Chemistry and toxicology of pyrrolizidine alkaloids:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
London u.a.
Acad. Pr.
1986
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | X, 393 S. |
| ISBN: | 0124805701 |
Internformat
MARC
| LEADER | 00000nam a2200000 c 4500 | ||
|---|---|---|---|
| 001 | BV000480802 | ||
| 003 | DE-604 | ||
| 005 | 00000000000000.0 | ||
| 007 | t | ||
| 008 | 870612s1986 |||| 00||| eng d | ||
| 020 | |a 0124805701 |9 0-12-480570-1 | ||
| 035 | |a (OCoLC)12419056 | ||
| 035 | |a (DE-599)BVBBV000480802 | ||
| 040 | |a DE-604 |b ger |e rakddb | ||
| 041 | 0 | |a eng | |
| 049 | |a DE-12 |a DE-355 |a DE-703 |a DE-29T |a DE-Er8 |a DE-19 | ||
| 050 | 0 | |a QP801.P855 | |
| 050 | 0 | |a RA1242.P9 | |
| 082 | 0 | |a 615.9/5 |2 19 | |
| 084 | |a VK 8620 |0 (DE-625)147544:253 |2 rvk | ||
| 084 | |a VW 5300 |0 (DE-625)147765:253 |2 rvk | ||
| 100 | 1 | |a Mattocks, A. R. |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Chemistry and toxicology of pyrrolizidine alkaloids |
| 264 | 1 | |a London u.a. |b Acad. Pr. |c 1986 | |
| 300 | |a X, 393 S. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 2 | |a Alcaloïde pyrrolizidine - toxicité | |
| 650 | 4 | |a Pyrrolizidines | |
| 650 | 4 | |a Pyrrolizidines - Toxicologie | |
| 650 | 4 | |a Pyrrolizidine Alkaloids | |
| 650 | 4 | |a Pyrrolizidine Alkaloids |x toxicity | |
| 650 | 4 | |a Pyrrolizidines | |
| 650 | 4 | |a Pyrrolizidines |x Toxicology | |
| 650 | 0 | 7 | |a Greiskraut |g Gattung |0 (DE-588)4158134-9 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Pyrrolizidinderivate |0 (DE-588)4176533-3 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Pyrrolizidinalkaloide |0 (DE-588)4369901-7 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Toxikologie |0 (DE-588)4060538-3 |2 gnd |9 rswk-swf |
| 689 | 0 | 0 | |a Greiskraut |g Gattung |0 (DE-588)4158134-9 |D s |
| 689 | 0 | 1 | |a Pyrrolizidinalkaloide |0 (DE-588)4369901-7 |D s |
| 689 | 0 | |5 DE-604 | |
| 689 | 1 | 0 | |a Greiskraut |g Gattung |0 (DE-588)4158134-9 |D s |
| 689 | 1 | 1 | |a Pyrrolizidinalkaloide |0 (DE-588)4369901-7 |D s |
| 689 | 1 | 2 | |a Toxikologie |0 (DE-588)4060538-3 |D s |
| 689 | 1 | |5 DE-604 | |
| 689 | 2 | 0 | |a Pyrrolizidinderivate |0 (DE-588)4176533-3 |D s |
| 689 | 2 | |5 DE-604 | |
| 856 | 4 | 2 | |m GBV Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000296770&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-000296770 | ||
Datensatz im Suchindex
| _version_ | 1804114934106161152 |
|---|---|
| adam_text | CHEMISTRY AND TOXICOLOGY OF PYRROLIZIDINE ALKALOIDS A. R. MATTOCKS
TOXICOLOGY UNIT MEDICAL RESEARCH COUNCIL LABORATORIES CARSHALTON,
SURREY, UNITED KINGDOM 1986 ACADEMIC PRESS HARCOURT BRACE JOVANOVICH,
PUBLISHERS LONDON ORLANDO SAN DIEGO NEW YORK AUSTIN MONTREAL SYDNEY
TOKYO TORONTO CONTENTS PREFACE IX 1 STRUCTURES AND PLANT SOURCES OF
PYRROLIZIDINE ALKALOIDS I. INTRODUCTION 1 II. PLANT SOURCES AND
STRUCTURES 1 III. PYRROLIZIDINE BASES 10 IV. NECIC ACIDS 12 V.
