New insights into cell and membrane transport processes:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York [u.a.]
Plenum Press
1986
|
| Schriftenreihe: | New horizons in therapeutics
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XXI, 434 S. Ill. |
| ISBN: | 0306421836 |
Internformat
MARC
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| 245 | 1 | 0 | |a New insights into cell and membrane transport processes |c ed. by George Poste ... |
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Datensatz im Suchindex
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| adam_text | New Insights into
Cell and Membrane
Transport Processes
Edited by
GEORGE POSTE and
STANLEY T CROOKE
Smith Kline amp; French Laboratories
Philadelphia, Pennsylvania
PLENUM PRESS • NEW YORK AND LONDON
Contents
I Na+, K+, and H+ TRANSPORT
Chapter 1
Molecular Properties of Voltage-Sensitive Sodium Channels
William A Catterall
1 Introduction : 3
2 Physiological Properties of Sodium Channels 3
3 Neurotoxins as Molecular Probes of Sodium Channels 4
4 Identification of Protein Components of Sodium Channels
in Neurons 6
5 Molecular Size of the Sodium Channel 7
6 Protein Subunits of the Purified Sodium Channel 8
7 Reconstitution of Sodium Channel Function from
Purified Components 10
8 The Amino Acid Sequence of the Sodium Channel
as Inferred from cDNA Clones 16
References 19
H PROTON PUMPS AND ELECTROCHEMICAL GRADIENTS
Chapter 2
Studies of a Biological Energy Transducer: The lac Permease of
Escherichia coli
H R Kaback
1 Introduction 23
2 Morphology and Permeability of Proteoliposomes
Reconstituted with lac Permease 26
xii Contents
3 A Single Polypeptide is Required for Lactose Transport 27
4 Reconstitution of Active Transport in Proteoliposomes
Containing lac Permease and Cytochrome o Oxidase 28
5 Secondary Structure of lac Permease 29
6 Immunologic Reagents as Structure/Function Probes 32
7 Subunit Structure 34
8 Oligonucleotide-Directed Site-Specific Mutagenesis 35
References 36
s
Chapter 3
The Erythrocyre Anion-Exchange Protein: Primary Structure Deduced
from the cDNA Sequence and a Model for Its Arrangement within the
Plasma Membrane
Ron R Kopito and Harvey F Lodish
1 Overview 39
2 Introduction 39
3 Materials and Methods 42
3 1 Isolation of cDNA Clones and DNA Sequencing 42
3 2 Computer-Assisted DNA Sequence Analysis 42
3 3 Cell Culture 42
3 4 RNA Blot Hybridization 42
4 Results 43
4 1 Mouse and Human Band 3 Share Sequence Homology 43
4 2 Band 3 Has Three Structural Domains 45
4 3 Band 3 Expression Is Regulated during Differentiation
of MEL Cells 51
5 Discussion 51
5 1 Transmembrane Orientation of the
Band 3 Polypeptide 51
5 2 Location of the H2DIDS-Binding Lysines in Band 3 53
5 3 The Structure and Mechanism of the Anion-Exchange
Site 54
References 57
Chapter 4
The Lysosomal Proton Pump
P Harikumar and John P Reeves
1 Introduction 61
2 ATP-Dependent Acidification of Lysosomes 61
Contents xiii
3 Characteristics of the Lysosomal Proton Pump 63
3 1 Electrogenicity 65
3 2 Inhibitors 68
3 3 Nucleotide Specificity 69
4 Lysosome Vesicles 69
References 73
Chapter 5
Ion Pumps, Ion Pathways, Ion Sites
George Sachs, John Cuppoletti, Robert D Gunther, Jonathan Kaunitz,
John Mendlein, Edwin C Rabon, and Bjorn Wallmark
1 Introduction 75
2 The Lysosomal H + Pump 77
