Xenobiotic metabolism and disposition: the design of studies on novel compounds
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Baton Rouge, Fla.
CRC Press
1989
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | 220 S. Ill. |
| ISBN: | 084936163X |
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| adam_text | IMAGE 1
XENOBIOTIC METABOLISM
AND DISPOSITION
EDITED BY
R. KATO, R. W. ESTABROOK AND M. N. CAYEN
PROCEEDINGS OF THE 2ND INTERNATIONAL ISSX MEETING - KOBE, JAPAN, MAY
16-20,1988
TAYLOR & FRANCIS
LONDON * NEW YORK * PHILADELPHIA 1989
IMAGE 2
CONTENTS
PREFACE XI
1 . MOLECULAR BIOLOGY AND MULTIPLICITY OF ANIMAL AND HUMAN CYTOCHROME
P-450
CHARACTERIZATION OF HUMAN LIVER CYTOCHROME P-450 3
PROTEINS, MRNAS, AND GENES F.P. GUENGERICH, R.W. BORK, C. GED, T.M.
BELLEW, D.R. UMBENHAUER. T. MUTO, P.H. BEAUNE, N. SHINRIKI, P.K.
SRIVASTAVA AND R.S. UOYD
MOLECULAR SIMILARITY AND DIVERSITY OF CYTOCHROME P-450 11
MOLECULES Y. FUJII-KURIYAMA, H. KIMURA, Y. HIGASHI, K. SOGAWA, T.
SHIMIZU, M. HATANO AND O. GOTOH
STRUCTURE AND EVOLUTION OF THE POLYMORPHIC D.EBRISOQUINE 21
4-HYDROXYLASE GENES IN MAN AND RAT F.J. GONZALEZ, E. MATSUNAGA, M.
UMENO, S. KIMURA, R.C. SKODA, J.P. HARDWICK, H.V. GELBOINANDU.A. MEYER
EXPRESSION OF CYTOCHROME P-450 AND NADPH-CYTOCHROME P-450 29 REDUCTASE
GENES IN YEAST H. OHKAWA, Y. YABUSAKI, T. SAKAKI, H. MURAKAMI AND M.
SHIBATA
HORMONAL REGULATION OF HEPATIC CYTOCHROME P-450 37
V. YAMAZOE, M. SHIMADA, N. MURAYAMA, K. NAGATA AND R.KATO
TISSUE SPECIFIC INDUCIBILITY OF MEMBERS OF THE CYTOCHROME 45
P450IA GENE SUB-FAMILY IN RAT AND MAN D. SESARDIC, A.R. BOOBIS ANDD.S.
DAVIES
2. NON-P-450 ENZYMES IN METABOLISM OF XENOBIOTICS IN ANIMALS AND HUMANS
DETOXICATION REACTIONS OF GLUTATHIONE AND GLUTATHIONE 55
TRANSFERASES B. KETTERER, B. COLES AND D.J. MEYER
REGULATION OF GLUTATHIONE S-TRANSFERASE YA SUBUNIT GENE 63
EXPRESSION R.G. KING, C.A. TELAKOWSKI-HOPKINS AND C.B. PICKETT
MULTIPLICITY OF GLUTATHIONE S-TRANSFERASES IN RODENTS 73
AND HUMANS; RAT P (7-7) FORM AS A NEW MARKER ENZYME FOR PROCESSES
INVOLVED IN CHEMICAL CARCINOGENESIS K. SATO, K. SATO, S. TSUCHIDA, I.
HATAYAMA AND T. ISHIKAWA
IMAGE 3
GENETIC DEFICIENCIES AND EXPRESSION OF UDP- 81
GLUCURONOSYLTRANSFERASES B. BURCHELL, M.R. JACKSON, D. HARDING, M.W.H.
COUGHTRIE, S. FOURNEL-GIGLEUX, R. WOOSTER, S.M. WILSON AND R. HUME
HUMAN LIVER UDP-GLUCURONOSYLTRANSFERASE: IN VITRO 89
ASSESSMENT OF MULTIPLICITY AND SUBSTRATE SPECIFICITY J.O. MINERS, K.J.
LILLY WHITE, A.P. MATTHEWS, K. YOOVATHAWORN, M. PONGMARUTAI, P.I.
