The pharmacology of lymphocytes:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Berlin [u.a.]
Springer
1988
|
| Schriftenreihe: | Handbook of experimental pharmacology
85 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XXII, 626 S. Ill., graph. Darst. |
| ISBN: | 3540186093 0387186093 |
Internformat
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| 245 | 1 | 0 | |a The pharmacology of lymphocytes |c contributors S. S. Alkan ... Ed. M. A. Bray ... |
| 264 | 1 | |a Berlin [u.a.] |b Springer |c 1988 | |
| 300 | |a XXII, 626 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Handbook of experimental pharmacology |v 85 | |
| 650 | 7 | |a Farmacologie |2 gtt | |
| 650 | 7 | |a Immunologie |2 gtt | |
| 650 | 4 | |a Immunopharmacologie | |
| 650 | 7 | |a Lymfocyten |2 gtt | |
| 650 | 2 | |a Lymphocyte - Immunologie | |
| 650 | 2 | |a Lymphocyte - Physiologie | |
| 650 | 4 | |a Lymphocytes | |
| 650 | 4 | |a Immunopharmacology | |
| 650 | 4 | |a Lymphocytes | |
| 650 | 4 | |a Lymphocytes |x immunology | |
| 650 | 4 | |a Lymphocytes |x physiology | |
| 650 | 0 | 7 | |a Pharmakologie |0 (DE-588)4045687-0 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Lymphozyt |0 (DE-588)4036762-9 |2 gnd |9 rswk-swf |
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| 689 | 1 | 1 | |a Pharmakologie |0 (DE-588)4045687-0 |D s |
| 689 | 1 | |5 DE-604 | |
| 700 | 1 | |a Bray, Michael A. |e Sonstige |4 oth | |
| 700 | 1 | |a Alkan, Sefik S. |e Sonstige |4 oth | |
| 830 | 0 | |a Handbook of experimental pharmacology |v 85 |w (DE-604)BV002390716 |9 85 | |
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Datensatz im Suchindex
| _version_ | 1804115257088540672 |
|---|---|
| adam_text | CONTENTS
GLOSSARY OF COMMON IMMUNOLOGICAL
TERMS 1
PART 1
CHAPTER 1
THE EVOLUTION,
ONTOGENY, AND PHYSIOLOGIC FUNCTION OF LYMPHOCYTES
J.
KLEIN
. WITH
7 FIGURES 11
A. WHAT IS A LYMPHOCYTE? 11
B. PHYLOGENETIC ORIGIN OF LYMPHOCYTES 13
C. ONTOGENETIC ORIGIN OF LYMPHOCYTES 15
D. GENERATION OF THE B CELL REPERTOIRE 19
E. GENERATION OF THE T CELL REPERTOIRE 22
F. GENETICALLY CONTROLLED NONRESPONSIVENESS 28
G. LYMPHOCYTE FUNCTION 31
REFERENCES 33
CHAPTER 2
DE NOVO EXPRESSION OF RECEPTORS ON T CELLS
J.
M. WILLIAMS
AND
T.
