Hormones and their actions: 2 Specific actions of protein hormones
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Amsterdam [u.a.]
Elsevier
1988
|
| Schriftenreihe: | New comprehensive biochemistry
18,B |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XV, 366 S. Ill., graph. Darst. |
| ISBN: | 044480997X |
Internformat
MARC
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| 245 | 1 | 0 | |a Hormones and their actions |n 2 |p Specific actions of protein hormones |c ed. B. A. Cooke ... |
| 264 | 1 | |a Amsterdam [u.a.] |b Elsevier |c 1988 | |
| 300 | |a XV, 366 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a New comprehensive biochemistry |v 18,B | |
| 490 | 0 | |a New comprehensive biochemistry |v ... | |
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Datensatz im Suchindex
| _version_ | 1805066617712803840 |
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| adam_text |
IMAGE 1
CONTENTS
LIST OF CONTRIBUTORS V
CHAPTER 1. G PROTEINS AND TRANSMEMBRANE SIGNALLING, BY L. BIRNBAUMER, J.
CODINA, R. MATTERA, A. YATANI AND A.M. BROWN L
1. INTRODUCTION 1
2. THE G PROTEINS IDENTIFIED BY FUNCTION AND PURIFICATION 5
2.1. G S, THE STIMULATORY REGULATORY COMPONENT OF ADENYLYL CYCLASE 5
2.2. TRANSDUEIN (T), THE LIGHT-ACTIVATED GTPASE 8
2.3. G;, THE INHIBITORY REGULATORY COMPONENT OL ADCNYLYL CYCIASE 9
2.4. G,,, A PTX SUBSTRATE WITH AN A SUBUNIT OF M R 39000 10
2.5. G PS, THE REGULATORY COMPONENTS OF PHOSPHOLIPASC (PHL) ACTIVITY 11
2.6. G K, THE ACTIVATOR OF 'LIGAND-GATED' K' CHANNELS: MECHANISM OF
MUSCARINIC REGULATION OF ATRIAL PACING 13
3. G PROTEINS DETECTED BY ADP-RIBOSYLATION 17
3.1. LABELING WITH CTX 18
3.2. LABELING WITH PTX 19
4. G PROTEIN STRUCTURE BY CLONING 20
4.1. THE A SUBUNITS 21
4.2. THE (I SUBUNITS 31
4.3. THE Y SUBUNIT: ITS ROLE AS A MEMBRANE ANCHOR 32
5. G PROTEIN MEDIATION OF RECEPTOR REGULATION OF ION CHANNELS 32
5.1. EFFECTS OF INHIBITORY RECEPTORS ON K ' CHANNELS IN TISSUES OTHER
THAN HEART ATRIA . . 32
5.2. INHIBITORY REGULATION OF VOLTAGE-GATED CA 2+ CHANNELS: DIRECT OR
INDIRECT INVOLVEMENT OF A G PROTEIN? 35
5.3. STIMULATORY REGULATION OF CA 2' CHANNELS: DIRECT G PROTEIN COUPLING
IN SPITE OF REGULATION BY CAMP-DCPCNDENT PROTEIN KINASC A 36
6. CONCLUDING REMARKS 38
ACKNOWLEDGEMENTS 39
REFERENCES 39
CHAPTER 2. INOSITOL PHOSPHOLIPIDS AND CELLULAR SIGNALLING, BY G.R. GUY
AND
C.J. KIRK 47
1. INTRODUCTION 47
2. INOSITOL PHOSPHOLIPIDS 48
3. ROLE OF GTP-BINDING PROTEINS IN RECEPTOR-RESPONSE COUPLING 50
4. PRODUCTS OF PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATC HYDROLYSIS AND
THEIR ROLES AS SECOND MESSENGERS IN THE CELL 52
4.1. INOSITOL TRISPHOSPHATE AND CALCIUM MOBILISATION 52
IMAGE 2
4.2. DIACYLGLYCEROL MOBILISATION AND THE ACTIVATION OF PROTEIN KINASE C
52
