Aspects of the Merrifield peptide synthesis:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Berlin [u.a.]
Springer
1978
|
| Schriftenreihe: | Reactivity and structure
8 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | VIII, 102 S. graph. Darst. |
| ISBN: | 3540088725 0387088725 |
Internformat
MARC
| LEADER | 00000nam a2200000 cb4500 | ||
|---|---|---|---|
| 001 | BV002255182 | ||
| 003 | DE-604 | ||
| 005 | 20130220 | ||
| 007 | t | ||
| 008 | 890928s1978 d||| |||| 00||| eng d | ||
| 020 | |a 3540088725 |9 3-540-08872-5 | ||
| 020 | |a 0387088725 |9 0-387-08872-5 | ||
| 035 | |a (OCoLC)4004519 | ||
| 035 | |a (DE-599)BVBBV002255182 | ||
| 040 | |a DE-604 |b ger |e rakddb | ||
| 041 | 0 | |a eng | |
| 049 | |a DE-12 |a DE-91G |a DE-20 |a DE-355 |a DE-29T |a DE-19 |a DE-83 |a DE-188 | ||
| 050 | 0 | |a QD431 | |
| 082 | 0 | |a 547.7/56 |2 19 | |
| 084 | |a VK 8560 |0 (DE-625)147540:253 |2 rvk | ||
| 084 | |a CHE 820f |2 stub | ||
| 100 | 1 | |a Birr, Christian |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Aspects of the Merrifield peptide synthesis |c Christian Birr |
| 264 | 1 | |a Berlin [u.a.] |b Springer |c 1978 | |
| 300 | |a VIII, 102 S. |b graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Reactivity and structure |v 8 | |
| 650 | 7 | |a Organische verbindingen |2 gtt | |
| 650 | 7 | |a Peptiden |2 gtt | |
| 650 | 7 | |a Structuur-activiteit-relatie |2 gtt | |
| 650 | 7 | |a Synthese (chemie) |2 gtt | |
| 650 | 4 | |a Peptides |x Synthesis | |
| 650 | 4 | |a Peptides |x chemical synthesis | |
| 650 | 0 | 7 | |a Peptidsynthese |0 (DE-588)4173715-5 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Merrifield-Technik |0 (DE-588)4249446-1 |2 gnd |9 rswk-swf |
| 689 | 0 | 0 | |a Merrifield-Technik |0 (DE-588)4249446-1 |D s |
| 689 | 0 | |5 DE-604 | |
| 689 | 1 | 0 | |a Peptidsynthese |0 (DE-588)4173715-5 |D s |
| 689 | 1 | 1 | |a Merrifield-Technik |0 (DE-588)4249446-1 |D s |
| 689 | 1 | |5 DE-604 | |
| 689 | 2 | 0 | |a Peptidsynthese |0 (DE-588)4173715-5 |D s |
| 689 | 2 | |5 DE-604 | |
| 830 | 0 | |a Reactivity and structure |v 8 |w (DE-604)BV000895108 |9 8 | |
| 856 | 4 | 2 | |m HBZ Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=001481966&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 940 | 1 | |q TUB-nveb | |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-001481966 | ||
| 980 | 4 | |a (DE-12)AK02470024 | |
Datensatz im Suchindex
| _version_ | 1804116711814725632 |
|---|---|
| adam_text | Titel: Aspects of the Merrifield peptide synthesis
Autor: Birr, Christian
Jahr: 1978
Contents
1
Introduction
.......................
1
2
The
Principle
......................
3
2.1
Aspects
of
the
Strategy..................
6
2.2
The
Statistical
Point
of
View
on
Solid
Phase
Reactions
....
9
3
Chemical
Details
of
the
Method
..............
16
3.1
The
Polymer
Support,
Its
Choice,
Properties,
and
Preparation
.
.
16
3.1.1
Introduction
and
Conversion
of
Functional
Sites
on
Polymer
.
.
21
3.1.2
Binding
of
Amino
Acids
and
Peptides
...........
31
3.1.3
Analysis
of
Support-Bound
Amino
Acid
Derivatives
.....
32
3.2
The
Deprotection
and
Deprotonation
...........
36
3.2.1
Aspects
on
Choice
of
Protecting
Groups
..........
37
3.2.2
Deprotecting
Reagents..................
39
3.2.3
Deprotonation
Problems.................
40
3.2.4
Analysis
of
Deprotection
and
Deprotonation
........
42
3.3
The
Peptide
Bond
Formation...............
47
3.3.1
Dicyclohexylcarbodiimide
Activation............
47
3.3.2
Symmetric
and
Mixed
Amino
Acid
Anhydrides
.......