B. STROM
37
A. T CELL ACTIVATION AND DE NOVO EXPRESSION OF RECEPTORS 37
B. THERAPEUTIC IMPLICATIONS 44
I. IMMUNOSUPPRESSIVE THERAPY WITH M7/20 IL-2
RECEPTOR-SPECIFIC ANTIBODY 45
II. THE EFFECT OF ART 18 IL-2 RECEPTOR-SPECIFIC ANTIBODY TREATMENT
IN RAT CARDIAC ALLOGRAFTS 46
III. ART
18 MAB THERAPY SPARES SUPPRESSOR T CELLS 48
REFERENCES 48
CHAPTER 3
MEMBRANE EVENTS
DURING LYMPHOCYTE
ACTIVATION
J. T. RANSOM
AND
J. C. CAMBIER 53
A. INTRODUCTION 53
B. PHOSPHATIDYLINOSITOL TURNOVER 53
I. B CELLS 54
II. T CELLS 55
HTTP://D-NB.INFO/880231467
XII CONTENTS
C. PROTEIN KINASE C TRANSLOCATION 56
I. T CELLS 56
II. B CELLS 57
D. ELECTROPHYSIOLOGIC STUDIES 58
I. K
+
CHANNELS 58
II. CA
2+
CHANNELS 62
III. NA
+
CHANNELS 65
E. FLUORESCENT PROBE AND RADIOISOTOPE STUDIES 65
I. MEMBRANE POTENTIAL 66
II. INTRACELLULAR FREE CA
2 +
LEVELS 67
III. CYTOPLASMIC ALKALINIZATION 72
IV. REGULATORY VOLUME RESPONSES 74
REFERENCES 76
CHAPTER 4
INTRACELLULAR EVENTS DURING
LYMPHOCYTE ACTIVATION
R. G.
COFFEY
. WITH 1 FIGURE R 83
A. INTRODUCTION 83
B. CYTOSKELETAL CHANGES 86
C. LIPID CHANGES 88
I. PHOSPHATIDYLINOSITOL METABOLISM 88
II. PHOSPHATIDYLCHOLINE METABOLISM 92
III. ARACHIDONIC ACID METABOLISM 93
IV. SUMMARY OF LIPID CHANGES 97
D. TRANSPORT CHANGES 97
I. IONS 98
II. NUTRIENTS 105
E. CHANGES IN CYCLIC NUCLEOTIDES AND PROTEIN PHOSPHORYLATION . . . .107
I. CYCLIC AMP 107
II. CYCLIC GMP 109
III. PROTEIN PHOSPHORYLATION 112
F. CONCLUSIONS 117
REFERENCES 118
PART 2
CHAPTER 5
GENERATION AND
MEASUREMENT OF ANTIBODIES
H. F. J.
SAVELKOUL, S. S. PATHAK
, N.
R. SABBELE
, AND
R. BENNER
WITH 3 FIGURES 141
A. INTRODUCTION 141
I. B CELL DEVELOPMENT LEADING TO ANTIBODY PRODUCTION 142
II. ANTIBODIES AS DIAGNOSTIC TOOLS 143
CONTENTS
XIII
B. INDUCTION OF ANTIBODY FORMATION 143
I. IN VITRO ANTIBODY FORMATION 144
II. IN VIVO ANTIBODY FORMATION 145
C. MEASUREMENT OF IMMUNOGLOBULIN SECRETION AT THE CELLULAR LEVEL . .155
1. CELL SUSPENSIONS FROM LYMPHOID ORGANS OF MICE 155
2. CELL SUSPENSIONS OF HUMAN ORIGIN 156
I. ANTIBODY-SECRETING CELL ASSAYS 156
D. MEASUREMENT OF CIRCULATING IMMUNOGLOBULINS 165
I. PRECIPITATION-BASED ASSAYS 166
II. AGGLUTINATION-BASED ASSAYS 167
III. LIGAND-BINDING ASSAYS 168
REFERENCES 175
CHAPTER 6 -
MONOCLONAL
ANTIBODIES TO LYMPHOCYTE
SURFACE MOLECULES AS PROBES
FOR LYMPHOCYTE
FUNCTIONS
M. A. TALLE
AND
G. GOLDSTEIN 187
A. INTRODUCTION 187
B. METHODS FOR MONOCLONAL ANTIBODY GENERATION 187
I. IMMUNIZATION STRATEGIES 188
II. FUSION 189
III. SCREENING 190
IV. CLONING 191
C. FUNCTIONAL MOLECULES 192
I. T CELL LINEAGE RESTRICTED 193
II. GROWTH FACTOR RECEPTORS 196
III. RECEPTORS FOR COMPONENTS OF COMPLEMENT 199
IV. LEUKOCYTE ADHESION MOLECULES LFA-1 AND LFA-3 201
D. RECOGNITION MOLECULES 202
I. T4 AND T8: CLASS II AND CLASS I RECOGNITION MOLECULES .... 202
II. T CELL RECEPTOR FOR ANTIGEN 204
E. SUMMARY 205
REFERENCES 205
CHAPTER 7
INTERLEUKIN 1 PRODUCTION FROM VARIOUS CELLS AND
MEASUREMENT OF ITS MULTIPLE
BIOLOGIC ACTIVITIES
C. A. DINARELLO 215
A.