5. METABOLISM OF THE HYDROLYSIS PRODUCTS OF PTDLNS 4,5-P 2 54
5.1. INOSITOL TRISPHOSPHATE 54
5.2. DIACYLGLYCEROL 56
6. FERTILISATION, PROLIFERATION AND ONCOGCNCS 56
6.1. ROLE OF INOSITOL LIPID DEGRADATION 56
6.2. INFLUENCE OF IONOPHORES AND SYNTHETIC STIMULATORS OF PROTEIN KINASE
C 58
6.3. ONCOGCNCS 59
7. RELEASE OF ARACHIDONIC ACID 59
7.1. MECHANISMS OF ARACHIDONATE LIBERATION 59
8. SUMMARY 61
REFERENCES 61
CHAPTER 3. THE ROLE OF CALCIUM BINDING PROTEINS IN SIGNAL TRANSDUCTION,
BY
N.C. KHANNA, M. TOKUDA AND D.M. WAISMAN 63
1. INTRODUCTION 63
2. THE CALCIUM TRANSIENT 65
3. CALCIUM BINDING PROTEINS AND SIGNAL TRANSDUCTION 67
4. CALCIUM BINDING PROTEINS: STRUCTURE AND FUNCTION 69
4.1. EXTRACELLULAR CALCIUM BINDING PROTEINS 70
4.2. MEMBRANOUS CALCIUM BINDING PROTEINS 70
4.3. INTRACELLULAR CALCIUM BINDING PROTEINS 74
4.3.1. THE-EF'DOMAIN FAMILY 74
4.3.2. THE ANNCXIN-FOLD FAMILY 77
4.3.3. MISCELLANEOUS CALCIUM BINDING PROTEINS 79
5. CALCIUM BINDING PROTEINS AND CELLULAR FUNCTION 80
5.1. MUSCLE CONTRACTION 81
5.1.1. ACTIN BASED REGULATION (SKELETAL AND CARDIAC MUSCLE) 81
5.1.2. MYOSIN BASED REGULATION (SMOOTH MUSCLE) 82
5.2. METABOLISM 83
5.3. SECRETION AND EXOCYTOSIS 84
5.4. EGG FERTILIZATION AND MATURATION 86
5.5. CELL GROWTH AND PROLIFERATION 87
REFERENCES 89
CHAPTER 4. MECHANISM OF ACTION OF CA 2+ -DEPENDENT HORMONES, BY
H. RASMUSSEN AND P. Q. BARRETT 93
1. INTRODUCTION 93
2. CELLULAR CALCIUM METABOLISM 94
2.1. PLASMA MEMBRANE 95
2.2. ENDOPLASMIC RETICULUM 97
2.3. MITOCHONDRIAL MATRIX 98
3. MECHANISMS OF CA 2~ MESSENGER GENERATION 99
4. MESSENGER CALCIUM 99
4.1. COORDINATED CHANGES IN PI AND CA 2~ METABOLISM 100
4.2. SMOOTH MUSCLE CONTRACTION 102
4.3. COORDINATE CHANGES IN CAMP AND CA 2+ METABOLISM 103
IMAGE 3
4.3.1. K*-MEDIATED ALDOSTERONE SECRETION 103
4.3.2. CONTROL OF HEPATIC METABOLISM BY GLUCAGON 105
5. SYNARCHIC REGULATION 106
5.1. REGULATION OF INSULIN SECRETION BY CCK AND GLUCOSE 106
6. INTEGRATION OF EXTRACELLULAR MESSENGER INPUTS 109
REFERENCES 110
CHAPTER 5. MECHANISM OF ACTION OF PITUITARY HORMONE RELEASING AND
INHIBITING
FACTORS, BY C. DENEF 113
1. THE ADENYLATE CYCLASE-CAMP SYSTEM 114
1. TRH 114
2. VIP 114
3. DA 115
4. LHRH 116
5. CRF 117
1.6. VASOPRESSIN 117
1.7. G R F A N D S R IF 117
2. THE CA 2+ MESSENGER SYSTEM 118
2.1. TRH 118
2.2. VIP 119
2.3. DA 120
2.4. LHRH 120
2.5. CRF 121
2.6. VASOPRESSIN 122
2.7. GRF AND SRIF 122
3. THE INOSITOL POLYPHOSPHATC-DIACYLGLYCEROL-PROTEIN KINASE C SYSTEM 123
3.1. TRH 123
3.2. VIP 124
3.3. DA 124
3.4. LHRH 124
3.5. CRF AND VASOPRESSIN 125
3.6. GRF AND SRIF 126
4. ARACHIDONIC ACID DERIVATIVES 126
4.1. TRH 126
4.2. VIP 127
4.3. DA 127
4.4. LHRH 128
4.5. CRF AND VASOPRESSIN 128
4.6. GRF AND SRIF 129
5. CONCLUDING REMARKS 130
REFERENCES 130
CHAPTER 6. MECHANISM OF GONADOTROPIN RELEASING HORMONE ACTION, BY L.
