Chemical neurobiology: an introduction to neurochemistry
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
New York
Freeman
1986
|
| Ausgabe: | 1. print. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Literaturangaben |
| Beschreibung: | XVI, 507 S. zahlr. Ill., graph. Darst. |
| ISBN: | 0716716941 |
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Datensatz im Suchindex
| _version_ | 1804116730303217664 |
|---|---|
| adam_text | CHEMICAL
NEUROBIOLOGY
An Introduction to Neurochemistry
H F Bradford
Professor of Neurobiology
The Royal College of Science,
Imperial College of Science and Technology
South Kensington, London
•B
W H Freeman and Company
New York
Contents
Preface xv
Chapter 1: Neurons: Organization for Interaction 1
Neuronal Systems 3
Neuronal Structure 8
Fibrillar Protein Systems in Neural Cells 12
Neurotubules 13
Neurofilaments 28
Microfilaments 20
Axoplasmic Flow 20
Neuronal Membrane Structure 22
Membrane Proteins 22
Membrane Lipids 28
Organization of Myelin Membranes 29
The Myelination Process 31
Myelin Composition 32
Myelin Proteolipid Protein 34
Myelin Basic Protein 35
Molecular Organization of Myelin 38
vii
viii CONTENTS
The Forms and Ultrastructure of Synapses 38
Synaptic Structures 40
Synaptic Systems 45
Specific Biochemical Markers for Neurons 52
Neurotransmitter-Synthesizing Enzymes 53
The 14-3-2 Protein 54
Tetanus and Cholera Toxins 54
Other Neuron-specific Proteins 55
Chapter 2: Glial Cells: Mechanical and Functional Supporting
Cells of the Nervous System 62
Glial Systems 62
Types of Glial Cell 63
Glia of the Peripheral Nervous System 69
Ependymal Cells 69
Neuron and Glia Interrelationships 75
The Fluid Filter System and the Blood-Brain Barrier 77
The Extracellular Space in Brain 83
Glial Cell Intercommunication 87
Insulating Function of Glial Cells 88
Exchanges of Metabolites Between Neurons and Glia 89
Exchanges of Macromolecules Between Neurons and Glia 92
Guiding Role of Glia During Neuronal Development 92
Electrical Influences of Neurons on Glia 93
Glial Cell Responses to Injury and Inflammation 94
Neurotransmitter Transport Systems in Glia 95
Specific Markers for Glia 96
Enzyme Markers 96
Specific Proteins and Other Glial Markers 98
Neurons and Glia in Cell Culture 100
Categories of Cell Culture 100
Bulk-Prepared Neurons and Glia 108
Isolated Neurons 108
Isolated Glial Cells 108
Uses of Bulk Preparations 110
Chapter 3: Brain Glucose and Energy Metabolism: The Linkage
to Function 118
Brain Energy Metabolism in Vivo 118
The Vulnerable Brain 118
What the Brain Takes from the Blood and Adds to It 118
Contents ix
Glucose: The Primary Substrate 121
The Regional Use of Glucose 125
Metabolism During Extremes of Brain Activity: Anesthesia and
Convulsion 131
Energy Phosphate Turnover 133
The Total Energy Charge of Neural Tissue 133
Monitoring ATP Levels with [31P]nmr 136
Key Substrates and Brain Function 137
Brain Energy Metabolism in Vitro 138
Linkage to Excitation 140
Lactate Formation 141
Glucose Metabolism: The Pathways Involved 141
Amino Acid Formation 141
The GABA-Shunt Pathway 141
Glutamate and Aspartate Formation 142
Glutamine and Alanine 146
Cellular Compartmentation of Metabolism 146
Neuronal and Glial Substrates 146
Computer Models 147
Chapter 4: Neurotransmitters: Chemical Target Seekers 155
Neurotransmitter Systems 157
Identification Criteria 158
Second Messengers and Ionophores 161
The Cholinergic Neurotransmitter System 165
Synthesis and Storage of Acetylcholine 265
Release of Acetylcholine 167
Pharmacology of Cholinergic Synapses 173
Postsynaptic Acetylcholine Receptors 174
Location of Neural Pathways Employing Acetylcholine 177
The Catecholamine and Indoleamine Neurotransmitter
Systems 179
Synthesis and Storage of Norepinephrine, Dopamine, and
Serotonin 179
Release of Norepinephrine, Dopamine, and Serotonin 188
Pharmacology of Biogenic Amine Systems 193
Postsynaptic Norepinephrine Receptors 195
Isolation of Biogenic Amine Receptor Proteins 202
