An introduction to genetic analysis:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York
Freeman
1986
|
| Ausgabe: | 3. ed. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | 1. u. 2. Aufl. u.d.T.: Suzuki, David T.: An introduction to genetic analysis |
| Beschreibung: | X, 612 S. Ill., graph. Darst. |
| ISBN: | 0716717050 |
Internformat
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Datensatz im Suchindex
| _version_ | 1804115455071223808 |
|---|---|
| adam_text | An introduction to
Genetic Analysis
THIRDEDITION
• David T Suzuki
University of British Columbia
• Anthony J F Griffiths
University of British Columbia
Q Jeffrey H Miller
University of California, Los Angeles
° Richard C Lewontin
Harvard University
W H Freeman and Company / New York
Contents Preface ix
1 Genetics and the Organism 1
The Scope of Genetics 1
Gene Transmission 2
Gene and Organism 3
Techniques of Genetic Analysis 9
Genetics and Human Affairs 11
2 Mendelian Analysis 14
Mendel s Experiments 14
Simple Mendelian Genetics in Humans 23
Simple Mendelian Genetics in Agriculture 25
The Origin of Variants 26
Genetic Dissection 26
Summary 28
Problems 29
3 Chromosome Theory of Inheritance 33
Mitosis and Meiosis 33
The Chromosome Theory of Heredity 40
Sex Chromosomes in Other Species 47
The Chromosome Theory in Review 50
Mendelian Genetics and Sexual Cycles 52
Summary 56
Problems 57
4 Extensions to Mendelian Analysis 60
Variations on Dominance Relations 60
Multiple Alleles 62
Lethal Genes 66
Several Genes Affecting the Same Character 67
Penetrance and Expressivity 71
Summary 72
Problems 73
5 Linkage I: Basic Eukaryotic Chromosome
Mapping 79
The Discovery of Linkage 79
vi CONTENTS
Recombination 81
Linkage Symbolism 82
Linkage of Genes on the X Chromosome 83
Linkage Maps 84
Double Crossovers 87
The x2 Test 89
Early Thoughts on the Nature of Crossing-
Over 93
Linkage Mapping by Recombination in
Humans 94
Summary 96
Problems 96
6 Linkage II: Special Eukaryotic Chromosome
Mapping Techniques 101
Mapping Functions 101
Tetrad Analysis 105
Mitotic Segregation and Recombination 113
Mapping Human Chromosomes 117
Summary 119
Problems 122
7 Gene Mutation 127
Somatic Versus Germinal Mutation 128
Types of Mutations 129
The Usefulness of Mutations 130
Selective Systems 133
Mutagens in Genetic Analysis 142
Mutation Breeding 143
Summary 144
Problems 144
8 Chromosome Mutation I: Changes in
Chromosome Structure 147
The Topography of Chromosomes 147
T ypes of Changes in Chromosome Structure 150
Summary 162
Problems 162
9 Chromosome Mutation II: Changes in
Chromosome Number 168
Abnormal Euploidy 168
Aneuploidy 175
Chromosome Mechanics in Plant Breeding 181
Summary 181
Problems 182
10 DNA Structure 185
DNA: The Genetic Material 185
The Structure of DNA 188
Replication of DNA 193
DNA and the Gene 200
Summary 203
Problems 203
11 The Nature of the Gene 206
How Genes Work 206
Gene-Protein Relations 207
Temperature-Sensitive Alleles 215
Genetic Fine Structure 217
Colinearity of Gene and Protein 223
Complementation 223
Mutational Sites 225
Summary 229
Problems 230
12 DNA Function 236
Transcription 236
Translation 239
The Genetic Code 244
Cracking the Code 250
Summary 256
Problems 258
13 Recombination in Bacteria and Their
Viruses 264
Bacterial Conjugation 265
Bacterial Transformation 275
CONTENTS vii
Phage Genetics 276
Transduction 282
Summary 289
Problems 289
14 Manipulation of DNA 296
The Power of Base Complementarity 296
Recombinant DNA and Genetic
Engineering 301
Applications of Recombinant DNA
