5
Biosynthesis of Glycosaminoglycans and Proteoglycans
Nancy B Schwartz and Neil R Smalheiser
1 Introduction 77 1 5 1
2 Proteoglycan Assembly 152
2 1 Core Proteins 152
2 2 Nucleotide Sugar Precursors 155
2 3 Glycosaminoglycan Chain Assembly 156
2 4 Polysaccharide Modification 159
2 5 Biosynthesis of Hyaluronic Acid 163
2 6 Regulation of Synthesis 164
3 Cellular Aspects of Proteoglycan Biosynthesis 167
3 1 Basal Laminae versus Oriented Extracellular Channels 168
3 2 Adherons 169
3 3 Cell-Associated Matrix Molecules 169
3 4 Mesenchymelike Matrices 171
3 5 Intracellular Proteoglycans 172
xii CONTENTS
4 Biosynthetic Alterations as an Experimental Tool 173
4 1 Biosynthetic Mutants in Whole Organisms 173
4 2 Biosynthetic Mutants in Cultured Cells 174
4 3 P-Xylosides 175
5 Specific Glycosaminoglycan Chain Modifications 175
6 Conclusion 177
7 References 177
Chapter 6
Lysosomal Degradation of Glycoproteins and Glycosaminoglycans
Larry W Hancock and Glyn Dawson
1 Introduction 187
2 Glycoprotein Catabolism 188
2 1 The Structure of Glycoprotein-Associated Oligosaccharides 188
2 2 Catabolism of 0-Linked Oligosaccharide Chains 188
2 3 Catabolism of N-Linked Oligosaccharide Chains 190
2 4 Catabolism of the Polypeptide Backbone 192
2 5 Delivery of Catabolic Enzymes and Glycoprotein Substrates to the
Lysosome 193
2 6 Inhibitors of Glycoprotein Catabolism 193
3 Glycosaminoglycan Catabolism 197
3 1 Catabolism of the Oligosaccharide Chains 197
3 2 Catabolism of the Polypeptide Backbone 199
3 3 Summary 199
3 4 Delivery of Substrate Proteoglycans to the Lysosome 199
4 Synthesis and Targeting of Lysosomal Enzymes 200
4 1 Mannose 6-Phosphate-Mediated Targeting 200
4 2 Mannose 6-Phosphate-Independent Targeting 200
4 3 Proteolytic Processing 201
4 4 Mannose-6-Phfisphate Receptor-Mediated Endocytosis 201
5 Regulation of Lysosomal Catabolism 202
5 1 Lysosomal Activity and Stability of Catabolic Enzymes 202
5 2 Synthesis of Lysosomal Enzymes 203
5 3 Turnover of Lysosomal Enzymes 204
6 Nonlysosomal Catabolism of Glycoproteins and
Glycosaminoglycans 204
6 1 Cytoplasmic Catabolism 204
6 2 Extracellular Catabolism 207
7 Catabolism of Neural-Specific Glycoconjugates 207
7 1 The HNK-1/L2 Epitope 207
7 2 Neural Cell Adhesion Molecules (NCAMs) 208
7 3 Other Neural Glycoconjugates 208
8 Developmental Modulation of Catabolic Enzymes 208
CONTENTS xiii
9 Future Directions 209
10 References 210
Chapter 7
Glycoproteins of the Synapse
James W Gurd
1 Introduction 219
2 Characterization of Subcellular Fractions Used for the Identification of
Synaptic Glycoproteins 220
3 Identification and Characterization of Synaptic Glycoproteins 221
3 1 Oligosaccharide Composition of Synaptic Glycoproteins 221
3 2 Identification of Synaptic Glycoproteins 222
4 Phosphorylation of Synaptic Glycoproteins 227
5 Biosynthesis and Modification 228
6 Developmental Aspects 230
7 Immunological Approaches to the Study of Synaptic Glycoproteins 232
8 Concluding Remarks 234
9 References 235
Chapter 8
Glycoproteins of Myelin and Myelin-Forming Cells
Richard H Quarles
