The chemistry and function of proteins:
Gespeichert in:
| Vorheriger Titel: | Haurowitz, Felix Chemistry and biology of proteins |
|---|---|
| 1. Verfasser: | |
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
New York
Acad. Press
1963
|
| Ausgabe: | 2. ed. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XIV, 455 S. graph. Darst. |
Internformat
MARC
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| 245 | 1 | 0 | |a The chemistry and function of proteins |c Felix Haurowitz |
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| 264 | 1 | |a New York |b Acad. Press |c 1963 | |
| 300 | |a XIV, 455 S. |b graph. Darst. | ||
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Datensatz im Suchindex
| _version_ | 1804116381360193536 |
|---|---|
| adam_text | 1 1 j
The CHEMISTRY and
FUNCTION of
PROTEINS
SECOND EDITION
By Felix Haurowitz
Distinguished Service Profe ssor of Chemistry
Ind iana University, Bloomington, Indiana
$)
y ACADEMIC PRESS • New Yorh and London
Contents
FOREWORD v I f
(
LIST OF ABBREVIATIONS ix
I Role of Proteins in Biology 1
i | References 5
I
II Purification, Isolation, and Determination of Proteins 6
, A Methods of Isolation and Separation from Nonprotein Material 6
t B Fractionation of Protein Mixtures 12
C The Problem of Protein Heterogeneity 15
I D Qualitative Tests for Proteins 19
-E Quantitative Determination of Proteins 20
^ References 22
III Tl ie Amino Acid Composition of Proteins 25
i
A Cleavage by Hydrolysis and Other Methods 25
B Determination of Rate of Hydrolysis 27
|CFractionationandIsolationofAminoAcids29
D Amino Acids: General Properties and Specific Reactions 33
: E Quantitative Determination of Amino Acids in Proteins 42
References - 48
IV Amino Acid Sequence and Primary Structure of
tlie Proteins 51
A General Technique 51
B Determination of the Ar-Terminal Amino Acids 52
C Determination of the C-Terminal Amino Acids 55
D Partial Degradation of Proteins and Separation of Peptides 57
References60
V Size and Shape of Protein Molecules 62
A Introduction The Molecular Weight of Proteins 62
B Osmotic Pressure of Proteins 65
C Diffusion Rate of Proteins 68
D Sedimentation Equilibrium 70
E Sedimentation Velocity of Proteins 72
xi
xii CONTENTS
F Viscosity of Protein Solutions
G Flow Birefringence
H Polarization of Fluorescence
I Light Scattering by Proteins
J Other Methods Used for the Determination of Molecular Weights and
the Shape of Proteins in Their Solutions
K Electron Micrography of Dry Proteins
L X-Ray Analysis of Protein Crystals
M Comparison of Molecular Weights and Shapes Found by Different
Methods
References
VI Electrochemistry and Hydration of Proteins 92
A Amino Acids as Dipolar Ions 92
B Ionization of Proteins 98
C Electrophoresis of Proteins • 104
D Hydration and the Specific Volume of Solutes 111
E Hydrationof Dry Protein - 115
F Hydration of Proteins in Solution 118
G Solubility of Proteins in Water 121
H The Dielectric Properties of Protein Solutions - 123
I The Role of Proteins in Energy Transmission 127
References 129
VII The Internal Structure of Glohul ar Proteins 132
A General Considerations
B Examination of Globular Proteins by X-Ray Diffraction
C Refractivity and Absorbancy of Protein Solutions
D The Optical Rotation and Rotary Dispersion
E Cross-Links in Globular Proteins
F Chemical Reactivity of Proteins
G The Problem of Branched or Cyclic Peptide Chains
H Denaturation of Proteins
I Kinetics and Thermodynamics of Denaturation
J Proteins in Interfaces
References
VIII Alhumins, Glohul ins, and Other Soluble Proteins 184
A Classification of Soluble Proteins 184
B Proteins of the Blood Serum : 184
C Fibrinogen and Its Conversion to Fibrin 193
D Milk Proteins 197
E Egg Proteins 199
F Vegetable Proteins 202
G Protamines and Histones 204
References 207
I
J!: CONTENTS Hit
IXvj-Structural Proteins (Scleroproteins and the Muscle
1 I -Proteins) • • • -311
A General Remark s 211
iB, Collagen and Gelatin 212
C 1 Keratin -217
Dj Fibroin • • -221
E; Other Scleroproteins 222
: F Biological Importance of Structural Proteins 223
,J G Muscle Proteins (Contractile Proteins) 224
i References • • • 230
I! •
X Combination of Proteins with Other Substances 234
II !
