Effect of carbohydrates on lipid metabolism: 38 tables
Gespeichert in:
| Weitere Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Basel ; München [u.a.]
Karger
1973
|
| Schriftenreihe: | Progress in biochemical pharmacology
8 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Literaturangaben |
| Beschreibung: | X, 310 S. graph. Darst. |
| ISBN: | 3805516002 |
Internformat
MARC
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| 001 | BV000942069 | ||
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| 245 | 1 | 0 | |a Effect of carbohydrates on lipid metabolism |b 38 tables |c ed. by I. Macdonald. List of contributors: Margaret J. Albrink ... |
| 264 | 1 | |a Basel ; München [u.a.] |b Karger |c 1973 | |
| 300 | |a X, 310 S. |b graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Progress in biochemical pharmacology |v 8 | |
| 500 | |a Literaturangaben | ||
| 650 | 2 | |a Glucides | |
| 650 | 2 | |a Lipides - Métabolisme | |
| 650 | 4 | |a Carbohydrates |x Physiological effect | |
| 650 | 4 | |a Lipid metabolism | |
| 650 | 0 | 7 | |a Kohlenhydrate |0 (DE-588)4164517-0 |2 gnd |9 rswk-swf |
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| 700 | 1 | |a Macdonald, Ian |d 1921- |0 (DE-588)138354391 |4 edt | |
| 700 | 1 | |a Albrink, Margaret J. |e Sonstige |4 oth | |
| 830 | 0 | |a Progress in biochemical pharmacology |v 8 |w (DE-604)BV000002187 |9 8 | |
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CONTENTS
THE
ENZYMES
OF
CARBOHYDRATE
DEGRADATION
F.
H
EINZ
,
HANNOVER-KLEEFELD
.
1
INTRODUCTION
.
2
GLUCOSE
METABOLISM
.
2
HEXOKINASE
.
2
PHOSPHOFRUCTOKINASE
.
6
PYRUVATE
KINASE
.
9
L-GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
.
11
PYRUVATE
DEHYDROGENASE
COMPLEX
.
13
GALACTOSE
METABOLISM
.
15
GALACTOKINASE
.
15
HEXOSE-L-PHOSPHATE
URIDYLYL
TRANSFERASE
.
16
URIDINE
DIPHOSPHOGLUCOSE
EPIMERASE
.
17
APPENDIX
.
18
FRUCTOSE
METABOLISM
.
18
KETOHEXOKINASE
.
19
ALDOLASE
.
25
D-TRIOKINASE
.
26
ALDEHYDE
DEHYDROGENASE
.
28
D-GLYCERATE
KINASE
.
29
D-GLYCERATE
DEHYDROGENASE
.
30
ALCOHOL
DEHYDROGENASE
(NAD-DEPENDENT)
.
30
ALCOHOL
DEHYDROGENASE
(NADP-DEPENDENT)
.
31
GLYCEROL
KINASE
.
32
FURTHER
METABOLISM
OF
TRIOSEPHOSPHATES
DERIVED
FROM
FRUCTOSE
.
33
METABOLIC
REGULATION
OF
FRUCTOSE
METABOLISM
AT
THE
CARBOHYDRATE
LEVEL.
.
33
XYLITOL
METABOLISM
.
34
DEHYDROGENATION
OF
XYLITOL
.
35
L-XYLULOSE
REDUCTASE
.
35
CONTENTS
VI
D-XYLULOSE
REDUCTASE
AND
L-IDITOL
DEHYDROGENASE
.
37
D-XYLULOKINASE
.
39
FURTHER
METABOLISM
OF
XYLITOL
INTERMEDIATES
IN
THE
PENTOSEPHOSPHATE
CYCLE.
.
39
SORBITOL
METABOLISM
.
41
DEHYDROGENATION
OF
SORBITOL
.
41
REFERENCES
.
41
LIPID
BIOSYNTHESIS
I.
R.
K
UPKE
,
HANNOVER-KLEEFELD
.
57
I.
INTRODUCTION
.
58
II.
BIOSYNTHESIS
OF
FATTY
ACIDS
.
58
III.
BIOSYNTHESIS
OF
STEROLS
AND
STEROL
DERIVATIVES
.
60
IV.
THE
INTRODUCTION
OF
SN-GLYCEROL-3-PHOSPHATE
INTO
COMPLEX
LIPIDS
.
62
A.
TYPE
I
REACTION
.
62
1.
BIOSYNTHESIS
OF
3-SN-LYSOPHOSPHATIDATE
AND
3-SN-PHOSPHATIDATE
.
