Cell commitment and differentiation:
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Cambridge ; New York
Cambridge University Press
1987
|
| Ausgabe: | 1. publ. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | X, 244 Seiten Illustrationen 25 cm |
| ISBN: | 0521308844 0521349648 |
Internformat
MARC
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| 100 | 1 | |a MacLean, Norman |d 1932- |e Verfasser |0 (DE-588)13975959X |4 aut | |
| 245 | 1 | 0 | |a Cell commitment and differentiation |c Norman Maclean ; Brian K. Hall |
| 250 | |a 1. publ. | ||
| 264 | 1 | |a Cambridge ; New York |b Cambridge University Press |c 1987 | |
| 300 | |a X, 244 Seiten |b Illustrationen |c 25 cm | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 505 | 8 | |a Machine derived contents note: 1. A first look at cell commitment; 2. Genomic constancy and nuclear totipotency; 3. Gene action and regulation; 4. The cell surface; 5. The extracellular environment; 7. The stability of determination and differentiation; 8. From embryo to adult; 9. Growth and form -- the consequences of differentiation; 10. Some model systems; 11. A final look at cell commitment | |
| 650 | 7 | |a Biologie moléculaire |2 ram | |
| 650 | 4 | |a Cellules - Différenciation | |
| 650 | 7 | |a Cellules - Différenciation |2 ram | |
| 650 | 4 | |a Cytologie du développement | |
| 650 | 4 | |a Cell Differentiation | |
| 650 | 4 | |a Cell determination | |
| 650 | 4 | |a Cell differentiation | |
| 650 | 0 | 7 | |a Cytogenetik |0 (DE-588)4070176-1 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Entwicklungsphysiologie |0 (DE-588)4152449-4 |2 gnd |9 rswk-swf |
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| 700 | 1 | |a Hall, Brian Keith |d 1941- |e Verfasser |0 (DE-588)121395979 |4 aut | |
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| 999 | |a oai:aleph.bib-bvb.de:BVB01-000443644 | ||
Datensatz im Suchindex
| _version_ | 1804115159989354496 |
|---|---|
| adam_text | IMAGE 1
CONTENTS
1 1.1 1.2
1.3 1.4 1.5
PREFACE ACKNOWLEDGEMENTS
A FIRST LOOK AT CELL COMMITMENT
INTRODUCTION ORIGINS AND IMPLICATIONS OF MULTICELLULARITY SIMPLE MODELS
OF DIFFERENTIATION EPIGENETIC INTERACTIONS SOME DEFINITIONS
PAGE IX X
1
3 6 9
10
2 GENOMIC CONSTANCY AND NUCLEAR TOTIPOTENCY
2.1 CELLS OF THE SAME TYPE ARE STRIKINGLY SIMILAR 14
2.2 CELL TYPES AND CELL CLONES 14
2.3 CELL TYPES RESEMBLE SPECIES 15
2.4 THE COMPLICATION OF THE CELL CYCLE 17 2.5 THE COMPLICATIONS OF CELL
AGE AND CELL STAGE 19
2.6 CELL DIFFERENTIATION IS STABLY MAINTAINED THROUGH SUCCESSIVE ROUNDS
OF CELL GROWTH AND DIVISION 19
2.7 CELLS OF THE SAME TYPE HAVE IDENTICAL PROGRAMMES OF GENE ACTIVITY 20
2.8 BOTH SYNTHESIS AND DEGRADATION ARE IMPORTANT IN DETERMINING
EFFECTIVE MOLECULAR CONCENTRATIONS 22
2.9 EVEN TERMINALLY DIFFERENTIATED CELLS COMMONLY RETAIN A FULL GENETIC
COMPLEMENT 2 3
2.10 AT LEAST SOME DIFFERENTIATED CELLS REMAIN GENETICALLY TOTIPOTENT 23
2.11 ARTIFICIAL HETEROKARYONS ALSO PROVIDE SITUATIONS FOR DETERMINING
NUCLEAR POTENCY 28
2.12 MECHANISMS THAT INDUCE PARTIAL GENETIC SHUTDOWN OR INCOMPETENCE OF
CELL NUCLEI ARE KNOWN 29
2.13 STEM CELLS ARE A DEVICE TO OFFSET THE GENETIC LIMITATIONS OF CELL
SPECIALIZATION 30
2.14 SOME CELLS BECOME GENETICALLY ALTERED BY SPECIAL GENE AMPLIFICATION
31 2.15 SUMMARY 31
3 GENE ACTION AND REGULATION
3.1 IN THE GENOMES OF EUKARYOTIC CELLS, PATTERNS OF GENE EXPRESSION ARE
VERY VARIABLE: SOME GENES ARE CONSTITUTIVELY EXPRESSED, WHILE OTHERS ARE