INTRODUCTION 215
B. PRODUCTION OF IL-1 IN VITRO 216
I. IL-1 INDUCTION FROM PERIPHERAL BLOOD MONOCYTES 216
II. CELL SOURCES OF IL-1 219
XIV CONTENTS
C. PRODUCTION OF IL-1 IN VIVO 223
I. DETECTION OF IL-1 IN THE CIRCULATION 223
II. DETECTION OF IL-1 IN SYNOVIAL FLUID 223
III. DETECTION OF IL-1 IN URINE 224
IV. DETECTION OF IL-1 IN PERITONEAL FLUID 224
D. ASSAYS FOR IL-1 225
I. LYMPHOCYTE ACTIVATION ASSAYS 225
II. INDUCTION OF ACUTE PHASE RESPONSES 226
III. ASSAYS FOR IL-1 EMPLOYING ITS CATABOLIC AND INFLAMMATORY
PROPERTIES 228
REFERENCES 229
CHAPTER 8
PRODUCTION AND
MEASUREMENT OF INTERLEUKIN2 AND INTERLEUKIN3
B. M.
STADLER
,
K.
HIRAI
, AND J.-F.
GAUCHAT
. WITH
8
FIGURES
235
A. INTRODUCTION 235
B. INTERLEUKIN 2 (IL-2) 235
I. THE T CELL GROWTH FACTOR, IL-2 235
II. PRODUCTION 236
III. MEASUREMENT 237
IV. STANDARDIZATION 239
V. MEASUREMENT OF IL-2 MRNA BY NORTHERN BLOT ANALYSIS .... 240
VI. MEASUREMENT OF IL-2 MRNA BY MICRODOT HYBRIDIZATION .... 241
C. INTERLEUKIN 3 (IL-3) 243
I. THE MULTILINEAGE-SPECIFIC HEMATOPOIETIC GROWTH FACTOR, IL-3 . 244
II. PRODUCTION 244
III. MEASUREMENT 244
D. HUMAN IL-3-LIKE FACTORS 246
E. CONCLUSIONS 248
REFERENCES 248
CHAPTER 9
PRODUCTION AND MEASUREMENT
OF INTERFERONS
S. S. ALKAN
. WITH
6
FIGURES
255
A. AN OVERVIEW OF THE INTERFERON SYSTEM 255
I. INTRODUCTION 255
II. DISCOVERY OF INTERFERONS 255
III. HETEROGENEITY OF INTERFERONS 256
IV. MULTIPLE BIOLOGIC EFFECTS OF INTERFERONS 257
B. INTERFERON INDUCTION/PRODUCTION 258
I. INDUCTION 258
II. INDUCTION/PRODUCTION BY CELLS IN VITRO 260
III. PRODUCTION IN VIVO 260
IV. MASS PRODUCTION AND PURIFICATION 261
CONTENTS XV
C. INTERFERON ASSAYS 263
I. BIOLOGIC ASSAYS 264
II. NONBIOLOGIC (IMMUNOLOGIC) ASSAYS 267
D. INTERFERON IN THE CLINIC AND ITS FUTURE 270
REFERENCES 271
CHAPTER 10
FACTORS REGULATING
IGE SYNTHESIS
C.
GAVERIAUX
, T.
PAYNE
, AND
F.
LOOR
. WITH 2 FIGURES 275
A. IGE REGULATION 275
I. DEVELOPMENT OF AN IGE RESPONSE 275
II. EVIDENCE FOR A SPECIFIC IGE ISOTYPE REGULATION 276
