Extended release dosage forms:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English Polish |
| Veröffentlicht: |
Boca Raton, Fla.
CRC Press
1987
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Aus dem Poln. übers. - Literaturangaben |
| Beschreibung: | 229 S. Ill., graph. Darst. |
| ISBN: | 0849343070 |
Internformat
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| 650 | 4 | |a Delayed-Action Preparations | |
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Datensatz im Suchindex
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| adam_text | EXTENDED-RELEASE DOSAGE FORMS AUTHOR LESZEK KROWCZYRISKI, PHAR. D.,
PH.D. PROFESSOR DEPARTMENT OF PHARMACEUTICAL TECHNOLOGY AND
BIOPHARMACEUTICS MEDICAL ACADEMY CRACOW, POLAND TRANSLATOR DOROTA
POR§BSKA BROZYNA, M. A. LECTURER FOREIGN LANGUAGE DEPARTMENT MEDICAL
ACADEMY CRACOW, POLAND CRC PRESS, INC. BOCA RATON, FLORIDA TABLE OF
CONTENTS CHAPTER 1 EXTENDED-RELEASE-DOSAGE FORMS 1 I. INTRODUCTION 1 II.
DEFINITIONS 4 III. THE PURPOSE OF PRODUCTION AND ADMINISTRATION OF
EXTENDED-RELEASE DOSAGE FORMS 6 IV. HISTORICAL OUTLINE OF
EXTENDED-RELEASE DOSAGE FORM DEVELOPMENT 7 V. OBJECTIVES OF
EXTENDED-RELEASE DOSAGE FORM PRODUCTION 10 REFERENCES 18 CHAPTER 2
BIOPHARMACEUTICAL ASPECTS OF THE PROLONGED-ACTION FORMULATIONS DESIGN 21
I. FUNDAMENTAL CONCEPTS OF BIOPHARMACEUTICS 21 II. DRUG ABSORPTION 21
III. PROTEIN BINDING OF A DRUG 24 IV. DRUG DISTRIBUTION AND METABOLISM
24 V. EXCRETION OF DRUG 25 VI. THE IMPORTANCE OF ELIMINATION HALF-LIFE
27 REFERENCES 30 CHAPTER 3 THEORETICAL PRINCIPLES APPLIED IN VARIOUS
EXTENDED-RELEASE DOSAGE FORMULATIONS 31 I. POSSIBILITIES OF DRUG-RELEASE
PROLONGATION 31 II. THE FILM THEORY OF DISSOLUTION 32 III. DISSOLUTION
FROM THE PARTICLE MIXTURE AND FROM THE MATRIX 33 IV. DISSOLUTION THROUGH
THE MEMBRANE 36 V. GRAPHIC INTERPRETATION OF THE DISSOLUTION PROCESS 39
VI. POSSIBILITIES OF DISSOLUTION-RATE MODIFICATIONS 40 A. EFFECT OF DRUG
SOLUBILITY 40 B. EFFECT OF THE DISSOLUTION SURFACE 4(1 C. EFFECT OF
CRYSTALLOGRAPHIC MODIFICATION 41 D. EFFECT OF SUBSTANCES IMPEDING
CONTACT WITH THE SOLVENT 41 VII. POSSIBILITIES OF DIFFUSION-RATE
MODIFICATIONS 42 A. EFFECT OF THE SEPARATING-LAYER THICKNESS 42 B.
EFFECT OF THE POROSITY OF THE MEMBRANE 43 C. EFFECT OF THE PARTITION
COEFFICIENT 45 D. EFFECT OF THE DIFFUSION COEFFICIENT 46 E. EFFECT OF
THE MOLECULE SIZE 46 F. EFFECT OF VISCOSITY 47 G. EFFECT OF THE
DIFFERENCE IN THE CONCENTRATION GRADIENT 48 VIII. PHYSIOLOGICAL
PARAMETERS 49 REFERENCES 4 C ) CHAPTER 4 MATHEMATICAL MODELS OF
EXTENDED-RELEASE DOSAGE FORM DESIGN .SI I. INTRODUCTION 51 II.
COMPARTMENT MODELS DESCRIBING DRUG CONCENTRATION IN THE BODY AFTER
DOSAGE- FORM ADMINISTRATION 51 A. ONE-COMPARTMENT MODEL 51 B.