NOMENCLATURE 12 VI. BIOSYNTHESIS 14 2 EXTRACTION, SEPARATION AND
ANALYSIS OF PYRROLIZIDINE ALKALOIDS I. INTRODUCTION 40 II. STABILITY OF
THE ALKALOIDS 41 III. EXTRACTION OF ALKALOIDS 42 IV. SEPARATION AND
PURIFICATION METHODS 46 V. DETECTION AND ESTIMATION OF PYRROLIZIDINE
ALKALOIDS AND THEIR METABOLITES 55 3 SYNTHESES OF NECINES, PYRROLIZIDINE
ALKALOIDS AND ANALOGUES AND PYRROLIC DERIVATIVES I. INTRODUCTION )....
62 II. SYNTHESES OF NECINES . 62 III. SYNTHESES OF NECIC ACIDS 69 IV.
SYNTHESES OF ESTER PAS AND OTHER NECINE ESTERS 69 V. OTHER SEMISYNTHETIC
PA DERIVATIVES AND ANALOGUES 78 VI. DEHYDRO-PYRROLIZIDINE ALKALOIDS AND
ANALOGUES 79 VII. RADIOACTIVE LABELLING 85 4 PHYSICAL PROPERTIES AND
SPECTROSCOPY OF PYRROLIZIDINE ALKALOIDS AND RELATED COMPOUNDS I.
INTRODUCTION 89 II. PHYSICAL CHARACTERISTICS OF PAS AND DERIVATIVES 89 V
VI CONTENTS III. OTHER PHYSICAL PROPERTIES 90 IV. SPECTROSCOPY 113 5
CHEMICAL PROPERTIES OF PYRROLIZIDINE ALKALOIDS AND THEIR
DEHYDRO-DERIVATIVES I. INTRODUCTION 130 II. CHEMISTRY OF PAS 131 III.
CHEMISTRY OF DEHYDRO-NECINES, DEHYDRO-PAS AND ANALOGOUS PYRROLES 143 6
METABOLISM, DISTRIBUTION AND EXCRETION OF PYRROLIZIDINE ALKALOIDS I.
METABOLISM AND THE CYTOTOXICITY OF PAS 158 II. METABOLIC PATHWAYS OF
HEPATOTOXIC PAS IN ANIMAL TISSUES 159 III. METABOLISM OF PA AT-OXIDES
172 IV. METABOLISM OF NON-HEPATOTOXIC PAS AND NECINES 172 V. PYRROLES AS
TOXIC METABOLITES 174 VI. TISSUE DISTRIBUTION AND EXCRETION 183 VII. PAS
AND THEIR METABOLITES IN INSECTS 189 7 TOXICOLOGY OF PYRROLIZIDINE
ALKALOIDS IN ANIMALS I. INTRODUCTION 191 II. TOXIC ACTIONS IN LABORATORY
ANIMALS 192 III. TOXICITY OF PAS IN LIVESTOCK 213 8 FURTHER TOXIC AND
OTHER BIOLOGICAL ACTIONS OF PYRROLIZIDINE ALKALOIDS, ANALOGUES AND
METABOLITES I. TOXICITY OF SEMISYNTHETIC PAS AND SYNTHETIC ANALOGUES 220
II. TOXIC ACTIONS OF PYRROLIC METABOLITES OF PAS AND ANALOGOUS COMPOUNDS
224 III. TOXICITY OF PAS AND PYRROLES TOWARDS THE LUNGS AND HEART 230
IV. BIOCHEMICAL EFFECTS OF PAS 243 V. PHARMACOLOGY OF PAS . . 246 VI.
OTHER BIOLOGICAL ACTIONS 246 9 EFFECTS OF PYRROLIZIDINE ALKALOIDS IN
HUMANS I. SOURCES OF HUMAN EXPOSURE TO PYRROLIZIDINE ALKALOIDS .. 250
II. HUMAN POISONING BY PAS 258 III. RISKS TO PEOPLE FROM EXPOSURE TO PAS
266 CONTENTS VII 10 MUTAGENIC, ANTIMITOTIC AND OTHER CELL-DAMAGING
EFFECTS OF PYRROLIZIDINE ALKALOIDS, PYRROLIC DERIVATIVES AND ANALOGUES
I. MUTAGENIC AND CLASTOGENIC ACTIVITY 272 II. ANTIMITOTIC ACTIVITY 281
11 CARCINOGENICITY AND ANTITUMOUR ACTIVITY OF PYRROLIZIDINE ALKALOIDS
AND PLANTS CONTAINING THEM I. GENERAL INTRODUCTION 290 II.
