Verfügbarkeit: Genes :: THWS Bibkatalog

Genes:

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Bibliographische Detailangaben
1. Verfasser:	Lewin, Benjamin (VerfasserIn)
Format:	Buch
Sprache:	English
Veröffentlicht:	New York [u.a.] Wiley 1987
Ausgabe:	3. ed.
Schlagworte:	Genetica Génétique Genetics Molekulargenetik Genetik Gen Lehrbuch
Online-Zugang:	Inhaltsverzeichnis
Beschreibung:	XX, 761 S. Ill., graph. Darst.
ISBN:	0471832782

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Datensatz im Suchindex

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adam_text	IMAGE 1 CONTENTS INTRODUCTION CELLS OBEY THE LAWS OF PHYSICS AND CHEMISTRY 3 HEREDITY WORKS THROUGH MACROMOLECULES 3PROTEINS CONSIST OF CHAINS OF AMINO ACIDS 4NONCOVALENT FORCES ARE IMPORTANT IN PROTEIN CONFORMATION 7 PROTEIN STRUCTURES ARE EXTREMELY DIVERSE 9HOW DO PROTEINS FOLD INTO THE CORRECT CONFORMATION? 11 PART 1 PNA AS A STORE OF INFORMATION IS CHAPTER 1 GENES ARE MUTABLE UNITS 17 DISCOVERY OF THE GENE 18THE ROLE OF CHROMOSOMES IN HEREDITY 22EACH GENE LIES ON A SPECIFIC CHROMOSOME 26GENES LIE IN A LINEAR ARRAY 27THE GENETIC MAP IS CONTINUOUS 30ONE GENE-ONE PROTEIN 31A DETAILED DEFINITION: THE CISTRON 33MAPPING MUTATIONS AT THE MOLECULAR LEVEL 35 CHAPTER 2 DNA IS THE GENETIC MATERIAL 37 THE DISCOVERY OF DNA 37DNA IS THE (ALMOST) UNIVERSAL GENETIC MATERIAL 39THE COMPONENTS OF DNA 41 XI IMAGE 2 X II CONTENTS DNA IS A DOUBLE HELIX 44 DNA REPLICATION IS SEMICONSERVATIVE 49 THE GENETIC CODE IS READ IN TRIPLETS 49 POINT MUTATIONS CHANGE SINGLE BASE PAIRS 52 MUTATIONS ARE CONCENTRATED AT HOTSPOTS 53 THE RATE OF MUTATION 55 CHAPTER 3 THE TOPOLOGY OF NUCLEIC ACIDS 57 DNA CAN BE DENATURED AND RENATURED 57 NUCLEIC ACIDS HYBRIDIZE BY BASE PAIRING 58 SINGLE STRANDED NUCLEIC ACIDS MAY HAVE SECONDARY STRUCTURE 60 INVERTED REPEATS AND SECONDARY STRUCTURE 63 DUPLEX DNA HAS ALTERNATIVE DOUBLE-HELICAL STRUCTURES 65 A LEFT-HANDED FORM OF DNA 66 CLOSED DNA CAN BE SUPERCOILED 68 SUPERCOILING INFLUENCES THE STRUCTURE OF THE DOUBLE HELIX 70 CHAPTER 4 ISOLATING THE GENE 72 RESTRICTION ENZYMES CLEAVE DNA INTO SPECIFIC FRAGMENTS 73 CONSTRUCTING A RESTRICTION MAP FROM THE FRAGMENTS 75 RESTRICTION SITES CAN BE USED AS GENETIC MARKERS 78 OBTAINING THE SEQUENCE OF DNA 83 PROKARYOTIC GENES AND PROTEINS ARE COLINEAR 86 EUKARYOTIC GENES CAN BE INTERRUPTED 87 SOME DNA SEQUENCES CODE FOR MORE THAN ONE PROTEIN 89 GENETIC INFORMATION CAN BE PROVIDED