50
3.3.3
Active
Esters......................
55
3.3.4
Redox
Condensation...................
55
3.3.5
Fragment
Condensation
on
Polymer
Phase
.........
57
3.3.6
Analysis
of
Peptide
Bond
Formation
...........
58
3.4
Suppression
of
Deletion
Sequences
............
60
3.5
Cleavage
of
Peptides
from
Polymer
Support.........
62
3.5.1
Acidic
Cleavage
Conditions................
62
3.5.1.1
Trifluoroacetic
Acid/Hydrogen
Bromide..........
62
3.5.1.2
Liquid
Hydrogen
Fluoride................
63
3.5.2
Basic
Cleavage
Conditions................
65
3.5.2.1
Base
Catalyzed
Transesterification.............
65
3.5.2.2
Hydrolysis.......................
67
VII
Contents
3.5.2J
Hydrazinolysis......................
67
3.5.2.4
Ammonolysis......................
68
3.5.3
Modified
Cleavages...................
69
4
A
utomatization
of
the
Merrifield
Peptide
Synthesis
.......
72
4.1
Components
of
an
Automatic
System............
72
4.1.1
Programming......................
73
4.1.2
Transport
and
Metering
of
Liquids.............
73
4.1.3
The
Reactor.......................
74
4.1.4
Control
of
Functions
and
of
the
Synthesis..........
76
4.2
Critical
Statement
on
Peptide
Synthesizers..........
79
5
Critical
View
on
the
Applicability
of
the
Merrifield
Synthesis
81
5.1
Aspects
on
Product
Isolation
and
Purification........
81
5.1.1
Problems
on
Identification
of
Impurities
..........
83
5.1.2
The
Demand
for
Analytical
Investigations..........
83
5.1.3
Synthetic
Peptides
for
Pharmaceuticals...........
84
5.2
Outlook
on
Disciplines
Related
to
Peptide
Chemistry.....
85
6
Conclusion
.......................
87
7
References
........................
88
A
uthor
Index
.........................
94
Subject
Index
.........................
97
VIII
|
| any_adam_object | 1 |
| author | Birr, Christian |
| author_facet | Birr, Christian |
| author_role | aut |
| author_sort | Birr, Christian |
| author_variant | c b cb |
| building | Verbundindex |
| bvnumber | BV002255182 |
| callnumber-first | Q - Science |
| callnumber-label | QD431 |
| callnumber-raw | QD431 |
| callnumber-search | QD431 |
| callnumber-sort | QD 3431 |
| callnumber-subject | QD - Chemistry |
| classification_rvk | VK 8560 |
| classification_tum | CHE 820f |
| ctrlnum | (OCoLC)4004519 (DE-599)BVBBV002255182 |
| dewey-full | 547.7/56 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 547 - Organic chemistry |
| dewey-raw | 547.7/56 |
| dewey-search | 547.7/56 |
| dewey-sort | 3547.7 256 |
| dewey-tens | 540 - Chemistry and allied sciences |
| discipline | Chemie / Pharmazie Chemie |
| format | Book |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>02023nam a2200553 cb4500</leader><controlfield tag="001">BV002255182</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">20130220 </controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">890928s1978 d||| |||| 00||| eng d</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">3540088725</subfield><subfield code="9">3-540-08872-5</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">0387088725</subfield><subfield code="9">0-387-08872-5</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)4004519</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV002255182</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rakddb</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-12</subfield><subfield code="a">DE-91G</subfield><subfield code="a">DE-20</subfield><subfield code="a">DE-355</subfield><subfield code="a">DE-29T</subfield><subfield code="a">DE-19</subfield><subfield code="a">DE-83</subfield><subfield code="a">DE-188</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">QD431</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">547.7/56</subfield><subfield code="2">19</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">VK 8560</subfield><subfield code="0">(DE-625)147540:253</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">CHE 820f</subfield><subfield code="2">stub</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Birr, Christian</subfield><subfield code="e">Verfasser</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Aspects of the Merrifield peptide synthesis</subfield><subfield code="c">Christian Birr</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Berlin [u.a.]</subfield><subfield code="b">Springer</subfield><subfield code="c">1978</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">VIII, 102 S.</subfield><subfield code="b">graph. Darst.