MACKENZIE AND D.J. BIRKETT
MULTIPLE DIHYDRODIOL DEHYDROGENASES AND THEIR 97
DIFFERENTIAL TOXICOLOGICAL SIGNIFICANCE F. OESCH AND J. KLEIN
3. DESIGN OF PRODRUGS, SOFT DRUGS AND SITE-SPECIFIC DRUG DELIVERY
PRODRUGS AND SITE-SPECIFIC DRUG DELIVERY 109
V. J. STELLA
DESIGN OF PRODRUGS FOR ORAL DRUG DELIVERY 117
G.L. AMIDON, G.D. LEESMAN, P.J. SINKO AND M. HU
EFFECTS OF SOME STRUCTURAL MODIFICATIONS TO COMPOUNDS 125
THAT FORM TOXIC INTERMEDIATES S.D. NELSON
APPLICATION OF LIPID MICROSPHERES FOR TARGETING THERAPY 133
Y. MIZUSHIMA
DRUG TARGETING THROUGH THE LYMPHATIC SYSTEM 141
S. MURANISHI
4. STEREOCHEMICAL ASPECTS OF DRUG METABOLISM AND DISPOSITION
CONCEPTUAL AND MECHANISTIC OVERVIEW OF STEREOSELECTIVE 153
DRUG METABOLISM 6. TESTA
ENANTIOMERIC ANALYSIS IN DRUG METABOLISM STUDIES 161
A.J. HUTT AND J. CALDWELL
STEREOCHEMISTRY OF P-450 CATALYZED REACTIONS 171
W.F. TRAGER
G
STEREOSELECTIVE DRUG METABOLISM AND PHARMACODYNAMIC 179
CONSEQUENCES CO. MEESE AND M. EICHELBAUM
STEREOSELECTIVE PROTEIN BINDING AND DRUG DISPOSITION 185
K. KIMURA, Y. MIZUNO, K. SUGIHARA AND Y. OHBE
IMAGE 4
STEREOSELECTIVE BIOTRANSFORMATION AND ITS TOXICOLOGICAL 193
IMPLICATIONS N.P.E. VERMEULEN
5. CHARACTERISTICS OF DRUG METABOLISM IN MAN: EXTRAPOLATION FROM ANIMALS
TO MAN
PROBLEMS IN EXTRAPOLATIONS FROM ANIMALS TO MAN 209
J.R. GILLETTE
SPECIES DIFFERENCES IN XENOBIOTIC CONJUGATION 217
J. CALDWELL, A. WEIL AND Y. TANAKA
RECONSTRUCTION OF IN VIVO METABOLISM FROM IN VITRO DATA 225
V. SUGIYAMA, Y. SAWADA, T. IGA AND M. HANANO
PHARMACOKINETIC SCALING FROM ANIMALS TO MAN: BASIC CONCEPTS 237 K.S.
PANG AND H. BOXENBAUM
PHARMACOKINETIC STUDIES IN THE SELECTION OF NEW DRUGS: 245
A CASE HISTORY ON DIHYDROPYRIDINE CALCIUM CHANNEL BLOCKERS M.J. HUMPHREY
6. ENVIRONMENTAL IMPLICATIONS IN XENOBIOTIC METABOLISM AND DISPOSITION
COMPARATIVE METABOLISM OF XENOBIOTICS IN THE 257
ENVIRONMENT; FUNDAMENTALS FOR RISK ASSESSMENT J. MIYAMOTO
PLANT METABOLISM OF HERBICIDES IN RELATION TO 267
DETOXIFICATION, SELECTIVITY, ANTIDOTING, AND SYNERGISM G.L LAMOUREUX
A NEW LOOK AT HEPATIC XENOBIOTIC METABOLISM AS A 275
DETERMINANT OF TOXICITY THRESHOLD IN ANIMALS T. NAKATSUGAWA AND J.M.
BECKER
CONJUGATION AND EXCRETION OF XENOBIOTICS BY FISH AND 283
AQUATIC INVERTEBRATES M.O. JAMES
STUDIES ON XENOBIOTIC METABOLISM USING FISH HEPATOCYTE 291
SYSTEM AS A TOOL FOR EVALUATION OF ENVIRONMENTAL SAFETY OF CHEMICALS T.
YOSHIDA, H.L-KOJIMA AND T. YUUKI
IMAGE 5
7. NEW ANALYTICAL METHODS IN DRUG METABOLISM AND
PHARMACOKINETICS
STABLE ISOTOPES: UNIQUE PROBES FOR MECHANISTIC STUDIES 301
OF XENOBIOTIC METABOLISM. APPLICATION TO STUDIES ON THE BIOACTIVATION OF
/V-METHYL-FORMAMIDE IN VITRO T.A. BAILLIE, P.G. PEARSON, M.D.