TWO-COMPARTMENT MODEL 52 III. CALCULATIONS OF TOTAL, INITIAL, AND
MAINTENANCE DOSES 53 A. DRUG RELEASE FROM A DOSAGE FORM OF ZERO-ORDER
KINETICS 53 B. DRUG RELEASE FROM A DOSAGE FORM OF FIRST-ORDER KINETICS
56 IV. EVALUATION OF EXTENDED-RELEASE DOSAGE FORM DESIGN 56 REFERENCES
58 CHAPTER 5 PARENTERAL EXTENDED-RELEASE DOSAGE FORMS: PRINCIPLES OF
TECHNOLOGY 59 I. GENERAL CONSIDERATIONS 59 A. ABSORPTION FROM THE SITE
OF INJECTION 59 II. SOLUTIONS 62 A. SOLUTIONS WITH THE ADDITION OF
MACROMOLECULES 62 B. OILY SOLUTIONS 63 III. SUSPENSIONS 65 A. FACTORS
INFLUENCING ABSORPTION RATE 65 B. ADJUVANTS 67 C. AQUEOUS SUSPENSIONS 67
D. OILY SUSPENSIONS 69 E. SUSPENSIONS OF MICRO- AND NANOPARTICLES 70 1.
ALBUMIN MICROSPHERES 71 2. GELATIN MICRO- AND NANOSPHERES 72 3.
POLYMERIC NANOPARTICLES 73 4. LIPOSOMES 76 IV. EMULSIONS 77 A. WATER IN
OIL EMULSIONS 77 B. OIL IN WATER EMULSIONS 80 C. MULTIPLE EMULSIONS 81
V. IMPLANTS 83 A. CONVENTIONAL IMPLANTS (PELLETS) 83 B. SILICONE
CAPSULES 84 C. SILICONE MATRIX DEVICES 86 D. PREPARATION OF SILICONE
CAPSULES AND MATRICES 88 E. OTHER MATERIALS FOR CAPSULE OR MATRIX
PREPARATION 90 1. POLYETHYLENE 90 2. POLYMETHYLMETHACRYLATE 90 3.
HYDROPHILIC POLYMERS 90 F. IMPLANTABLE OSMOTICALLY POWERED PUMPS 91
REFERENCES 92 CHAPTER 6 ORAL EXTENDED-RELEASE DOSAGE FORMS: PRINCIPLES
OF TECHNOLOGY 97 I. GENERAL CONSIDERATIONS 97 A TYPES OF ORAL
EXTENDED-RELEASE DOSAGE FORMS 97 B. GASTROINTESTINAL ABSORPTION 97 C.
CLASSIFICATION AND SYSTEMATIZATION OF ORAL EXTENDED-RELEASE DOSAGE FORMS
103 II. DOSAGE FORMS WITH CHEMICAL OR PHYSICAL-CHEMICAL BOUNDED DRUG 104
A. SLIGHTY SOLUBLE SALTS OR COMPLEXES 104 B DRUG BOUND ON ION-EXCHANGE
RESIN 104 III. COATING AS A TECHNOLOGY FOR PROLONGATION OF DRUG RELEASE
110 A. COATING METHODS ILL 1. DOUBLE-COMPRESSION TECHNIQUE ILL 2. PAN
COATING 112 3. AIR-SUSPENSION COATING TECHNIQUE 112 4.
MICROENCAPSULATION 114 A. SPRAY-DRYING TECHNIQUE 114 B. SPRAY-CONGEALING
TECHNIQUE 115 C. COACERVATION 115 D. INTERFACIAL POLYMERIZATION OR
POLYCONDENSATION 120 B. PERMEABILITY OF THE COATING MEMBRANE 122 C.
DOSAGE FORMS BASED ON A MEMBRANE COAT 123 IV. EMBEDDING AS THE
TECHNOLOGICAL PROCESS FOR PROLONGATION OF DRUG RELEASE 131 A. METHODS OF
DRUG EMBEDDING 132 1. EMBEDDING BY BLENDING A DRUG WITH A CARRIER AND
COMPRESSION 132 2. EMBEDDING BY MOLECULAR DISPERSION BY THE SOLVENT
METHOD 134 3. EMBEDDING BY SPRAY-DRYING GRANULATION TECHNIQUE 136 4.
EMBEDDING BY MELTING AND CONGEALING 136 5. EMBEDDING BY HOT EXTRUSION
MOLDING 138 6. EMBEDDING BY THE POLYMERIZATION TECHNIQUE 140 7.
EMBEDDING BY PRECIPITATION 141 B. DOSAGE FORMS BASED ON DRUG EMBEDDING
141 1. UNIFORM TABLETS CONTAINING EMBEDDED DRUG 142 2. PLASTIC-MATRIX
TABLETS 144 3. MULTILAYER TABLETS 147 REFERENCES 150 CHAPTER 7
EXTENDED-RELEASE DOSAGE FORMS FOR OTHER APPLICATION ROUTES 159 I. DOSAGE
FORMS APPLIED TO THE EYE 159 A. EYE DROPS WITH VISCOLIZERS 159 B.
OPHTHALMIC DISCS 159 C. OCULAR THERAPEUTIC SYSTEM 161 II. DOSAGE FORMS
APPLIED TO THE SKIN 162 A. POLYMER FILMS AS DRUG DELIVERY SYSTEMS 163 B.