BY DNA OR RNA 90 THE SCOPE OF THE PARADIGM 93 PART 2 TURNING GENES INTO PROTEINS 95 CHAPTER 5 THE ASSEMBLY LINE FOR PROTEIN SYNTHESIS 97 TRANSFER RNA IS THE ADAPTOR 98 MESSENGER RNA IS TRANSLATED BY RIBOSOMES 99 THE MEANING OF THE GENETIC CODE 103 THE RIBOSOMAL SITES OF ACTION 105 INITIATION NEEDS 30S SUBUNITS AND ACCESSORY FACTORS 106 A SPECIAL INITIATOR TRNA STARTS THE POLYPEPTIDE CHAIN 109 EUKARYOTIC INITIATION INVOLVES MANY FACTORS 112 ELONGATION FACTOR T BRINGS AMINOACYL-TRNA INTO THE A SITE 114 TRANSLOCATION MOVES THE RIBOSOME 116 FINISHING OFF: THREE CODONS TERMINATE PROTEIN SYNTHESIS 120 CHAPTER 6 TRANSFER RNA: THE TRANSLATIONAL ADAPTOR 122 THE UNIVERSAL CLOVERLEAF 123 THE TERTIARY STRUCTURE IS L-SHAPED 123 IMAGE 3 CONTENTS X I II HOW DO SYNTHETASES RECOGNIZE TRNAS? 126 DISCRIMINATION IN THE CHARGING STEP 128 CODON-ANTICODON RECOGNITION INVOLVES WOBBLING 129 TRNA CONTAINS MANY MODIFIED BASES 132 BASE MODIFICATION MAY CONTROL CODON RECOGNITION 135 MITOCHONDRIA HAVE MINIMAL TRNA SETS 135 MUTANT TRNAS READ DIFFERENT CODONS 137 SUPPRESSOR TRNAS COMPETE FOR THEIR CODONS 140 TRNA MAY INFLUENCE THE READING FRAME 142 CHAPTER 7 THE RIBOSOME TRANSLATION FACTORY 144 RIBOSOMES ARE COMPACT RIBONUCLEOPROTEIN PARTICLES 145 RIBOSOMAL PROTEINS INTERACT WITH RRNA 147 RECONSTITUTION IN VITRO MIMICS ASSEMBLY IN VIVO 150 SUBUNIT ASSEMBLY IS LINKED TO TOPOLOGY 151 ALL RIBOSOMAL COMPONENTS CAN BE MUTATED 152 RIBOSOMES HAVE SEVERAL ACTIVE CENTERS 154 THE ACCURACY OF TRANSLATION 156 CHAPTER 8 THE MESSENGER RNA TEMPLATE 15? THE TRANSIENCE OF BACTERIAL MESSENGERS 159 MOST BACTERIAL MRNAS ARE POLYCISTRONIC 161 TRANSLATION OF POLYCISTRONIC MESSENGERS 163 A FUNCTIONAL DEFINITION FOR EUKARYOTIC MRNA 164 THE POWER OF IN VITRO TRANSLATION SYSTEMS 166 MOST EUKARYOTIC MRNAS ARE POLYADENYLATED AT THE 3 END 168 ALL EUKARYOTIC MRNAS HAVE A METHYLATED CAP AT THE 5 END 169 INITIATION MAY INVOLVE BASE PAIRING BETWEEN MRNA AND RRNA 171 SMALL SUBUNITS MAY MIGRATE TO INITIATION SITES ON EUKARYOTIC MRNA 172 PROTEIN SYNTHESIS IS LINKED TO CELLULAR LOCATION 173 PART 3 CONTROLLING GENE EXPRESSION BY TRANSCRIPTION I8I CHAPTER 9 RNA POLYMERASE-PROMOTER INTERACTIONS CONTROL INITIATION 183 TRANSCRIPTION IS CATALYZED BY RNA POLYMERASE 184 BACTERIAL RNA POLYMERASE CONSISTS OF CORE ENZYME AND SIGMA FACTOR 185 EUKARYOTIC RNA POLYMERASES CONSIST OF MANY SUBUNITS 188 BACTERIAL SIGMA FACTOR CONTROLS BINDING TO DNA 189 TRANSCRIPTION UNITS