62
A)
ACYLATION
REACTIONS
.
62
B)
ALTERNATE
PATHWAYS
FOR
THE
BIOSYNTHESIS
OF
3-SN-LYSOPHOSPHAT
IDATE
AND
3-SN-PHOSPHATIDE
.
71
2.
BIOSYNTHESIS
OF
ACYLGLYCEROLS
.
73
A)
SN-GLYCEROL-3-PHOSPHATE
PATHWAY
.
73
B)
MONOACYLGLYCEROL
PATHWAY
.
74
C)
OPERATION
OF
BOTH
PATHWAYS
.
76
D)
COMPARTMENTAL
AND
STEREOCHEMICAL
STUDIES
.
76
3.
BIOSYNTHESIS
OF
BASE
CONTAINING
DIACYLGLYCEROLS
.
77
A)
INCORPORATION
OF
BASES
.
77
B)
N-METHYLATION
.
79
C)
LECITHIN:
CHOLESTEROL
ACYLTRANSFERASE
REACTION
.
82
D)
LOCALIZATION
OF
THE
PHOSPHOGLYCERIDE
SYNTHETIZING
ENZYME
SYSTEMS
IN
THE
CELL
.
84
E)
MISCELLANEOUS
.
85
4.
BIOSYNTHESIS
OF
CDP-DIACYLGLYCEROLS
.
86
5.
BIOSYNTHESIS
OF
3-SN-PHOSPHATIDYLINOSITOL
.
91
6.
BIOSYNTHESIS
OF
3-SN-PHOSPHATIDYLSERINE
.
92
B.
TYPE
II
REACTION
.
92
1.
BIOSYNTHESIS
OF
3-SN-PHOSPHATIDYLGLYCEROL
AND
DERIVATIVES
.
92
A)
BIOSYNTHESIS
OF
3-SN-PHOSPHATIDYLGLYCEROL
.
92
B)
FORMATION
OF
3,3'-SN-DIPHOSPHATIDYLGLYCEROL
(CARDIOLIPIN)
.
94
C.
CONTROL
OF
PHOSPHOGLYCERIDE
BIOSYNTHESIS
.
96
V.
BIOSYNTHESIS
OF
GLYCOLIPIDS
INCLUDING
SPHINGOLIPIDS
.
97
VI.
BIOSYNTHESIS
OF
PLASMALOGENS
.
97
VIL
SELECTED
ASPECTS
ON
LIPID
BIOSYNTHESIS
IN
MAMMALIAN
ORGANS
.
97
A.
LIPID
BIOSYNTHESIS
FROM
FRUCTOSE
IN
LIVER
.
98
B.
LIPID
BIOSYNTHESIS
FROM
ACETATE
IN
ARTERIES
.
103
CONTENTS
VII
C.
LIPID
BIOSYNTHESIS
IN
VARIOUS
MAMMALIAN
ORGANS
.
106
D.
FACTORS
INFLUENCING
LIPOGENESIS
.
106
VIII.
ACKNOWLEDGEMENTS
.
106
IX.
REFERENCES
.
106
TRIGLYCERIDE
TURNOVER
IN
MAN.
EFFECTS
OF
DIETARY
CARBOHYDRATE
P.
J.
N
ESTEL
,
CANBERRA
.
125
I.
INTRODUCTION
.
126
II.
MEASUREMENT
OF
THE
TURNOVER
OF
PLASMA
TRIGLYCERIDE
.
127
A.
REINJECTION
OF
TRIGLYCERIDE-CONTAINING
LIPOPROTEINS
.
128
B.
INJECTION
OF
ARTIFICIAL
FAT
EMULSIONS
.
129
C.
ISOTOPIC
PRECURSOR-PRODUCT
MODELS
.
130
1.
PULSE
INJECTIONS
OF
RADIOLABELLED
PRECURSORS
.
130
2.
CONSTANT
INFUSION
OF
PRECURSOR
.
133
3.
HEPATIC
SECRETION
OF
RADIOLABELLED
TRIGLYCERIDE
.
136
D.
NON-ISOTOPIC
METHODS
.
138
E.
COMPARISON
OF
TRIGLYCERIDE
TURNOVER
WITH
DIFFERENT
METHODS
.
138
III.
PRECURSORS
OF
PLASMA
TRIGLYCERIDE
FATTY
ACIDS
.
139
A.
PLASMA
FREE
FATTY
ACIDS
.
139
B.
GLUCOSE
.
142
C.
HEPATIC
FATTY
ACIDS
.
144
IV.
TRIGLYCERIDE
REMOVAL
.
146
V.
CONCLUSIONS
.