III. MODELS OF IGE REGULATION 276
IV. METHODS FOR MEASURING IGE-SPECIFIC IMMUNOREGULATION . . . .281
B. PRODUCTION AND MEASUREMENT OF IGE-REGULATING FACTORS 282
I. SUPPRESSIVE-FACTOR OF ALLERGY (SFA) 282
II. HUMAN IGE-BINDING FACTORS (IGE-BF) 282
III. IGE CLASS-SPECIFIC SUPPRESSIVE FACTORS OF T CELL ORIGIN (IGE-TSF)
283
IV. IGE-BINDING FACTORS (IGE-BF) 284
V. GLYCOSYLATION-ENHANCING AND -INHIBITING FACTORS (GEF AND GIF) 286
C. FUTURE DEVELOPMENTS 287
REFERENCES 287
CHAPTER 11
GENERATION, BIOLOGY,
AND ASSAY OF EFFERENT LYMPHOKINES
D. GEMSA 291
A. INTRODUCTION 291
B. MIGRATION-INHIBITORY. FACTOR (MIF) 292
I. ORIGINAL OBSERVATIONS AND BIOLOGIC CHARACTERISTICS 292
II. CELLULAR SOURCE 292
III. MOLECULAR CHARACTERISTICS 293
IV. MEASUREMENT 293
C. MACROPHAGE-ACTIVATING FACTOR (MAF) 294
I. ORIGINAL OBSERVATIONS AND BIOLOGIC CHARACTERISTICS 294
II. MOLECULAR CHARACTERISTICS 295
III. SEVERAL MAFS AND STEPS IN MACROPHAGE ACTIVATION 296
IV. MEASUREMENT 297
D. TUMOR NECROSIS FACTOR (TNF-A) 298
I. ORIGINAL OBSERVATIONS 298
II. BIOLOGIC CHARACTERISTICS 298
III. MOLECULAR CHARACTERISTICS 299
IV. TNF RECEPTORS 300
V. IDENTITY OF TNF-A WITH CACHECTIN 300
VI. MEASUREMENT 301
XVI CONTENTS
E. LYMPHOTOXIN (TNF-/3) 301
I. ORIGINAL OBSERVATIONS 301
II. BIOLOGIC CHARACTERISTICS 302
III. PRODUCER CELLS 302
IV. MOLECULAR CHARACTERISTICS 303
V. SYNERGISM WITH OTHER CYTOKINES AND EFFECTS ON LYMPHOCYTES . 303
VI. ANTICARCINOGENIC ACTIVITY 304
VII. MEASUREMENT 304
F. OSTEOCLAST-ACTIVATING FACTOR (OAF) 304
I. BIOLOGIC CHARACTERISTICS 304
II. MOLECULAR CHARACTERISTICS 305
III. MEASUREMENT 306
G. SOLUBLE IMMUNE RESPONSE SUPPRESSOR (SIRS) 306
I. BIOLOGIC CHARACTERISTICS 306
II. MOLECULAR CHARACTERISTICS 307
III. MEASUREMENT 307
H. CHEMOTACTIC CYTOKINES 308
I. BIOLOGIC CHARACTERISTICS 308
II. THE SEARCH FOR MOLECULAR CHARACTERIZATION 309
III. MEASUREMENT 309
J. CONCLUDING REMARKS 310
REFERENCES 311
CHAPTER 12
LYMPHOCYTE PURIFICATION,
GROWTH, CLONING
AND FUNCTIONAL
ASSAYS
M. J.
H.
RATCLIFFE
AND J.