EXTEND FROM PROMOTERS TO TERMINATORS 192 PROMOTERS INCLUDE CONSENSUS SEQUENCES 193 RNA POLYMERASE CAN BIND TO PROMOTERS IN VITRO 195 SUBSTITUTION OF SIGMA FACTORS MAY CONTROL INITIATION 200 PROMOTERS FOR RNA POLYMERASE II ARE UPSTREAM OF THE STARTPOINT 206 RNA POLYMERASE II PROMOTERS ARE MULTIPARTITE 209 TRANSCRIPTION FACTORS RECOGNIZE PARTICULAR CONSENSUS SEQUENCES 211 IMAGE 4 X IV CONTENTS ENHANCERS ARE BIDIRECTIONAL ELEMENTS THAT ASSIST INITIATION 213 RNA POLYMERASE III HAS A DOWNSTREAM PROMOTER 216 CHAPTER 10 A PANOPLY OF OPERONS: THE LACTOSE PARADIGM AND OTHERS 219 INDUCTION AND REPRESSION ARE CONTROLLED BY SMALL MOLECULES 220 STRUCTURAL GENE CLUSTERS ARE COORDINATELY CONTROLLED 220 REPRESSOR PROTEIN BINDS TO THE OPERATOR 223 THE OPERATOR IS C/S-ACTING 225 HOW DOES REPRESSOR BLOCK TRANSCRIPTION? 227 CONTACTS IN THE OPERATOR 228 REPRESSOR IS A MULTIMERIC DNA-BINDING PROTEIN 229 GETTING OFF DNA AND STORING SURPLUS REPRESSOR 231 A PARADOX OF INDUCTION 234 REPRESSION CAN OCCUR AT MULTIPLE LOCI 234 DISTINGUISHING POSITIVE AND NEGATIVE CONTROL 235 CATABOLITE REPRESSION INVOLVES POSITIVE REGULATION AT THE PROMOTER 236 HARD TIMES PROVOKE THE STRINGENT RESPONSE 240 TRANSLATION MAY BE AUTOGENOUSLY CONTROLLED 242 SMALL RNA MOLECULES CAN REGULATE TRANSLATION 244 CHAPTER 11 CONTROL AT TERMINATION: ATTENUATION AND ANTITERMINATION 248 TWO TERMINATION MODES IN E. COLI INVOLVE PALINDROMES 249 EUKARYOTIC TERMINATION ALSO INVOLVES SECONDARY STRUCTURE OR U-RUNS 251 ALTERNATIVE SECONDARY STRUCTURES CONTROL ATTENUATION 252 THE GENERALITY OF ATTENUATION 256 HOW DOES E. COLI RHO FACTOR WORK? 259 ANTITERMINATION DEPENDS ON SPECIFIC SITES 261 MORE SUBUNITS FOR RNA POLYMERASE? 267 CHAPTER 12 LYTIC CASCADES AND LYSOGENIC REPRESSION 269 LYTIC DEVELOPMENT IS CONTROLLED BY A CASCADE 270 FUNCTIONAL CLUSTERING IN PHAGES T7 AND T4 272 THE LAMBDA LYTIC CASCADE RELIES ON ANTITERMINATION 274 LYSOGENY IS MAINTAINED BY AN AUTOGENOUS CIRCUIT 277 REPRESSOR IS A DIMER THAT BINDS COOPERATIVELY AT EACH OPERATOR 279 HOW IS REPRESSOR SYNTHESIS ESTABLISHED? 285 ANTIREPRESSOR IS NEEDED FOR LYTIC INFECTION 287 A DELICATE BALANCE: LYSOGENY VERSUS LYSIS 289 PART 4 PERPETUATION OF DNA 293 CHAPTER 13 THE REPLICON: UNIT OF REPLICATION 295 SEQUENTIAL REPLICATION FORMS EYES 296 THE BACTERIAL GENOME IS A SINGLE REPLICON 298 IMAGE 5 CONTENTS XV CONNECTING REPLICATION TO THE CELL CYCLE 299 EACH EUKARYOTIC CHROMOSOME CONTAINS MANY REPLICONS 300 