Nonhuman primates in perinatal research:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York u.a.
Wiley
1988
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XXV, 472 S. Ill. |
| ISBN: | 0471849162 |
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| 650 | 4 | |a Pregnancy Complications |x veterinary | |
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Datensatz im Suchindex
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|---|---|
| adam_text | NONHUMAN PRIMATES
IN PERINATAL RESEARCH
Edited by
Yves W Brans, M D
Professor and Director of Neonatal Research
Departments of Pediatrics and Obstetrics and Gynecology
Wayne State University
Detroit, Michigan
Associate Scientist (Adjunct)
Department of Physiology and Medicine
Southwest Foundation for Biomedical Research
San Antonio, Texas • ;
and
Thomas J Kuehl, Ph D
Associate Scientist
Department of Physiology and Medicine
Southwest Foundation for Biomedical Research
San Antonio, Texas
WILEY
A WILEY-INTERSCIENCE PUBLICATION
JOHN WILEY amp; SONS
New York • Chichester • Brisbane • Toronto • Singapore
Henley-on-Thames, Oxon
Telephone 0491 573602
Contents
Introduction
Andrew G Hendrickx and Pamela Binkerd
PART ONE THE PREGNANT PRIMATE
1 Endocrinology of Pregnancy 13
Eugene D Albrecht and Gerald J Pepe
Biosynthesis of Steroid Hormones during Pregnancy in
Primates, 14
Formation of Estrogen and Progesterone by the Corpus
Luteum of Pregnancy, 14
Formation of Estrogen by the Placenta, 14
Formation of Progesterone by the Placenta, 23
17a-Hydroxyprogesterone and Androgens during
Pregnancy, 30
Metabolism and Production of Corticosteroid during
Pregnancy in Primates, 30
Formation of Corticosteroid, 31
Metabolism of Cortisol, 32
Corticosteroids in the Circulation, 33
Regulation of Metabolism of Cortisol, 37
Fetal Adrenal Function and Regulation, 40
Anatomical Development of the Fetal/Neonatal
Adrenal, 40
Biochemical Maturation of the Fetal/Neonatal
Adrenal, 42
Regulation of Fetal/Neonatal Adrenal Maturation and
Function, 46
Formation of Protein Hormone by the Placenta during
Pregnancy in Primates, 52
Chorionic Gonadotropin, 32
xv
XVi CONTENTS
Chorionic Somatomammotropin, 55
Pregnancy-Specific Pi-Glycoproteins, 56
Summary, 59
References, 60
2 Pregnancy-Induced Hypertension: Experimental Studies
in the Nonhuman Primate, with Clinical Correlation 79
Papineni S Rao, Denis Cavanagh, and
Robert A Knuppel
Cardiovascular Effects, 80
Hypertension, 80
Blood Volume and Cardiac Output, 84
Pathophysiology of the Kidney, 86
Uteroplacental Circulation, 90
The Role of Eicosanoids, 91
Nutritional Aspects, 93
Conclusion, 93
References, 94
3 Anatomy and Function of the Myometrium 101
Robert H Hayashi
Functional Anatomy of the Myometrium, 101
Physiology and Pharmacology of Myometrial
Contractility, 103
Conclusion, 108
References, 108
4 Perspective on the Pregnant Primate 111
Robert F Williams and Karlis Adamsons
Pregnancy-Induced Hypertension, 111
Initiation of Labor, 112
Roles of Pregnancy in Primates, 113
Pregnancy-Induced Anovulation, 113
Effects of Pregnancy on Cardiovascular Function, 114
Effects of Pregnancy on the Occurrence of Gynecologic
Cancers, 114
References, 115
CONTENTS XVii
PART TWO THE EMBRYO
5 Fertilization and Preimplantation Embryonic Development 119
W Richard Dukelow and Mundhir T
Ridha
Preovulatory Events on the Ovarian Surfaces, 119
Induction of Ovulation, 122
Seasonal Responses, 123
Sperm Capacitation, 124
Sperm Enzymes, 125
Sperm Penetration of the Oocyte, 126
In Vivo Fertilization and Timed Mating, 127
In Vitro Fertilization and Embryo Transfer, 128
Conclusion, 132
References, 132
6 Implantation and Early Embryonic Development in
Primates 139
Allen C Enders and Andrew G Hendrickx
The Preimplantation Blastocyst (Stage 3), 139
Trophoblast, 140
Inner Cell Mass, 141
Implantation (Stages 4 and 5), 141
Trophoblast, 142
Extraembryonic Mesoderm, 144
Yolk Sac, 145
Amnion, 146
Embryonic Disk, 146
Stage 6, 147
Extraembryonic Constituents, 147
Embryonic Disk, 147
Stages 7 and 8, 147
Embryonic disk, 149
Stages 9 to 13, 151
External Form, 151
Brain and Spinal Cord, 151