THREADGILL, W.N. HOWALD, D.-H. HAN, N.E. MACKENZIE, A.J. SHAW AND A.
GESCHER
DETECTION OF UNSTABLE INTERMEDIATES BY FAST ATOM 309
BOMBARDMENT AND PLASMA DESORPTION MASS SPECTROMETRY C. FENSELAU, M.
ALAI, Z.-M. YUAN AND C. MURPHY
ULTRAMICROANALYSIS OF PROSTAGLANDINS AND OTHER LIPID 317
MEDIATORS BY GAS CHROMATOGRAPHY/NEGATIVE ION CHEMICAL IONIZATION MASS
SPECTROMETRY I. A. BLAIR, B.W. CHRISTMAN, K. YAMASHITA AND J. CAPDEVILA
ULTRAMICROANALYSIS OF DRUGS UTILIZING HPLC- 325
PEROXYOXALATE CHEMILUMINESCENCE DETECTION K. IMAI, A. NISHITANI, Y.
TSUKAMOTO AND H. AKITOMO
NMR IMAGING AND 13 C/ 31 P NMR SPECTROSCOPIC STUDIES OF 333
DRUG ACTION IN EXPERIMENTAL ANIMAL MODELS S.M. COHEN, P.F. MALATESTA
ANDJ.G. WERRMANN
QUANTITATIVE WHOLE BODY AUTORADIOGRAPHY 341
S. NAGATSUKA
8. REACTIVE INTERMEDIATES IN CELL TOXICITY, MUTAGENESIS AND
CARCINOGENESIS
CHEMICAL CHARACTERIZATION OF REACTIVE INTERMEDIATES 351
N. CASTAGNOLI, JR., M. SHIGENAGA, E. WU, L LEUNG, P. LAMPEN AND A.
TREVOR
METABOLIC ACTIVATION AND PROTEIN COVALENT BINDING 359
CHEMISTRY OF BROMOBENZENE AND DERIVATIVES R.P. HANZLIK, P.E. WELTER, N.
NARASIMHAN AND J.A. BUBEN
BIOCHEMICAL MECHANISMS OF CELL TOXICITY. 367
THE ROLE OF A CA 2+ -ACTIVATED ENDONUCLEASE D.J. MCCONKEY AND S.
ORRENIUS
METABOLIC ACTIVATION OF ARYLAMINE DERIVATIVES OF 375
CARCINOGENIC POLYCYCLIC NITROAROMATIC HYDROCARBONS F.F. KADLUBAR, M.A.
BUTLER?S.J. CULP, C.H. TEITEL, P.P. FU, A.U. SHAIKH, K.B. DELCLOS
ANDF.A. BELAND
FURTHER METABOLIC ACTIVATIONS OF MUTAGENIC AND 383
CARCINOGENIC A/-HYDROXYARYLAMINE BY CONJUGATING ENZYMES R. KATO AND Y.
YAMAZOE
IMAGE 6
HYDROXYMETHYL SULFATE ESTERS AS REACTIVE METABOLITES OF 393
THE CARCINOGENS, 7-METHYI-, AND 7,12-DIMETHYL- BENZ[A]ANTHRACENES AND
5-METHYLCHRYSENE T. WATABE, K. OGURA, H. OKUDA AND A. HIRATSUKA
9. THE SCIENTIFIC BASIS AND PERSPECTIVES OF THERAPEUTIC DRUG MONITORING
THE CLINICAL PHARMACOLOGICAL DIMENSIONS OF THERAPEUTIC 403
DRUG MONITORING F. SJOQVIST
THE SCIENTIFIC BASIS AND PERSPECTIVES OF THERAPEUTIC 411
DRUG MONITORING: DRUG DISPOSITION IN RENAL DISEASE FT HORI, A. KAMIYA,
M. YASUHARA, Y. TANIGAWARA AND K. INUI
TOXICOKINETICS IN DRUG DEVELOPMENT 419
I.Y. ZAGHLOUL, V.K. BATRAANDA. YACOBI
PHARMACODYNAMIC BASIS FOR THERAPEUTIC DRUG MONITORING 427
B. WHITING AND A. W. KELMAN
POPULATION PHARMACOKINETICS FOR INDIVIDUALIZING DRUG 435
DOSAGE REGIMENS C.C. PECK
PERSPECTIVES OF THERAPEUTIC DRUG MONITORING 441
T. ISHIZAKI
10. PATHOPHYSIOLOGICAL CONSEQUENCES OF DEFECTIVE DRUG METABOLIZING
ENZYMES
PATHOPHYSIOLOGICAL CONSEQUENCES OF DEFECTIVE DRUG- 453
METABOLIZING ENZYMES: SOME PHARMACOGENETIC CONCEPTS AND IMPLICATIONS FT
AYESH AND FL.L SMITH
PHARMACOGENETIC POLYMORPHISM: MEPHENYTOIN HYDROXYLATION 467 DEFICIENCY
T. INABA
SLOW DRUG HYDROXYLATION-IMPLICATIONS FOR PATIENT 475
MANAGEMENT AND DRUG UTILIZATION F. SJOQVIST
CEPHALOSPORIN-INDUCED HYPOPROTHROMBINEMIA: 483
PHARMACOGENETIC ASPECTS J.J. LIPSKY
IMPLICATIONS OF DRUG METABOLISM BY MYELOPEROXIDASE 491
J.P. UETRECHT
IMAGE 7
HYDROXYLATION AND ACETYLATION PHENOTYPES AS GENETIC 499
RISK FACTORS IN CERTAIN MALIGNANCIES /. FTOOFS, N. DRAKOULIS, J.