3 The H+Pump of Renal Medulla 79
4 Gastric H+-K+ ATPase 82
4 1 Resting Vesicles 82
4 2 Stimulated Vesicles 85
5 The Ca2 + Pump of Rough Endoplasmic Reticulum 87
6 Pharmacology of the H+-K+ ATPase 91
6 1 Potassium Site Antagonists 91
6 2 Sulfhydryl Reagents 92
References , 94
III CALCIUM CHANNELS AND THE CALCIUM PUMP
Chapter 6
Shifts between Modes of Calcium Channel Gating as a Basis for
Pharmacologic Modulation of Calcium Influx in Cardiac, Neuronal,
and Smooth-Muscle-Derived Cells
A P Fox, P Hess, J B Lansman, B Nilius, M C Nowycky,
andR W Tsien
1 Introduction - 99
2 Experimental Methods 100
xiv Contents
3 Large-Conductance Ca2+ Channels in a Smooth Muscle
Cell Line 101
4 Modal Activity and Bay K 8644 Response in A10 Cells
and Sensory Neurons 102
5 Graded Shifts in the Balance between Modes 105
6 Modes of Gating as a Framework for Describing
Modulatbry Effects 108
7 Nimodipine as an Example of Ca2+ Antagonists That
Stabilize Mode 0 110
8 p-Adrenergic Stimulation Promotes Mode 1 Rather than
Mode 2 113
9 Changes in Ca2+ Channel Inactivation with p-Adrenergic
Stimulation 116
10 How Similar are Large-Conductance Ca2+ Channels in
Various Cell Types? 118
11 Distinguishing Between L-Type Ca2+ Channels and Other
Types of Ca2+ Channels 118
12 Possible Differences among L-Type Ca2+Channels 119
13 Calcium-Agonist-Promoted Mode 2 Gating: A General
Property of L-Type Channels? 119
14 Questions about the Basis of Spontaneously Occurring Mode
2 Activity 120
15 Altered Balance between Modes of Channel Gating during p
Stimulation of Cardiac Ca2+ Channels 121
16 Comparison Between Up-Modulation by p Agonists and
Down-Modulation by Ca2+ Antagonists such as
Nimodipine 121
References 122
Chapter 7
Chemical Pharmacology ofCa2+ Channel Ligands
D J Triggle, A Skattelbol, D Rampe, A Joslyn, and P Gengo
1 Introduction 125
2 Specific Sites of Interaction for 1,4-Dihydropyridines 127
3 Topographic and Functional Relationship of Ligand-Binding
Sites to Ca2+ Channels 133
4 Regulation of Ligand-Binding Sites and Function at the
Calcium Channel 136
Contents xv
5 Conclusions and Prospective 139
References 140
Chapter 8
Information Flow in the Calcium Messenger System
Howard Rasmussen, Itaru Kojima, and Paula Barrett
1 Introduction 145
2 Calcium as Messenger 146
2 1 Calcium as Messenger during Sustained
Cellular Response 148
2 2 Autoregulation of Cytosolic Calcium Concentration 148
2 3 Sensitivity Modulation 149
3 Two-Branch Model of Cell Activation 150
4 Validation of the Two-Branch System 153
4 1 Phosphotidylinositide Turnover 153
4 2 Cellular Calcium Metabolism 154
4 3 Patterns of Protein Phosphorylation 155
5 Role of Ca2+ in the Operation of the C-Kinase Branch 156
5 1 Calcium and Activation of C-Kinase 157
5 2 Calcium and C-Kinase Turnover Rate 158
5 3 Temporal Integration of Response 160
6 General Applicability of the Model 161
6 1 Peptide Hormone Secretion 161
6 2 Smooth Muscle Contraction 162
7 Alternative Modalities of Gain Control 164
8 Set Point Control by cAMP 165
9 Membrane Ca2+ Cycling as a General Regulatory Device 168
References 169
Chapter 9
Neutrophil Activation, Polyphosphoinositide Hydrolysis, and the
Guanine Nucleotide Regulatory Proteins
Paul H Naccache and Ramadan I Sha afi
1 Introduction 175
2 Biochemical Events Associated with Cellular Activation 176