Technology 321
Genetic Diseases 324
Recombinant DNA and Social
Responsibility 327
Summary 328
Problems 329
15 Mechanisms of Genetic Change I: Gene
Mutation 333
The Molecular Basis of Gene Mutations 333
Biological Repair Mechanisms 346
Mutators 349
Reversion Analysis- 351
The Ames Test 351
Summary 353
Problems 354
16 Mechanisms of Genetic Change II:
Recombination 356
General Homologous Recombination 356
Site-Specific Recombination 362
Summary 365
Problems 365
17 Mechanisms of Genetic Change III:
Transposable Genetic Elements 367
Transposable Genetic Elements in
Prokaryotes 367
Mechanism of Transposition 372
Rearrangements Mediated by Transposable
Elements 373
Transposable Genetic Elements in
Eukaryotes 374
Summary 383
Problems 383
18 Genetic Control Mechanisms in
Prokaryotes 385
The lac System: Negative Control 385
Catabolite Repression of the lac Operon: Positive
Control 390
Positive Control with Superimposed Negative
Control: The Arabinose Operon 393
Metabolic Pathways 393
The Tryptophan Genes: Negative Control with
Superimposed Attenuation 394
The A Phage: A Complex of Operons 397
Multioperon Repression 398
Structure of Regulatory Proteins 400
Summary 400
Problems 402
19 The Chromosome and Genetic Control
Mechanisms in Eukaryotes 404
The Structure and Activity of Chromosomes 404
Eukaryote Gene Function and Organization 413
Sequence Organization 416
Gene Regulation in Eukaryotes 428
Summary 430
Problems 430
20 The Extranuclear Genome 433
Variegation in Leaves of Higher Plants 435
Poky Neurospora 437
The Heterokaryon Test 438
Shell Coiling in Snails: A Red Herring 438
Extranuclear Genes in Chlamydomonas 439
Mitochondrial Genes in Yeast 442
An Overview of the Mitochondrial Genome 447
How Many Copies? 450
CONTENTS
Other Examples of Extranuclear
Inheritance 451
Summary 452
Problems 452
21 Developmental Genetics 456
Nuclear and Cytoplasmic Factors in
Development 456
Are Nuclei of Differentiated Cells
Totipotent? 459
Turning Genes Off and On 463
Mutations as Developmental Markers 471
The Genetics of Development 477
Special Cases of Differentiation 488
Summary 498
Problems 499
22 Quantitative Genetics 504
Some Basic Statistical Notions 505
Genotypes and Phenotypic Distribution 511
Norm of Reaction and Phenotypic
Distribution 514
The Heritability of a Trait 514
Determining Norms of Reaction 516
Quantifying Heritability 519
Counting and Locating the Genes 523
More on Analyzing Variance 525
Summary 530
Problems 530
23 Population Genetics 533
Darwin s Revolution 533
Variation and Its Modulation 534
The Sources of Variation 541
The Effect of Sexual Reproduction on
Variation 544
Selection 550
Balanced Polymorphism 555
Multiple Adaptive Peaks 557
Artificial Selection 558
Random Events 559
A Synthesis of Forces 561
The Origin of Species 563
Summary 563
Problems 564
Further Reading 567
Glossary 573
Answers to Selected Problems 589
Index 606
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| title | An introduction to genetic analysis |
| title_auth | An introduction to genetic analysis |
| title_exact_search | An introduction to genetic analysis |
| title_full | An introduction to genetic analysis David T. Suzuki ... |
| title_fullStr | An introduction to genetic analysis David T. Suzuki ... |
| title_full_unstemmed | An introduction to genetic analysis David T. Suzuki ... |
| title_short | An introduction to genetic analysis |
| title_sort | an introduction to genetic analysis |
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