Eye, 153
Ear, 155
Nose, 155
XVili CONTENTS
Pituitary, 155
Face and Pharynx, 155
Limb, 156
Nonhuman Primates as Models of Development, 156
References, 157
7 In Vitro Development of the Primate Embryo 161
Valerie Pope, Earle Pope, and Lee Beck
Procedures for Studying the Development of Primate Embryos
through Attachment Stages In Vitro, 162
Nonsurgical Embryo Recovery, 162
Embryo Culture Conditions, 163
Criteria for Evaluating Cultured Primate Embryos, 164
Future of Cultured Primate Embryos in Experimental
Embryology, 170
Model Development, 170
Applied Research Using Cultured Primate Embryos, 172
References, 172
8 Placental Morphology 175
Marshall L Houston
Classification I: Source of Embryonic Vascularization, 175
Classification II: The Grosser Classification, 177
Classification III: Gross Shape of the Placenta, 180
Placental Circulation, 181
References, 182
9 Perspective on the Embryo 185
Duane C Kraemer
PART THREE THE FETUS
10 Bioelectronic Monitoring of the Fetus 195
Robert H Hayashi
The Model, 195
Late Deceleration, 196
Cord Occlusion, 197
Antepartum Monitoring, 198
Conclusion, 199
References, 199
CONTENTS XlX
11 Amnlotic Fluid Volume, Composition, Ingestlon, and
Digestion by the Fetus 201
Yves W Brans
Amniotic Fluid Volume, 202
Methods, 202
Results, 204
Amniotic Fluid Composition during the Second Half of
Gestation, 205
pH, 205
Osmolality, 205
Creatinine, 205
Protein, 206
Free Amino Acids, 207
AOD45o, 207
Lecithin/Sphingomyelin Ratio, 208
Ingestion and Digestion of Amniotic Fluid by the Fetus, 209
Conclusion, 211
References, 213
12 Model of Diabetes: Fetal Hyperinsulinemla and
Macrosomia 217
John B Susa and Robert Schwartz
The Human Infant of the Diabetic Mother, 217
Hyperinsulinemia in the Nonhuman Primate Fetus, 219
Effects of Chronic Hyperinsulinemia on the Rhesus
Fetus, 221
References, 227
13 Chronic Instrumentation of the Fetal Primate 231
Yuji Murata, Shunichi Fujisaki, Chikara
Endo, and Chester B Martin, Jr
Surgical Procedures, 232
Preoperative Care, 232
Anesthesia, 233
Surgery, 234
Postoperative Care, 237
Restraint, 238
Chairing Method, 238
Tether-and-Swivel Method, 241
References, 241
XX CONTENTS
14 Intrauterine Intervention: Fetal Surgery in the Nonhuman
Primate 245
Alan W Flake, Michael R Harrison, and
N Scott Adzick
Fetal Surgical Techniques and Feasibility, 246
Anesthetic, Surgical, and Tocolytic Management, 246
Results, 250
Clinical Significance, 251
Uterine Electromyographic Response to Fetal Surgery, 251
Uterine EMG Studies, 252
Clinical Significance, 254
Maternal Outcome after Fetal Surgery, 256
Maternal Morbidity and Mortality, 256
Future Reproductive Potential and the Uterine
Stapler, 258
Conclusion, 260
References, 260
15 Model of Cigarette Smoking 263
Walter R Rogers and Thomas J Kuehl
Introduction, 263
Effects of Cigarette Smoking, 263
Need for Animal Model, 264
Animal Experiments, 264
Representative Results, 264
Limitations of Most Animal Models, 264
Advantages of Nonhuman Primate-Smoking Models, 265
Baboon Model of Cigarette Smoking, 265
Preliminary Studies of Smoking in Pregnant Baboons, 266
Methods, 266
Results, 267
Need for Additional Experiments, 269
References, 270
16 Perspective on the Fetus 275
Chester B Martin, Jr and Yuji Murata
The Laboratory Primate as a Model for Fetal Physiology and
Disease, 275
Experimental Conditions, 277
CONTENTS XXi
The Fragile Chronic Preparation, 277
Acute versus Chronic Observations, 277
Equivalence of Gestational Ages at Study, 278
Choice of the Laboratory Primate for Fetal Research, 278
References, 279
PART FOUR THENEONATE
SECTION A Pulmonary and Cardiovascular Functions
17 Pathology of Perinatal Lung Disease 285
Jacqueline J Coalson
Comparison between Lungs of Human and Nonhuman
Primates, 285
Model of Sudden Infant Death Syndrome, 286
Models of Pulmonary Infections, 287
Models of Hyaline Membrane Disease and Bronchopulmonary
Dysplasia, 288
Other Models To Be Developed, 294
Conclusion, 294
References, 294
18 Surfactant Studies 299
Robert V Kotas
Pulmonary Surface Active Material, 299
A Challenge to the Tradition, 301
Studies in Primates, 303
