Approaches to elucidate mechanisms in teratogenesis: [papers presented at the 8th CIIT Conference on Toxicology, held in Research Triangle Park, NC, Apr. 2 - 3, 1986]
Saved in:
| Format: | Book |
|---|---|
| Language: | Undetermined |
| Published: |
Washington u.a.
Hemisphere Publ. Corp.
1987
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| Series: | Chemical Industry Institute of Toxicology series
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| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XVI, 285 S. Ill. |
| ISBN: | 0891165843 |
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Record in the Search Index
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| adam_text | APPROACHES TO ELUCIDATE MECHANISMS IN TERATOGENESIS EDITED BY FRANK
WELSCH CHEMICAL INDUSTRY INSTITUTE OF TOXICOLOGY OHEMISPHERE PUBLISHING
CORPORATION, WASHINGTON A SUBSIDIARY OF HARPER & ROW, PUBLISHERS, INC.
CAMBRIDGE NEW YORK PHILADELPHIA SAN FRANCISCO LONDON MEXICO CITY SAO
PAULO SINGAPORE SYDNEY CONTENTS CONTRIBUTORS PREFACE XI XV CHAPTER 1
TERATOGENESIS OF RETINOIDS: ASPECTS OF SPECIES DIFFERENCES AND
TRANSPLACENTAL PHARMACOKINETICS HEINZ NAU, D. M. KOCHHAR, J. M. CREECH
KRAFT, B. LOEFBERG, J. REINERS, AND TH. SPARENBERG INTRODUCTION
PHARMACOKINETIC BASIS OF SPECIES DIFFERENCES TERATOGENESIS OF RETINOIDS
TRANSPLACENTAL PHARMACOKINETICS OF RETINOIDS CONCLUSIONS REFERENCES 1 3
4 7 10 12 CONTENTS CHAPTER 2 STRUCTURE-TERATOGENICITY RELATIONSHIPS OF
VALPROIC ACID CONGENERS IN WHOLE-EMBRYO CULTURE NIGEL A. BROWN, MARY E.
COAKLEY, AND DAVID 0. CLARKE 17 INTRODUCTION 17 MATERIALS AND METHODS 18
RESULTS 21 DISCUSSION 25 SUMMARY 29 REFERENCES 29 CHAPTER 3
TERATOGENICITY AND DISPOSITION OF THE GLYCOL ETHER 2-METHOXYETHANOL AND
THEIR RELATIONSHIP IN CD-1 MICE R. B. SLEET, J. A. GREENE, AND FRANK
WELSCH 33 INTRODUCTION 33 METHODS AND MATERIALS 34 RESULTS 39 DISCUSSION
49 SUMMARY 56 REFERENCES 56 CHAPTER 4 STUDIES ON MECHANISMS AND
DOSE-RESPONSE RELATIONSHIPS OF PRENATAL TOXICITY THOMAS PLATZEK,
REINHARD MEISTER, IBRAHIM CHAHOUD, GERD BOCHERT, RALF KROWKE, AND
DEITHER NEUBERT 59 J INTRODUCTION 59 ATTEMPT TO QUANTITATIVELY CORRELATE
DNA ALKYLATION IN EMBRYOS WITH ABNORMAL PRENATAL DEVELOPMENT 60 STUDIES
ON THE FEASIBILITY OF ESTABLISHING DOSE-RESPONSE RELATIONSHIPS FOR
PRENATAL TOXICITY AND ON THE REPRODUCIBILITY OF SEGMENT II TESTS 71 RISK
ASSESSMENT FROM EXPERIMENTAL DATA TO VERY LOW DOSES OR INCIDENCES 75
SUMMARY 79 REFERENCES 79 CONTENTS CHAPTER 5 UNCOORDINATED DEVELOPMENT OF
