DNA, chromatin and chromosomes:
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Oxford [u.a.]
Blackwell
1981
|
| Ausgabe: | 1. publ. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XVII, 281 S. Ill., graph. Darst. |
| ISBN: | 0632005548 |
Internformat
MARC
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| 100 | 1 | |a Bradbury, Edwin Morton |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a DNA, chromatin and chromosomes |c E. M. Bradbury ; Norman Maclean ; Harry R. Matthews* |
| 250 | |a 1. publ. | ||
| 264 | 1 | |a Oxford [u.a.] |b Blackwell |c 1981 | |
| 300 | |a XVII, 281 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 7 | |a Chromatin |2 swd | |
| 650 | 4 | |a Chromatin | |
| 650 | 4 | |a Chromosomes | |
| 650 | 4 | |a DNA | |
| 650 | 4 | |a Gene expression | |
| 650 | 0 | 7 | |a Chromatin |0 (DE-588)4010152-6 |2 gnd |9 rswk-swf |
| 689 | 0 | 0 | |a Chromatin |0 (DE-588)4010152-6 |D s |
| 689 | 0 | |5 DE-604 | |
| 700 | 1 | |a MacLean, Norman |d 1932- |e Verfasser |0 (DE-588)13975959X |4 aut | |
| 700 | 1 | |a Matthews, Harry R. |e Verfasser |4 aut | |
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Datensatz im Suchindex
| _version_ | 1804116600556617728 |
|---|---|
| adam_text | IMAGE 1
CONTENTS
PREFACE, XI SUMMARY OF CHAPTERS, XIII
ABBREVIATIONS, XVIII
1 COMPONENTS OF EUKARYOTIC CHROMATIN, 1 1.1 INTRODUCTION, 1 1.2
COMPONENTS OF EUKARYOTIC CHROMATIN, 2 1.3 COMPLEXITY OF EUKARYOTIC
CHROMATIN, 3
1.4 STRUCTURE OF DNA, 4 1.4.1 A NEW DNA STRUCTURE, 10 1.5 CHROMOSOMAL
PROTEINS, 11 1.5.1 HISTONES, 11
1.5.2 PROPERTIES OF HISTONES, 12 1.5.3 HISTONES H3 AND H4,14 1.5.4
HISTONES H2A AND H2B, 15 1.5.5 VERY LYSINE-RICH HISTONES, 16
1.5.6 HISTONE VARIABILITY, 17 1.6 CHEMICAL MODIFICATIONS OF HISTONES, 20
1.6.1 METHYLATION OF HISTONES, 20
1.6.2 ACETYLATION OF HISTONES, 20 1.6.3 HISTONE PHOSPHORYLATION, 20
1.6.4 PROTEIN A24,22 1.7 HISTONE COMPLEXES, 22 1.8 INTERACTIONS AND
CONFORMATIONS OF HISTONES, 23
1.8.1 H2A,H2B,H3ANDH4,23 1.8.2 HISTONE HI, 24 1.9 PROTAMINES, 25 1.10
NON-HISTONE PROTEINS, 25 1.11 HMG PROTEINS. 30 1.11.1 PROPERTIES OF HMG
PROTEINS, 30 1.11.2 SEQUENCES OF HMG PROTEINS, 31 HMG 14,31 HMG 17,31
HMG LAND 2,33 1.11.3 SEQUENCES OF HMG PROTEINS, 33 1.12 CONFORMATIONAL
STUDIES OF HMG PROTEINS, 33 1.13 INTERACTIONS OF HMG PROTEINS WITH DNA,
33 1.14 UBIQUITIN,34 1.15 FURTHER READING, 34
IMAGE 2
VI CONTENTS
2 CHROMATIN STRUCTURE, 35 2.1 INTRODUCTION, 35 2.2 SUB-UNIT STRUCTURE OF
CHROMATIN, 35 , 2.3 THE NUCLEOSOME. 37
2.3.1 COMPOSITION OF THE NUCLEOSOME, 37 2.3.2 VARIABILITY IN DNA CONTENT
OF NUCLEOSOMES. 37 2.3.3 CHROMATIN CORE PARTICLES, 39 2.4 STRUCTURE OF
THE NUCLEOSOME AND CORE PARTICLE, 40 2.4.1 DIGESTION OF CHROMATIN WITH
DNASE I AND DNASE II, 40 2.4.2 SPATIAL DISTRIBUTION OF HISTONES AND DNA