PSAM and Defense of the Lung, 306
Surfactant Replacement, 306
References, 307
19 Cardiopulmonary Studies and High-Frequency Ventilation 311
Robert A deLemos, Alicia Guajardo, and
Keith Meredith
Animal Models for Use in Studies of Cardiopulmonary
Physiology in Immature and Mature Neonates, 311
Studies of Pulmonary Development and Hyaline Membrane
Disease, 312
Studies on the Pathogenesis of Pulmonary Injury in Hyaline
Membrane Disease and Effects of Mechanical
Ventilation, 313
XXll CONTENTS
Use of the Premature Nonhuman Primate to Develop
Therapeutic Strategies for the Management of Pulmonary
Disease, 316
Use of Premature Nonhuman Primates as Models for
Cardiovascular Disease and Physiology, 317
Summary, 318
References, 318
20 Structure and Function of the Developing Diaphragm 321
Roger J M McCarter and Leo C Maxwell
Methods, 321
Results and Discussion, 322
Composition of the Diaphragm, 322
Contractile Properties, 327
Fatigability, 328
Summary, 330
References, 330
21 Baboon Model for Meconium Aspiration 333
/ Chris Carey
22 The Development of Extracorporeal Membrane
Oxygenation for the Treatment of Human Neonates Using
Nonhuman Primates as Models 337
/ Devn Cornish and Dale R Gerstmann
The Use of Primates as Subjects for Research on
Extracorporeal Circulation, 338
History of the Development of Clinical Extracorporeal
Membrane Oxygenation, 339
The Role of Research with Nonhuman Primates in the
Development of Neonatal ECMO, 341
The Use of ECMO Research in Nonhuman Primates ,as a
Model for Controlled Studies of Neonatal Pulmonary
Diseases, 343
Potential Future Applications of Neonatal ECMO, 345
References, 348
23 Pharmacology of Cerebral and Mesenteric Arteries 357
Shigehiro Hayashi and Myung K Park
Adrenergic Pharmacology, 357
Unique Adrenergic Characteristics of Nonprimate Cerebral
Circulation, 357
CONTENTS XXiii
Cerebral and Extracerebral Arteries of Primates, 359
Newborn Primates, 361
Pharmacology of Prostaglandins, 363
Prostaglandins in the Perinatal Period, 364
Role of Prostaglandins in the Adult Cerebral
Circulation, 364
Role of Prostaglandins in the Cerebral Circulation of the
Newborn Primate, 365
Role of Prostaglandins in the Mesenteric Vasculature, 367
References, 369
24 Perspective on Neonatal Pulmonary Cardiovascular
Functions 375
Robert V Kotas
SECTION B Body Composition, Nutrition, Behavior, and Infections
25 Fetal and Neonatal Body Composition 381
Yves W Brans
Body Water Content and Distribution, 383
Absolute Volumes of Water, 383
Relative Volumes in Proportion to Birth Weight, 383
Body Fat, 390
Conclusion, 390
References, 390
26 Blllrubln Metabolism in Fetus and Neonate 393
Charles E Cornelius
Bile Pigment Composition, 393
Bile Pigment Disposition in the Fetus, 395
Physiologic Neonatal Hyperbilirubinemia, 397
Prevention of Neonatal Hyperbilirubinemia by
Metalloporphyrins, 400
Kernicterus, 402
Extrahepatic Biliary Atresia, 404
Bile Salt Metabolism, 405
References, 406
XXiV CONTENTS
27 Behavioral Testing 411
Walter R Rogers
Scales of Human Neurobehavioral Assessment, 411
Introduction, 411
Monitoring Development during the First Few Years of
Life, 412
Models in Nonhuman Primates, 414
Examples of Neurobehavioral Assessments, 414
Example of a Neonatal Neurobehavioral Scale for Nonhuman
Primates, 415
Conclusions, 418
References, 419
28 A Rhesus Monkey Model of Neonatal Group B
Streptococcal Infection 421
Val G Hemming and William T London
Model of GBS Infection in Rhesus Monkeys, 422
The Organism, 422
The Rhesus Mother and Infant, 422
Routes of GBS Challenge, 423
Clinical Observations, 424
Culture Studies of GBS-Challenged Monkeys, 424
Results of Rhesus Monkey GBS Studies, 424
Intravenous Inoculation of GBS, 424
Intracerebral Inoculation of GBS, 425
Intratracheal Inoculation of GBS, 425
Intragastric Inoculation of GBS, 425
Intraamniotic Inoculation of GBS in Term Rhesus
Monkeys, 426
Comparison with Human Disease, 429
References, 430
29 Fetal, Neonatal, and Maternal Growth and Hydration: A
Brief Overview 435
Donald B Cheek, Oswald M Petrucco,
and Arnold Gillespie
Fetal Growth and Hydration, 435
Neonatal Growth and Hydration, 439
