Chemical specificity in biological interactions:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York, NY
Acad. Press
1954
|
| Schriftenreihe: | Memoirs of the University Laboratory of Physical Chemistry Related to Medicine and Public Health, Harvard University
3 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | 234 S. |
Internformat
MARC
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| 245 | 1 | 0 | |a Chemical specificity in biological interactions |c ed. by Frank Ross Newman Gurd |
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| 490 | 1 | |a Memoirs of the University Laboratory of Physical Chemistry Related to Medicine and Public Health, Harvard University |v 3 | |
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Datensatz im Suchindex
| _version_ | 1804116575498797056 |
|---|---|
| adam_text | IMAGE 1
TABLE OF CONTENTS
CONTRIBUTORS V
FOREWORD VII
PREFACE IX
CHAPTER I. CHEMICAL SPECIFICITY IN BIOLOGICAL INTERACTIONS . . .. I
EDWIN J. COHN
I. SPECIFIC REVERSIBLE INTERACTIONS BETWEEN METALS AND PROTEINS I
SOLUBILITY OF ZINC INSULINATES IN WATER, 2; SOLUBILITY OF PLASMA CHOLINE
ESTERASE IN ETHANOL-WATER MIXTURES, 4; RATIO BETWEEN COULOMBIC AND OTHER
FORCES IN ETHANOL- WATER MIXTURES AND IN ENVIRONMENTS OF HIGHER DIELEC-
TRIC CONSTANT, 6
II. THE NUMBER OF SITES ON CERTAIN PROTEINS WHICH INTERACT SPECIFICALLY
WITH CERTAIN METALS 7
INTERACTIONS WITH IRON, COPPER, AND ZINC OF THE METAL- COMBINING PROTEIN
OF PLASMA, 7; INTERACTIONS OF CAD- MIUM AND ZINC WITH ALKALINE
PHOSPHATASE OF PLASMA,
7; INTERACTIONS OF SERUM ALBUMIN WITH MERCURY AND ZINC, 8
III. ON THE PROCESSING OF THE PROTEINS OF BIOLOGICAL SYSTEMS. 12
AVOIDANCE OF CHANGES IN PH, 13; AVOIDANCE OF OXIDA- TION, 13; VALUE OF
SPECIFIC METALLIC REAGENTS, 14 REFERENCES 15
CHAPTER II. T HE EFFECTS OF X-RAY AND OTHER RADIATION ON PROTEINS AND
LIVING TISSUES 17
SHIELDS WARREN
SUMMARY 28
REFERENCES 28
CHAPTER III. PHYSICAL AND CHEMICAL PROPERTIES OF THE STEROIDS R E- LATED
TO PROTEIN BINDING 29
RICHARD B. TURNER
INTRODUCTION 29
STEROCHEMICAL CONFIGURATIONS 30
CONFORMATIONS: POLAR AND EQUATORIAL BONDS 33
CONFORMATIONS IN FUSED RING SYSTEMS 37
CONFORMATIONS OF STEROIDS 38
XIII
IMAGE 2
XIV CONTENTS
STEROID-PROTEIN INTERACTIONS: POSSIBLE MODES OF BINDING . 42 REFERENCES
46
C H A P T ER IV. K O N R AD D O B R I N ER (1902-1952) 49
T H O M AS F. G A L L A G H ER
C H A P T ER V. BIOCHEMICAL PROBLEMS OF THE STEROID H O R M O N ES . ..
50
THOMAS F. GALLAGHER
INTRODUCTION 50
DISTRIBUTION IN TISSUES AND FATE OF THE STEROID HORMONES. 5 56 60 63
64
CHAPTER VI. SOME STUDIES ON THE ACTIVE PRINCIPLES OF THE POSTERIOR
PITUITARY GLAND 65
LOCALIZED EFFECTS OF STEROID HORMONES PRECURSORS OF THE STEROID
HORMONES. . SUMMARY REFERENCES
VINCENT DU VIGNEAUD INTRODUCTION PURIFICATION AND ANALYSIS OF OXYTOCIN
PURIFICATION AND ANALYSIS OF VASOPRESSIN
FURTHER CHARACTERIZATION OF THE ACTIVE PRINCIPLES REFERENCES
CHAPTER VII. T HE INFLUENCE OF ION-EXCHANGE CHROMATOGRAPHY UPON OUR
CONCEPT OF THE STRUCTURE OF RIBONUCLEIC ACID . .
WALDO E. COHN
INTRODUCTION THE NEW ISOMERS OF THE NUCLEOTIDES INTERNUCLEOTIDE LINKAGES
BRANCHING
REFERENCES
65 66 69
71 73
75
75 76 81 84
CHAPTER VIII. SPECIAL PROBLEMS IN THE FORMATION OF METAL COMPLEXES 90
CHARLES D. CORYELL
I. THE IONIC-COVALENT TRANSITION IN IRON-GROUP COMPLEXES 90 II. COMPLEX
FORMATION WITH IONS OF DIFFERENT METALS. . . 96 III. SPECIFICITY IN
COMPLEX FORMATION OF HEMOGLOBIN ARID FERRIHEMOGLOBIN 106
REFERENCES 112
CHAPTER IX. INTERACTIONS OF METALS WITH SMALL MOLECULES IN RELA- TION TO
METAL-PROTEIN COMPLEXES 114
JACK SCHUBERT
BULK AND TRACE METALS 115
COMPLEXING GROUPS OF BIOLOGICAL IMPORTANCE 115 RELATION OF COMPLEX ION
STABILITY TO CHEMICAL SPECIFICITY 116 POINTS TO CONSIDER WHEN APPLYING
DATA ON METAL-SMALL MOLECULE INTERACTION TO METAL-PROTEIN INTERACTION .