1 Introduction and Overview of the Chemical Structure of PNS and CNS
Myelin 243
2 P0 Glycoprotein 244
2 1 Introduction 244
2 2 Chemistry 244
2 3 Biosynthesis and Metabolism 245
2 4 Localization and Structural Function in Compact PNS Myelin 246
2 5 Phylogeny 248
2 6 Involvement in Peripheral Nerve Diseases 248
3 Myelin-Associated Glycoprotein (MAG) 249
3 1 Introduction 249
3 2 Chemical Properties 250
3 3 Development, Biosynthesis, and Metabolism 252
3 4 Monoclonal Antibodies Binding to a Carbohydrate Determinant in
MAG and Other Glycoconjugates 253
3 5 Function 255
3 6 Phylogeny 261
3 7 Clinical Aspects 261
x/V CONTENTS
4 Other Glycoproteins Associated with Myelin and Myelin-Forming
Cells 264
4 1 19- to 28-kDa Glycoproteins of PNS Myelin 264
4 2 170-kDa Glycoprotein of PNS Myelin 264
4 3 Myelin/Oligodendrocyte Glycoprotein 265
4 4 Adhesion Proteins Produced by Myelin-Forming Cells 265
4 5 Other Little-Characterized Glycoproteins of Myelin and Myelin-
Forming Cells 266
5 Conclusions and Perspectives 266
6 References 267
Chapter 9
Axonal Transport and Intracellular Sorting of Glycoconjugates
Jeffry F Goodrum, George C Stone, and Pierre Morell
1 Introduction to Axonal Transport 277
2 Axonal Transport Methodology 279
2 1 Radioisotope Methodology Is Used to Study Glycoconjugate
Transport 279
22A Specific Example: Glycoprotein Transport in the Optic System 279
3 Intracellular Sorting of Glycoconjugates and the Initiation of Axonal
Transport 281
3 1 The Initiation Phase of Axonal Transport 281
3 2 Routing of Proteins and Glycoproteins during the Initiation of Fast
Axonal Transport 283
4 Axonal Transport of Glycoconjugates 285
4 1 Transport of Glycoproteins 285
4 2 Transport of Glycosaminoglycans 292
4 3 Transport of Glycolipids 294
5 Fate of Transported Glycoconjugates 296
5 1 Transported Glycoconjugates May Be Modified at Their
Destinations 296
5 2 Transported Glycoconjugates May Be Redistributed to New
Locations 297
5 3 Glycoconjugates Are Components of Retrograde Transport 298
5 4 Many Glycoconjugates Exhibit an Apparent Biphasic Metabolic
Turnover at Nerve Endings 299
6 Future Prospects 301
7 References 301
Chapter 10
Synaptic Vesicle Glycoproteins and Proteoglycans
Steven S Carlson
1 Introduction 309
2 Synapsin 1 311
CONTENTS xv
3 p38 or Synaptophysin 312
4 p65 316
5 SV2 318
6 Synaptic Vesicle Proteoglycan 320
7 Terminal Anchorage Protein One (TAP-1) 326
8 Conclusions 330
9 References 331
Chapter 11
Carbohydrate Recognition, Cell Interactions, and Vertebrate Neural
Development
M A Hynes, J Dodd, and T M Jessell
1 Introduction 337
2 Complex Oligosaccharide Structures on Neural Cells 338
3 Proteins Involved in Saccharide Recognition 340
3 1 Ca2 +-Dependent Carbohydrate Binding Proteins 341
3 2 Ca2+-Independent Soluble Lectins 341
3 3 Glycosyltransferases 342
4 Carbohydrate-Mediated Cell-Cell Interactions 342
4 1 Recognition of Circulating Glycoproteins by Hepatic Lectins 342
4 2 Mammalian Sperm-Egg Interactions 343
4 3 Compaction of Preimplantation Mouse Embryos 344
4 4 Lymphocyte Homing 345
5 Carbohydrate Recognition in the Nervous System 346
