Biotransformation of organic nitrogen compounds:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | German |
| Veröffentlicht: |
Basel ; München u.a.
Karger
1988
|
| Schriftenreihe: | Progress in basic and clinical pharmacology
1 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | VIII, 217 S. |
| ISBN: | 3805546505 |
Internformat
MARC
| LEADER | 00000nam a2200000 cb4500 | ||
|---|---|---|---|
| 001 | BV000740155 | ||
| 003 | DE-604 | ||
| 005 | 00000000000000.0 | ||
| 007 | t | ||
| 008 | 880504s1988 |||| 00||| ger d | ||
| 020 | |a 3805546505 |9 3-8055-4650-5 | ||
| 035 | |a (OCoLC)17106269 | ||
| 035 | |a (DE-599)BVBBV000740155 | ||
| 040 | |a DE-604 |b ger |e rakddb | ||
| 041 | 0 | |a ger | |
| 049 | |a DE-12 |a DE-19 |a DE-355 |a DE-188 | ||
| 050 | 0 | |a QP801.N55 | |
| 082 | 0 | |a 615/.314 |2 19 | |
| 084 | |a VS 5450 |0 (DE-625)147692:253 |2 rvk | ||
| 245 | 1 | 0 | |a Biotransformation of organic nitrogen compounds |c vol. ed. A. K. Cho ... |
| 264 | 1 | |a Basel ; München u.a. |b Karger |c 1988 | |
| 300 | |a VIII, 217 S. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Progress in basic and clinical pharmacology |v 1 | |
| 650 | 4 | |a Biotransformation (Métabolisme) | |
| 650 | 4 | |a Composés organiques azotés - Métabolisme | |
| 650 | 4 | |a Cytochrome P-450 | |
| 650 | 4 | |a Médicaments - Métabolisme | |
| 650 | 4 | |a Biotransformation (Metabolism) | |
| 650 | 4 | |a Cytochrome P-450 | |
| 650 | 4 | |a Drugs |x Metabolism | |
| 650 | 4 | |a Nitrogen |x metabolism | |
| 650 | 4 | |a Organonitrogen compounds |x Metabolism | |
| 650 | 4 | |a Oxidation-Reduction | |
| 650 | 4 | |a Pharmaceutical Preparations |x metabolism | |
| 650 | 0 | 7 | |a Stickstofforganische Verbindungen |0 (DE-588)4043811-9 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Biotransformation |0 (DE-588)4006908-4 |2 gnd |9 rswk-swf |
| 655 | 7 | |0 (DE-588)4143413-4 |a Aufsatzsammlung |2 gnd-content | |
| 689 | 0 | 0 | |a Stickstofforganische Verbindungen |0 (DE-588)4043811-9 |D s |
| 689 | 0 | 1 | |a Biotransformation |0 (DE-588)4006908-4 |D s |
| 689 | 0 | |5 DE-604 | |
| 700 | 1 | |a Cho, Arthur K. |e Sonstige |4 oth | |
| 830 | 0 | |a Progress in basic and clinical pharmacology |v 1 |w (DE-604)BV000725111 |9 1 | |
| 856 | 4 | 2 | |m GBV Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000463389&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-000463389 | ||
Datensatz im Suchindex
| _version_ | 1804115192140791808 |
|---|---|
| adam_text | BIOTRANSF ORMATION OF ORGANIC NITROGEN COMPOUNDS VOLUME EDITORS A.K.
CHO, LOS ANGELES, CALIF. B. LINDEKE, SOLNA 29 FIGURES AND 11 TABLES,
1988 BASEL * MIINCHEN * PARIS * LONDON * NEW YORK * NEW DELHI *
SINGAPORE * TOKYO * SYDNEY CONTENTS PREFACE IX INTRODUCTION BY ARTHUR K.
CHO 1 /. CHEMISTRY OF ORGANIC NITROGEN COMPOUNDS CHO, A.K.,FUKUTO,J.M,
LOS ANGELES, CALIF 6 I. INTRODUCTION 6 II. AMINES 6 A. CHEMICAL
PROPERTIES 6 B. OXIDATION 12 III. HYDROXYLAMINES 17 A. CHEMICAL
PROPERTIES 17 B. OXIDATION 17 IV. NITROXIDES 18 A. CHEMICAL PROPERTIES
18 V. HYDRAZINES 19 A. CHEMICAL PROPERTIES 19 B. OXIDATION 20 VI.
NITROSO COMPOUNDS 20 A. CHEMICAL PROPERTIES 20 B. REDUCTION 21 VII.
OXIMES 21 VIII. NITRO COMPOUNDS 22 REFERENCES 22 //. CYTOCHROME P450 IN
NITROGEN METABOLISM MIWA, G.T., WALSH, J.S.,RAHWAY,N.J 27 I.