cvi Contents
3 Relevance of Polyphosphoinositide Hydrolysis to the
Activation of the Neutrophils 178
3 1 Effects of Chemotactic Factors on Polyphosphoinositide
Metabolism in the Neutrophils 178
3 2 Protein Kinase C and the Neutrophils 181
4 The Role of the Guanine-Nucleotide-Binding Regulatory
Proteins in Signal Transduction and Calcium Mobilization
in Neutrophils 186
5 Conclusions: A Model for Neutrophil Activation 189
References 192
IV INOSITOL LIPIDS AND THE CALCIUM-MEDIATED
CELLULAR RESPONSES
Chapter 10
Agonist-Dependent Phosphoinositide Metabolism:
A Bifurcating Signal Pathway
Michael J Berridge
1 Introduction 201
2 Formation of PIP2 203
3 Receptor Coupling of PIP2-Specific Phosphodiesterase:
Possible Role of a G Protein 205
4 Inositol Trisphosphate and DG Formation 207
5 Second Messenger Mode of Action 208
References 211
Chapter 11
Hormone-Induced Inositol Lipid Breakdown and Calcium-Mediated
Cellular Responses in Liver
John R Williamson, Suresh K Joseph, Kathleen E Coll,
Andrew P Thomas, Arthur Verhoeven, and Marc Prentki
1 Introduction 217
2 Inositol- 1,4,5-Trisphosphate as a Calcium-Mobilizing
Second Messenger 220
Contents xvii
3 Hormone Effects on Ca2+Fluxes 232
4 Summary 241
References 241
Chapter 12
Comparison of the Na+ Pump and the Ouabain-Resistant K+
Transport System with Other Metal Ion Transport ATPases
Leigh English, Benjamin White, and Lewis Cantley
1 Introduction 249
2 ATP-Dependent Metal Ion Pumps 250
3 Sodium Pump Structure 251
4 Ouabain-Resistant K+ Transport System 255
References 257
Chapter 13
Current Concepts of Tumor Promotion by Phorbol Esters and
Related Compounds
Catherine A O Brian, Rob M Liskamp, John P Arcoleo,
W -L Wendy Hsiao, Gerard M Housey,
and I Bernard Weinstein
1 The Two-Stage Model of Carcinogenesis 261
2 Cellular Effects of Phorbol Esters and
Membrane-Associated Receptors 262
3 Effects of Tumor Promoters on Protein Kinase C 263
4 Inhibition of Protein Kinase C by Tamoxifen 265
5 Substrates for Protein Kinase C 268
6 Compartmentalization of Protein Kinase C 269
7 Tumor Promotion, Growth Factors, and Oncogenes 270
8 Applied Aspects in Therapeutics 271
References 272
xviii Contents
V CELL POLARITY AND MEMBRANE TRANSPORT PROCESSES
Chapter 14
lntracellular Protein Topogenesis
Gu nter Blobel, Peter Walter, and Reid Gilmore
References 282
Chapter 15
Analysis of Epithelial Cell Surface Polarity Development with
Monoclonal Antibodies
George K Ojakian
1 Introduction 285
2 Monoclonal Antibodies against the MDCK Cell Surface 286
3 Cell Surface Distribution of Membrane Glycoproteins 287
4 Tight Junctions and the Development of Cell
Surface Polarity 291
5 Identification of Nephron-Segment-Specific Cell
Surface Proteins 295
6 High-Resistance MDCK Cells as a Model for the
Collecting Tubule 297
References 301
Chapter 16
Frequency and Time Domain Analysis of Epithelial
Transport Regulation
Simon A Lewis and John W Hanrahan
1 Introduction 305
2 Differentiating between Possible Mechanisms of
Transport Regulation 307
2 1 Impedence Analysis 307
Contents xix
2 2 Noise (Fluctuation) Analysis 309
2 3 Patch Clamp 311
3 Results Obtained from Frequency Domain Analysis 312
3 1 Membrane Area 312
3 2 Channel Density 318
3 3 Single-Channel Properties 320
4 Summary 323
References 323
Chapter 17