R. LAMB
319
A. INTRODUCTION 319
I. TISSUE CULTURE 320
II. FREEZING AND THAWING OF CELLS 321
B. T CELL GROWTH AND CLONING 321
I. INTRODUCTION 321
II. IN VIVO GENERATION OF ANTIGEN-PRIMED T CELLS 322
III. FEEDER CELLS 322
IV. ANTIGEN IN VITRO 323
V. SOURCES OF INTERLEUKIN 2 323
VI. ANTIGEN-INDEPENDENT GROWTH AND CLONING 324
VII. ANTIGEN-DEPENDENT T CELL LINES 325
VIII. CLONING FROM ANTIGEN-DEPENDENT T CELL LINES 327
IX. USE OF TRANSFORMED CELL LINES 329
X. T CELL HYBRIDISATION 329
XI. VIRAL TRANSFORMATION 330
XII. SUMMARY 331
C. B CELL GROWTH AND CLONING 332
I. INTRODUCTION 332
II. SPONTANEOUSLY TRANSFORMED CELLS 332
III. EPSTEIN-BARR VIRUS TRANSFORMATION OF HUMAN B CELLS .... 334
CONTENTS XVII
IV. ABELSON VIRUS TRANSFORMATION OF MURINE B CELLS 335
V. B CELL HYBRIDISATION 335
VI. GROWTH AND CLONING OF TRANSFORMED CELLS 336
VII. PURIFICATION OF NORMAL B CELLS 337
VIII. SUMMARY 339
D. CONCLUDING REMARKS 339
REFERENCES 340
CHAPTER 13
SCREENING STRATEGIES FOR
DETECTING IMMUNOTHERAPEUTIC
AGENTS
S. C.
GILMAN
,
R. T.
MAGUIRE
, AND
A. J.
LEWIS
. WITH
1 FIGURE 345
A. INTRODUCTION 345
B. GENERAL PRINCIPLES OF IMMUNOTHERAPEUTIC DRUG DEVELOPMENT .... 345
I. TARGET DISEASES 347
II. CELLULAR TARGETS FOR IMMUNOTHERAPEUTIC AGENTS 348
C. SCREENING METHODOLOGY 349
I. QUANTIFICATION OF LYMPHOCYTES 351
II. FUNCTIONAL ASSAYS 351
D. FUTURE DEVELOPMENTS IN SCREENING METHODOLOGY 354
I. BIOCHEMICAL ASSAYS OF LYMPHOCYTE ACTIVATION 354
II. RADIORECEPTOR ASSAYS 355
III. MONOCLONAL ANTIBODIES 355
E. CLINICAL TRIALS OF IMMUNOTHERAPEUTIC AGENTS 356
REFERENCES 357
PART 3
CHAPTER 14
SELECTED AUTACOIDS
AS MODULATORS OF LYMPHOCYTE
FUNCTION
M. M. KHAN
AND
K.
L.
MELMON
. WITH
7 FIGURES 363
A. INTRODUCTION 363
B. HISTAMINE 365
C. CATECHOLAMINES 373
D. PROSTAGLANDINS AND LEUKOTRIENES 375
E. CONCLUDING REMARKS 378
REFERENCES 380
CHAPTER 15
LIPID
MEDIATORS AND
LYMPHOCYTE FUNCTION
M. J.
PARNHAM
AND
W.
ENGLBERGER
. WITH
2 FIGURES 385
A. INTRODUCTION 385
B. ESSENTIAL FATTY ACIDS 387
I. ROLE IN LYMPHOCYTE ACTIVATION 387
XVIII
CONTENTS
II. ACTIONS ON LYMPHOCYTES IN VITRO 387
III. ACTIONS ON LYMPHOCYTES IN VIVO 388
C. PROSTAGLANDIN E 390
I. CELL-MEDIATED IMMUNITY 390
II. HUMORAL IMMUNITY 397
D. OTHER PROSTAGLANDINS AND THROMBOXANES 401
E. LIPOXYGENASE METABOLITES 402
I. EFFECTS IN VITRO 402
II. EFFECTS IN VIVO 404
F. PEROXIDES 405
G. PLATELET-ACTIVATING FACTOR . . 406
REFERENCES 406
CHAPTER 16
THYMIC HORMONES AND
LYMPHOCYTE FUNCTIONS
J.-F.
BACH
AND
M.
DARDENNE
415
A. INTRODUCTION 415
B. CHEMISTRY OF THE FOUR AVAILABLE THYMIC PEPTIDES 416
I. THYMOSIN AL 416
II. THYMOPOIETIN 416
III. THYMULIN 416
IV. THYMIC HUMORAL FACTOR 417
C. EFFECT OF THYMIC HORMONES ON LYMPHOCYTE MARKERS AND FUNCTIONS . 417
I. MARKER STUDIES 418
II. EFFECT ON T CELL FUNCTIONS 418
III. MODE OF ACTION AT THE CELLULAR LEVEL 419
D. CONCLUSIONS 419
REFERENCES 420
PART 4
CHAPTER 17
GLUCOCORTICOSTEROIDS
T. W.
BEHRENS
AND J. S.
GOODWIN
. WITH
6 FIGURES 425
A. INTRODUCTION 425
B. HISTORY 425
C. EFFECTS OF STEROIDS ON LYMPHOCYTE FUNCTION IN VIVO 426
D. EFFECTS OF STEROIDS ON LYMPHOCYTE FUNCTION IN VITRO 428
I. HUMORAL IMMUNITY 428
II. CELLULAR IMMUNITY 430
E. EFFECTS OF STEROIDS ON MONOKINES AND LYMPHOKINES IN VITRO .... 432
F. MECHANISMS OF ACTION 434
G. CONCLUSION 436
REFERENCES 436
CONTENTS
XIX
CHAPTER 18
SLOW ACTING
ANTIRHEUMATICS
P.
E.