INTRODUCTION 27 A- HISTORICAL 27 B. CRITERIA FOR CYTOCHROME P450
INVOLVEMENT 28 CONTENTS VI II. THE CYTOCHROME P450 SYSTEM 29 III.
IV-OXIDATION REACTIONS 30 A. OXIDATION STATE I 31 B. OXIDATION STATE II
38 C. OXIDATION STATE III 40 IV. NITROGEN REDUCTION 41 A. NITRO
REDUCTION 41 B. AZO REDUCTION 42 C. JV-OXIDE REDUCTION 43 V. CHEMICAL
MODELS FOR CYTOCHROME P450-CATALYZED OXIDATION/REDUCTION REACTIONS 44
VI. ONE-ELECTRON NITROGEN OXIDATIONS 50 VII. CONCLUSION 51
ACKNOWLEDGMENTS 53 REFERENCES 53 ///. NITROGENOUS COMPOUNDS AS LIGANDS
TO HEMOPORPHYRINS - THE CONCEPT OF METABOLIC-INTERMEDIARY COMPLEXES
LINDEKE, B., SOLNA, PAULSEN-SORMAN, U., UPPSALA 63 I. INTRODUCTION 63
II. SPECTRAL PERTURBATIONS 63 III. SOME GENERAL PROPERTIES OF HEMIN IRON
66 IV. NITROGENOUS COMPOUNDS GENERATING CYTOCHROME P450 MI COMPLEXES ...
68 A. AMINES 70 B. JV-HYDROXYLAMINES 70 C. C-NITROSO COMPOUNDS 72 D.
NITRONES 72 E. NITRO COMPOUNDS 73 F. IV-OXIDES 74 G. COMPOUNDS
CONTAINING THE N-N FUNCTIONAL GROUP 74 H. NITROGEN HETEROCYCLES 74 I.
TERTIARY AMINE-CONTAINING MACROLIDE ANTIBIOTICS 75 V. STRUCTURE-ACTIVITY
RELATIONSHIPS 75 A. AMPHETAMINE CLASS COMPOUNDS 76 B. OTHER ALIPHATIC
AMINES 77 C. HYDRAZINES 78 D. ENANTIOSELECTIVITY 79 VI. THE
HETEROGENEITY OF LIGAND-BINDING HEMOPROTEINS AND LIGAND GENERATION 81
VII. EVENTS LEADING TO LIGAND FORMATION 83 A. C-N COMPOUNDS CONTAINING A
PRIMARY NITROGEN ATOM 83 B. C-N COMPOUNDS CONTAINING A TERTIARY OR
SECONDARY NITROGEN ATOM .. 84 C. N-N COMPOUNDS CONTAINING A PRIMARY
NITROGEN ATOM 85 VIII. CONCLUSION 86 CONTENTS VII APPENDIX 88 REFERENCES
96 IV. NITROGEN OXYGENATION BY FLAVIN ENZYMES PROUGH,R.A., LOUISVILLE,
KY 103 I. INTRODUCTION 103 A. HISTORICAL 103 B. MONOAMINE OXYDASES 108
C. FLAVIN-CONTAINING MONOOXYGENASE 108 II. THE FAD-CONTAINING
MONOOXYGENASE 108 A. SUBSTRATE SPECIFICITY 108 B. LOCALIZATION 109 C.
PURIFICATION 110 D. PHYSICAL PROPERTIES 110 E. CATALYTIC PROPERTIES ILL
F. EFFECTORS 116 III. METHODOFASSAY 117 IV. SPECIES AND DEVELOPMENTAL
ASPECTS 118 V. CRITERIA FOR INVOLVEMENT IN REACTIONS 120 VI. CONCLUSION
124 ACKNOWLEDGMENTS 125 REFERENCES 126 V. NITROGEN OXIDATION IN
CARCINOGENESIS QUON,C.Y.,WAUKEGAN,ILL 132 I. INTRODUCTION 132 II.
HISTORICAL BACKGROUND 132 III. ACTIVATION STEPS 133 A. AF-HYDROXYLATION
133 B. ESTERIFICATION 135 C. FREERADICALS 138 D. PROSTAGLANDINHSYNTHASE
140 IV. STRUCTURE ACTIVITY RELATIONSHIPS 141 A. AROMATIC AMINES 141 B.
AROMATIC AMIDES 143 C. AMINOAZO DYES 144 V. COVALENT BINDING TO
MACROMOLECULES 146 A. SITES OF COVALENT BINDING 146 B. TYPES OF COVALENT
BINDING 146 VI. MECHANISMS OF CHEMICAL CARCINOGENESIS 149 VII.