IN NUCLEOSOMES, 41 2.4.3 SHAPE OF THE NUCLEOSOME AND CORE PARTICLE, 42
2.5 STRUCTURAL ROLES OF DIFFERENT HISTONES, 45 2.5.1 INTERACTIONS OF
HISTONES IN CORE PARTICLES, 46 2.6 SUMMARY OF CORE PARTICLE AND
NUCLEOSOME STRUCTURE, 47 2.7 HIGHER ORDER STRUCTURE, 47 2.7.1
ARRANGEMENT OF NUCLEOSOMES IN THE NUCLEOFILAMENT, 48 2.7.2 30
NM CHROMATIN FILAMENT, 49 2.7.3 HISTONE HI AND HIGHER ORDER CHROMATIN
STRUCTURES, 50 2.8 STRUCTURE OF THE METAPHASE CHROMOSOME, 50 2.9
CHROMOSOME BANDING, 52 2.9.1 C BANDS, 53 2.9.2 Q BANDS, 55 2.9.3 G
BANDS, 56 2.9.4 R BANDS. 56 2.9.5 N BANDS, 56 2.10 HISTONE MODIFICATIONS
AND CHROMATIN STRUCTURE, 57 2.11 GENERAL REVIEWS, 59 2.12 MORE ADVANCED
READING, 59
3 THE GENOMES OF BACTERIA, VIRUSES, PLASMIDS, MITOCHONDRIA AND
CHLOROPLASTS, 61 3.1 BACTERIAL GENOME, 62 3.1.1 STRUCTURE OF THE GENOME,
62
3.1.2 MECHANISMS OF GENETIC VARIATION IN BACTERIA, 63 MUTATION, 63
TRANSFORMATION, 66 CONJUGATION, 67 TRANSDUCTION, 68
3.1.3 ARRANGEMENT OF GENES ON THE BACTERIAL GENOME, 69 3.1.4 CONTROL OF
GENE EXPRESSION IN BACTERIA, 70 TRANSCRIPTIONAL CONTROL-POSITIVE AND
NEGATIVE, 70 THE LAC OPERON, 70 THE ARABINOSE OPERON-POSITIVE AND
NEGATIVE CONTROL, 74 THE ARGININE SYTEM-DISPERSED GENES, 76 THE ROLE OF
RNA POLYMERASE, 76
3.1.5 DNA REPLICATION IN BACTERIA, 78 3.2 VIRUSES, 78 3.2.1 SIMIAN VIRUS
40,82
IMAGE 3
CONTENTS VII
INFECTIVE CYCLE, 83 THE SV40 CHROMOSOME, 84 SV40 DNA REPLICATION, 84
SV40 TRANSCRIPTION, 85 3.2.2 T4 PHAGE, 88 T4 ORGANIZATION, 88 INFECTIVE
CYCLE, 89 T4 GENOME, 89 T4 TRANSCRIPTION, 90
3.2.3 PHAGE LAMBDA-ORGANIZATIONAL LYSIS OR LYSOGENY-HOW THE CHOICE IS
MADE, 91 INSERTION OF THE PHAGE GENOME IN LYSOGENY, 94 GENE
TRANSCRIPTION IN PHAGE LAMBDA, 94 3.2.4 SINGLE STRANDED DNA PHAGES, 95
3.2.5 RNA PHAGES, 97 3.2.6 VIROIDS,98 3.3 PLASMIDS, 101
3.3.1 SEX FACTOR AND BACTERIAL CONJUGATION, 103 3.3.2 COLICIN PLASMIDS,
105 3.3.3 DRUG RESISTANCE FACTORS, 106
3.3.4 CROWN GALL PLASMID, 107 3.3.5 CHIMAERIC PLASMIDS, 107 3.4 THE
GENOMES OF MITOCHONDRIA AND CHLOROPLASTS, 107 3.4.1 RECOMBINATION OF
MITOCHONDRIAL DNA IN YEAST, 109
3.4.2 CHLOROPLAST DNA, 111 3.5 FURTHER READING, 112
SEQUENCE AND GENE ARRANGEMENTS IN DNA, 113 4.1 DNA CONTENT, 113 4.2 DNA
REASSOCIATION. 114 4.3 DNA SATELLITES, 119
4.4 INTERSPERSION OF MIDDLE REPETIVE AND SINGLE COPY DNA, 122 4.5 DNA
CLASSES, 130 4.5.1 INVERTED REPEATES, 130 4.5.2 SIMPLE SEQUENCE DNA, 134
EVOLUTION IN A SIMPLE SEQUENCE SATELLITE DNA, 135 4.5.3 MIDDLE
REPETITIVE DNA, 137 4.5.4 SINGLE COPY DNA, 138 4.6 DETERMINATION OF THE
NUCLEOTIDE SEQUENCES OF NUCLEIC ACIDS, 138
4.6.1 RESTRICTION ENZYMES, 138 4.6.2 DIRECT SEQUENCING, 140 4.7 GENETIC
ENGINEERING IN VITRO AND MOLECULAR CLONING, 141 4.7.1 RNA DEPENDENT DNA
POLYMERASE, 144
4.7.2 DNA POLYMERASE 1,145 4.7.3 RESTRICTION ENZYMES, 146 4.7.4