LIPSKY
. WITH
1
FIGURE
441
A. INTRODUCTION 441
B. CHARACTERISTICS OF THERAPY 442
C. THE IMMUNOLOGIC BASIS OF RHEUMATOID ARTHRITIS 442
D. DISEASE-MODIFYING ANTIRHEUMATIC DRUGS 445
E. SUMMARY 449
REFERENCES 450
CHAPTER 19
CYCLOPHOSPHAMIDE
R. R. BARTLETT
. WITH
3
FIGURES
453
A. INTRODUCTION 453
B. EFFECTS OF CYCLOPHOSPHAMIDE ON CELLS OF THE IMMUNE SYSTEM .... 454
C. IMMUNOMODULATION BY CYCLOPHOSPHAMIDE 455
I. IMMUNOSUPPRESSION AND IMMUNOSTIMULATION IN VIVO 455
II. TOLERANCE INDUCTION AND TERMINATION 456
III. IN VITRO ACTIVITIES 457
D. EFFECTS OF CYCLOPHOSPHAMIDE ON AUTOIMMUNE ANIMAL MODELS . . . 461
I. ADJUVANT ARTHRITIS DISEASE OF LEWIS RATS 461
II. MURINE MODELS FOR SYSTEMIC LUPUS ERYTHEMATOSUS 461
E. CLINICAL ASPECTS OF CYCLOPHOSPHAMIDE THERAPY 464
F. SUMMARY 464
REFERENCES 465
CHAPTER 20
LOBENZARIT (CCA)
Y.
SHIOKAWA
. WITH
5 FIGURES 471
A. INTRODUCTION 471
B. CHEMISTRY 471
C. TOXICOLOGY 472
D. PHARMACOKINETICS 472
E. IMMUNOPHARMACOLOGIC STUDIES 472
I. PREVENTION OF AUTOIMMUNE DISEASE AND IMMUNOMODULATION
IN MRL-MP-LPR/LPR (MRL/1) MICE 472
II. PREVENTION OF AUTOIMMUNE DISEASE AND IMMUNOMODULATION IN
NZB/NZW F, HYBRID MICE 473
III. THERAPEUTIC EFFECT ON ADJUVANT ARTHRITIS IN RATS 475
IV. NO INHIBITORY EFFECT ON ACUTE INFLAMMATION 476
V. IMMUNOREGULATORY EFFECTS 476
VI. EFFECTS ON IMMUNOCOMPETENT CELLS 476
F. CLINICAL STUDIES 479
I. MULTICENTER DOUBLE-BLIND CONTROLLED STUDY 479
II. LONG-TERM STUDY 480
XX CONTENTS
III. GLOBAL ASSESSMENT OF RADIOLOGIC CHANGES IN THE HAND 481
IV. IMMUNOPHARMACOLOGIC DATA IN HUMANS 483
V. SIDE EFFECTS 485
G. CONCLUSIONS 485
REFERENCES 485
CHAPTER 21
CYCLOSPORINS: IMMUNOPHARMACOLOGIC
PROPERTIES OF NATURAL CYCLOSPORINS
P. C.
HIESTAND
AND
H.
U.
GUBLER
.
WITH 2 FIGURES 487
A. INTRODUCTION 487
B. IN VITRO METHODS 488
I. PROLIFERATIVE RESPONSE OF LYMPHOCYTES TO MITOGENIC STIMULATION . 490
II. GENERATION OF SOLUBLE FACTORS AFFECTING THE IMMUNE RESPONSE . 490
III. PROLIFERATIVE RESPONSE OF LYMPHOCYTES TO ALLOGENEIC STIMULATION:
MURINE MIXED LYMPHOCYTE REACTION 491
IV. INDUCTION OF CYTOTOXIC T CELLS IN A ONE-WAY MIXED LYMPHOCYTE
REACTION 492
V. PRIMARY HUMORAL IMMUNE RESPONSE TO SHEEP RED BLOOD CELLS . 492
VI. SECONDARY HUMORAL IMMUNE RESPONSE AGAINST A T CELL-SPECIFIC
ANTIGEN (DNP-KLH) IN VITRO 492
VII. CYTOTOXIC AND CYTOSTATIC ACTIVITY IN VITRO WITH THE P-815
MASTOCYTOMA CELL LINE 493
C. IN VIVO METHODS 494
I. FORMATION OF PLAQUE-FORMING CELLS (HUMORAL IMMUNE RESPONSE) 494
II. DELAYED-TYPE HYPERSENSITIVITY REACTION IN MICE 495
III. LOCALIZED GRAFT-VERSUS-HOST REACTION 495
D. AUTOIMMUNE DISEASE MODELS 495
I. FREUND S ADJUVANT-INDUCED ARTHRITIS 495
II. FORMATION OF AUTOANTIBODIES IN EXPERIMENTAL ALLERGIC
MYASTHENIA GRAVIS 497
E. TRANSPLANTATION MODELS 497
I. SKIN ALLOGRAFT REACTION IN MICE 497
II. KIDNEY ALLOGRAFT REACTION IN RATS 497
III. HETEROTOPIC HEART TRANSPLANTATION IN RATS 497
F. DISCUSSION 499
REFERENCES 500
CHAPTER 22
MURAMYL DIPEPTIDES
M.