Maternal Growth and Hydration during Pregnancy, 441
References, 446
CONTENTS XXV
Conclusion 451
Yves W Brans and Thomas J Kuehl
Overview of Topics Not Otherwise Discussed in the
Book, 451
Effect of Nutrition on Mother and Fetus, 451
Chronic Studies during Pregnancy, 452
Fetal Monitoring by Ultrasonography, 453
Model of Perinatal Asphyxia, 453
Model of Intrauterine Growth Retardation, 454
Model of Hyaline Membrane Disease and
Bronchopulmonary Dysplasia, 454
Neonatal Intensive Care of Nonhuman Primates, 455
Overview of the Use of Nonhuman Primates in Perinatal
Research, 456
Assessment of This Book by the Reader, 457
References, 460
Index 463
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| publisher | Wiley |
| record_format | marc |
| spelling | Nonhuman primates in perinatal research ed. by Yves W. Brans ... New York u.a. Wiley 1988 XXV, 472 S. Ill. txt rdacontent n rdamedia nc rdacarrier Modèles animaux dans la recherche Primates (Animaux de laboratoire) Périnatalogie - Recherche - Méthode Reproduction - Recherche - Méthode Animal models in research Disease Models, Animal Perinatology Perinatology Research Methodology Pregnancy Complications veterinary Pregnancy, Animal Primates Primates as laboratory animals Reproduction Research Methodology Primaten (DE-588)4047256-5 gnd rswk-swf Fortpflanzung (DE-588)4017982-5 gnd rswk-swf Tiermodell (DE-588)4140660-6 gnd rswk-swf Perinatale Medizin (DE-588)4045170-7 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Primaten (DE-588)4047256-5 s Fortpflanzung (DE-588)4017982-5 s DE-604 Perinatale Medizin (DE-588)4045170-7 s Tiermodell (DE-588)4140660-6 s Brans, Yves W. Sonstige oth HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000512955&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Nonhuman primates in perinatal research Modèles animaux dans la recherche Primates (Animaux de laboratoire) Périnatalogie - Recherche - Méthode Reproduction - Recherche - Méthode Animal models in research Disease Models, Animal Perinatology Perinatology Research Methodology Pregnancy Complications veterinary Pregnancy, Animal Primates Primates as laboratory animals Reproduction Research Methodology Primaten (DE-588)4047256-5 gnd Fortpflanzung (DE-588)4017982-5 gnd Tiermodell (DE-588)4140660-6 gnd Perinatale Medizin (DE-588)4045170-7 gnd |
| subject_GND | (DE-588)4047256-5 (DE-588)4017982-5 (DE-588)4140660-6 (DE-588)4045170-7 (DE-588)4143413-4 |
| title | Nonhuman primates in perinatal research |
| title_auth | Nonhuman primates in perinatal research |
| title_exact_search | Nonhuman primates in perinatal research |
| title_full | Nonhuman primates in perinatal research ed. by Yves W. Brans ... |
| title_fullStr | Nonhuman primates in perinatal research ed. by Yves W. Brans ... |
| title_full_unstemmed | Nonhuman primates in perinatal research ed. by Yves W. Brans ... |
| title_short | Nonhuman primates in perinatal research |
| title_sort | nonhuman primates in perinatal research |
| topic | Modèles animaux dans la recherche Primates (Animaux de laboratoire) Périnatalogie - Recherche - Méthode Reproduction - Recherche - Méthode Animal models in research Disease Models, Animal Perinatology Perinatology Research Methodology Pregnancy Complications veterinary Pregnancy, Animal Primates Primates as laboratory animals Reproduction Research Methodology Primaten (DE-588)4047256-5 gnd Fortpflanzung (DE-588)4017982-5 gnd Tiermodell (DE-588)4140660-6 gnd Perinatale Medizin (DE-588)4045170-7 gnd |
| topic_facet | Modèles animaux dans la recherche Primates (Animaux de laboratoire) Périnatalogie - Recherche - Méthode Reproduction - Recherche - Méthode Animal models in research Disease Models, Animal Perinatology Perinatology Research Methodology Pregnancy Complications veterinary Pregnancy, Animal Primates Primates as laboratory animals Reproduction Research Methodology Primaten Fortpflanzung Tiermodell Perinatale Medizin Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000512955&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT bransyvesw nonhumanprimatesinperinatalresearch |