JENNES
AND P.M. CONN 135
1. INTRODUCTION 135
2. STRUCTURE OF GNRH 135
3. THE BIOCHEMICAL PROPERTIES OF THE GNRH RECEPTOR 137
IMAGE 4
4. LOCALIZATION OF THE GNRH RECEPTOR 138
5. ROLE OF RECEPTOR MIEROAGGREGATION 139
6. RELATIONSHIPS BETWEEN GNRH RECEPTOR NUMBER AND CELLULAR RESPONSE 141
7. SECOND MESSENGER SYSTEMS 142
8. CALCIUM AS A SECOND MESSENGER 143
9. PHOSPHOLIPIDS 145
10. DIACYLGLYCEROLS 146
L L . G TP BINDING PROTEINS 147
12. PROTEIN KINASE C 147
13. CONCLUSION 148
ACKNOWLEDGEMENT 150
REFERENCES 150
CHAPTER 7. THE MECHANISMS OF ACTION OF LUTEINIZING HORMONE. 1.
LUTEINIZING
HORMONE-RECEPTOR INTERACTIONS, BY B.A. COOKE AND F.F.G. ROMMERTS. . . .
155
1. INTRODUCTION 155
2. THE STRUCTURE OF LH 156
3. THE LH RECEPTOR 157
3.1. PURIFICATION AND CHARACTERIZATION 157
3.2. INTERACTION OF LH WITH ITS RECEPTOR 158
3.3. LH RECEPTOR RECYCLING AND SYNTHESIS 159
3.4. REGULATION OF LH RECEPTORS 160
REFERENCES 161
CHAPTER 8. THE M E C H A N I S MS OF A C T I ON OF L U T E I N I Z I NG
H O R M O N E. II. TRANSDUCING
S Y S T E MS A ND B I O L O G I C AL EFFECTS, BY F . F . G. R O M M E R
TS AND B . A. C O O KE . . . 163
1. LH RECEPTOR TRANSDUCING SYSTEMS 163
1.1. FORMATION OF CYCLIC AMP 164
1.2. THE PHOSPHOINOSITIDE CYCLE 164
1.3. ARACHIDONIC ACID: RELEASE AND METABOLISM TO PROSTAGLANDINS AND
LEUKOTRIENES . . . 165 1.4. CONTROL AND ACTION OF INTRACCLLULAR CALCIUM
166
2. STEROIDOGENESIS 166
2.1. SECOND MESSENGERS 167
2.2. FORMATION AND POSSIBLE ROLES OF SPECIFIC (PHOSPHO)PROTEINS 168
2.3. CONTROL MECHANISMS IN MITOCHONDRIA 169
3. DESENSITIZATION AND DOWN REGULATION 171
3.1. UNCOUPLING OF THE LH RECEPTOR FROM THE ADENYLATE CYCLASE SYSTEM 171
3.2. REVERSAL OF DESENSITIZATION 172
3.3. INHIBITION OF STEROIDOGENCSIS IN LH DESENSITIZED CELLS 172
4. OTHER EFFECTS OF LH 173
5. LH ACTION ON GONADAL CELLS IN PERSPECTIVE 175
REFERENCES 178
IMAGE 5
CHAPTER 9. MECHANISM OF ACTION OF FSH IN THE OVARY, BY K.D. DAHL AND
A.J.W. HSUEH 181
1. INTRODUCTION 181
2. BIOCHEMISTRY OF FSH 181
2.1. A, /SSUBUNITS 181
2.2. CARBOHYDRATE CONTENT 181
3. FSH RECEPTORS IN TARGET CELLS 182
3.1. RADIOLIGAND RECEPTOR ASSAY 183
3.2. AGONISTIC AND ANTAGONISTIC EFFECTS OF FSH ANALOGS 183
4. ACTIVATION OF THE PROTEIN KINASE A PATHWAY 184
4.1. COUPLING BETWEEN THE FSH RECEPTOR AND ADENYLATE CYCLASE 184
4.2. STIMULATION OF PROTEIN KINASE A 185
5. FSH INDUCTION OF GRANULOSA CELL DIFFERENTIATION 185
5.1. LH AND PRL RECEPTORS, AND/3-ADRENERGIC RESPONSIVENESS 185
5.2. LIPOPROTEIN RECEPTORS 186
5.3. GAP JUNCTION AND MICROVILLI FORMATION 186
6. FSH STIMULATION OF STEROIDOGENIC ENZYMES 186
6.1. AROMATASE INDUCTION 187