5 1 Cell Recognition in the Retinotectal System 347
5 2 Carbohydrate Recognition in the Spinal Cord 350
5 3 Neuromuscular Junction 356
6 Carbohydrate Structures on Neural Cell Adhesion Molecules 357
7 Conclusions 359
8 References 360
Chapter 12
Polysialic Acid as a Regulator of Cell Interactions
Urs Rutishauser
1 An Introduction to NCAM 367
1 1 Classification of Different Cell Adhesion Molecules 367
1 2 Biochemistry of the NCAM Polypeptide 368
1 3 NCAM Function in Development 369
2 NCAM Polysialic Acid 371
2 1 Content and Properties 371
2 2 Effects on NCAM-Mediated Cell-Cell Aggregation 372
2 3 Reagents for the Analysis of NCAM PSA 373
2 4 Developmental Regulation of NCAM PSA 374
xvi CONTENTS
3 Evidence That NCAM PSA Can Regulate Cell Interactions 375
3 1 Cell Contact-Dependent Biochemical Changes 375
3 2 NCAM PSA Content Alone Can Regulate the Function of Other
Cell Surface Ligands 376
4 Proposed Mechanism for NCAM-Mediated Regulation of Cell
Interactions 376
5 Discussion 377
6 References 379
Chapter 13
Extracellular Matrix Adhesive Glycoproteins and Their Receptors in the
Nervous System
Philippe Douville and Salvatore Carbonetto
1 Introduction 383
2 Organization of the ECM of the Nervous System 384
3 Adhesive Glycoproteins of the ECM 385
3 1 Laminin 385
3 2 Fibronectin 389
3 3 Type IV Collagen 390
3 4 Other Adhesive ECM Glycoproteins 391
4 Receptors for ECM Components 392
4 1 Integrins 393
4 2 High-Affinity 67-kDa Laminin Receptor 395
4 3 High-Affinity 120/140-kDa Laminin Receptor 397
4 4 Other ECM Receptors 398
5 Nerve Fiber Growth on Extracellular Matrices—Concluding Remarks 399
6 References 401
Chapter 14
Hyaluronate and Hyaluronate-Binding Proteins of Brain
Bryan P Toole
1 Hyaluronate Synthesis during Embryonic Development 411
2 Hyaluronate and Cell Behavior 411
3 Hyaluronate-Binding Proteins and Hyaluronate-Cell Surface
Interactions 413
4 Hyaluronate-Binding Proteins in Brain 414
5 References 416
Chapter 15
Inborn Errors of Complex Carbohydrate Catabolism
Glyn Dawson and Larry W Hancock
1 Introduction 421
CONTENTS xvii
2 Inborn Errors of Glycolipid and Glycoprotein Catabolism 423
2 1 Neuraminidase Deficiency 423
2 2 GlcNAc Phosphotransferase Deficiency (I-Cell Disease;
Mucolipidosis II) 425
2 3 (3-Galactosidase Deficiency (GM1 Gangliosidosis) 426
2 4 Combined Neuraminidase-Lysosomal (3-Galactosidase
Deficiency 427
2 5 Globoid Cell Leukodystrophy (Krabbe s Disease) 427
2 6 N-Acetyl-(3-hexosaminidase Deficiencies 427
2 7 a-Mannosidosis 429
2 8 (3-Mannosidosis 429
2 9 a-Fucosidosis 430
2 10 Aspartylglucosaminuria (AGU) 431
2 11 a-Galactosidase Deficiency (Fabry s Disease) 431
2 12 ,/V-Acetyl-a-galactosaminidase Deficiency 431
2 13 Arylsulfatase A Deficiency (Metachromatic Leukodystrophy) 432
2 14 Multiple Sulfatase Deficiency (MSD) 432
2 15 Ceramidase Deficiency (Farber s Lipogranulomatosis) 432
2 16 3-Glucosidase Deficiency (Gaucher s Disease) 432
2 17 Neuronal Ceroid Lipofuscinosis (Batten s Disease) 433
2 18 Lysosomal (Acid) a-Glucosidase Deficiency (Pompe s
Disease) 433
2 19 Sialic Acid Storage Diseases 434
2 20 Other Diseases Involving Glycoconjugates 435