Location of Neural Pathways Employing Biogenic Amines 204
X CONTENTS
t
The Epinephrine Neurotransmitter System 208
Synthesis and Storage of Epinephrine 209
Release and Turnover of Epinephrine in Brain 209
Pharmacology of Epinephrine Neurons 209
Location of Epinephrine Neurons 210
The Amino Acid Neurotransmitter System 210
Two Excitatory Amino Acids: Glutamate and Aspartate 211
Synthesis and Storage of Glutamate and Aspartate 211
Release and Inactivation of Glutamate and Aspartate 214
Pharmacology of Glutamate and Aspartate 219
Isolation of Glutamate and Aspartate Receptors 225
Location of Pathways Employing Glutamate and Aspartate 225
Two Inhibitory Amino Acids: GAB A and Glycine 229
GABA Synthesis 229
Glycine Synthesis 232
Release and Inactivation of GABA and Glycine 232
Pharmacology of GABA and Glycine 234
Isolation of GABA Receptors 240
Location of Pathways Employing GABA and Glycine 241
Taurine: A Doubtful Neurotransmitter 242
Taurine Synthesis 243
Release of Taurine 245
The Purines ATP and AMP: Unexpected
Neurotransmitters 246
Purinergic Receptors 248
Synthesis, Storage, and Inactivation of Purines 249
Histamine: A Neurotransmitter Role for an Old
Compound? 250
Synthesis and Storage of Histamine 250
Release, Turnover, and Inactivation of Histamine 251
Pharmacology of Histamine 251
Location of Histamine Pathways 253
Chapter 5: Neuropeptides: The Rising Generation of
Neuroactive Substances 265
Peptidergic Systems 266
Special Features 266
Substance P 269
Enkephalins and Endorphins 273
Somatostatin 282
Contents x
Thyrotropin-Releasing Hormone 284
Luteinizing Hormone-Releasing Hormone 287
Angiotensin 288
Neurotensin 290
Oxytocin and Vasopressin 291
Cholecystokinin 293
Vasoactive Intestinal Peptide 295
Neuropeptide Y 296
Carnosine 298
Bombesin 300
Other Peptides 302
Chapter 6: The Synaptosome: An In Vitro Model of the
Synapse 311
Metabolic Properties of the Synaptosome 315
Synaptosomal Membrane Potentials 317
Purity of Synaptosome Fractions 320
Neurotransmitter-Releasing Properties 322
Transport Properties of Synaptosomes 325
High-Affinity and Low-Affinity Transport 325
Homoexchange and the Relationship Between Uptake and
Release 328
Calcium Transport 329
Experimental Uses of Synaptosome Preparations 330
Synaptosome Subpopulations 330
Presynaptic Receptors 330
Phospholipid and Protein Biosynthesis 331
Specialized Synaptosome Preparations 332
Synaptosome Preparations from Nonmammalian Sources 332
Giant Synaptosomes 335
Preparation of Nerve Terminal Components From
Synaptosomes 337
Synaptic Junctions or Complexes 339
Postsynaptic Density and Lattice 343
Protein Constituents of Synaptic Junctional Structures 347
Chapter 7: Synapses: Their Development and Dynamics 353
Nerve Fiber Growth and Synapse Formation 353
Pathfinding by Neuronal Fibers During Development 354
Chemical Influences on Nerve Fiber Growth 356
xii CONTENTS
Synapse Formation 361
Regeneration of Synapses in Adult Brains 364
Brain Tissue Grafts 364
Maintenance of Synaptic Regions 366
Synaptic Events and Neurotransmitter Release
Mechanisms 367
Calcium Entry and Neurotransmitter Release 367
Vesicular Theory of Neurotransmitter Release 371
Vesicles or Cytoplasm: The Source of Released
Neurotransmitter 373
Cotransmission: The Release of More than One
Neurotransmitter 384
Presynaptic Receptors: The Control of Neurotransmitter
Release 388
Categories of Presynaptic Receptor 390
Peripheral Presynaptic Receptors 393
Excitatory Peripheral Presynaptic Receptors 394
Dopaminergic and Cholinergic Presynaptic Interactions in the
Peripheral Nervous System 395
Presynaptic Receptors Operated by Other Neurotransmitters and
Modulators 396
Presynaptic Receptors in the Central Nervous System 396
Mechanisms of Presynaptic Receptor Action 398
Neurotransmitter Interactions 399
Neurotransmitter Interactions in the Basal Ganglia 400
Dendritic Release of Neurotransmitter 402
The Output of the Basal Ganglia 402
Is Neurotransmitter Released from All Regions of the Neuronal
Cell Surface? 402