6.1.1. ENZYME INDUCTION 187
6.1.2. TWO-CELL, TWO-GONADOTROPIN THEORY 187
6.1.3. GRANULOSA CELL AROMATASE BIOASSAY FOR FSH 188
6.2. INDUCTION OF CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYMES 188
6.3. INDUCTION OF THE 3/3-HYDROXYSTEROID DEHYDROGENASE ENZYME 188
7. FSH STIMULATION OF INHIBIN BIOSYNTHESIS 188
8. FSH STIMULATION OF TISSUE-TYPE PLASMINOGEN ACTIVATOR 189
9. CONCLUSION 190
REFERENCES 190
CHAPTER 10. THE MECHANISM OF ACTH IN THE ADRENAL CORTEX, BY
P.J. HORNSBY 193
1. ACTH AND THE CYCLIC AMP INTRACELLULAR MESSENGER SYSTEM 193
1.1. THE INTRACELLULAR MESSENGER FOR ACTH 193
1.2. SPARE CYCLIC AMP GENERATING CAPACITY AND ITS FUNCTION 194
1.3. THE INTERACTION OF THE ACTH RECEPTOR WITH ADENYLATE CYCLASE 194
1.4. CYCLIC AMP-DEPENDENT PROTEIN KINASE IN THE ADRENAL CORTEX 195
1.5. THE PATHWAY OF BIOSYNTHESIS OF STEROIDS IN THE ADRENAL CORTEX 195
1.5.1. THE ENZYMES OF STEROIDOGENESIS 195
1.5.2. ZONATION OF STEROIDOGENESIS 196
1.6. THE REGULATION BY ACTH OF THE RATE-LIMITING STEP OF
STEROIDOGENESIS, THE CONVERSION OF CHOLESTEROL TO PREGNENOLONC 197
1.6.1. NATURE OF THE RATE-LIMITING STEP: LIMITATION ON CELLULAR MOVEMENT
OF CHOLESTEROL 197
1.6.2. SUPPLY OF CHOLESTEROL TO THE PRECURSOR POOL AVAILABLE FOR
STEROIDOGENESIS. . . 198 1.6.3. ACTH REGULATION OF THE CHOLESTEROL POOL
198
1.6.4. REGULATION OF THE RATE-LIMITING STEP BY CYCLIC AMP-DEPENDCNT
PROTEIN KINASE 199 1.7. THE REGULATION OF THE SYNTHESIS OF THE
STEROIDOGENIC ENZYMES BY ACTFI 200
IMAGE 6
1.7.1. THE INTEGRATION OF THE SHORT- AND LONG-TERM ACTIONS OF ACTH TO
PROVIDE
INCREASED STEROIDOGENESIS 200
1.7.2. MECHANISM OF ENZYME INDUCTION BY CYCLIC AMP 201
1.8. INDIRECT ACTION OF ACTH ON GROWTH AND METABOLISM 202
2. INTERACTION OF THE ACTH/CYCLIC AMP SYSTEM WITH OTHER HORMONES AND
INTRACELLULAR MESSENGERS 203
2.1. ZONAL DIFFERENCES 203
2.2. INTERACTIONS AT ADENYLATE CYCLASC 204
2.3. ACTH AND CYCLIC GMP 205
2.4. ACTH AND THE CALCIUM INTRACELLULAR MESSENGER SYSTEM 206
2.4.1. ZONAL DIFFERENCES 206
2.4.2. THE CALCIUM SECOND MESSENGER SYSTEM IN THE ADRENAL CORTEX 206
2.4.3. CYCLIC AMP PHOSPHODIESTERASE 206
2.5. ACTH AND PROTEIN KINASE C 207
2.5.1. C-KINASE IN THE ADRENAL CORTEX: PRESENCE AND STEROIDOGENIC
EFFECTS 207 2.5.2. COORDINATE REGULATION OF ADRENAL ENZYME SYNTHESIS BY
A-AND C-KINASES . . . 207 2.5.3. MECHANISMS FOR REGULATION OF
STEROIDOGENIC ENZYMES THAT DIFFER IN ACTIVITY BETWEEN THE DIFFERENT
ZONES 207
2.5.4. THE ORIGIN OF ZONATION IN THE CORTEX 208
REFERENCES 209
CHAPTER 11. MECHANISM OF ACTION OF ANGIOTENSIN 11, BY P.Q. BARRETT,
W.B. BOLLAG AND H. RASMUSSEN 211
1. INTRODUCTION 211
2. ALL RECEPTORS 212