ISOLATING THE ORIGINS OF YEAST REPLICONS 303 REPLICATION CAN PROCEED THROUGH EYES, ROLLING CIRCLES, OR D LOOPS 303 PLASMID INCOMPATIBILITY IS CONNECTED WITH COPY NUMBER 307 CHAPTER 14 THE APPARATUS FOR PNA REPLICATION 312 DNA POLYMERASES: THE ENZYMES THAT MAKE DNA 313 DNA SYNTHESIS IS SEMIDISCONTINUOUS 316 OKAZAKI FRAGMENTS ARE PRIMED BY RNA 317 THE COMPLEXITY OF THE BACTERIAL REPLICATION APPARATUS 319 INITIATING SYNTHESIS OF A SINGLE DNA STRAND 320 MOVEMENT OF THE PRIMOSOME 322 INITIATING REPLICATION AT DUPLEX ORIGINS 325 THE REPLICATION APPARATUS OF PHAGE T4 329 THE PROBLEM OF LINEAR REPLICONS 331 CHAPTER 15 SYSTEMS THAT SAFEGUARD DNA 335 THE OPERATION OF RESTRICTION AND MODIFICATION 336 THE ALTERNATE ACTIVITIES OF TYPE I ENZYMES 338 THE DUAL ACTIVITIES OF TYPE III ENZYMES 341 DEALING WITH INJURIES IN DNA 342 EXCISION-REPAIR SYSTEMS IN . COLI 345 RECOMBINATION-REPAIR SYSTEMS IN E. COLI 347 AN SOS SYSTEM OF MANY GENES 348 MAMMALIAN REPAIR SYSTEMS 350 PART 5 CONSTITUTION OF THE EUKARYOTIC GENOME 351 CHAPTER 16 THE EXTRAORDINARY POWER OF DNA TECHNOLOGY 353 ANY DNA SEQUENCE CAN BE CLONED IN BACTERIA 354 CONSTRUCTING THE CHIMERIC DNA 355 COPYING MRNA INTO DNA 358 ISOLATING INDIVIDUAL GENES FROM THE GENOME 359 WALKING ALONG THE CHROMOSOME 361 EUKARYOTIC GENES CAN BE EXPRESSED IN PROKARYOTIC SYSTEMS 364 CHAPTER 17 A CONTINUUM OF SEQUENCES INCLUDES STRUCTURAL GENES 367 THE C-VALUE PARADOX DESCRIBES VARIATIONS IN GENOME SIZE 367 REASSOCIATION KINETICS DEPEND ON SEQUENCE COMPLEXITY 369 EUKARYOTIC GENOMES CONTAIN SEVERAL SEQUENCE COMPONENTS 371 NONREPETITIVE DNA COMPLEXITY CAN ESTIMATE GENOME SIZE 372 EUKARYOTIC GENOMES CONTAIN REPETITIVE SEQUENCES 372 MODERATELY REPETITIVE DNA CONSISTS OF MANY DIFFERENT SEQUENCES 373 IMAGE 6 X VI CONTENTS MEMBERS OF REPETITIVE SEQUENCE FAMILIES ARE RELATED BUT NOT IDENTICAL 375 MOST STRUCTURAL GENES LIE IN NONREPETITIVE DNA 377 HOW MANY NONREPETITIVE GENES ARE EXPRESSED? 378 ESTIMATING GENE NUMBERS BY THE KINETICS OF RNA-DRIVEN REACTIONS 379 GENES ARE EXPRESSED AT WIDELY VARYING LEVELS 381 OVERLAPS BETWEEN MRNA POPULATIONS 382 CHAPTER 18 THE ORGANIZATION OF INTERRUPTED GENES 384 GENES COME IN ALL SHAPES AND SIZES 385 INTRONS IN GENES CODING FOR RRNA AND TRNA 388 EXON-INTRON JUNCTIONS HAVE A CONSENSUS SEQUENCE 388 ONE GENE S INTRON CAN BE ANOTHER GENE S EXON 389 HOW DID INTERRUPTED GENES EVOLVE? 