The Epithelial Sodium Channel
Lawrence G Palmer
1 Introduction 327
2 Description of the Na+ Channel 329
2 1 Single-Channel Conductance 329
2 2 Selectivity 329
2 3 Current-Voltage Relationship 332
2 4 The Outer Mouth of the Channel 332
2 5 The Inner Mouth of the Channel 337
2 6 Single Filing 338
3 Regulation of the Na+ Channel 338
3 1 Regulation by External Na+ 338
3 2 Regulation by Hormones 339
3 3 Other Factors 340
4 Conclusion 341
References 341
VI ENDOCYTOSIS AS A CELL TRANSPORT PATHWAY
Chapter 18
Uptake and Intracellular Processing of Cell Surface Receptors:
Current Concepts and Prospects
Colin R Hopkins
1 Introduction 347
2 Clathrin-Coated Pits 348
xx Contents
3 The Role of the Clathrin Lattice 348
4 Receptor Recycling 349
5 Formation and Longevity of Coated Pits 350
6 Uptake from the Fluid Phase 351
7 The Endosome Compartment 351
8 Selective Routing of Ligands and Receptors 353
9 The Internalization of Effector Ligands 355
10 Conclusions 356
References 356
Chapter 19
Sorting in the Prelysosomal Compartment (CURL): Immunoelectron
Microscopy of Receptors and Ligands
Hans J Geuze, Alan L Schwartz, Jan W Slot, Ger J Strous,
and Jos E Zijderhand-Bleekemolen
1 Introduction 361
2 Immunogold Detection of Receptors and Ligands 363
3 Ultrastructural Observations of Different
Receptor Systems 364
3 1 The Asialoglycoprotein Receptor 364
3 2 The Mannose-6-Phosphate Receptor 368
3 3 The Polymeric IgA Receptor 370
3 4 Colocalization of ASGP-R, MP-R, and IgA-R 371
4 Concluding Remarks 373
References 373
Chapter 20
Mechanisms of Molecular Sorting in Endosomes
Ira Mellman
1 Introduction 377
2 Endosome Ontogeny and Morphology 379
2 1 The Life History of Endosomes 379
2 2 Three-Dimensional Structure of Endosomes
and Lysosomes 380
Contents xxi
3 Acidification of Endosomes 382
3 1 The Endosome H + ATPase 383
3 2 Proton Translocation in Other Endocytic
and Secretary Organelles 384
3 3 Acidification-Defective Mutant Cell Lines 385
3 4 Endosome Acidification Mutants Also Exhibit Altered
Golgi Function 386
4 The Role of Endosome Acidity and Ligand Valency in Fc
Receptor Transport 387
4 1 The Structure and Function of the Mouse Macrophage
Fc Receptor 387
4 2 Ligand Valency and Fc Receptor Transport 389
4 3 The Role of Intravesicular pH in Fc
Receptor Transport 392
4 4 Mechanisms of Molecular Sorting 393
5 Biochemistry of Endosomes and Lysosomes 395
5 1 The Isolation and Characterization of Endosomes
and Lysosomes 395
5 2 Structure of the Lysosomal Membrane 396
References 399
Chapter 21
Transport of Protein Toxins across Cell Membranes
Simon Van Heyningen
1 Introduction 403
2 Toxins That Affect Protein Synthesis 405
2 1 Diphtheria Toxin 405
2 2 The Toxin from Pseudomonas aeruginosa 407
2 3 Abrin, Ricin, Viscumin, and Modeccia 408
2 4 Shigella Toxin 409
3 Toxins That Activate Adenylate Cyclase 409
3 1 Cholera Toxin 409
3 2 Other Toxins That Affect Adenylate Cyclase 415
4 Neurotoxins 416
4 1 Tetanus Toxin 416
4 2 Botulinus Toxin 418
5 Conclusion 418
References 418
Index 425
|
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| genre | (DE-588)1071861417 Konferenzschrift 1985 Philadelphia Pa. gnd-content Stoffstransport <Biologie> gnd |
| genre_facet | Konferenzschrift 1985 Philadelphia Pa. Stoffstransport <Biologie> |