DNALIGASE, 146 4.8 HISTONE GENES, 149 4.9 ADENOVIRUS DNA, 150
IMAGE 4
VIII CONTENTS
CHAPTER 4 CONTINUED 4.10 GENES FOR 5S RIBOSOMAL RN A, 154 4.11 GENES FOR
LARGE RIBOSOMAL RNAS, 154 4.12 EXTRA CHROMOSOMAL PALINDROMES, 160
4.13 IMMUNOGLOBIN GENES AND SOMATIC REARRANGEMENT, 162 4.14 INTERVENING
SEQUENCES, 166 4.15 EUKARYOTIC PROMOTER SEQUENCES, 167 4.16 FURTHER
READING, 169
5 THE CELL CYCLE AND REPLICATION, 171 5.1 CELL PROLIFERATION: THE
MITOTIC CYCLE, 171 5.2 EVIDENCE FOR SPECIFIC CELL CYCLE STAGES, 174 5.3
MEIOSIS, 177 5.4 GENETIC RECOMBINATION, 177 5.5 SYNTHESIS OF CHROMOSOMAL
COMPONENTS IN THE CELL CYCLE, 183 5.6 CHANGES IN CHROMOSOME STRUCTURE
DURING THE CELL CYCLE, 191 5.7 CHROMOSOME CHANGES IN DIFFERENTIATION,
192 5.8 HISTONE MODIFICATIONS, 193 5.9 THE SUB-UNIT STRUCTURE OF
TRANSCRIPTIONALLY ACTIVE CHROMATIN, 198 5.10 FURTHER READING, 201
6 TRANSCRIPTIONALLY ACTIVE CHROMOSOMES, 203 6.1 THE LAMPBRUSH
CHROMOSOME, 203 6.1.1 THE STRUCTURE OF LAMPBRUSH CHROMOSOMES, 204 6.1.2
A CLOSER LOOK AT THE LOOPS, 208
6.1.3 TRANSCRIPTIONAL ACTIVITY ON THE LAMPBRUSH, 209 6.1.4 WHAT KIND OF
RNA IS MADE ON THE LOOPS?, 210 6.1.5 THE PROTEIN ON THE LOOPS, 212 6.1.6
DOESTHELOOPMOVE?,213 THE MASTER AND SLAVES MODEL AND THE LAMPBRUSH
CHROMOSOME, 213 6.1.7 DNA SEQUENCES AND GENES ON THE LOOP, 214 6.2 THE
POLYTENE CHROMOSOME, 214
6.2.1 STRANDEDNESS AND REPLICATION, 215 6.2.2 BANDS, INTERBANDS AND
CHROMOMERES, 219 6.2.3 WHERE ARE THE GENES?, 220 6.2.4 PUFFS ON POLYTENE
CHROMOSOMES, 221
HEAT-SHOCK PUFFS, 224 6.2.5 THE EFFECTS OF ECDYSONE, 224 6.2.6 DNA
SEQUENCING AND THE POLYTENE CHROMOSOME, 225
6.2.7 VARIATION IN DNA CONTENT, 226 6.3 MODELS OF CHROMATIN
ORGANIZATION. THE LAMPBRUSH VERSUS THE POLYTENE, 227 6.4 FURTHER
READING, 228
7 CHROMATIN ACTIVITY AND GENE REGULATION, 231 7.1 THE MECHANISM OF
TRANSCRIPTION, 231 7.2 THE SELECTIVITY OF TRANSCRIPTION, 235 7.3
UNTRANSCRIBEDDNA,235 7.4 SELECTIVE READING OF TRANSCRIBABLE DNA, 235
IMAGE 5
CONTENTS
7.5 POSITIVE AND NEGATIVE CONTROL, 239 7.6 CHROMOSOME INACTIVATION, 239
7.6.1 HETEROCHROMATIN AND EUCHROMATIN, 239 7.6.2 MITOTIC CHROMOSOMES,
242 7.7 REGULATION AT A GROSS LEVEL, 243
7.7.1 CONTROL OF LARGE TRACTS OF CHROMATIN, 243 7.7.2 CONTROLLED
EXPRESSION OF HOMOLOGOUS TRACTS, 243 7.7.3 CHROMATIN CONDENSATION IN
INTERPHASE NUCLEI, 244 7.8 CONTROL OF INDIVIDUAL GENE SEQUENCES, 244
7.8.1 BACTERIAL OPERONS, 244 7.8.2 SEQUENTIAL CONTROL OF GENE EXPRESSION
IN BACTERIA, 246 7.8.3 MULTIPLE GENE COPIES IN BACTERIA, 246
7.8.4 CONTROL OF INDIVIDUAL SEQUENCES IN EUKARYOTES, 246 7.8.5
HYPOTHESES OF GENE CONTROL IN EUKARYOTES, 247 COMINGS, 248 CALLAN, 248
EDSTROM AND LAMBERT, 248
GEOGIEV, 249 BRITTEN AND DAVIDSON, 249 SENSOR GENES, 249 INTEGRATOR
GENES, 249