ONLY RARELY TRANSCRIBED 33
3.2 SITUATIONS OF TOTAL GENETIC SHUTDOWN 35 3.3 EVIDENCE FOR
CONSTITUTIVE EXPRESSION OF SOME GENES 3 6
3.4 MANY GENES ARE EXPRESSED ONLY IN CERTAIN TISSUES, OFTEN FOR VERY
SHORT PERIODS OF THE LIFE OF AN INDIVIDUAL CELL 36
3.5 SOME DNA IS NEVER TRANSCRIBED IN ANY CELL 38
3.6 MECHANISMS OF GENE REGULATION AND EXPRESSION 39
3.7 TRANSCRIPTIONAL REGULATION - CHROMATIN CONFORMATION 39
3.8 TRANSCRIPTIONAL REGULATION - DNA METHYLATION 43
3.9 TRANSCRIPTIONAL REGULATION - HISTONE ACETYLATION 48
3.10 TRANSCRIPTIONAL REGULATION - PROTEIN A24 49
3.11 TRANSCRIPTIONAL REGULATION - GENE REGULATORY MOLECULES 49
3.12 EVIDENCE FOR SPECIFIC GENE REGULATORY MOLECULES 52
3.13 TRANSCRIPTIONAL REGULATION - PROMOTER AND ENHANCER SEQUENCES 5 5
3.14 POST-TRANSCRIPTIONAL REGULATION 56
3.15 SOME RNA IS CAPPED AND TAILED 56
3.16 RNA IS PROCESSED TO REMOVE INTRON SEQUENCES 5 7
3.17 MOST RNA IS NEVER EXPORTED FROM THE NUCLEUS 58
3.18 MESSAGE DEGRADATION RATES ARE SIGNIFICANT 58
3.19 THERE IS NO EVIDENCE FOR SPECIAL REGULATION DURING TRANSLATION 58
3.20 POST-TRANSLATIONAL MODIFICATIONS TO PROTEINS 60
3.21 GENE EXPRESSION IN MITOCHONDRIA AND CHLOROPLASTS 60
IMAGE 2
VI
CONTENTS
3.22 A NOTE ON GENE AMPLIFICATION 3.23 GENE REGULATION AND
DIFFERENTIATION 3.24 SUMMARY
THE CELL SURFACE 4.1
4.2
4.3
4.4
4.5
4.6
4.7
4.8
4.9
ALL CELLS ARE BOUNDED BY A PLASMA MEMBRANE THE PERMEABILITY OF THE CELL
MEMBRANE IS DIFFERENT FOR SMALL MOLECULES LARGE MOLECULES MOVE IN AND
OUT OF CELLS BY ELABORATE PROCESSES OF ENDOCYTOSIS AND EXOCYTOSIS
EXOCYTOSIS IS THE MECHANISM
WHEREBY MOLECULES ARE SECRETED BY CELLS MULTICELLULAR PLANTS AND ANIMALS
ARE
VERY DIFFERENTLY ORGANIZED IN TERMS OF INTERCELLULAR COMMUNICATION SOME
JUNCTIONS OF ANIMAL CELLS ARE IMPERMEABLE
GAP JUNCTIONS ARE AREAS OF SELECTIVE COMMUNICATION GAP JUNCTIONS ARE
WIDELY DISTRIBUTED
AND MAY PLAY IMPORTANT ROLES IN DIFFERENTIATION DESMOSOMES ARE ADHERING
JUNCTIONS THAT SERVE TO HOLD CELLS TOGETHER 4.10 PLANT CELLS COMMUNICATE
BY
PLASMODESMATA 4.11 CELL MOVEMENT INVOLVES THE CELL SURFACE 4.12 CELLS OF
THE SAME TYPE OFTEN DISPLAY
PREFERENTIAL ASSOCIATION 4.13 THE CELL SURFACE AND DIFFERENTIATION 4.14
SUMMARY
5 THE EXTRACELLULAR ENVIRONMENT 5.1 INTRINSIC FACTORS THAT REGULATE
DIFFERENTIATION 5.2 HORMONES AND THE DIFFERENTIATION OF
ANIMAL AND PLANT CELLS 5.3 MORPHOGENS 5.4 THE EXTRACELLULAR MATRIX 5.5
EPITHELIAL-MESENCHYMAL INTERACTIONS
5.6 LATER INTERACTIONS WITH ADJACENT TISSUES 5.7 SUMMARY
61 62 62
63
66
66
71
71
72
72
74
74
75
75
76
77 78
6 FROM EGG TO EMBRYO 6.1 COMMITMENT DURING DEVELOPMENT 100 6.2 MOSAIC
DEVELOPMENT 102
6.3 DETERMINATION OF GERM CELLS VS SOMATIC CELLS 104
6.4 REGULATIVE DEVELOPMENT 107
6.5 MATERNAL CYTOPLASMIC CONTROL 111 6.6 MORPHOGENETIC FIELDS 112
6.7 SUMMARY 113
7 THE STABILITY OF DETERMINATION AND DIFFERENTIATION
7.1 CELL DETERMINATION CAN ONLY BE ASSESSED EXPERIMENTALLY 115
7.2 HOW STABLE IS THE STATE OF DETERMINATION ? 115
7.3 IMAGINAL DISC CELLS OCCASIONALLY CHANGE THEIR FATE - THIS IS CALLED
TRANSDETERMINATION 118
7.4 TRANSDETERMINATION IS DISTINCT FROM HOMEOTIC MUTATION 118
7.5 CELL PROLIFERATION WITH IMAGINAL DISCS IS OF SPECIAL INTEREST 120
7.6 DETERMINATION CAN ALSO BE ALTERED IN PLANTS 122
7.7 THE DIFFERENTIATED STATE IS MOST COMMONLY CHARACTERIZED BY
REMARKABLE STABILITY 124
7.8 MANY PLANTS LEND THEMSELVES TO EXPERIMENTS IN CELLULAR TOTIPOTENCY
BECAUSE OF VEGETATIVE PROPAGATION 125
7.9 ALTERED COMMITMENT IN DIFFERENTIATED ANIMAL CELLS 125