Chapter 8: Central Neurotransmitter Systems
and Behavior 412
Research Strategies 413
Catecholamines and Behavior 414
Dopaminergic Systems 414
Catecholaminergic Systems and Self-Stimulation 417
Self-Administration Experiments 420
Dopamine Receptor Subpopulations 424
Serotonin Systems and Behavior 424
Inhibitory Actions 424
Contents
Excitatory Actions 425
Other Serotonin-Mediated Behaviors 426
Serotonin and Sleep 427
Serotonin Receptor Subpopulations 428
Monoaminergic Neural Organization and Behavior: A
Summary 428
Acetylcholine Systems and Behavior 429
Tremor 430
Circling Behavior 431
Arousal 431
Peptides and Behavior 432
Angiotensin and Drinking Behavior 433
Luteinizing Hormone-Releasing Hormone and Sexual
Behavior 433
Thyrotropin-Releasing Hormone, Somatostatin, and Physiological
Response 434
Neurotensin and Dopaminergic Systems 435
Cholecystokinin and Feeding Behavior 435
Vasopressin and Memory Processes 435
Endogenous Opioid Peptides 436
Chapter 9: The Failure of Neurotransmitter Systems in
Disorders of the Brain and Nervous System 442
Imbalance of Synaptic Action 442
Movement Disorders 443
Parkinson s Disease 443
Dyskinesias 452
Huntington s Chorea 453
Drug-Induced Dyskinesias 458
Psychological Disorders 459
Schizophrenia 459
Depressive Illness 463
Senile Dementia 466
Epilepsy 470
Categories of Fit 470
Etiology of Epilepsy 470
The Epileptic Focus 472
Animal Models of Epilepsy 473
Neurotransmitters Involved in Epilepsy 474
Anticonvulsants: Mechanism of Action 477
XIV
t CONTENTS
Hepatic Coma States 477
Disturbances in Serotonin in Hepatic Coma 478
Changes in Other Monoamines in Hepatic Coma 480
Myasthenia Gravis 482
Appendix 491
Index 495
|
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| indexdate | 2024-07-09T15:43:09Z |
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| spelling | Bradford, Henry F. Verfasser aut Chemical neurobiology an introduction to neurochemistry H. F. Bradford 1. print. New York Freeman 1986 XVI, 507 S. zahlr. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Literaturangaben Nervous System cabt Neurochemistry cabt Brain Chemistry Brain chemistry Neurochemistry Neurochemie (DE-588)4041872-8 gnd rswk-swf Gehirn (DE-588)4019752-9 gnd rswk-swf Biochemie (DE-588)4006777-4 gnd rswk-swf Neurobiologie (DE-588)4041871-6 gnd rswk-swf Neurobiologie (DE-588)4041871-6 s DE-604 Neurochemie (DE-588)4041872-8 s Gehirn (DE-588)4019752-9 s Biochemie (DE-588)4006777-4 s HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=001493083&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Bradford, Henry F. Chemical neurobiology an introduction to neurochemistry Nervous System cabt Neurochemistry cabt Brain Chemistry Brain chemistry Neurochemistry Neurochemie (DE-588)4041872-8 gnd Gehirn (DE-588)4019752-9 gnd Biochemie (DE-588)4006777-4 gnd Neurobiologie (DE-588)4041871-6 gnd |
| subject_GND | (DE-588)4041872-8 (DE-588)4019752-9 (DE-588)4006777-4 (DE-588)4041871-6 |
| title | Chemical neurobiology an introduction to neurochemistry |
| title_auth | Chemical neurobiology an introduction to neurochemistry |
| title_exact_search | Chemical neurobiology an introduction to neurochemistry |
| title_full | Chemical neurobiology an introduction to neurochemistry H. F. Bradford |
| title_fullStr | Chemical neurobiology an introduction to neurochemistry H. F. Bradford |
| title_full_unstemmed | Chemical neurobiology an introduction to neurochemistry H. F. Bradford |
| title_short | Chemical neurobiology |
| title_sort | chemical neurobiology an introduction to neurochemistry |
| title_sub | an introduction to neurochemistry |
| topic | Nervous System cabt Neurochemistry cabt Brain Chemistry Brain chemistry Neurochemistry Neurochemie (DE-588)4041872-8 gnd Gehirn (DE-588)4019752-9 gnd Biochemie (DE-588)4006777-4 gnd Neurobiologie (DE-588)4041871-6 gnd |
| topic_facet | Nervous System Neurochemistry Brain Chemistry Brain chemistry Neurochemie Gehirn Biochemie Neurobiologie |
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