2.1. REGULATION OF RECEPTOR AFFINITY 212
2.2. REGULATION OF RECEPTOR NUMBER 213
3. RECEPTOR-GUANINE NUCLCOTIDC INTERACTIONS 214
4. TRANSDUCING ENZYME ACTIVATION 214
4.1. ADENYLATE CYCLASE 215
4.2. PHOSPHOLIPASE C 216
4.2.1. ACTIVATION VIA G-PROTEINS 216
4.2.2. SUBSTRATE(S) 216
4.2.3. PRODUCTS (SECOND MESSENGERS) 217
5. ALL-INDUCED CHANGES IN CALCIUM METABOLISM 219
5.1. INTRACELLULAR CALCIUM CONCENTRATION 219
5.2. CALCIUM MOBILIZATION 219
5.3. TOTAL CELL CALCIUM 220
5.4. CALCIUM ENTRY 220
6. INTEGRATION OF SIGNALS AND CELLULAR RESPONSE 222
6.1. INITIATION OF RESPONSE 223
6.2. MAINTENANCE OF RESPONSE 224
6.3. TEMPORAL RELATIONSHIP OF THE TWO PHASES 226
REFERENCES 228
CHAPTER 12. MECHANISMS OF ACTION OF GLUCAGON, BYJ.H. EXTON 231
1. INTRODUCTION 231
2. THE GLUCAGON RECEPTOR 232
IMAGE 7
3. GUANINC NUCLEOTIDE BINDING REGULATORY PROTEIN 233
4. ADENYLATE CYCLASC CATALYTIC SUBUNIT 235
5. CAMP AND CAMP-DEPENDCNT PROTEIN KINASE 236
6. SUBSTRATES OF CAMP-DEPENDCNT PROTEIN KINASE IN LIVER 239
6.1. PHOSPHORYLASE B KINASE 239
6.2. GLYCOGEN SYNTHASE 241
6.3. PYRUVATE KINASE 242
6.4. 6-PHOSPHOFRUCTO 2-KINASE/FRUCTOSE 2.6-BISPHOSPHATASE 244
6.5. ACCTYL-COA CARBOXYLASE, ATP-CITRATE LYASC 245
7. EFFECTS OF GLUCAGON ON CELL CALCIUM 245
8. SYNERGISTIC INTERACTION BETWEEN GLUCAGON AND CALCIUM-MOBILIZING
AGONISTS IN LIVER . . . 250 9. INHIBITORY ACTION OF PHORBOL ESTERS ON
GLUCAGON-INDUCED CALCIUM MOBILIZATION 252
10. OTHER ACTIONS OF GLUCAGON 252
11. SUMMARY 256
REFERENCES 259
CHAPTER 13. MECHANISM OF ACTION OF GROWTH HORMONE, BY M. WALLIS 265
1. THE GROWTH HORMONE-PROLACTIN FAMILY 265
2. GROWTH HORMONE AND THE CONTROL OF SOMATIC GROWTH 266
3. RECEPTORS FOR GROWTH HORMONE 267
3.1. DISTRIBUTION OF GROWTH HORMONE RECEPTORS 267
3.2. HETEROGENEITY OF GROWTH HORMONE RECEPTORS 268
3.3. STRUCTURE AND PURIFICATION OF GROWTH HORMONE RECEPTORS 269
3.4. SIGNAL TRANSDUCTION FOLLOWING BINDING OF GROWTH HORMONE TO ITS
RECEPTOR 271
3.5. REGULATION OF GROWTH HORMONE RECEPTOR LEVELS 271
4. SOMATOMEDINS/IGFS AND THE ACTIONS OF GROWTH HORMONE 273
4.1. THE NATURE OF SOMATOMEDINS 273
4.2. THE ACTIONS OF SOMATOMEDINS 273
4.3. SOMATOMEDIN-BINDING PROTEINS 274
4.4. SYNTHESIS AND SECRETION OF SOMATOMEDINS 274
4.5. REGULATION OF SOMATOMEDIN PRODUCTION BY GROWTH HORMONE 275
4.6. BIOCHEMICAL MECHANISMS INVOLVED IN THE ACTION OF GROWTH HORMONE ON
SOMATOMEDIN C PRODUCTION 276
4.7. SOMATOMEDIN C AND SOMATIC GROWTH 277
5. ACTIONS OF GROWTH HORMONE ON PRODUCTION OF OTHER SPECIFIC PROTEINS
278
6. ACTIONS OF GROWTH HORMONE ON PROTEIN METABOLISM 279
6.1. ACTIONS OF GROWTH HORMONE ON PROTEIN SYNTHESIS IN THE LIVER 279