EMBRYONIC TISSUE FOLLOWING CYTOTOXIC DAMAGE MICHAEL H. L. SNOW
INTRODUCTION DISCUSSION SUMMARY REFERENCES 83 83 93 97 97 CHAPTER 6
INTRACELLULAR PH OF RODENT EMBRYOS AND ITS ASSOCIATION WITH TERATOGENIC
RESPONSE WILLIAM J. SCOTT, JR., CAROL A. DUGGAN, CLAIRE M. SCHREINER,
MICHAEL D. COLLINS, AND HEINZ NAU 99 INTRODUCTION 99 INTRACELLULAR PH OF
RODENT EMBRYOS AT DIFFERENT DEVELOPMENTAL STAGES 100 PHARMACOKINETIC
IMPLICATIONS 101 ALTERATION OF EMBRYONIC PHJ BY TERATOGENS 103 SUMMARY
105 REFERENCES 105 NOTE ADDED IN PROOF 107 CHAPTER 7 THE ROLE OF
MATERNAL SERUM FACTORS IN DIABETES-INDUCED EMBRYOPATHIES AS STUDIED IN
WHOLE-EMBRYO CULTURE 7 . W. SADLER, E. S. HUNTER, III, WAYNE BALKAN, AND
R. E. WYNN 109 INTRODUCTION 109 KETONE BODIES 111 SOMATOMEDIN INHIBITORS
115 SYNERGISM STUDIES 118 REFERENCES 119 CHAPTER 8 MOLECULAR AND
METABOLIC ASPECTS OF CYCLOPHOSPHAMIDE TERATOGENESIS PHILIP E. MIRKES 123
INTRODUCTION 123 METABOLIC ASPECTS OF CP TERATOGENICITY 124 CONTENTS
MOLECULAR ASPECTS OF CP TERATOGENICITY FUTURE TRENDS REFERENCES 132 142
144 CHAPTER 9 CHAPTER 10 RECEPTOR-DEPENDENT MECHANISMS OF CRANIOFACIAL
MALFORMATIONS ROBERT M. PRATT GLUCOCORTICOID-INDUCED CLEFT PALATE
DIOXINS AND THEIR RECEPTORS IN CRANIOFACIAL 149 149 DEVELOPMENT
RETINOID-INDUCED CRANIOFACIAL MALFORMATIONS SUMMARY REFERENCES REACTIVE
INTERMEDIATES IN CHEMICAL TERATOGENESIS M. R. JUCHAU, C. HARRIS, B. K.
BEYER, AND A. G. FANTEL INTRODUCTION GENERATION OF REACTIVE
INTERMEDIATES IN BIOLOGICAL SYSTEMS: GENERAL CONSIDERATIONS CYTOCHROME
P450-DEPENDENT GENERATION OF REACTIVE, EMBRYOTOXIC INTERMEDIATES
CYTOCHROME P450-INDEPENDENT GENERATION OF REACTIVE, EMBRYOTOXIC
INTERMEDIATES SUMMARY AND CONCLUSIONS REFERENCES 155 158 160 160 167 167
169 171 173 178 179 CHAPTER 11 RAT EMBRYO LIMB CELLS IN CULTURE: ABILITY
TO METABOLIZE XENOBIOTICS O. P. FLINT AND L. P. BROWN . 185 INTRODUCTION
185 METHODS 186 RESULTS 188 CONCLUSION 194 REFERENCES 194 CONTENTS
CHAPTER 12 MECHANISMS BY WHICH RETINOIDS INTERCEPT DEVELOPMENTAL EVENTS
OF THE MAMMALIAN LIMB D. M. KOCHHAR INTRODUCTION RESULTS AND DISCUSSION
SUMMARY REFERENCES 197 197 199 208 210 CHAPTER 13 RETINOIC ACID-INDUCED
ALTERATION OF CHONDROCYTE GENE EXPRESSION: IMPLICATIONS FOR A
TERATOGENIC MECHANISM WALTER E. HORTON, JR., YOSHIHIKO YAMADA, AND JOHN
R. HASSELL 215 INTRODUCTION 215 MATERIALS AND METHODS 216 RESULTS AND
DISCUSSION 217 SUMMARY 228 REFERENCES 228 CHAPTER 14 TERATOGEN
INTERFERENCE WITH CELL INTERACTIONS: CELL-TO-CELL CHANNEL DISRUPTION AS
A POTENTIAL MECHANISM OF ABNORMAL DEVELOPMENT FRANK WELSCH, DONALD B.
