Cell and molecular biology of the cytoskeleton:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York u.a.
plenum Pr.
1986
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XIV, 340 S. Ill. |
| ISBN: | 0306421755 |
Internformat
MARC
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| 245 | 1 | 0 | |a Cell and molecular biology of the cytoskeleton |c ed. by Jerry W. Shay |
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| 300 | |a XIV, 340 S. |b Ill. | ||
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Datensatz im Suchindex
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|---|---|
| adam_text | CELL and
MOLECULAR
BIOLOGY of the
CYTOSKELETON
Edited by
Jerry W Shay
University of Texas Health Science Center
Dallas, Texas
PLENUM PRESS • NEW YORK AND LONDON
Contents
Chapter 1
Probing the Cytoskeleton by Microinjection
Brigitte M Jockusch, Annette Fiichtbauer, Christiane Wiegand,
and Bernd Honer
1 Introduction 1
2 The Microtubule System 2
2 1 Analyzing the Equilibrium between Tubulin and
Microtubules 2
2 2 Studying Microtubular Dynamics 3
2 3 Analyzing Microtubule-Bound Organelle Transport 5
2 4 Introducing Antitubulins 6
3 The Microfilament-System 9
3 1 Studying Actin Dynamics 9
3 2 Studying the Dynamics of Actin-Associated Proteins 13
3 3 Reorganizing Microfilament Patterns by Introducing
Structural Proteins 14
3 4 Introducing Phalloidin 19
3 5 Using Antibodies against Microfilament Proteins 20
4 The Intermediate Filament System 27
4 1 Introducing Antibodies 27
4 2 Introducing mRNA 29
5 The Coated Vesicle System 29
6 Conclusion 30
References 32
ix
X Contents
Chapter 2
Structural Aspects of Intermediate Filaments
Norbert Geisler and Klaus Weber
1 Introduction 41
2 Domain Organization of IF Proteins 42
3 Neurofilaments 46
4 Organization of the Sequences along the Rod Domain 48
5 Comparison of the Six Nonepithelial Proteins along the Rod
Domain 49
6 Structural Characterization of the Rod 51
7 From the Rodlike Protofilament to the 10-nm Filament 53
8 Structure and Function of the Terminal Domains in IF Proteins 58
8 1 The Involvement of Headpieces in Filament Formation 58
8 2 Structural Characterization of the Tailpieces 60
8 3 Are the Carboxyterminal Tailpieces Appendages
Communicating between Stiff Filaments and the
Cytoplasm? 62
9 Addendum 64
References 64
Chapter 3
The Structure and Evolution of Intermediate Filament Genes
Dennis R Roop and Peter M Steinert
1 Introduction 69
1 1 Correlation of Keratin Gene Expression with Differentiation
State 70
1 2 Correlation of Keratin Subunit Structure with Differential
Expression 71
2 Structure of Intermediate Filament Genes 73
3 A Model for the Evolution of Intermediate Filament Genes 75
3 1 Evolution of the Rod Domains of Intermediate Filament
Genes 75
3 2 Evolution of the End Domains 78
4 Conclusion 81
References 81
Chapter 4
Differential Expression of the Genes Encoding the Keratins of
Cultured Human Epidermal Cells
Elaine Fuchs, Douglas Marchuk, and Angela Tyner
1 Introduction 85
2 The Structure of the 8-nm Keratin Filaments of Epidermis 86
Contents xi
3 The Genes Encoding the Human Epidermal Keratins 94
4 Structure of the Two Types of Keratin Genes and Their Relation
to Other Intermediate-Filament Genes 97
5 Regulation of the Type I and Type II Keratin Genes 100
References 103
Chapter 5
Organization and Expression of the Vimentin and Desmin Genes
Wim Quax and Hans Bloemendal
1 The Discovery of Intermediate Filaments 109
2 The Diversity of IF Subunits 110
3 The Genes Encoding IF 114
4 Expression of the Cloned Desmin Gene 118
4 1 In Lens Cells 118
4 2 Expression of the Hamster Desmin Gene in Human
Epithelial (HeLa) Cells 121
5 Chromosome Localization of the Human Vimentin and Desmin
Gene 125
References 127
Chapter 6
Actin: A Regulator of Cell Growth and Differentiation
Stephen R Farmer
1 Introduction 131
2 Cell Morphology and Growth and Differentiation 131
2 1 Cell Configuration 131
• 2 2 Cytoskeletal Organization 133
3 Regulation of Actin Gene Expression 135
4 Is Actin a Protooncogene? 141
5 Mechanisms by Which Actin May Regulate Cell Growth and
Differentiation 143
References 146
Chapter 7
The Actin Genes in Caenorhabditis elegans
Michael Krause and David Hirsh
1 Introduction 151
2 Genomic Organization 152
3 Sequence Analysis 153
4 Transcription 158
xii Contents
5 Translational Products 163
6 Identification of Actin Mutants 165
7 Actin Gene Organization in Revertants of Actin Mutants 167
8 Transcription in Revertants 169
9 Future Prospects 175
References 176
Chapter 8
Implications of Microtubule Polarity for Microtubule Function
Ursula Eutenetier
1 Introduction 179
2 Background and Methods for Determining MT Polarity 179