150
VI.
REFERENCES
.
153
INFLUENCE
OF
FRUCTOSE
ON
HEPATIC
SYNTHESIS
OF
LIPIDS
D.
Z
AKIM
,
SAN
FRANCISCO,
CALIF.
.
161
I.
INTRODUCTION
.
161
H.
THE
SYNTHESIS
OF
FATTY
ACIDS
.
162
A.
PATHWAY
FOR
FATTY
ACID
SYNTHESIS
.
162
B.
REGULATION
OF
FATTY
ACID
SYNTHESIS
.
164
HI.
THE
EFFECT
OF
FRUCTOSE
ON
THE
AMOUNTS
OF
FATTY
ACID
SYNTHETIZING
ENZYMES.
.
167
IV.
THE
EFFECT
OF
FRUCTOSE
ON
THE
DYNAMIC
REGULATION
OF
FATTY
ACID
SYNTHESIS
.
170
A.
THE
EFFECTS
OF
FRUCTOSE
ON
THE
CONCENTRATIONS
OF
METABOLIC
INTERMEDIATES.
170
B.
THE
EFFECTS
OF
FRUCTOSE
ON
THE
ESTERIFICATION
OF
FATTY
ACIDS
.
172
C.
THE
CONVERSION
OF
14
C-FRUCTOSE
TO
FATTY
ACIDS
.
176
D.
ACUTE
EFFECTS
OF
FRUCTOSE
ON
THE
SYNTHESIS
OF
FATTY
ACIDS
FROM
ACETATE.
.
177
E.
THE
CONVERSION
OF
14
C-FRUCTOSE
TO
GLYCERIDE-GLYCEROL
.
179
V.
MECHANISM
OF
THE
DIFFERENTIAL
EFFECTS
OF
FRUCTOSE
AND
GLUCOSE
ON
HEPATIC
LIPO
GENESIS
.
180
VI.
CONCLUSIONS
.
183
VIL
REFERENCES
.
183
CONTENTS
VM
DIETARY
CARBOHYDRATES
AND
ADIPOSE
TISSUE
METABOLISM
A.
V
RANA
AND
P.
F
ABRY
,
PRAGUE
.
189
I.
HOMEOSTATIC
ROLE
OF
ADIPOSE
TISSUE
.
189
II.
CARBOHYDRATE
METABOLISM
IN
ADIPOSE
TISSUE
.
191
III.
EFFECTS
OF
CARBOHYDRATE
INGESTION
ON
ADIPOSE
TISSUE
METABOLISM
.
195
IV.
EFFECTS
OF
THE
TYPE
OF
DIETARY
CARBOHYDRATE
ON
ADIPOSE
TISSUE
METABOLISM
.
199
V.
REFERENCES
.
208
EFFECTS
OF
DIETARY
CARBOHYDRATES
ON
SERUM
LIPIDS
I.
M
ACDONALD
,
LONDON
.
216
I.
INTRODUCTION
.
216
II.
COMMON
DIETARY
CARBOHYDRATES
.
218
III.
IMMEDIATE
EFFECTS
ON
SERUM
LIPIDS
OF
CARBOHYDRATE
CONSUMPTION
.
219
IV.
EFFECTS
OF
DIETARY
CARBOHYDRATE
ON
THE
LEVEL
OF
LIPID
IN
FASTING
SERUM
.
221
A.
TRIGLYCERIDE
.
221
B.
CHOLESTEROL
.
224
C.
PHOSPHOLIPID
.
226
V.
FACTORS
AFFECTING
DIETARY
CARBOHYDRATE:
SERUM
LIPID
RELATIONSHIPS
.
227
A.
DIETARY
FAT
.
227
B.
SEX
.
229
VI.
OTHER
FACTORS
WHICH
CAN
INFLUENCE
THE
DIETARY
CARBOHYDRATE:
SERUM
LIPID
RELATIONSHIPS
.
231
A.
SPECIES
.
231
B.
DIETARY
PROTEIN
.
231
C.
FREQUENCY
OF
INGESTION
.
232
VII.
SUGGESTED
EXPLANATIONS
FOR
THE
DIFFERENCE
BETWEEN
DIETARY
CARBOHYDRATES
ON
THE
RESPONSE
OF
SERUM
TRIGLYCERIDE
LEVEL
.
232
VIII.
CONCLUSIONS
.
233
IX.
REFERENCES
.
233
DIETARY
CARBOHYDRATES
IN
LIPID
DISORDERS
IN
MAN
M
ARGARET
J.
A
LBRINK
,
MORGANTOWN,
W.
VA
.