| id | DE-604.BV000599267 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T15:16:22Z |
| institution | BVB |
| isbn | 0306421836 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-000372559 |
| oclc_num | 13526216 |
| open_access_boolean | |
| owner | DE-12 DE-91G DE-BY-TUM DE-355 DE-BY-UBR DE-20 DE-188 |
| owner_facet | DE-12 DE-91G DE-BY-TUM DE-355 DE-BY-UBR DE-20 DE-188 |
| physical | XXI, 434 S. Ill. |
| publishDate | 1986 |
| publishDateSearch | 1986 |
| publishDateSort | 1986 |
| publisher | Plenum Press |
| record_format | marc |
| series2 | New horizons in therapeutics |
| spelling | New insights into cell and membrane transport processes ed. by George Poste ... New York [u.a.] Plenum Press 1986 XXI, 434 S. Ill. txt rdacontent n rdamedia nc rdacarrier New horizons in therapeutics Biological Transport Biological transport Congresses Cell Membrane Permeability Cell membranes Congresses Membrantransport (DE-588)4038575-9 gnd rswk-swf Physiologie (DE-588)4045981-0 gnd rswk-swf Stofftransport Biologie (DE-588)4443397-9 gnd rswk-swf Zelle (DE-588)4067537-3 gnd rswk-swf (DE-588)1071861417 Konferenzschrift 1985 Philadelphia Pa. gnd-content Stoffstransport <Biologie> gnd rswk-swf Stofftransport Biologie (DE-588)4443397-9 s Zelle (DE-588)4067537-3 s Physiologie (DE-588)4045981-0 s DE-604 Membrantransport (DE-588)4038575-9 s Stoffstransport <Biologie> f Poste, George Sonstige oth HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000372559&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | New insights into cell and membrane transport processes Biological Transport Biological transport Congresses Cell Membrane Permeability Cell membranes Congresses Membrantransport (DE-588)4038575-9 gnd Physiologie (DE-588)4045981-0 gnd Stofftransport Biologie (DE-588)4443397-9 gnd Zelle (DE-588)4067537-3 gnd |
| subject_GND | (DE-588)4038575-9 (DE-588)4045981-0 (DE-588)4443397-9 (DE-588)4067537-3 (DE-588)1071861417 |
| title | New insights into cell and membrane transport processes |
| title_auth | New insights into cell and membrane transport processes |
| title_exact_search | New insights into cell and membrane transport processes |
| title_full | New insights into cell and membrane transport processes ed. by George Poste ... |
| title_fullStr | New insights into cell and membrane transport processes ed. by George Poste ... |
| title_full_unstemmed | New insights into cell and membrane transport processes ed. by George Poste ... |
| title_short | New insights into cell and membrane transport processes |
| title_sort | new insights into cell and membrane transport processes |
| topic | Biological Transport Biological transport Congresses Cell Membrane Permeability Cell membranes Congresses Membrantransport (DE-588)4038575-9 gnd Physiologie (DE-588)4045981-0 gnd Stofftransport Biologie (DE-588)4443397-9 gnd Zelle (DE-588)4067537-3 gnd |
| topic_facet | Biological Transport Biological transport Congresses Cell Membrane Permeability Cell membranes Congresses Membrantransport Physiologie Stofftransport Biologie Zelle Konferenzschrift 1985 Philadelphia Pa. Stoffstransport <Biologie> |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000372559&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT postegeorge newinsightsintocellandmembranetransportprocesses |