f A Intermolecular Forces 234
fB Combination of Proteins with Inorganic Ions 237
C Combination of Proteins with Organic Dyes 231
t D Combination of Proteins with Other Organic Substances 238
i! References • 243
XI Conjugated Proteins • • • 245
• ! A Survey on Composition and Properties 245
B Lipoproteins • • -246
C Glycoproteins (Mucoproteins) 250
: D Metalloproteins • • -256
I E Hemoglobin: General Properties 261
| F Hemoglobin: Combination with 0 and Other Ligands Conformation 264
G The Specificity of Hemoglobins 271
H Other Chromoproteins 277
I Nucleoproteins • • -279
References • • -289
XII Enzymes: Proteins with Enzymatic Properties 296
A The Function of Proteins as Enzymes and Apoenzymes 296
B The Active Site of Enzymes 299
- C Specificity of Enzymes 303
D The Enzyme-Substrate Complex 307
i E Kinetics of Enzyme Reactions • 310
F Proteinases and Peptidases 315
I G Other Nonoxidative Enzymes 321
H Enzymes Involved in Oxidoreduction • 327
References • • -340
XIII Proteins with Hormone Action 347
A General Remarks • • • 347
B Thyroglobulin and the Thyroid Hormones 347
C Insulin • • -349
xiv CONTENTS
D Oxytocin and Vasopressin
E The Melanocyte-Stimulating Hormone (MSH) or Intermedin
F Adrenocorticotropic Hormone (ACTH) or Corticotropin
G Other Hormones of the Anterior Pituitary Lobe
H Other Protein Hormones and Peptides with Hormone-like Action
References
XIV Toxins (Toxic Proteins)
A Bacterial Exotoxins
B Bacterial Endotoxins
C Cyclic Peptides
D Other Toxins
References
XV Role of Proteins in Immunological Reactions
A Antigens
B Antibodies: Their Detection and Isolation
C Antigen-Antibody Interaction
D The Mechanism of Antibody Formation
E Complement
References
XVI Protein Biosynthesis
A Introduction 3 9 4
B Amino Acid Supply 3 9 5
C Nonenzymatic Formation of Peptide Bonds 3 9 9
D Formation of Peptide Bonds by Proteolytic Enzymes 4 0 2
E Activation of Amino Acids for Protein Biosynthesis 4 0 5
F Incorporation of Amino Acids into Ribonucleoprotein Particles 4 0 9
G The Sites and the Rate of Protein Biosynthesis 4 1 1
H The Problem of Peptide Intermediates 4 1 6
I The Role of DNA and Messenger RNA in Protein Biosynthesis 4 1 9
J The Action of Analogs, Mutagens, and Inducers 4 2 1
K Templates and the Coding Problem 4 2 3
References 4 4 0
INDEX
|
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| dewey-full | 547.75 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 547 - Organic chemistry |
| dewey-raw | 547.75 |
| dewey-search | 547.75 |
| dewey-sort | 3547.75 |
| dewey-tens | 540 - Chemistry and allied sciences |
| discipline | Chemie / Pharmazie Biologie Chemie |
| edition | 2. ed. |
| format | Book |
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| indexdate | 2024-07-09T15:37:36Z |
| institution | BVB |
| language | English |
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| physical | XIV, 455 S. graph. Darst. |
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| spelling | Haurowitz, Felix 1896-1987 Verfasser (DE-588)101558910 aut The chemistry and function of proteins Felix Haurowitz 2. ed. New York Acad. Press 1963 XIV, 455 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Bioquimica larpcal Proteinas larpcal Protéines Quimica Organica larpcal Proteins Proteine (DE-588)4076388-2 gnd rswk-swf Proteine (DE-588)4076388-2 s DE-604 1. Auflage Haurowitz, Felix Chemistry and biology of proteins HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=001265111&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Haurowitz, Felix 1896-1987 The chemistry and function of proteins Bioquimica larpcal Proteinas larpcal Protéines Quimica Organica larpcal Proteins Proteine (DE-588)4076388-2 gnd |
| subject_GND | (DE-588)4076388-2 |
| title | The chemistry and function of proteins |
| title_auth | The chemistry and function of proteins |
| title_exact_search | The chemistry and function of proteins |
| title_full | The chemistry and function of proteins Felix Haurowitz |
| title_fullStr | The chemistry and function of proteins Felix Haurowitz |
| title_full_unstemmed | The chemistry and function of proteins Felix Haurowitz |
| title_old | Haurowitz, Felix Chemistry and biology of proteins |
| title_short | The chemistry and function of proteins |
| title_sort | the chemistry and function of proteins |
| topic | Bioquimica larpcal Proteinas larpcal Protéines Quimica Organica larpcal Proteins Proteine (DE-588)4076388-2 gnd |
| topic_facet | Bioquimica Proteinas Protéines Quimica Organica Proteins Proteine |
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