392 PART 6 CLUSTERS OF RELATED SEQUENCES 397 CHAPTER 19 STRUCTURAL GENES BELONG TO FAMILIES OF VARIOUS SIZES 399 GLOBIN GENES ARE ORGANIZED IN TWO CLUSTERS 400 UNEQUAL CROSSING-OVER REARRANGES GENE CLUSTERS 402 MANY THALASSEMIAS RESULT FROM UNEQUAL CROSSING-OVER 402 GENE CLUSTERS SUFFER CONTINUAL REORGANIZATION 405 SEQUENCE DIVERGENCE DISTINGUISHES TWO TYPES OF SITES IN DNA 406 THE EVOLUTIONARY CLOCK TRACES THE DEVELOPMENT OF GLOBIN GENES 408 PSEUDOGENES ARE DEAD ENDS OF EVOLUTION 409 GENE FAMILIES ARE COMMON FOR ABUNDANT PROTEINS 411 A VARIETY OF TANDEM GENE CLUSTERS CODE FOR HISTONES 412 GENES FOR RRNA AND TRNA ARE REPEATED 415 A TANDEM REPEATING UNIT CONTAINS BOTH RRNA GENES 416 5S GENES AND PSEUDOGENES ARE INTERSPERSED 418 AN EVOLUTIONARY DILEMMA: HOW ARE MULTIPLE ACTIVE COPIES MAINTAINED? 419 CHAPTER 20 GENOMES SEQUESTERED IN ORGANELLES 422 ORGANELLE GENES SHOW NONMENDELIAN INHERITANCE 422 ORGANELLE GENOMES ARE CIRCULAR DNA MOLECULES 423 ORGANELLES EXPRESS THEIR OWN GENES 424 THE LARGE MITOCHONDRIAL GENOME OF YEAST 427 THE COMPACT MITOCHONDRIAL GENOME OF MAMMALS 428 RECOMBINATION OCCURS IN (SOME) ORGANELLE DNAS 430 REARRANGEMENTS OF YEAST MITOCHONDRIAL DNA 430 CHAPTER 21 ORGANIZATION OF SIMPLE SEQUENCE DNA 432 HIGHLY REPETITIVE DNA FORMS SATELLITES 433 SATELLITE DNAS OFTEN LIE IN HETEROCHROMATIN 434 IMAGE 7 CONTENTS XVII ARTHROPOD SATELLITES HAVE VERY SHORT IDENTICAL REPEATS 435 MAMMALIAN SATELLITES CONSIST OF HIERARCHICAL REPEATS 435 RECONSTRUCTING THE STAGES OF MOUSE SATELLITE DNA EVOLUTION 438 VARIATIONS IN THE PRESENT REPEATING UNIT 439 THE CONSEQUENCES OF UNEQUAL CROSSING OVER 440 CROSSOVER FIXATION COULD MAINTAIN IDENTICAL REPEATS 442 PART 7 REACHING MATURITY: RNA PROCESSING 4 CHAPTER 22 CUTTING AND TRIMMING STABLE RNA 445 RNAASE III RELEASES THE PHAGE T7 EARLY MRNAS 448 CLEAVAGES ARE NEEDED TO RELEASE PROKARYOTIC AND EUKARYOTIC RRNAS 450 TRNA GENES ARE CUT AND TRIMMED FROM CLUSTERS BY SEVERAL ENZYMES 454 CHAPTER 23 RNA AS CATALYST: MECHANISMS OF SPLICING 458 YEAST TRNA SPLICING INVOLVES CUTTING AND REJOINING 459 RNA CAN HAVE CATALYTIC ACTIVITY 461 SOME MITOCHONDRIAL INTRONS ARE RELATED TO SELF-SPLICING INTRONS 465 AN INTRON THAT MAY CODE FOR A REGULATOR PROTEIN 468 NUCLEAR RNA SPLICING FOLLOWS PREFERRED PATHWAYS 472 NUCLEAR SPLICING JUNCTIONS MAY BE INTERCHANGEABLE 473 A NUCLEAR SPLICEOSOME GENERATES A LARIAT 475 ARE SNRNAS INVOLVED IN SPLICING? 478 ARE SPLICING REACTIONS RELATED? 