CONCLUDING REMARKS 151 REFERENCES 151 CONTENTS VIII VI. NITROGEN
OXIDATION IN TOXICITY PROUGH, R.A., ERIKSON, J.M., WIEBKIN, P.,
LOUISVILLE, KY 161 I. CHEMICAL REACTIVITY OF OXIDIZED COMPOUNDS 161 A.
AMINE OXIDES 162 B. HYDROXYLAMINES 162 C. IV-HYDROXYAMIDES 163 D.
AF-NITROSAMINES 163 E. NITRO-COMPOUNDS 164 F. AZO- AND DIAZENE
DERIVATIVES 164 G. AZOXY DERIVATIVES 165 II. BIOLOGICAL REACTIVITY OF
OXIDIZED NITROGEN DERIVATIVES 165 A. AMINE OXIDES 165 B. HYDROXYLAMINES
166 C. IV-HYDROXYAMIDES 168 D. #-NITROSAMINES 169 E. NITRO-COMPOUNDS 170
F. AZO- AND DIAZENE DERIVATIVES 172 G. AZOXY DERIVATIVES 175 III.
COVALENT BINDING AND TOXICITY 176 REFERENCES 178 VII. METABOLIC
DISPOSITION OF NITROGEN FUNCTIONALITIES CHO, A.K., LOS ANGELES, CALIF
184 I. INTRODUCTION 184 II. AMINES 184 A. OXIDATION 185 B. CONJUGATIVE
REACTIONS 187 III. HYDROXYLAMINES AND A^-OXIDES 188 A. REDUCTION 189 B.
OXIDATION 190 C. CONJUGATION 194 IV. HYDRAZINES 195 A. OXIDATION 195 B.
CONJUGATION 199 V. OXIMES 199 VI. NITROSO-COMPOUNDS 200 VII.
AZO-COMPOUNDS 200 VIII. NITRO-COMPOUNDS 201 A. REDUCTION OF AROMATIC
NITRO-GROUPS 201 B. REDUCTION OF NITROFURANS 201 C. ALIPHATIC
NITRO-COMPOUNDS 203 IX. CONCLUSIONS 205 REFERENCES 206 SUBJECTLNDEX 213
|
| any_adam_object | 1 |
| building | Verbundindex |
| bvnumber | BV000740155 |
| callnumber-first | Q - Science |
| callnumber-label | QP801 |
| callnumber-raw | QP801.N55 |
| callnumber-search | QP801.N55 |
| callnumber-sort | QP 3801 N55 |
| callnumber-subject | QP - Physiology |
| classification_rvk | VS 5450 |
| ctrlnum | (OCoLC)17106269 (DE-599)BVBBV000740155 |
| dewey-full | 615/.314 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 615 - Pharmacology and therapeutics |
| dewey-raw | 615/.314 |
| dewey-search | 615/.314 |
| dewey-sort | 3615 3314 |
| dewey-tens | 610 - Medicine and health |
| discipline | Chemie / Pharmazie Medizin |
| format | Book |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>02086nam a2200529 cb4500</leader><controlfield tag="001">BV000740155</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">00000000000000.0</controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">880504s1988 |||| 00||| ger d</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">3805546505</subfield><subfield code="9">3-8055-4650-5</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)17106269</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV000740155</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rakddb</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">ger</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-12</subfield><subfield code="a">DE-19</subfield><subfield code="a">DE-355</subfield><subfield code="a">DE-188</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">QP801.N55</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">615/.314</subfield><subfield code="2">19</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">VS 5450</subfield><subfield code="0">(DE-625)147692:253</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Biotransformation of organic nitrogen compounds</subfield><subfield code="c">vol. ed. A. K. Cho ...</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Basel ; München u.a.</subfield><subfield code="b">Karger</subfield><subfield code="c">1988</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">VIII, 217 S.</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="490" ind1="1" ind2=" "><subfield code="a">Progress in basic and clinical pharmacology</subfield><subfield code="v">1</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Biotransformation (Métabolisme)</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Composés organiques azotés - Métabolisme</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Cytochrome P-450</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Médicaments - Métabolisme</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Biotransformation (Metabolism)</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Cytochrome P-450</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Drugs</subfield><subfield code="x">Metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Nitrogen</subfield><subfield code="x">metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Organonitrogen compounds</subfield><subfield code="x">Metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Oxidation-Reduction</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Pharmaceutical Preparations</subfield><subfield code="x">metabolism</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Stickstofforganische Verbindungen</subfield><subfield code="0">(DE-588)4043811-9</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Biotransformation</subfield><subfield code="0">(DE-588)4006908-4</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="655" ind1=" " ind2="7"><subfield code="0">(DE-588)4143413-4</subfield><subfield code="a">Aufsatzsammlung</subfield><subfield code="2">gnd-content</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">Stickstofforganische Verbindungen</subfield><subfield code="0">(DE-588)4043811-9</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="1"><subfield code="a">Biotransformation</subfield><subfield code="0">(DE-588)4006908-4</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Cho, Arthur K.