. . . 117
IMAGE 3
CONTENTS
XV
CATION-PROTON ANTAGONISM AND BINDING AFFINITIES-CHEM- ICAL
CONSIDERATIONS I2O
SYSTEMS OF BIOLOGICAL INTEREST 123
COMPLEX FORMATION AND CATALYSIS BY METAL IONS . . .. 127 MEASUREMENT OF
THE STABILITY OF A COMPLEX ION 131
FACTORS GOVERNING STABILITY OF METAL-ION COMPLEXES WITH FUNCTIONAL
GROUPINGS IN SMALL MOLECULES AND PROTEINS . . 1 33 OBSERVATIONS
CONCERNING RELATIVE STABILITY OF COMPLEX IONS 136
BERYLLIUM INHIBITION OF ALKALINE PHOSPHATASES 145 METAL CHELATES IN
RELATION TO DRUG ACTION 150
ION EXCHANGE RESINS AS MODELS FOR PROTEINS 159
CONCLUDING COMMENTS 160
REFERENCES 160
CHAPTER X. T HE SPECIFICITY OF METAL COMPLEX FORMATION 164
GEROLD SCHWARZENBACH
I. COMPLEXES WITH SIMPLE LIGANDS 164
II. CHELATE COMPLEXES 169
III. CHELATE COMPLEXES WITH CONDENSED RINGS 183
IV. COMPLEXING PARTNERS WITH WEAK LIGAND ATOMS . . . . 1 86 V. REASONS
FOR THE METAL SPECIFICITY INVOLVED IN PROTEIN REACTIONS 189
1. SPATIAL REQUIREMENTS, 189; 2. NATURE OF THE LIGAND ATOMS, 189; 3.
EFFECT OF COORDINATED METAL CATIONS ON ENZYMATIC PROCESSES, 190
REFERENCES 192
CHAPTER XI. T HE INTERACTION OF PROTEINS WITH SMALL MOLECULES AND IONS
193
GEORGE SCATCHARD, WALTER L. HUGHES, JR., FRANK R. N. GURD, AND PHILIP E.
WILCOX I. GENERAL DISCUSSION 193
1. INTRODUCTION, 193; 2. ASSOCIATION CONSTANTS, 194; 3. ELECTROSTATIC
INTERACTIONS, 194; 4. AVERAGE BINDING, !95L 5 CLASSICAL CONSTANTS, 196;
6. ACID-BASE TITRATION CURVES, 197 II. ANION BINDING 200
BINDING OF ORGANIC ANIONS, 205 III. CATION BINDING 207
I. COMPETITION WITH HYDROGEN ION, 207; 2. STOICHI- OMETRY AND INTRINSIC
ASSOCIATION CONSTANTS, 210; 3. AFFINITIES OF CATIONS FOR THE REACTIVE
GROUPS OF PROTEINS AND OF RELATED SMALL MOLECULES, 212
REFERENCES 218
AUTHOR INDEX 221
SUBJECT INDEX 228
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| language | English |
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| series | Memoirs of the University Laboratory of Physical Chemistry Related to Medicine and Public Health, Harvard University |
| series2 | Memoirs of the University Laboratory of Physical Chemistry Related to Medicine and Public Health, Harvard University |
| spelling | Chemical specificity in biological interactions ed. by Frank Ross Newman Gurd New York, NY Acad. Press 1954 234 S. txt rdacontent n rdamedia nc rdacarrier Memoirs of the University Laboratory of Physical Chemistry Related to Medicine and Public Health, Harvard University 3 Biochemistry Spezifität (DE-588)4130843-8 gnd rswk-swf Biochemische Reaktion (DE-588)4145593-9 gnd rswk-swf Biochemische Reaktion (DE-588)4145593-9 s Spezifität (DE-588)4130843-8 s DE-604 Gurd, Frank R. Sonstige oth Memoirs of the University Laboratory of Physical Chemistry Related to Medicine and Public Health, Harvard University 3 (DE-604)BV001895509 3 SWB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=001391486&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Chemical specificity in biological interactions Memoirs of the University Laboratory of Physical Chemistry Related to Medicine and Public Health, Harvard University Biochemistry Spezifität (DE-588)4130843-8 gnd Biochemische Reaktion (DE-588)4145593-9 gnd |
| subject_GND | (DE-588)4130843-8 (DE-588)4145593-9 |
| title | Chemical specificity in biological interactions |
| title_auth | Chemical specificity in biological interactions |
| title_exact_search | Chemical specificity in biological interactions |
| title_full | Chemical specificity in biological interactions ed. by Frank Ross Newman Gurd |
| title_fullStr | Chemical specificity in biological interactions ed. by Frank Ross Newman Gurd |
| title_full_unstemmed | Chemical specificity in biological interactions ed. by Frank Ross Newman Gurd |
| title_short | Chemical specificity in biological interactions |
| title_sort | chemical specificity in biological interactions |
| topic | Biochemistry Spezifität (DE-588)4130843-8 gnd Biochemische Reaktion (DE-588)4145593-9 gnd |
| topic_facet | Biochemistry Spezifität Biochemische Reaktion |
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