CARCINOGENICITY 291 III. ANTITUMOUR ACTIVITY OF PYRROLIZIDINE ALKALOIDS,
DERIVATIVES AND ANALOGUES 310 12 RELATIONSHIPS BETWEEN STRUCTURE,
METABOLISM AND TOXICITY I. INTRODUCTION 316 II. ESSENTIAL FEATURES OF
CYTOTOXIC PAS AND METABOLITES .... 317 III. METABOLIC ACTIVATION AND
DETOXIFICATION 318 IV. FACTORS DETERMINING TOXICITY 320 V. CONCLUDING
REMARKS 328 REFERENCES 32 9 INDEX 369
|
| any_adam_object | 1 |
| author | Mattocks, A. R. |
| author_facet | Mattocks, A. R. |
| author_role | aut |
| author_sort | Mattocks, A. R. |
| author_variant | a r m ar arm |
| building | Verbundindex |
| bvnumber | BV000480802 |
| callnumber-first | Q - Science |
| callnumber-label | QP801 |
| callnumber-raw | QP801.P855 RA1242.P9 |
| callnumber-search | QP801.P855 RA1242.P9 |
| callnumber-sort | QP 3801 P855 |
| callnumber-subject | QP - Physiology |
| classification_rvk | VK 8620 VW 5300 |
| ctrlnum | (OCoLC)12419056 (DE-599)BVBBV000480802 |
| dewey-full | 615.9/5 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 615 - Pharmacology and therapeutics |
| dewey-raw | 615.9/5 |
| dewey-search | 615.9/5 |
| dewey-sort | 3615.9 15 |
| dewey-tens | 610 - Medicine and health |
| discipline | Chemie / Pharmazie Medizin |
| format | Book |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>02132nam a2200565 c 4500</leader><controlfield tag="001">BV000480802</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">00000000000000.0</controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">870612s1986 |||| 00||| eng d</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">0124805701</subfield><subfield code="9">0-12-480570-1</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)12419056</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV000480802</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rakddb</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-12</subfield><subfield code="a">DE-355</subfield><subfield code="a">DE-703</subfield><subfield code="a">DE-29T</subfield><subfield code="a">DE-Er8</subfield><subfield code="a">DE-19</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">QP801.P855</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RA1242.P9</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">615.9/5</subfield><subfield code="2">19</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">VK 8620</subfield><subfield code="0">(DE-625)147544:253</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">VW 5300</subfield><subfield code="0">(DE-625)147765:253</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Mattocks, A. R.</subfield><subfield code="e">Verfasser</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Chemistry and toxicology of pyrrolizidine alkaloids</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">London u.a.</subfield><subfield code="b">Acad. Pr.</subfield><subfield code="c">1986</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">X, 393 S.</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="650" ind1=" " ind2="2"><subfield code="a">Alcaloïde pyrrolizidine - toxicité</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Pyrrolizidines</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Pyrrolizidines - Toxicologie</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Pyrrolizidine Alkaloids</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Pyrrolizidine Alkaloids</subfield><subfield code="x">toxicity</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Pyrrolizidines</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Pyrrolizidines</subfield><subfield code="x">Toxicology</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Greiskraut</subfield><subfield code="g">Gattung</subfield><subfield code="0">(DE-588)4158134-9</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Pyrrolizidinderivate</subfield><subfield code="0">(DE-588)4176533-3</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Pyrrolizidinalkaloide</subfield><subfield code="0">(DE-588)4369901-7</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Toxikologie</subfield><subfield code="0">(DE-588)4060538-3</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">Greiskraut</subfield><subfield code="g">Gattung</subfield><subfield code="0">(DE-588)4158134-9</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="1"><subfield