</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="490" ind1="1" ind2=" "><subfield code="a">Reactivity and structure</subfield><subfield code="v">8</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Organische verbindingen</subfield><subfield code="2">gtt</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Peptiden</subfield><subfield code="2">gtt</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Structuur-activiteit-relatie</subfield><subfield code="2">gtt</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Synthese (chemie)</subfield><subfield code="2">gtt</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Peptides</subfield><subfield code="x">Synthesis</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Peptides</subfield><subfield code="x">chemical synthesis</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Peptidsynthese</subfield><subfield code="0">(DE-588)4173715-5</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Merrifield-Technik</subfield><subfield code="0">(DE-588)4249446-1</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">Merrifield-Technik</subfield><subfield code="0">(DE-588)4249446-1</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="689" ind1="1" ind2="0"><subfield code="a">Peptidsynthese</subfield><subfield code="0">(DE-588)4173715-5</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="1" ind2="1"><subfield code="a">Merrifield-Technik</subfield><subfield code="0">(DE-588)4249446-1</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="1" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="689" ind1="2" ind2="0"><subfield code="a">Peptidsynthese</subfield><subfield code="0">(DE-588)4173715-5</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="2" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="830" ind1=" " ind2="0"><subfield code="a">Reactivity and structure</subfield><subfield code="v">8</subfield><subfield code="w">(DE-604)BV000895108</subfield><subfield code="9">8</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">HBZ Datenaustausch</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=001481966&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="940" ind1="1" ind2=" "><subfield code="q">TUB-nveb</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-001481966</subfield></datafield><datafield tag="980" ind1="4" ind2=" "><subfield code="a">(DE-12)AK02470024</subfield></datafield></record></collection> |
| id | DE-604.BV002255182 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T15:42:51Z |
| institution | BVB |
| isbn | 3540088725 0387088725 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-001481966 |
| oclc_num | 4004519 |
| open_access_boolean | |
| owner | DE-12 DE-91G DE-BY-TUM DE-20 DE-355 DE-BY-UBR DE-29T DE-19 DE-BY-UBM DE-83 DE-188 |
| owner_facet | DE-12 DE-91G DE-BY-TUM DE-20 DE-355 DE-BY-UBR DE-29T DE-19 DE-BY-UBM DE-83 DE-188 |
| physical | VIII, 102 S. graph. Darst. |
| psigel | TUB-nveb |
| publishDate | 1978 |
| publishDateSearch | 1978 |
| publishDateSort | 1978 |
| publisher | Springer |
| record_format | marc |
| series | Reactivity and structure |
| series2 | Reactivity and structure |
| spelling | Birr, Christian Verfasser aut Aspects of the Merrifield peptide synthesis Christian Birr Berlin [u.a.] Springer 1978 VIII, 102 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Reactivity and structure 8 Organische verbindingen gtt Peptiden gtt Structuur-activiteit-relatie gtt Synthese (chemie) gtt Peptides Synthesis Peptides chemical synthesis Peptidsynthese (DE-588)4173715-5 gnd rswk-swf Merrifield-Technik (DE-588)4249446-1 gnd rswk-swf Merrifield-Technik (DE-588)4249446-1 s DE-604 Peptidsynthese (DE-588)4173715-5 s Reactivity and structure 8 (DE-604)BV000895108 8 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=001481966&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Birr, Christian Aspects of the Merrifield peptide synthesis Reactivity and structure Organische verbindingen gtt Peptiden gtt Structuur-activiteit-relatie gtt Synthese (chemie) gtt Peptides Synthesis Peptides chemical synthesis Peptidsynthese (DE-588)4173715-5 gnd Merrifield-Technik (DE-588)4249446-1 gnd |
| subject_GND | (DE-588)4173715-5 (DE-588)4249446-1 |
| title | Aspects of the Merrifield peptide synthesis |
| title_auth | Aspects of the Merrifield peptide synthesis |
| title_exact_search | Aspects of the Merrifield peptide synthesis |
| title_full | Aspects of the Merrifield peptide synthesis Christian Birr |
| title_fullStr | Aspects of the Merrifield peptide synthesis Christian Birr |
| title_full_unstemmed | Aspects of the Merrifield peptide synthesis Christian Birr |
| title_short | Aspects of the Merrifield peptide synthesis |
| title_sort | aspects of the merrifield peptide synthesis |
| topic | Organische verbindingen gtt Peptiden gtt Structuur-activiteit-relatie gtt Synthese (chemie) gtt Peptides Synthesis Peptides chemical synthesis Peptidsynthese (DE-588)4173715-5 gnd Merrifield-Technik (DE-588)4249446-1 gnd |
| topic_facet | Organische verbindingen Peptiden Structuur-activiteit-relatie Synthese (chemie) Peptides Synthesis Peptides chemical synthesis Peptidsynthese Merrifield-Technik |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=001481966&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000895108 |
| work_keys_str_mv | AT birrchristian aspectsofthemerrifieldpeptidesynthesis |