MEMBRANE-CONTROLLED DRUG DELIVERY SYSTEMS 164 III. INTRAUTERINE
THERAPEUTIC SYSTEM 167 REFERENCES 168 CHAPTER 8 EXCIPIENTS USED IN THE
FORMULATION OF EXTENDED-RELEASE DOSAGE FORMS 171 I. INTRODUCTION 171 II.
NATURAL PRODUCTS 171 A. GELATIN AND OTHER PROTEINS 171 B. CARBOHYDRATES
AND RELATED ACIDS 172 C. RESINS 172 D. FATS AND WAXES I 73 III.
CHEMICALLY MODIFIED NATURAL PRODUCTS 174 A. DERIVATIVES OF CELLULOSE 174
B. GALACTOMANNAN PRODUCTS 176 IV. SYNTHETIC POLYMERS 176 A. INSOLUBLE
POLYMERS 176 B. SOLUBLE VINYL DERIVATIVES 176 C. SILICONES 179 D.
METHACRYLATE POLYMERS 180 E. BIODEGRADABLE POLYMERS 182 F. EPOXY RESINS
184 REFERENCES 184 CHAPTER 9 QUALITY CONTROL METHODS FOR
EXTENDED-RELEASE DOSAGE FORMS 189 I. INTRODUCTION 189 II. DISSOLUTION
TEST FOR SOLID ORAL DOSAGE FORMS 190 III. RELEASE-RATE CONTROL FROM
OTHER EXTENDED-RELEASE DOSAGE FORMS 198 IV. IN VIVO EVALUATION OF
EXTENDED-RELEASE DOSAGE FORMS 200 V. CORRELATION OF IN VITRO/IN VIVO
DATA 205 REFERENCES 208 CHAPTER 10 PERSPECTIVES FOR THE FUTURE OF DRUG
DELIVERY SYSTEMS DEVELOPMENT 211 REFERENCES 214 INDEX 215
|
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| author_facet | Krówczyński, Leszek |
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| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 615 - Pharmacology and therapeutics |
| dewey-raw | 615/.191 |
| dewey-search | 615/.191 |
| dewey-sort | 3615 3191 |
| dewey-tens | 610 - Medicine and health |
| discipline | Chemie / Pharmazie Medizin |
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| genre | Kontrollierte Wirkstofffreizetzung gnd |
| genre_facet | Kontrollierte Wirkstofffreizetzung |
| id | DE-604.BV000713915 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T15:18:15Z |
| institution | BVB |
| isbn | 0849343070 |
| language | English Polish |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-000445973 |
| oclc_num | 13700959 |
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| owner | DE-12 DE-19 DE-BY-UBM DE-355 DE-BY-UBR |
| owner_facet | DE-12 DE-19 DE-BY-UBM DE-355 DE-BY-UBR |
| physical | 229 S. Ill., graph. Darst. |
| publishDate | 1987 |
| publishDateSearch | 1987 |
| publishDateSort | 1987 |
| publisher | CRC Press |
| record_format | marc |
| spelling | Krówczyński, Leszek Verfasser aut Extended release dosage forms author Leszek Krówczyński Boca Raton, Fla. CRC Press 1987 229 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Aus dem Poln. übers. - Literaturangaben Médicaments-retard Médicaments-retard ram Delayed-Action Preparations Drugs Controlled release Kontrollierte Wirkstofffreisetzung (DE-588)4165181-9 gnd rswk-swf Arzneimittel (DE-588)4003115-9 gnd rswk-swf Kontrollierte Wirkstofffreizetzung gnd rswk-swf Kontrollierte Wirkstofffreisetzung (DE-588)4165181-9 s DE-604 Kontrollierte Wirkstofffreizetzung f Arzneimittel (DE-588)4003115-9 s GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000445973&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Krówczyński, Leszek Extended release dosage forms Médicaments-retard Médicaments-retard ram Delayed-Action Preparations Drugs Controlled release Kontrollierte Wirkstofffreisetzung (DE-588)4165181-9 gnd Arzneimittel (DE-588)4003115-9 gnd |
| subject_GND | (DE-588)4165181-9 (DE-588)4003115-9 |
| title | Extended release dosage forms |
| title_auth | Extended release dosage forms |
| title_exact_search | Extended release dosage forms |
| title_full | Extended release dosage forms author Leszek Krówczyński |
| title_fullStr | Extended release dosage forms author Leszek Krówczyński |
| title_full_unstemmed | Extended release dosage forms author Leszek Krówczyński |
| title_short | Extended release dosage forms |
| title_sort | extended release dosage forms |
| topic | Médicaments-retard Médicaments-retard ram Delayed-Action Preparations Drugs Controlled release Kontrollierte Wirkstofffreisetzung (DE-588)4165181-9 gnd Arzneimittel (DE-588)4003115-9 gnd |
| topic_facet | Médicaments-retard Delayed-Action Preparations Drugs Controlled release Kontrollierte Wirkstofffreisetzung Arzneimittel Kontrollierte Wirkstofffreizetzung |
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