PARANT
AND
L.
CHEDID 503
A. INTRODUCTION 503
B. IN VIVO QUANTITATIVE AND QUALITATIVE CHANGES IN SPECIFIC IMMUNE
RESPONSES PRODUCED BY MPDS 504
I. CHARACTERISTICS OF ANTIBODY RESPONSES AFTER MDP TREATMENT. . 504
CONTENTS
XXI
II. T CELL-MEDIATED RESPONSES 505
III. IMMUNOSUPPRESSION 506
C. IN VIVO CHANGES IN CELL COMPARTMENTS OF THE IMMUNE SYSTEM
FOLLOWING MDP ADMINISTRATION 506
D. ROLE OF LYMPHOCYTE POPULATIONS IN ANTIBODY RESPONSES OF CELL
CULTURES STIMULATED WITH MDPS 507
E. IN VITRO DIRECT RESPONSES OF LYMPHOCYTES TO MDP IN THE ABSENCE
OF ANTIGENIC STIMULATION 509
I. MITOGENIC EFFECT OF MDPS 509
II. POLYCLONAL ACTIVATION 509
III. INFLUENCE OF MDPS ON MITOGENIC RESPONSES 510
IV. EFFECT OF MDP ON THYMOMA CELL LINES 510
V. IN VITRO NK CELL INDUCTION 510
F. IN VITRO INDIRECT RESPONSES OF LYMPHOCYTES TO MDPS 511
G. CONCLUSIONS 512
REFERENCES 512
CHAPTER 23
ANTIPURINES AND
PURINE METABOLISM
G.
WOLBERG
. WITH
1 FIGURE 517
A. GENERAL INTRODUCTION 517
B. ANTIPURINES: 6-MERCAPTOPURINE AND AZATHIOPRINE 517
I. HISTORICAL PERSPECTIVE/BACKGROUND 517
II. METABOLISM 518
III. EFFECTS ON LYMPHOCYTE SUBSETS 519
C. ADENOSINE DEAMINASE AND PURINE NUCLEOSIDE PHOSPHORYLASE
DEFICIENCIES 525
D. CONCLUSIONS 527
REFERENCES 528
CHAPTER 24
ISOPRINOSINE AND
NPT 15392: HYPOXANTHINE-CONTAINING IMMUNOMODULATORS
J.
GORDON
AND
TH. GINSBERG
.
WITH 5 FIGURES 535
A. ISOPRINOSINE 535
I. CHEMISTRY 535
II. PHARMACOKINETICS AND BIOAVAILABILITY 536
III. PHARMACOLOGY 537
IV. TOXICOLOGY 537
V. PHARMACODYNAMICS 539
VI. CLINICAL EFFICACY AND SAFETY 543
B. NPT
15392 546
I. TOXICOLOGY 546
II. IMMUNOPHARMACOLOGY 547
III. CLINICAL EXPERIENCE 549
REFERENCES 549
XXII
CONTENTS
CHAPTER 25
BACTERIAL AND FUNGAL PRODUCTS
H.
TAKADA
, J.
HAMURO
, AND S.
KOTANI
. WITH
7 FIGURES 555
A. BACTERIAL PRODUCTS AS MITOGENS AND IMMUNOMODULATORS 555
I. BACTERIAL PEPTIDOGLYCANS 555
II. ENDOTOXIC LIPOPOLYSACCHARIDE AND LIPID A 558
III. OUTER MEMBRANE PROTEIN 559
IV. LIPOTEICHOIC ACIDS AND RELATED AMPHIPHILES 559
V. OTHERS 561
VI. SPECULATION 562
B. FUNGAL POLYSACCHARIDES AS IMMUNOPOTENTIATORS AGAINST CANCER . . . 563
I. LENTINAN 564
II. KRESTIN AND SCHIZOPHYLLAN 569
REFERENCES 570
CHAPTER 26
NONSTEROIDAL ANTI-INFLAMMATORY
DRUGS: EFFECTS ON LYMPHOCYTE FUNCTION
K. BRUNE 577
A. INTRODUCTION 577
B. PRINCIPAL EFFECTS OF NONSTEROIDAL ANTI-INFLAMMATORY DRUGS 577
C. EFFECTS OF NONSTEROIDAL ANTI-INFLAMMATORY DRUGS ON
LYMPHOCYTES 578
I. CLINICAL OBSERVATIONS 578
II. T CELL EFFECTS 580
III. B CELL EFFECTS 580
D. CONCLUSION AND OUTLOOK 582
REFERENCES 582
CHAPTER 27
FUTURE PROSPECTS FOR
DRUGS DESIGN OF LYMPHOCYTE MODULATORS
J.