7.10 SOME SUBSTANCES ARE KNOWN TO BE ABLE TO ALTER THE DIFFERENTIATED
STATE OF CERTAIN CELLS 131
7.11 DOES THE AGE OF THE TISSUE OR OF THE ORGANISM HAVE EFFECTS ON THE
STABILITY OF DIFFERENTIATION ? 132
7.12 THE ROLE OF CELL DIVISION AND DEDIFFERENTIATION IN
TRANSDIFFERENTIATION 132
7.13 WHEREIN LIES THE IMPRESSIVE STABILITY
79
80 86 92 95
99 99
7.14
8 8.1 8.2 8.3 8.4 8.5
8.6
OF THE DIFFERENTIATED STATE ? SUMMARY
FROM EMBRYO TO ADULT CELL LINEAGES PROGRESSIVE DETERMINATION LATE
COMMITMENT STEM CELLS DEDIFFERENTIATION AND REDIFFERENTIATION NEOPLASIA
133 133
134 139 144 145
146 146
IMAGE 3
8.7 PROGRAMMED NUMBERS OF CELL
DIVISIONS
8.8 SUMMARY
9 GROWTH AND FORM - THE CONSEQUENCES OF DIFFERENTIATION
9.1 9.2 9.3
9.4 9.5 9.6 9.7
9.8
10
10.1 10.2 10.3 10.4 10.5 10.6
SELF-ASSEMBLY CORTICAL INHERITANCE OF FORM MORPHOGENETIC MOVEMENTS
POSITIONAL INFORMATION PROGRAMMED CELL DEATH CELLULAR CONTROL OF GROWTH
GROWTH FACTORS SUMMARY
SOME MODEL SYSTEMS THE NEURAL CREST TERATOCARCINOMAS CELL FUSION THE
IMMUNE SYSTEM HOMEOTIC GENES AND MUTANTS ERYTHROPOIESIS
151 152
153 157 157 161
164 167 169 170
171 176 179
182 188 193
11
11.1 11.2
11.3
11.4 11.5 11.6
11.7
11.8 11.9 11.10 11.11 11.12
A FINAL LOOK AT CELL COMMITMENT
INTRODUCTION DISTINCTIONS BETWEEN DETERMINATION AND DIFFERENTIATION
NUCLEAR TOTIPOTENCY - REAL OR ILLUSORY NUCLEUS AND CYTOPLASM THE CELL
AND ITS ENVIRONMENT THE HEART OF THE MATTER - HOW DO CELLS BECOME
COMMITTED ? DEDIFFERENTIATION AND REDIFFERENTIATION THE TIME OF
DETERMINATION ORDER FROM CHAOS MORPHOGENESIS MODELS OF COMMITMENT FUTURE
PATHS
REFERENCES INDEX
VU
CONTENTS
201
202
204 205 206
208
212 214 216 218
218 219
221 2 37
|
| any_adam_object | 1 |
| author | MacLean, Norman 1932- Hall, Brian Keith 1941- |
| author_GND | (DE-588)13975959X (DE-588)121395979 |
| author_facet | MacLean, Norman 1932- Hall, Brian Keith 1941- |
| author_role | aut aut |
| author_sort | MacLean, Norman 1932- |
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| callnumber-sort | QH 3607 |
| callnumber-subject | QH - Natural History and Biology |
| classification_tum | BIO 756f BIO 186f BIO 200f |
| contents | Machine derived contents note: 1. A first look at cell commitment; 2. Genomic constancy and nuclear totipotency; 3. Gene action and regulation; 4. The cell surface; 5. The extracellular environment; 7. The stability of determination and differentiation; 8. From embryo to adult; 9. Growth and form -- the consequences of differentiation; 10. Some model systems; 11. A final look at cell commitment |
| ctrlnum | (OCoLC)14212229 (DE-599)BVBBV000710242 |
| dewey-full | 574.87/612 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 574 - [Unassigned] |
| dewey-raw | 574.87/612 |
| dewey-search | 574.87/612 |
| dewey-sort | 3574.87 3612 |
| dewey-tens | 570 - Biology |
| discipline | Biologie |
| edition | 1. publ. |
| format | Book |
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| id | DE-604.BV000710242 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T15:18:11Z |
| institution | BVB |
| isbn | 0521308844 0521349648 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-000443644 |
| oclc_num | 14212229 |
| open_access_boolean | |
| owner | DE-12 DE-M49 DE-BY-TUM DE-29 DE-188 |
| owner_facet | DE-12 DE-M49 DE-BY-TUM DE-29 DE-188 |
| physical | X, 244 Seiten Illustrationen 25 cm |
| publishDate | 1987 |
| publishDateSearch | 1987 |
| publishDateSort | 1987 |