RECEPTOR GENES, 250 PAUL, 250 MACLEAN AND HILDER, 251
HOLLIDAYANDPUGH,251
7.8.6 SOME GENERAL COMMENTS ABOUT THE HYPOTHESES, 253 7.9 FURTHER
ASPECTS OF GENE REGULATION IN EUKARYOTES, 259 7.9.1 ACTIONS OF HORMONES
IN GENE EXPRESSION, 259
7.9.2 MODIFICATIONS OF CHROMATIN AND DNA, 261 7.9.3 MULTIPLE GENE
COPIES, 262 7.9.4 ALLELIC EXCLUSION, 264 7.9.5 EPISOMES AND PLASMIDS IN
GENE EXPRESSION, 264 THE ROLE OF INSERTION ELEMENTS (IS), 265 7.9.6 POST
TRANSCRIPTIONAL CONTROL, 265 7.10 FURTHER READING, 267
IX
GLOSSARY, 269
INDEX, 275
|
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| id | DE-604.BV002146042 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T15:41:05Z |
| institution | BVB |
| isbn | 0632005548 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-001407733 |
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| owner_facet | DE-12 DE-91 DE-BY-TUM DE-188 DE-19 DE-BY-UBM |
| physical | XVII, 281 S. Ill., graph. Darst. |
| publishDate | 1981 |
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| publisher | Blackwell |
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| spelling | Bradbury, Edwin Morton Verfasser aut DNA, chromatin and chromosomes E. M. Bradbury ; Norman Maclean ; Harry R. Matthews* 1. publ. Oxford [u.a.] Blackwell 1981 XVII, 281 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Chromatin swd Chromatin Chromosomes DNA Gene expression Chromatin (DE-588)4010152-6 gnd rswk-swf Chromatin (DE-588)4010152-6 s DE-604 MacLean, Norman 1932- Verfasser (DE-588)13975959X aut Matthews, Harry R. Verfasser aut SWB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=001407733&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Bradbury, Edwin Morton MacLean, Norman 1932- Matthews, Harry R. DNA, chromatin and chromosomes Chromatin swd Chromatin Chromosomes DNA Gene expression Chromatin (DE-588)4010152-6 gnd |
| subject_GND | (DE-588)4010152-6 |
| title | DNA, chromatin and chromosomes |
| title_auth | DNA, chromatin and chromosomes |
| title_exact_search | DNA, chromatin and chromosomes |
| title_full | DNA, chromatin and chromosomes E. M. Bradbury ; Norman Maclean ; Harry R. Matthews* |
| title_fullStr | DNA, chromatin and chromosomes E. M. Bradbury ; Norman Maclean ; Harry R. Matthews* |
| title_full_unstemmed | DNA, chromatin and chromosomes E. M. Bradbury ; Norman Maclean ; Harry R. Matthews* |
| title_short | DNA, chromatin and chromosomes |
| title_sort | dna chromatin and chromosomes |
| topic | Chromatin swd Chromatin Chromosomes DNA Gene expression Chromatin (DE-588)4010152-6 gnd |
| topic_facet | Chromatin Chromosomes DNA Gene expression |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=001407733&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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