479 CHAPTER 24 CONTROL OF RNA PROCESSING 483 HNRNA IS LARGE AND UNSTABLE 483 MRNA IS DERIVED FROM HNRNA 485 POLYADENYLATION AND THE GENERATION OF 3 ENDS 487 IS THERE CONTROL AFTER TRANSCRIPTION? 489 MODELS FOR CONTROLLING GENE EXPRESSION 491 THE POTENTIAL OF CELLULAR POLYPROTEINS 494 PART 8 T HE P A C K A G I NG OF D NA 497 CHAPTER 25 ABOUT GENOMES AND CHROMOSOMES 49? CONDENSING VIRAL GENOMES INTO THEIR COATS 500 THE BACTERIAL GENOME IS A NUCLEOID WITH MANY SUPERCOILED LOOPS 503 THE CONTRAST BETWEEN INTERPHASE CHROMATIN AND MITOTIC CHROMOSOMES 507 THE EUKARYOTIC CHROMOSOME AS A SEGREGATION DEVICE 509 SOME GENES ARE EXTRACHROMOSOMAL 512 IMAGE 8 XVIII CONTENTS THE EXTENDED STATE OF LAMPBRUSH CHROMOSOMES 513 POLYTENY FORMS GIANT CHROMOSOMES 515 TRANSCRIPTION DISRUPTS THE CHROMOSOME STRUCTURE 517 CHAPTER 26 CHROMATIN STRUCTURE: THE NUCLEOSOME 519 THE PROTEIN COMPONENTS OF CHROMATIN 520 THE NUCLEOSOME IS THE BASIC SUBUNIT OF ALL CHROMATIN 521 THE CORE PARTICLE IS HIGHLY CONSERVED 524 DNA IS COILED AROUND THE HISTONE OCTAMER 525 SUPERCOILING AND THE PERIODICITY OF DNA 530 ARE NUCLEOSOMES ARRANGED IN PHASE? 531 THE PATH OF NUCLEOSOMES IN THE CHROMATIN FIBER 533 LOOPS, DOMAINS, AND SCAFFOLDS 535 CHAPTER 27 THE NATURE OF ACTIVE CHROMATIN 538 NUCLEOSOME ASSEMBLY VERSUS CHROMATIN REPRODUCTION 539 NUCLEOSOME ASSEMBLY REQUIRES NONHISTONE PROTEINS 540 ARE TRANSCRIBED GENES ORGANIZED IN NUCLEOSOMES? 542 THE DNAASE-SENSITIVE DOMAINS OF TRANSCRIBABLE CHROMATIN 545 HISTONES ARE TRANSIENTLY MODIFIED 546 GENE EXPRESSION IS ASSOCIATED WITH DEMETHYLATION 549 DNAASE HYPERSENSITIVE SITES CHANGE CHROMATIN STRUCTURE 551 STRUCTURAL FLEXIBILITY IN DNA 555 SPECULATIONS ABOUT THE NATURE OF GENE ACTIVATION 557 PART 9 THE DYNAMIC GENOME: DNA IN FLUX SEI CHAPTER 28 RECOMBINATION AND OTHER TOPOLOGICAL MANIPULATIONS OF DNA 563 RECOMBINATION REQUIRES SYNAPSIS OF HOMOLOGOUS DUPLEX DNAS 564 BREAKAGE AND REUNION INVOLVES HETERODUPLEX DNA 565 DO DOUBLE-STRAND BREAKS INITIATE RECOMBINATION? 568 ISOLATION OF RECOMBINATION INTERMEDIATES 569 THE STRAND-EXCHANGE FACILITY OF RECA 571 RECA AND THE CONDITIONS OF RECOMBINATION 574 GENE CONVERSION ACCOUNTS FOR INTERALLELIC RECOMBINATION 576 TOPOLOGICAL MANIPULATION OF DNA 578 GYRASE INTRODUCES NEGATIVE SUPERCOILS IN DNA 580 SPECIALIZED RECOMBINATION RECOGNIZES SPECIFIC SITES 582 STAGGERED BREAKAGE AND REUNION IN THE CORE 583 INVERSION CAN CONTROL GENE EXPRESSION 586 CHAPTER 29 TRANSPOSABLE ELEMENTS IN BACTERIA 589 INSERTION SEQUENCES ARE SIMPLE TRANSPOSONS 