242
I.
INTRODUCTION
.
243
II.
ATHEROGENESIS
.
243
A.
THE
HYPERLIPIDEMIAS
.
243
B.
ROLE
OF
CHOLESTEROL
.
244
C.
TRIGLYCERIDES
.
244
CONTENTS
IX
HI.
NONATHEROGENIC
RISK
FACTORS
.
245
A.
SUDDEN
DEATH
.
245
B.
R61E
OF
OBESITY
.
246
C.
ROLE
OF
TRIGLYCERIDES
.
246
IV.
R61E
OF
DIETARY
CARBOHYDRATE
IN
ASCVD
.
247
A.
EVOLUTION
OF
MAN
'
S
DIET
.
248
1.
MAN
THE
HUNTER
.
248
2.
THE
ADVENT
OF
AGRICULTURE
.
248
3.
THE
INDUSTRIAL
REVOLUTION
.
249
B.
EPIDEMIOLOGIC
STUDIES
OF
THE
EFFECT
OF
DIETARY
CARBOHYDRATE
.
250
1.
RELATIONSHIP
BETWEEN
INTAKE
OF
COMPLEX
CARBOHYDRATE
AND
DIABETES.
250
2.
RELATIONSHIP
BETWEEN
SUGAR
INTAKE,
DIABETES
AND
ASCVD
.
250
C.
EFFECT
OF
VARIOUS
CARBOHYDRATES
ON
GLUCOSE
TOLERANCE
.
251
1.
COMPLEX
CARBOHYDRATE
.
252
2.
METABOLIC
DIFFERENCES
BETWEEN
GLUCOSE
AND
FRUCTOSE
.
252
A)
LIVER
.
252
B)
OTHER
TISSUES
.
252
3.
EFFECT
OF
FRUCTOSE
AND
GLUCOSE
ON
GLUCOSE
TOLERANCE
.
252
V.
METABOLIC
CORRELATES
OF
OBESITY
.
254
A.
INSULIN
RESISTANCE
.
254
B.
EFFECT
OF
DIET
ON
PLASMA
INSULIN
.
257
VI.
METABOLIC
CHARACTERISTICS
OF
HYPERTRIGLYCERIDEMIA
.
257
A.
INSULIN
RESISTANCE
.
257
B.
EFFECT
OF
VERY
HIGH
CARBOHYDRATE
DIET
ON
SERUM
LIPIDS
.
257
1.
CARBOHYDRATE-INDUCED
LIPEMIA
.
257
2.
EFFECT
OF
TYPE
OF
CARBOHYDRATE
ON
TRIGLYCERIDES
.
258
3.
MECHANISM
OF
CARBOHYDRATE-INDUCED
LIPEMIA
.
260
4.
MECHANISM
OF
BASAL
HYPERTRIGLYCERIDEMIA
.
260
C.
DIETARY
TREATMENT
OF
HYPERTRIGLYCERIDEMIA
.
263
1.
WEIGHT
LOSS
.
263
2.
CARBOHYDRATE
RESTRICTIONS
.
263
VII.
SUMMARY
.
265
VIII.
REFERENCES
.
265
TRIGLYCERIDE
METABOLISM
IN
DIABETES
MELLITUS
E.
A.
N
IKKILA
,
HELSINKI
.
271
I.
INTRODUCTION
.
271
II.
PREVALENCE
OF
HYPERTRIGLYCERIDEMIA
IN
HUMAN
DIABETES
.
273
III.
PLASMA
FFA
CONCENTRATION
AND
TURNOVER
IN
INSULIN
DEFICIENCY
.
276
TV.
HEPATIC
METABOLISM
OF
FATTY
ACIDS
AND
TRIGLYCERIDES
IN
INSULIN
DEFICIENCY.
.
277
A.
UPTAKE
AND
ESTERIFICATION
OF
FFA
.
277
B.
HEPATIC
SYNTHESIS
OF
FATTY
ACIDS
.
279
V.
SECRETION
OF
TRIGLYCERIDES
BY
THE
DIABETIC
LIVER
.
280
CONTENTS
X
VI.
REMOVAL
OF
PLASMA
TRIGLYCERIDES
IN
INSULIN
DEFICIENCY
.
282
VII.
ALTERATIONS
OF
LIPOPROTEIN
LIPASE
ACTIVITY
IN
DIABETES
.
283
VIII.
TRIGLYCERIDE
METABOLISM
IN
DIABETES
WITH
HYPERINSULINISM
.
285
A.
EFFECT
OF
INSULIN,
GLUCOSE
AND
OBESITY
ON
PLASMA
FFA
METABOLISM
.