| publisher | Cambridge University Press |
| record_format | marc |
| spelling | MacLean, Norman 1932- Verfasser (DE-588)13975959X aut Cell commitment and differentiation Norman Maclean ; Brian K. Hall 1. publ. Cambridge ; New York Cambridge University Press 1987 X, 244 Seiten Illustrationen 25 cm txt rdacontent n rdamedia nc rdacarrier Machine derived contents note: 1. A first look at cell commitment; 2. Genomic constancy and nuclear totipotency; 3. Gene action and regulation; 4. The cell surface; 5. The extracellular environment; 7. The stability of determination and differentiation; 8. From embryo to adult; 9. Growth and form -- the consequences of differentiation; 10. Some model systems; 11. A final look at cell commitment Biologie moléculaire ram Cellules - Différenciation Cellules - Différenciation ram Cytologie du développement Cell Differentiation Cell determination Cell differentiation Cytogenetik (DE-588)4070176-1 gnd rswk-swf Entwicklungsphysiologie (DE-588)4152449-4 gnd rswk-swf Zelldifferenzierung (DE-588)4067536-1 gnd rswk-swf Zelldifferenzierung (DE-588)4067536-1 s Cytogenetik (DE-588)4070176-1 s DE-604 Entwicklungsphysiologie (DE-588)4152449-4 s Hall, Brian Keith 1941- Verfasser (DE-588)121395979 aut SWB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000443644&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | MacLean, Norman 1932- Hall, Brian Keith 1941- Cell commitment and differentiation Machine derived contents note: 1. A first look at cell commitment; 2. Genomic constancy and nuclear totipotency; 3. Gene action and regulation; 4. The cell surface; 5. The extracellular environment; 7. The stability of determination and differentiation; 8. From embryo to adult; 9. Growth and form -- the consequences of differentiation; 10. Some model systems; 11. A final look at cell commitment Biologie moléculaire ram Cellules - Différenciation Cellules - Différenciation ram Cytologie du développement Cell Differentiation Cell determination Cell differentiation Cytogenetik (DE-588)4070176-1 gnd Entwicklungsphysiologie (DE-588)4152449-4 gnd Zelldifferenzierung (DE-588)4067536-1 gnd |
| subject_GND | (DE-588)4070176-1 (DE-588)4152449-4 (DE-588)4067536-1 |
| title | Cell commitment and differentiation |
| title_auth | Cell commitment and differentiation |
| title_exact_search | Cell commitment and differentiation |
| title_full | Cell commitment and differentiation Norman Maclean ; Brian K. Hall |
| title_fullStr | Cell commitment and differentiation Norman Maclean ; Brian K. Hall |
| title_full_unstemmed | Cell commitment and differentiation Norman Maclean ; Brian K. Hall |
| title_short | Cell commitment and differentiation |
| title_sort | cell commitment and differentiation |
| topic | Biologie moléculaire ram Cellules - Différenciation Cellules - Différenciation ram Cytologie du développement Cell Differentiation Cell determination Cell differentiation Cytogenetik (DE-588)4070176-1 gnd Entwicklungsphysiologie (DE-588)4152449-4 gnd Zelldifferenzierung (DE-588)4067536-1 gnd |
| topic_facet | Biologie moléculaire Cellules - Différenciation Cytologie du développement Cell Differentiation Cell determination Cell differentiation Cytogenetik Entwicklungsphysiologie Zelldifferenzierung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000443644&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT macleannorman cellcommitmentanddifferentiation AT hallbriankeith cellcommitmentanddifferentiation |