590 COMPOSITE TRANSPOSONS HAVE IS MODULES 592 IMAGE 9 CONTENTS X IX ONLY ONE MODULE OF TN10 IS FUNCTIONAL 594 THE MODULES OF TN5 ARE ALMOST IDENTICAL BUT VERY DIFFERENT 596 CONSERVATIVE VERSUS REPLICATIVE RECOMBINATION 597 INTERMEDIATES IN TRANSPOSITION 599 CHAPTER 30 MOBILE ELEMENTS IN EUKARYOTES 6Q5 CONTROLLING ELEMENTS IN MAIZE ARE TRANSPOSABLE 605 DS MAY TRANSPOSE OR CAUSE CHROMOSOME BREAKAGE 607 DS TRANSPOSITION IS CONNECTED WITH REPLICATION 609 THE RETROVIRUS LIFE CYCLE INVOLVES TRANSPOSITION-LIKE EVENTS 610 RETROVIRUSES MAY TRANSDUCE CELLULAR SEQUENCES 614 RNA-DEPENDENT TRANSPOSITIONS MAY HAVE OCCURRED IN THE CELL 616 THE ALU FAMILY 617 YEAST TY ELEMENTS RESEMBLE RETROVIRUSES 618 MANY TRANSPOSABLE ELEMENTS RESIDE IN D. MELANOGASTER 620 THE ROLE OF TRANSPOSABLE ELEMENTS IN HYBRID DYSGENESIS 622 CHAPTER 31 ENGINEERING CHANGES IN THE GENOME 625 TISSUE-SPECIFIC VARIATIONS OCCUR IN THE DROSOPHILA GENOME 626 SELECTION OF AMPLIFIED GENOMIC SEQUENCES 628 EXOGENOUS SEQUENCES CAN BE INTRODUCED BY TRANSFECTION 632 TRANSFECTED DNA CAN ENTER THE GERM LINE 634 PART 10 GENES IN DEVELOPMENT 639 CHAPTER 32 REARRANGEMENTS AND THE GENERATION OF IMMUNE DIVERSITY 64 ORGANIZATION OF IMMUNOGLOBULINS 642 IMMUNOGLOBULIN GENES ARE ASSEMBLED FROM THEIR PARTS 645 THE DIVERSITY OF GERM-LINE INFORMATION 647 JOINING REACTIONS GENERATE ADDITIONAL DIVERSITY 649 RECOMBINATION OF V AND C GENES GENERATES DELETIONS AND REARRANGEMENTS 650 SOME POSSIBLE CAUSES OF ALLELIC EXCLUSION 653 CONTINUING DNA RECOMBINATION CAUSES CLASS SWITCHING 654 EARLY HEAVY-CHAIN EXPRESSION CAN BE CHANGED BY RNA PROCESSING 656 SOMATIC MUTATION GENERATES ADDITIONAL DIVERSITY 658 T-CELL RECEPTOR IS RELATED TO IMMUNOGLOBULINS 659 COMPLEXITY OF MAJOR HISTOCOMPATIBILITY LOCI 660 CHAPTER 33 CHANGING GENE ORGANIZATION FROM WITHIN AND WITHOUT 664 YEAST HAS SILENT AND ACTIVE LOCI FOR MATING TYPE 664 SILENT AND ACTIVE CASSETTES HAVE THE SAME SEQUENCES 666 UNIDIRECTIONAL TRANSPOSITION IS INITIATED BY THE RECIPIENT MAT LOCUS 669 IMAGE 10 XX _ _ _ _ _ ^ __ CONTENTS TRYPANOSOMES REARRANGE DNA TO EXPRESS THE SURFACE ANTIGEN 670 THE INTERACTION OF TI PLASMID DNA WITH THE PLANT GENOME 675 CHAPTER 34 GENE REGULATION: CHANGING PATTERNS OF EXPRESSION 681 MAPPING MUTATIONS IN EXONS AND INTRONS 682 SOME BACKGROUND ABOUT DROSOPHILA DEVELOPMENT 685 COMPLEX LOCI ARE EXTREMELY LARGE AND INVOLVED IN REGULATION 689 A COMMON CODING MOTIF: THE HOMEO BOX 695 CHAPTER 35 ONCOGENES: ABERRANT GENE EXPRESSION AND CANCER 698 TRANSFORMING VIRUSES MAY CARRY ONCOGENES 699 RETROVIRAL ONCOGENES HAVE CELLULAR COUNTERPARTS 701 RAS PROTO-ONCOGENES CAN BE ACTIVATED BY MUTATION 703 MYC AND OTHER ONCOGENES ARE ACTIVATED BY INSERTIONS, TRANSLOCATIONS, AND AMPLIFICATION 706 IMMORTALIZATION AND TRANSFORMATION 711 POSSIBLE FUNCTIONS FOR ONCOPROTEINS 712 EPILOGUE LANDMARK CHANGES IN PERSPECTIVES 719 GLOSSARY 721 INDEX 739
any_adam_object	1
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genre_facet	Lehrbuch
id	DE-604.BV001245832
illustrated	Illustrated
indexdate	2024-07-09T15:25:46Z
institution	BVB
isbn	0471832782
language	English
oai_aleph_id	oai:aleph.bib-bvb.de:BVB01-000748924
oclc_num	14069165
open_access_boolean
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publishDate	1987
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publisher	Wiley
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spelling	Lewin, Benjamin Verfasser aut Genes Benjamin Lewin 3. ed. New York [u.a.] Wiley 1987 XX, 761 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Genetica gtt Génétique Génétique ram Genetics Molekulargenetik (DE-588)4039987-4 gnd rswk-swf Genetik (DE-588)4071711-2 gnd rswk-swf Gen (DE-588)4128987-0 gnd rswk-swf (DE-588)4123623-3 Lehrbuch gnd-content Genetik (DE-588)4071711-2 s DE-604 Molekulargenetik (DE-588)4039987-4 s DE-188 Gen (DE-588)4128987-0 s 1\p DE-604 SWB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000748924&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk
spellingShingle	Lewin, Benjamin Genes Genetica gtt Génétique Génétique ram Genetics Molekulargenetik (DE-588)4039987-4 gnd Genetik (DE-588)4071711-2 gnd Gen (DE-588)4128987-0 gnd
subject_GND	(DE-588)4039987-4 (DE-588)4071711-2 (DE-588)4128987-0 (DE-588)4123623-3
title	Genes
title_auth	Genes
title_exact_search	Genes
title_full	Genes Benjamin Lewin
title_fullStr	Genes Benjamin Lewin
title_full_unstemmed	Genes Benjamin Lewin
title_short	Genes
title_sort	genes
topic	Genetica gtt Génétique Génétique ram Genetics Molekulargenetik (DE-588)4039987-4 gnd Genetik (DE-588)4071711-2 gnd Gen (DE-588)4128987-0 gnd
topic_facet	Genetica Génétique Genetics Molekulargenetik Genetik Gen Lehrbuch
url	http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000748924&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
work_keys_str_mv	AT lewinbenjamin genes

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