286
B.
EFFECT
OF
INSULIN,
HYPERGLYCEMIA
AND
OBESITY
ON
HEPATIC
TRIGLYCERIDE
SYNTHESIS
AND
RELEASE
.
287
LIPOATROPHIC
DIABETES
.
289
SUMMARY
.
290
ACKNOWLEDGEMENTS
.
290
.
REFERENCES
.
290
INDEX
.
300 |
| any_adam_object | 1 |
| author2 | Macdonald, Ian 1921- |
| author2_role | edt |
| author2_variant | i m im |
| author_GND | (DE-588)138354391 |
| author_facet | Macdonald, Ian 1921- |
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| bvnumber | BV000942069 |
| ctrlnum | (OCoLC)463002298 (DE-599)BVBBV000942069 |
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| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 610 - Medicine and health |
| dewey-raw | 610 |
| dewey-search | 610 |
| dewey-sort | 3610 |
| dewey-tens | 610 - Medicine and health |
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| id | DE-604.BV000942069 |
| illustrated | Illustrated |
| indexdate | 2024-08-22T00:53:25Z |
| institution | BVB |
| isbn | 3805516002 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-000575853 |
| oclc_num | 463002298 |
| open_access_boolean | |
| owner | DE-19 DE-BY-UBM DE-355 DE-BY-UBR DE-11 DE-188 DE-578 |
| owner_facet | DE-19 DE-BY-UBM DE-355 DE-BY-UBR DE-11 DE-188 DE-578 |
| physical | X, 310 S. graph. Darst. |
| psigel | HUB-ZB011200802 |
| publishDate | 1973 |
| publishDateSearch | 1973 |
| publishDateSort | 1973 |
| publisher | Karger |
| record_format | marc |
| series | Progress in biochemical pharmacology |
| series2 | Progress in biochemical pharmacology |
| spelling | Effect of carbohydrates on lipid metabolism 38 tables ed. by I. Macdonald. List of contributors: Margaret J. Albrink ... Basel ; München [u.a.] Karger 1973 X, 310 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Progress in biochemical pharmacology 8 Literaturangaben Glucides Lipides - Métabolisme Carbohydrates Physiological effect Lipid metabolism Kohlenhydrate (DE-588)4164517-0 gnd rswk-swf Lipidstoffwechsel (DE-588)4035875-6 gnd rswk-swf Lipidstoffwechsel (DE-588)4035875-6 s Kohlenhydrate (DE-588)4164517-0 s DE-604 Macdonald, Ian 1921- (DE-588)138354391 edt Albrink, Margaret J. Sonstige oth Progress in biochemical pharmacology 8 (DE-604)BV000002187 8 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000575853&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Effect of carbohydrates on lipid metabolism 38 tables Progress in biochemical pharmacology Glucides Lipides - Métabolisme Carbohydrates Physiological effect Lipid metabolism Kohlenhydrate (DE-588)4164517-0 gnd Lipidstoffwechsel (DE-588)4035875-6 gnd |
| subject_GND | (DE-588)4164517-0 (DE-588)4035875-6 |
| title | Effect of carbohydrates on lipid metabolism 38 tables |
| title_auth | Effect of carbohydrates on lipid metabolism 38 tables |
| title_exact_search | Effect of carbohydrates on lipid metabolism 38 tables |
| title_full | Effect of carbohydrates on lipid metabolism 38 tables ed. by I. Macdonald. List of contributors: Margaret J. Albrink ... |
| title_fullStr | Effect of carbohydrates on lipid metabolism 38 tables ed. by I. Macdonald. List of contributors: Margaret J. Albrink ... |
| title_full_unstemmed | Effect of carbohydrates on lipid metabolism 38 tables ed. by I. Macdonald. List of contributors: Margaret J. Albrink ... |
| title_short | Effect of carbohydrates on lipid metabolism |
| title_sort | effect of carbohydrates on lipid metabolism 38 tables |
| title_sub | 38 tables |
| topic | Glucides Lipides - Métabolisme Carbohydrates Physiological effect Lipid metabolism Kohlenhydrate (DE-588)4164517-0 gnd Lipidstoffwechsel (DE-588)4035875-6 gnd |
| topic_facet | Glucides Lipides - Métabolisme Carbohydrates Physiological effect Lipid metabolism Kohlenhydrate Lipidstoffwechsel |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000575853&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000002187 |
| work_keys_str_mv | AT macdonaldian effectofcarbohydratesonlipidmetabolism38tables AT albrinkmargaretj effectofcarbohydratesonlipidmetabolism38tables |