Chemical aspects of the structure of small peptides: an introduction
Gespeichert in:
| 1. Verfasser: | |
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| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Copenhagen
Munksgaard
1960
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| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | 194 S. |
Internformat
MARC
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Datensatz im Suchindex
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| adam_text | CHEMICAL ASPECTS OF
THE STRUCTURE
OF SMALL PEPTIDES
AN INTRODUCTION
Dorothy Writich
M A Cantab D Sc Oxon D Sc Lond
Visiting Research Professor at Smith College
Massachusetts USA
MUNKSGAARD • COPENHAGEN
PLENUMPRESSINC
/
TABLE OF CONTENTS
CHAPTER I
From the globular proteins to small peptides
I—I The problem of finding structures for the globular proteins 1
1-2 Small peptides as today s focus in the organic chemical approach to peptide
structure 8
1—3 The cyclol structure for the pepi ide moiety of five ergot alkaloids 10
1-4 The Asp Lys dipeptide containing a multiple peptide grouping 13
1-5 Model molecules containing mult iple peptide groupings 15
I-6 Ideas of the amide and cyclol systems 16
References • • 19
CHAPTER II
An organic chemical formulation of the amide and cyclol theories
II-l The amide hypothesis 21
II—2 The cyclol hypothesis as a generalization of the amide hypothesis 22
II-3 Characteristics of the multiple peptide groupings 26
II-4 Forms assumed by the monomers in the amide and cyclol systems 30
II—5 A comparison with the original formulation of the cyclol theory 35
11-6 Hydrogen bridges within amide and cyclol structures 36
II-7 Hydrogen bridge systems suggested by the cyclol hypothesis 36
II-S The two types of structure for peptides within the amide system 37
II—0 The R-compositions and R-constitutions of polypeptide chains 38
11—10 Degenerations of polypeptide chains and possible secondary syntheses 39
II—1] Some peptides containing cyclol groupings, and their degenerations 42
, 11-12 The significance of polypeptide chains as degradation products of peptides 49
II-13 Some double a-monomers 50
11-14 The a-imino acids obtained from peptides, and their homologues 56
11-15 The a,co monomers and co- ami co,cu -monomers obtained from peptides, and
their homologues 58
11-16 The extended amide hypothesis and branched polypeptide chains 60
IT-17 Amide groupings containing C-N bonds of the four different kinds 62
II-l 8 The extended cyclol hypothesis in parallel with the extended amide hypothe
sis 67
11-19 Some structural fragments in «,to-peptides 69
11-20 Imbalances of a- and OJ-NH, groups and a- and co-COOH groups in peptides 73
11-21 The varying interpretations of data afforded by the amide and cyclol systems 76
11-22 Some structural features of bacitracin A 78
11-23 A branch point at the phenylalanine monomer ? 79
11-24 The bonds uniting the lysine and aspartic acid monomers 81
11-25 The generalized peptide grou pings in a wider context 84
11-26 The special character of the two-bond peptide groupings 86
11-27 Amine and carboxyl transfers 88
11-28 Two-bond peptide groupings as intermediates in certain enzymic reactions ? 90
11-29 Other two-bond groupings as intermediates in some enzymic reactions 92
11-30 The non-peptide grouping in gramicidin 94
11-31 How can labile groupings be stabilized ? 95
11-32 The place in organic chemistry of the multiple peptide groupings 96
II-Appendix A Certain ortho groupings and related multiple groupings 99
II-Appendix B Excerpts from the Works of Emil Fischer 100
References 101
CHAPTER III
Structures for small peptides within the amide- and cyclol systems
III-l Introduction 103
III-2 Structure types for small a-peptides 103
III-3 Some structure types for tripeptides 106
III-4 Some structure types for tetrapeptides 108
III-5 Degeneration products of tripeptides and tetrapeptides Ill
III-6 Certain issues introduced by the cyclol structures 115
III-7 Some general considerations 116
HI-8 A few structure types for pentapeptides 117
III-9 Intermolecular proton migrations and the formation of larger peptides 118
111-10 Some hydrogen-bridged dimers and trimers and other oligomers 120
III-11 The R-compositions and R-constitutions of a peptide with a structure of
given type 121
111-12 The bearing of t he R-constitutions of peptides on routes of degeneration 122
111-13 The embedding of a hydantoin or piperazine ring in peptide structures 124
111-14 On the significance of degradation products containing hydantoin or piper
azine rings 127
111-15 The history of the ergot tripeptide structure 129
111-16 The occasion for the new structure 131
111-17 The reductive cleavage of the tripeptides 132
111-18 The investigation of the tripeptides by high temperature cleavage 133
III-19 The conditioned stability of the new structure 133
111-20 Stabilizing factors in the tripeptide structures 135
111-21 Limitations in hydrolytic degradation studies 137
111-22 Determining the r- or D-forms of the monomers in peptides 139
III-23 A change in chemical constitution or a superposed fine structure ? 141
References 144
CHAPTER IV
Growing points in peptide studies
IY-1 Introduction 145
IV-2 Peptides as an expression of the nature of their monomers 146
IV-3 The broader viewpoint regarding peptide groupings 147
IV-4 Other issues 149
IV-5 Developments suggested by the researches on the ergot tripeptides 150
IV-6 Double a-monomers and the penicillin structures 159
IV-7 The trend towards structures of higher connexity 166
IV-8 Model molecules suggested by Asp Lys 168
IV-9 The bearing of Asp Lys on the structure of bacitracin A 171
IV-10 A polycyclic structure for bacitracin A ? 172
IV-11 Asp Lys as one of a set of a,u)-dipeptides 1 77
IV-12 Towards the synthesis of mull ipie peptide groupings by transannular inter
actions 179
References 185
Index of subjects 187
Index of authors 192
|
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| spelling | Wrinch, Dorothy Verfasser aut Chemical aspects of the structure of small peptides an introduction Dorothy Wrinch Copenhagen Munksgaard 1960 194 S. txt rdacontent n rdamedia nc rdacarrier Peptides Peptide (DE-588)4045125-2 gnd rswk-swf Peptide (DE-588)4045125-2 s DE-604 HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=001391470&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Wrinch, Dorothy Chemical aspects of the structure of small peptides an introduction Peptides Peptide (DE-588)4045125-2 gnd |
| subject_GND | (DE-588)4045125-2 |
| title | Chemical aspects of the structure of small peptides an introduction |
| title_auth | Chemical aspects of the structure of small peptides an introduction |
| title_exact_search | Chemical aspects of the structure of small peptides an introduction |
| title_full | Chemical aspects of the structure of small peptides an introduction Dorothy Wrinch |
| title_fullStr | Chemical aspects of the structure of small peptides an introduction Dorothy Wrinch |
| title_full_unstemmed | Chemical aspects of the structure of small peptides an introduction Dorothy Wrinch |
| title_short | Chemical aspects of the structure of small peptides |
| title_sort | chemical aspects of the structure of small peptides an introduction |
| title_sub | an introduction |
| topic | Peptides Peptide (DE-588)4045125-2 gnd |
| topic_facet | Peptides Peptide |
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