3 Inborn Errors of Glycosaminoglycan Catabolism 435
3 1 a-L-Iduronidase Deficiency (Hurler-Scheie s Disease; Types IH
and IS) 435
3 2 Iduronate Sulfate Sulfatase Deficiency (Hunter s Disease;
Type II) 437
3 3 The Sanfilippo Syndromes (Type III) 437
3 4 GalNAc-6-sulfate Sulfatase Deficiency (Morquio s Disease;
Type IV) 438
3 5 Proteoglycan (3-Galactosidase Deficiency (Type V) 438
3 6 GalNAc-4-sulfate Sulfatase Deficiency (Maroteaux-Lamy
Syndrome; Type VI) 439
3 7 (3-Glucuronidase Deficiency (Type VII) 439
4 Future Directions 439
5 References 440
Index 449
|
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| publisher | Plenum Press |
| record_format | marc |
| spelling | Neurobiology of glycoconjugates ed. by Richard U. Margolis ... New York u.a. Plenum Press 1989 XVII, 453 S. Ill. txt rdacontent n rdamedia nc rdacarrier Glycoconjugués - Métabolisme Glycolipides Glycoprotéines Neurobiologie Neurochimie Glycoconjuages Glycoconjugates metabolism Glycolipids Glycoproteins Neurobiology Neurochemistry Neurobiologie (DE-588)4041871-6 gnd rswk-swf Neurochemie (DE-588)4041872-8 gnd rswk-swf Glykokonjugate (DE-588)4131221-1 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Glykokonjugate (DE-588)4131221-1 s Neurochemie (DE-588)4041872-8 s DE-604 Neurobiologie (DE-588)4041871-6 s Margolis, Richard U... Sonstige (DE-588)116771046 oth HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=001685635&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Neurobiology of glycoconjugates Glycoconjugués - Métabolisme Glycolipides Glycoprotéines Neurobiologie Neurochimie Glycoconjuages Glycoconjugates metabolism Glycolipids Glycoproteins Neurobiology Neurochemistry Neurobiologie (DE-588)4041871-6 gnd Neurochemie (DE-588)4041872-8 gnd Glykokonjugate (DE-588)4131221-1 gnd |
| subject_GND | (DE-588)4041871-6 (DE-588)4041872-8 (DE-588)4131221-1 (DE-588)4143413-4 |
| title | Neurobiology of glycoconjugates |
| title_auth | Neurobiology of glycoconjugates |
| title_exact_search | Neurobiology of glycoconjugates |
| title_full | Neurobiology of glycoconjugates ed. by Richard U. Margolis ... |
| title_fullStr | Neurobiology of glycoconjugates ed. by Richard U. Margolis ... |
| title_full_unstemmed | Neurobiology of glycoconjugates ed. by Richard U. Margolis ... |
| title_short | Neurobiology of glycoconjugates |
| title_sort | neurobiology of glycoconjugates |
| topic | Glycoconjugués - Métabolisme Glycolipides Glycoprotéines Neurobiologie Neurochimie Glycoconjuages Glycoconjugates metabolism Glycolipids Glycoproteins Neurobiology Neurochemistry Neurobiologie (DE-588)4041871-6 gnd Neurochemie (DE-588)4041872-8 gnd Glykokonjugate (DE-588)4131221-1 gnd |
| topic_facet | Glycoconjugués - Métabolisme Glycolipides Glycoprotéines Neurobiologie Neurochimie Glycoconjuages Glycoconjugates metabolism Glycolipids Glycoproteins Neurobiology Neurochemistry Neurochemie Glykokonjugate Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=001685635&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT margolisrichardu neurobiologyofglycoconjugates |