STEDMAN, AND JOHNNY L. CARSON 233 INTRODUCTION 233 MATERIALS AND METHODS
236 RESULTS AND DISCUSSION ; 239 SUMMARY 250 REFERENCES 251 CHAPTER 15
THE APPLICATION OF BASIC DEVELOPMENTAL BIOLOGY DATA TO CLINICAL
TERATOLOGICAL PROBLEMS ROBERT L BRENT 255 INTRODUCTION ETIOLOGY OF
CONGENITAL MALFORMATIONS MECHANISMS OF TERATOGENESIS 255 255 258
CONTENTS CHAPTER 16 INDEX USING BASIC SCIENCE DATA TO EVALUATE THE
ALLEGATION OF TERATOGENICITY FOR A PARTICULAR CHEMICAL OR DRUG EXAMPLES
OF APPLYING THE CONCEPT OF PLAUSIBILITY TO ALLEGED TERATOGENESIS SUMMARY
REFERENCES PANEL DISCUSSION 261 264 264 265 269 281
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| isbn | 0891165843 |
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| physical | XVI, 285 S. Ill. |
| publishDate | 1987 |
| publishDateSearch | 1987 |
| publishDateSort | 1987 |
| publisher | Hemisphere Publ. Corp. |
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| series2 | Chemical Industry Institute of Toxicology series |
| spelling | Approaches to elucidate mechanisms in teratogenesis [papers presented at the 8th CIIT Conference on Toxicology, held in Research Triangle Park, NC, Apr. 2 - 3, 1986] ed. by Frank Welsch Washington u.a. Hemisphere Publ. Corp. 1987 XVI, 285 S. Ill. txt rdacontent n rdamedia nc rdacarrier Chemical Industry Institute of Toxicology series Teratogenese (DE-588)4184740-4 gnd rswk-swf Chemikalie (DE-588)4009833-3 gnd rswk-swf (DE-588)1071861417 Konferenzschrift 1986 Research Triangle Park NC gnd-content Teratogenese (DE-588)4184740-4 s Chemikalie (DE-588)4009833-3 s DE-604 Welsch, Frank Sonstige oth GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000456823&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Approaches to elucidate mechanisms in teratogenesis [papers presented at the 8th CIIT Conference on Toxicology, held in Research Triangle Park, NC, Apr. 2 - 3, 1986] Teratogenese (DE-588)4184740-4 gnd Chemikalie (DE-588)4009833-3 gnd |
| subject_GND | (DE-588)4184740-4 (DE-588)4009833-3 (DE-588)1071861417 |
| title | Approaches to elucidate mechanisms in teratogenesis [papers presented at the 8th CIIT Conference on Toxicology, held in Research Triangle Park, NC, Apr. 2 - 3, 1986] |
| title_auth | Approaches to elucidate mechanisms in teratogenesis [papers presented at the 8th CIIT Conference on Toxicology, held in Research Triangle Park, NC, Apr. 2 - 3, 1986] |
| title_exact_search | Approaches to elucidate mechanisms in teratogenesis [papers presented at the 8th CIIT Conference on Toxicology, held in Research Triangle Park, NC, Apr. 2 - 3, 1986] |
| title_full | Approaches to elucidate mechanisms in teratogenesis [papers presented at the 8th CIIT Conference on Toxicology, held in Research Triangle Park, NC, Apr. 2 - 3, 1986] ed. by Frank Welsch |
| title_fullStr | Approaches to elucidate mechanisms in teratogenesis [papers presented at the 8th CIIT Conference on Toxicology, held in Research Triangle Park, NC, Apr. 2 - 3, 1986] ed. by Frank Welsch |
| title_full_unstemmed | Approaches to elucidate mechanisms in teratogenesis [papers presented at the 8th CIIT Conference on Toxicology, held in Research Triangle Park, NC, Apr. 2 - 3, 1986] ed. by Frank Welsch |
| title_short | Approaches to elucidate mechanisms in teratogenesis |
| title_sort | approaches to elucidate mechanisms in teratogenesis papers presented at the 8th ciit conference on toxicology held in research triangle park nc apr 2 3 1986 |
| title_sub | [papers presented at the 8th CIIT Conference on Toxicology, held in Research Triangle Park, NC, Apr. 2 - 3, 1986] |
| topic | Teratogenese (DE-588)4184740-4 gnd Chemikalie (DE-588)4009833-3 gnd |
| topic_facet | Teratogenese Chemikalie Konferenzschrift 1986 Research Triangle Park NC |
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