6.2. ACTIONS ON MUSCLE 279
7. ACTIONS OF GROWTH HORMONE ON LIPID AND CARBOHYDRATE METABOLISM 280
7.1. LIPID METABOLISM 281
7.2. CARBOHYDRATE METABOLISM 281
8. ACTIONS OF GROWTH HORMONE ON CELLULAR DIFFERENTIATION AND
PROLIFERATION 282
9. GROWTH HORMONE AND THE CONTROL OF LACTATION 283
10. APPLICATIONS OF MOLECULAR BIOLOGY TO THE STUDY OF THE ACTIONS OF
GROWTH HORMONE . . . 283 10.1. PROTEIN ENGINEERING OF GROWTH HORMONE
283
10.2. TRANSGENIC MICE 284
11. POTENTIATION OF THE ACTIONS OF GROWTH HORMONE BY MONOCLONAL
ANTIBODIES 284
12. GROWTH HORMONE VARIANTS 286
12.1. NATURALLY OCCURRING VARIANTS 286
IMAGE 8
12.2. THE MULTIVALENT NATURE OF GROWTH HORMONE 287
13. CONCLUSIONS 288
13.1. THE MULTIPLE ACTIONS OF GROWTH HORMONE 288
13.2. THE SIGNIFICANCE OF SOMATOMEDIN C/IGF-I 289
14. ADDENDUM 289
ACKNOWLEDGEMENTS 290
REFERENCES 290
CHAPTER 14. MECHANISM OF ACTION OF PROLACTIN, BY M. WALLIS 295
1. LACTOGENIC HORMONES 295
2. THE BIOLOGICAL ACTIONS OF PROLACTIN 296
2.1. ACTIONS ON THE MAMMARY GLAND 296
2.2. OTHER ACTIONS IN MAMMALS 297
2.3. ACTIONS IN LOWER VERTEBRATES 299
3. RECEPTORS FOR PROLACTIN 299
3.1. CHARACTERIZATION OF RECEPTORS 299
3.2. REGULATION OF PROLACTIN RECEPTORS 303
4. BIOCHEMICAL MODE OF ACTION OF PROLACTIN ON THE MAMMARY GLAND 304
4.1. ACTIONS ON MAMMARY GLAND DIFFERENTIATION AND DEVELOPMENT 304
4.2. EFFECTS ON SYNTHESIS OF MILK PROTEINS 306
4.3. EFFECTS ON OTHER MILK COMPONENTS 307
4.4. SECOND MESSENGERS IN THE ACTIONS OF PROLACTIN 307
5. ACTIONS OF PROLACTIN ON THE PIGEON CROP SAC 309
5.1. SYNLACTIN AND THE ACTIONS OF PROLACTIN 309
6. ACTIONS OF PROLACTIN ON THE IMMUNE SYSTEM 311
6.1. NB2 CELL PROLIFERATION 311
6.2. OTHER TISSUES AND CELLS OF THE IMMUNE SYSTEM 313
7. VARIANTS OF PROLACTIN 314
7.1. FRAGMENTS 314
7.2. GLYCOSYLATED PROLACTINS 314
8. PROLACTIN AND MAMMARY CANCER 314
9. CONCLUSIONS 315
REFERENCES 315
CHAPTER 15. STRUCTURE AND FUNCTION OF THE RECEPTOR FOR INSULIN, BY
M.D. HOUSLAY AND M.J.O. WAKELAM 321
1. INTRODUCTION 321
2. INSULIN RECEPTOR STRUCTURE 321
3. CLONING OF THE GENE FOR THE INSULIN RECEPTOR 324
4. INSULIN RECEPTOR INTERNALIZATION 325
5. INSULIN'S STIMULATION OF GLUCOSE TRANSPORT 328
6. INSULIN-LIKE GROWTH FACTORS (IGFS) 329
7. INSULIN RECEPTOR TYROSY] KINASE ACTIVITY 330
8. INSULIN AND ITS ACTION ON GUANINE NUCLEOTIDE REGULATORY PROTEINS 336
9. AN INTRACELLULAR 'MEDIATOR' OF INSULIN'S ACTION 341
10. CONCLUDING REMARKS 343
ACKNOWLEDGEMENTS 344
REFERENCES 345
IMAGE 9
CHAPTER 16. A COMPARISON OF THE STRUCTURES OF SINGLE POLYPEPTIDE CHAIN
GROWTH
FACTOR RECEPTORS THAT POSSESS PROTEIN TYROSINE KINASE-ACTIVITY, BY-W.J.