code="a">Pyrrolizidinalkaloide</subfield><subfield code="0">(DE-588)4369901-7</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="689" ind1="1" ind2="0"><subfield code="a">Greiskraut</subfield><subfield code="g">Gattung</subfield><subfield code="0">(DE-588)4158134-9</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="1" ind2="1"><subfield code="a">Pyrrolizidinalkaloide</subfield><subfield code="0">(DE-588)4369901-7</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="1" ind2="2"><subfield code="a">Toxikologie</subfield><subfield code="0">(DE-588)4060538-3</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="1" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="689" ind1="2" ind2="0"><subfield code="a">Pyrrolizidinderivate</subfield><subfield code="0">(DE-588)4176533-3</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="2" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">GBV Datenaustausch</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000296770&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-000296770</subfield></datafield></record></collection> |
| id | DE-604.BV000480802 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-09T15:14:36Z |
| institution | BVB |
| isbn | 0124805701 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-000296770 |
| oclc_num | 12419056 |
| open_access_boolean | |
| owner | DE-12 DE-355 DE-BY-UBR DE-703 DE-29T DE-Er8 DE-19 DE-BY-UBM |
| owner_facet | DE-12 DE-355 DE-BY-UBR DE-703 DE-29T DE-Er8 DE-19 DE-BY-UBM |
| physical | X, 393 S. |
| publishDate | 1986 |
| publishDateSearch | 1986 |
| publishDateSort | 1986 |
| publisher | Acad. Pr. |
| record_format | marc |
| spelling | Mattocks, A. R. Verfasser aut Chemistry and toxicology of pyrrolizidine alkaloids London u.a. Acad. Pr. 1986 X, 393 S. txt rdacontent n rdamedia nc rdacarrier Alcaloïde pyrrolizidine - toxicité Pyrrolizidines Pyrrolizidines - Toxicologie Pyrrolizidine Alkaloids Pyrrolizidine Alkaloids toxicity Pyrrolizidines Toxicology Greiskraut Gattung (DE-588)4158134-9 gnd rswk-swf Pyrrolizidinderivate (DE-588)4176533-3 gnd rswk-swf Pyrrolizidinalkaloide (DE-588)4369901-7 gnd rswk-swf Toxikologie (DE-588)4060538-3 gnd rswk-swf Greiskraut Gattung (DE-588)4158134-9 s Pyrrolizidinalkaloide (DE-588)4369901-7 s DE-604 Toxikologie (DE-588)4060538-3 s Pyrrolizidinderivate (DE-588)4176533-3 s GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000296770&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Mattocks, A. R. Chemistry and toxicology of pyrrolizidine alkaloids Alcaloïde pyrrolizidine - toxicité Pyrrolizidines Pyrrolizidines - Toxicologie Pyrrolizidine Alkaloids Pyrrolizidine Alkaloids toxicity Pyrrolizidines Toxicology Greiskraut Gattung (DE-588)4158134-9 gnd Pyrrolizidinderivate (DE-588)4176533-3 gnd Pyrrolizidinalkaloide (DE-588)4369901-7 gnd Toxikologie (DE-588)4060538-3 gnd |
| subject_GND | (DE-588)4158134-9 (DE-588)4176533-3 (DE-588)4369901-7 (DE-588)4060538-3 |
| title | Chemistry and toxicology of pyrrolizidine alkaloids |
| title_auth | Chemistry and toxicology of pyrrolizidine alkaloids |
| title_exact_search | Chemistry and toxicology of pyrrolizidine alkaloids |
| title_full | Chemistry and toxicology of pyrrolizidine alkaloids |
| title_fullStr | Chemistry and toxicology of pyrrolizidine alkaloids |
| title_full_unstemmed | Chemistry and toxicology of pyrrolizidine alkaloids |
| title_short | Chemistry and toxicology of pyrrolizidine alkaloids |
| title_sort | chemistry and toxicology of pyrrolizidine alkaloids |
| topic | Alcaloïde pyrrolizidine - toxicité Pyrrolizidines Pyrrolizidines - Toxicologie Pyrrolizidine Alkaloids Pyrrolizidine Alkaloids toxicity Pyrrolizidines Toxicology Greiskraut Gattung (DE-588)4158134-9 gnd Pyrrolizidinderivate (DE-588)4176533-3 gnd Pyrrolizidinalkaloide (DE-588)4369901-7 gnd Toxikologie (DE-588)4060538-3 gnd |
| topic_facet | Alcaloïde pyrrolizidine - toxicité Pyrrolizidines Pyrrolizidines - Toxicologie Pyrrolizidine Alkaloids Pyrrolizidine Alkaloids toxicity Pyrrolizidines Toxicology Greiskraut Gattung Pyrrolizidinderivate Pyrrolizidinalkaloide Toxikologie |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000296770&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT mattocksar chemistryandtoxicologyofpyrrolizidinealkaloids |