DREWS
AND W.
HAAS
. WITH 2
FIGURES 587
A. INTRODUCTION 587
B. POTENTIAL TARGETS FOR LYMPHOCYTE MODULATORS 587
C. LYMPHOCYTE MODULATORS 589
I. TRANSPLANTATION AND AUTOIMMUNITY 589
II. CHRONIC INFLAMMATORY PROCESSES 593
III. ACUTE HYPERSENSITIVITY REACTIONS 595
IV. INFECTIONS AND CANCER 597
D. CONCLUSIONS 602
REFERENCES 603
SUBJECT INDEX 611
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| id | DE-604.BV000805608 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T15:19:44Z |
| institution | BVB |
| isbn | 3540186093 0387186093 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-000504925 |
| oclc_num | 17547111 |
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| physical | XXII, 626 S. Ill., graph. Darst. |
| publishDate | 1988 |
| publishDateSearch | 1988 |
| publishDateSort | 1988 |
| publisher | Springer |
| record_format | marc |
| series | Handbook of experimental pharmacology |
| series2 | Handbook of experimental pharmacology |
| spelling | The pharmacology of lymphocytes contributors S. S. Alkan ... Ed. M. A. Bray ... Berlin [u.a.] Springer 1988 XXII, 626 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Handbook of experimental pharmacology 85 Farmacologie gtt Immunologie gtt Immunopharmacologie Lymfocyten gtt Lymphocyte - Immunologie Lymphocyte - Physiologie Lymphocytes Immunopharmacology Lymphocytes immunology Lymphocytes physiology Pharmakologie (DE-588)4045687-0 gnd rswk-swf Lymphozyt (DE-588)4036762-9 gnd rswk-swf Lymphozyt (DE-588)4036762-9 s DE-604 Pharmakologie (DE-588)4045687-0 s Bray, Michael A. Sonstige oth Alkan, Sefik S. Sonstige oth Handbook of experimental pharmacology 85 (DE-604)BV002390716 85 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000504925&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | The pharmacology of lymphocytes Handbook of experimental pharmacology Farmacologie gtt Immunologie gtt Immunopharmacologie Lymfocyten gtt Lymphocyte - Immunologie Lymphocyte - Physiologie Lymphocytes Immunopharmacology Lymphocytes immunology Lymphocytes physiology Pharmakologie (DE-588)4045687-0 gnd Lymphozyt (DE-588)4036762-9 gnd |
| subject_GND | (DE-588)4045687-0 (DE-588)4036762-9 |
| title | The pharmacology of lymphocytes |
| title_auth | The pharmacology of lymphocytes |
| title_exact_search | The pharmacology of lymphocytes |
| title_full | The pharmacology of lymphocytes contributors S. S. Alkan ... Ed. M. A. Bray ... |
| title_fullStr | The pharmacology of lymphocytes contributors S. S. Alkan ... Ed. M. A. Bray ... |
| title_full_unstemmed | The pharmacology of lymphocytes contributors S. S. Alkan ... Ed. M. A. Bray ... |
| title_short | The pharmacology of lymphocytes |
| title_sort | the pharmacology of lymphocytes |
| topic | Farmacologie gtt Immunologie gtt Immunopharmacologie Lymfocyten gtt Lymphocyte - Immunologie Lymphocyte - Physiologie Lymphocytes Immunopharmacology Lymphocytes immunology Lymphocytes physiology Pharmakologie (DE-588)4045687-0 gnd Lymphozyt (DE-588)4036762-9 gnd |
| topic_facet | Farmacologie Immunologie Immunopharmacologie Lymfocyten Lymphocyte - Immunologie Lymphocyte - Physiologie Lymphocytes Immunopharmacology Lymphocytes immunology Lymphocytes physiology Pharmakologie Lymphozyt |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000504925&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV002390716 |
| work_keys_str_mv | AT braymichaela thepharmacologyoflymphocytes AT alkansefiks thepharmacologyoflymphocytes |