BROCKMOLLER, I. JANICKE, M. CUPRUNOV AND J. RITTER
11 . METABOLISM AND PHARMACOKINETICS OF HIGH MOLECULAR-WEIGHT DRUGS
PHARMACOKINETICS OF PEPTIDES, PROTEINS AND OTHER POLAR 509
MACROMOLECULES C. MCMARTIN
CHANGES IN IMMUNOGENICITY AND PHARMACOKINETICS OF 517
ASPARAGINASE BY ITS CHEMICAL MODIFICATION H. WADA, I. IMAMURA AND Y.
INADA
METABOLISM AND DISPOSITION OF PROTEINS DERIVED FROM 523
RECOMBINANT TECHNOLOGY S.V. PIZZO, M. GONZALEZ-GRONOW, H. BERGERANDS.L
GONIAS
CONTROL OF PHARMACOKINETIC PROFILES OF MITOMYCIN C BY 531
DEXTRAN CONJUGATION M. HASHIDA, Y. TAKAKURA AND H. SEZAKI
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| spelling | Xenobiotic metabolism and disposition the design of studies on novel compounds ed. H. P. A. Illing Baton Rouge, Fla. CRC Press 1989 220 S. Ill. txt rdacontent n rdamedia nc rdacarrier Projet recherche Xénobiotique - Métabolisme Xénobiotiques - Métabolisme - Recherche - Technique Xenobiotics Metabolism Research Technique Xenobiotikum (DE-588)4193155-5 gnd rswk-swf Stoffwechsel (DE-588)4057699-1 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Xenobiotikum (DE-588)4193155-5 s Stoffwechsel (DE-588)4057699-1 s DE-604 Illing, H. P. Sonstige oth HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=001197421&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Xenobiotic metabolism and disposition the design of studies on novel compounds Projet recherche Xénobiotique - Métabolisme Xénobiotiques - Métabolisme - Recherche - Technique Xenobiotics Metabolism Research Technique Xenobiotikum (DE-588)4193155-5 gnd Stoffwechsel (DE-588)4057699-1 gnd |
| subject_GND | (DE-588)4193155-5 (DE-588)4057699-1 (DE-588)4143413-4 |
| title | Xenobiotic metabolism and disposition the design of studies on novel compounds |
| title_auth | Xenobiotic metabolism and disposition the design of studies on novel compounds |
| title_exact_search | Xenobiotic metabolism and disposition the design of studies on novel compounds |
| title_full | Xenobiotic metabolism and disposition the design of studies on novel compounds ed. H. P. A. Illing |
| title_fullStr | Xenobiotic metabolism and disposition the design of studies on novel compounds ed. H. P. A. Illing |
| title_full_unstemmed | Xenobiotic metabolism and disposition the design of studies on novel compounds ed. H. P. A. Illing |
| title_short | Xenobiotic metabolism and disposition |
| title_sort | xenobiotic metabolism and disposition the design of studies on novel compounds |
| title_sub | the design of studies on novel compounds |
| topic | Projet recherche Xénobiotique - Métabolisme Xénobiotiques - Métabolisme - Recherche - Technique Xenobiotics Metabolism Research Technique Xenobiotikum (DE-588)4193155-5 gnd Stoffwechsel (DE-588)4057699-1 gnd |
| topic_facet | Projet recherche Xénobiotique - Métabolisme Xénobiotiques - Métabolisme - Recherche - Technique Xenobiotics Metabolism Research Technique Xenobiotikum Stoffwechsel Aufsatzsammlung |
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