</subfield><subfield code="e">Sonstige</subfield><subfield code="4">oth</subfield></datafield><datafield tag="830" ind1=" " ind2="0"><subfield code="a">Progress in basic and clinical pharmacology</subfield><subfield code="v">1</subfield><subfield code="w">(DE-604)BV000725111</subfield><subfield code="9">1</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">GBV Datenaustausch</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000463389&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-000463389</subfield></datafield></record></collection> |
| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV000740155 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-09T15:18:42Z |
| institution | BVB |
| isbn | 3805546505 |
| language | German |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-000463389 |
| oclc_num | 17106269 |
| open_access_boolean | |
| owner | DE-12 DE-19 DE-BY-UBM DE-355 DE-BY-UBR DE-188 |
| owner_facet | DE-12 DE-19 DE-BY-UBM DE-355 DE-BY-UBR DE-188 |
| physical | VIII, 217 S. |
| publishDate | 1988 |
| publishDateSearch | 1988 |
| publishDateSort | 1988 |
| publisher | Karger |
| record_format | marc |
| series | Progress in basic and clinical pharmacology |
| series2 | Progress in basic and clinical pharmacology |
| spelling | Biotransformation of organic nitrogen compounds vol. ed. A. K. Cho ... Basel ; München u.a. Karger 1988 VIII, 217 S. txt rdacontent n rdamedia nc rdacarrier Progress in basic and clinical pharmacology 1 Biotransformation (Métabolisme) Composés organiques azotés - Métabolisme Cytochrome P-450 Médicaments - Métabolisme Biotransformation (Metabolism) Drugs Metabolism Nitrogen metabolism Organonitrogen compounds Metabolism Oxidation-Reduction Pharmaceutical Preparations metabolism Stickstofforganische Verbindungen (DE-588)4043811-9 gnd rswk-swf Biotransformation (DE-588)4006908-4 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Stickstofforganische Verbindungen (DE-588)4043811-9 s Biotransformation (DE-588)4006908-4 s DE-604 Cho, Arthur K. Sonstige oth Progress in basic and clinical pharmacology 1 (DE-604)BV000725111 1 GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000463389&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Biotransformation of organic nitrogen compounds Progress in basic and clinical pharmacology Biotransformation (Métabolisme) Composés organiques azotés - Métabolisme Cytochrome P-450 Médicaments - Métabolisme Biotransformation (Metabolism) Drugs Metabolism Nitrogen metabolism Organonitrogen compounds Metabolism Oxidation-Reduction Pharmaceutical Preparations metabolism Stickstofforganische Verbindungen (DE-588)4043811-9 gnd Biotransformation (DE-588)4006908-4 gnd |
| subject_GND | (DE-588)4043811-9 (DE-588)4006908-4 (DE-588)4143413-4 |
| title | Biotransformation of organic nitrogen compounds |
| title_auth | Biotransformation of organic nitrogen compounds |
| title_exact_search | Biotransformation of organic nitrogen compounds |
| title_full | Biotransformation of organic nitrogen compounds vol. ed. A. K. Cho ... |
| title_fullStr | Biotransformation of organic nitrogen compounds vol. ed. A. K. Cho ... |
| title_full_unstemmed | Biotransformation of organic nitrogen compounds vol. ed. A. K. Cho ... |
| title_short | Biotransformation of organic nitrogen compounds |
| title_sort | biotransformation of organic nitrogen compounds |
| topic | Biotransformation (Métabolisme) Composés organiques azotés - Métabolisme Cytochrome P-450 Médicaments - Métabolisme Biotransformation (Metabolism) Drugs Metabolism Nitrogen metabolism Organonitrogen compounds Metabolism Oxidation-Reduction Pharmaceutical Preparations metabolism Stickstofforganische Verbindungen (DE-588)4043811-9 gnd Biotransformation (DE-588)4006908-4 gnd |
| topic_facet | Biotransformation (Métabolisme) Composés organiques azotés - Métabolisme Cytochrome P-450 Médicaments - Métabolisme Biotransformation (Metabolism) Drugs Metabolism Nitrogen metabolism Organonitrogen compounds Metabolism Oxidation-Reduction Pharmaceutical Preparations metabolism Stickstofforganische Verbindungen Biotransformation Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000463389&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000725111 |
| work_keys_str_mv | AT choarthurk biotransformationoforganicnitrogencompounds |