3 MT Polarity and Spindle Function 187
4 MT Polarity and Intracellular Motility 193
References 196
Chapter 9
Molecular Mechanisms Controlling Tubulin Synthesis
Don W Cleveland
1 Introduction 203
2 Apparent Autoregulatory Control of Tubulin Synthesis in Animal
Cells 204
2 1 Tubulin Synthesis in Animal Cells Is Sensitive to the
Apparent Pool of Unpolymerized Subunits 204
2 2 Possible Molecular Levels for Regulating Tubulin Synthetic
Rates 207
2 3 Transient Induction of Tubulin Synthesis by Interferon 213
3 Programmed Synthesis of Tubulin during Flagellar Growth in
Unicellular Organisms 213
3 1 Regulated Synthesis of Tubulin Achieved through a
Combination of Transcriptional Control and mRNA
Stability in Chlamydomonas 214
3 2 Identification of Candidate DNA Sequences That Mediate
Tubulin Regulation in Chlamydomonas • 218
3 3 The Paradigm of Tubulin Regulation in Naegleria 219
3 4 Altered Tubulin Regulation in the Life Form Switch of the
Parasitic Protozoa Leishmania 219
4 Programmed Synthesis of Tubulin during the Cell Cycle 220
4 1 The Synchronous Cell Cycle of Physarum 220
4 2 Cell Cycle Regulation in Other Eukaryotes 221
5 Summary 222
References 223
Contents xiii
Chapter 10
Regulation of Tubulin Expression in Brain
Marcelle R Morrison and W Sue T Griffin
1 Introduction ! 227
2 Tubulin Proteins 228
2 1 Different Isoforms of a-and |3-Tubulins 228
2 2 Differential Localization of Brain a-and (3-Tubulin
Isoforms 229
2 3 Evidence for Posttranslational Modification 231
2 4 Developmental Regulation of Tubulin Isoforms 232
3 Tubulin Genes in Higher Eukaryotes 234
3 1 a-Tubulin Genes 234
3 2 (3-Tubulin Genes 234
4 Expression of a-Tubulin mRNAs 235
4 1 In Vitro Translation Products of a-Tubulin mRNAs 235
4 2 Hybridization Analysis of Different a-Tubulin mRNAs 235
5 Expression of (3-Tubulin mRNAs 237
5 1 In Vitro Translation Products of (3-Tubulin mRNAs 237
5 2 Hybridization Analysis of (3-Tubulin mRNAs 240
5 3 In Situ Hybridization of Chick (32-Tubulin cDNA in Rat
Cerebellum 244
6 Conclusions 245
References 251
Chapter 11
Tubulins from Plants, Fungi, and Protists: A Review
Louis C Morejohn and Donald E Fosket
1 Introduction: Scope and Objectives 257
2 Isolation and Identification of Tubulin 258
2 1 Assays for Tubulin 259
2 2 Ion-Exchange Chromatography 260
2 3 Drug Affinity Methods 262
2 4 Microtubule Polymerization and Depolymerization 263
2 5 Copolymerization with Heterologous Tubulins 265
2 6 Tubulin-Rich Organelles 265
2 7 Technical Problems • 268
3 Tubulin Dimer Structure 271
3 1 Amino Acid Sequences 271
3 2 Electrophoretic Resolution of a and (3 Subunits 275
3 3 Peptide Mapping Patterns 279
3 4 Immunology 282
3 5 Subunit Microheterogeneity 284
3 6 Posttranslational Modifications 287
xiv Contents
3 7 Multiple Tubulin Genes 290
3 8 Membrane-Associated Tubulin 292
4 Antimicrotubule Drugs 293
4 1 Colchicine Effects in Vivo 294
4 2 Colchicine Effects in Vitro 296
4 3 Antimicrotubule Herbicides 300
4 4 Benzimidazole Derivatives 304
4 5 Taxol 306
4 6 Other Agents 309
5 Summary and Future Directions 309
References 311
Index 331
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| isbn | 0306421755 |
| language | English |
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| spelling | Cell and molecular biology of the cytoskeleton ed. by Jerry W. Shay New York u.a. plenum Pr. 1986 XIV, 340 S. Ill. txt rdacontent n rdamedia nc rdacarrier Cytosquelette Cytoskeleton Molekularbiologie (DE-588)4039983-7 gnd rswk-swf Zellskelett (DE-588)4121944-2 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Zellskelett (DE-588)4121944-2 s Molekularbiologie (DE-588)4039983-7 s DE-604 Shay, Jerry W. Sonstige oth HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000342471&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
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| subject_GND | (DE-588)4039983-7 (DE-588)4121944-2 (DE-588)4143413-4 |
| title | Cell and molecular biology of the cytoskeleton |
| title_auth | Cell and molecular biology of the cytoskeleton |
| title_exact_search | Cell and molecular biology of the cytoskeleton |
| title_full | Cell and molecular biology of the cytoskeleton ed. by Jerry W. Shay |
| title_fullStr | Cell and molecular biology of the cytoskeleton ed. by Jerry W. Shay |
| title_full_unstemmed | Cell and molecular biology of the cytoskeleton ed. by Jerry W. Shay |
| title_short | Cell and molecular biology of the cytoskeleton |
| title_sort | cell and molecular biology of the cytoskeleton |
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| topic_facet | Cytosquelette Cytoskeleton Molekularbiologie Zellskelett Aufsatzsammlung |
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