GULLICK 349
1. INTRODUCTION 349
2. THE EGF RECEPTOR AND THE C-ERBB-2 PROTEIN 349
3. PLATELET-DERIVED GROWTH FACTOR RECEPTOR AND COLONY-STIMULATING FACTOR
1 RECEPTOR 354 4. SUMMARY 358
REFERENCES 359
SUBJECT INDEX 361 |
| any_adam_object | 1 |
| author_GND | (DE-588)172025273 |
| building | Verbundindex |
| bvnumber | BV002401475 |
| ctrlnum | (OCoLC)220281659 (DE-599)BVBBV002401475 |
| format | Book |
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| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV002401475 |
| illustrated | Illustrated |
| indexdate | 2024-07-20T03:21:12Z |
| institution | BVB |
| isbn | 044480997X |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-001559819 |
| oclc_num | 220281659 |
| open_access_boolean | |
| owner | DE-19 DE-BY-UBM DE-703 DE-355 DE-BY-UBR DE-12 DE-29 DE-83 DE-11 DE-188 |
| owner_facet | DE-19 DE-BY-UBM DE-703 DE-355 DE-BY-UBR DE-12 DE-29 DE-83 DE-11 DE-188 |
| physical | XV, 366 S. Ill., graph. Darst. |
| publishDate | 1988 |
| publishDateSearch | 1988 |
| publishDateSort | 1988 |
| publisher | Elsevier |
| record_format | marc |
| series | New comprehensive biochemistry |
| series2 | New comprehensive biochemistry |
| spelling | Hormones and their actions 2 Specific actions of protein hormones ed. B. A. Cooke ... Amsterdam [u.a.] Elsevier 1988 XV, 366 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier New comprehensive biochemistry 18,B New comprehensive biochemistry ... Hormones cabt Physiologie (DE-588)4045981-0 gnd rswk-swf Hormon (DE-588)4025864-6 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Hormon (DE-588)4025864-6 s Physiologie (DE-588)4045981-0 s DE-604 Cooke, Brian A. Sonstige (DE-588)172025273 oth (DE-604)BV000882717 2 New comprehensive biochemistry 18,B (DE-604)BV000003914 18,B SWB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=001559819&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Hormones and their actions New comprehensive biochemistry Hormones cabt Physiologie (DE-588)4045981-0 gnd Hormon (DE-588)4025864-6 gnd |
| subject_GND | (DE-588)4045981-0 (DE-588)4025864-6 (DE-588)4143413-4 |
| title | Hormones and their actions |
| title_auth | Hormones and their actions |
| title_exact_search | Hormones and their actions |
| title_full | Hormones and their actions 2 Specific actions of protein hormones ed. B. A. Cooke ... |
| title_fullStr | Hormones and their actions 2 Specific actions of protein hormones ed. B. A. Cooke ... |
| title_full_unstemmed | Hormones and their actions 2 Specific actions of protein hormones ed. B. A. Cooke ... |
| title_short | Hormones and their actions |
| title_sort | hormones and their actions specific actions of protein hormones |
| topic | Hormones cabt Physiologie (DE-588)4045981-0 gnd Hormon (DE-588)4025864-6 gnd |
| topic_facet | Hormones Physiologie Hormon Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=001559819&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000882717 (DE-604)BV000003914 |
| work_keys_str_mv | AT cookebriana hormonesandtheiractions2 |