Clinical aspects of endotoxin shock:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Amsterdam u.a.
Elsevier
1986
|
| Schriftenreihe: | Handbook of endotoxin
4 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XVI, 274 S. Ill. |
| ISBN: | 0444903909 |
Internformat
MARC
| LEADER | 00000nam a2200000 cb4500 | ||
|---|---|---|---|
| 001 | BV000466354 | ||
| 003 | DE-604 | ||
| 005 | 00000000000000.0 | ||
| 007 | t | ||
| 008 | 870612s1986 a||| |||| 00||| eng d | ||
| 020 | |a 0444903909 |9 0-444-90390-9 | ||
| 035 | |a (OCoLC)12975610 | ||
| 035 | |a (DE-599)BVBBV000466354 | ||
| 040 | |a DE-604 |b ger |e rakddb | ||
| 041 | 0 | |a eng | |
| 049 | |a DE-12 |a DE-19 |a DE-29 |a DE-188 | ||
| 050 | 0 | |a RC182.S4 | |
| 082 | 0 | |a 615.9/5299 |2 19 | |
| 245 | 1 | 0 | |a Clinical aspects of endotoxin shock |c ed.: R. A. Proctor |
| 264 | 1 | |a Amsterdam u.a. |b Elsevier |c 1986 | |
| 300 | |a XVI, 274 S. |b Ill. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Handbook of endotoxin |v 4 | |
| 650 | 4 | |a Choc infectieux | |
| 650 | 4 | |a Endotoxines - Effets physiologiques | |
| 650 | 4 | |a Endotoxins | |
| 650 | 4 | |a Endotoxins |x Physiological effect | |
| 650 | 4 | |a Septic shock | |
| 650 | 4 | |a Shock, Septic | |
| 650 | 0 | 7 | |a Endotoxinschock |0 (DE-588)4152196-1 |2 gnd |9 rswk-swf |
| 689 | 0 | 0 | |a Endotoxinschock |0 (DE-588)4152196-1 |D s |
| 689 | 0 | |5 DE-604 | |
| 700 | 1 | |a Proctor, Richard A. |e Sonstige |4 oth | |
| 830 | 0 | |a Handbook of endotoxin |v 4 |w (DE-604)BV000018178 |9 4 | |
| 856 | 4 | 2 | |m HEBIS Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000287359&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-000287359 | ||
Datensatz im Suchindex
| _version_ | 1804114919529906176 |
|---|---|
| adam_text | Handbook of Endotoxin
Series Editor: R A PROCTOR
VOLUME 4
Clinical Aspects of
Endotoxin Shock
Editor:
R A PROCTOR
University of Wisconsin Medical School,
Madison, Wisconsin, U S A
ELSEVIER
Amsterdam - New York - Oxford
Contents
Introduction
Chapter 1
Pathophysiology of endotoxin shock in man
D J Hale, J A Robinson, H S Loeb and R M Gunnar
1 Introduction 1
2 Clinical features 2
2 1 Epidemiology 2
2 2 Signs and symptoms of gram-negative shock 3
3 Hemodynamics of gram-negative shock 4
3 1 Systemic vascular resistance 4
3 2 Myocardial dysfunction 9
4 Miscellaneous pathophysiologic aspects of gram-negative shock 11
4 1 Acute respiratory distress 11
4 2 Disseminated intravascular coagulation 12
4 3 Arteriovenous shunting 13
5 Recent development in gram-negative shock 13
5 1 Endorphins 13
5 2 Endotoxin antibodies 13
6 Summary 14
References 15
Chapter 2
Pathologic manifestations of septic shock
L T Archer
1 Definitions of shock 18
2 History of animal models: endotoxin versus live organisms 18
3 Hemodynamic alterations 20
3 1 Overview 20
3 2 Myocardial dysfunction 20
vii
Contents
3 3 Classification of septic shock on the basis of hemodynamic
criteria
Animal species used in septic shock models
4 1 Clinical correlates of dog and baboon models
4 2 Therapy for lethal septic shock in the dog and baboon
4 3 Morphological evaluation in the baboon
Perfusion deficits contributing to tissue lesions
Tissue lesions
Specific organ distribution of lesions: a comparison of man,
baboon and dog
7 1 Adrenal glands
7 2 Liver
7 3 Kidneys
7 4 Lungs
7 5 Intestine
7 6 Heart
7 7 Brain
Prevention or reduction of morphologic lesions by methyl
prednisolone sodium succinate plus gentamicin sulfate (MPSS/GS)
8 1 Adrenal glands
8 2 Liver
8 3 Kidneys
8 4 Lungs
Clinical relevance of findings from studies in baboons
Summary
Acknowledgements
References
Chapter 3
Endotoxin shock in man caused by gram-negative bacilli - etiology,
clinical features, diagnosis, natural history and prevention
R J Hamill and D G Maki
1 Background and definitions 55
1 1 Definitions 56
1 2 History 59
2 Clinical features of gram-negative sepsis and endotoxic shock 62
viii
Contents
3 Laboratory diagnosis of gram-negative sepsis 66
3 1 Diagnosis of local gram-negative infections 66
3 2 Laboratory diagnosis of bacteremia 67
4 Sources of sepsis and microorganisms associated with
gram-negative endotoxic shock 73
4 1 Risk factors for gram-negative sepsis and endotoxic shock 73
4 2 Sources of gram-negative bacteremia and endotoxic shock 79
4 3 Microbiology of gram-negative bacteremia 92
4 4 Epidemic nosocomial bacteremias 94
5 Magnitude and secular trends of gram-negative bacteremia 99
5 1 Bacteremias occurring endemically 99
5 2 Epidemic nosocomial bacteremias 101
6 Natural history of gram-negative sepsis and risk factors for death 104
6 1 Risk factors for a fatal outcome 104
6 2 Management of gram-negative sepsis 106
6 3 The future 108
7 Prevention of gram-negative bacteremia 108
8 Summary 111
References 114
Chapter 4
Clinical applications of the Limulus amebocyte lysate test
J H Jorgensen
1 Background and mechanism of the Limulus amebocyte
lysate-endotoxin reaction 127
2 Limulus amebocyte lysate testing in the pharmaceutical industry 131
3 Clinical applications of the Limulus amebocyte lysate test 131
3 1 Detection of endotoxemia 131
3 2 Rapid diagnosis of gram-negative bacterial meningitis 141
3 3 Detection of gram-negative bacteriuria 144
3 4 Presumptive diagnosis of gonorrhea 147
3 5 Detection of gram-negative bacteria in ocular infections 150
3 6 Other clinical application of the Limulus amebocyte lysate
test 151
4 Summary 152
References 153
IX
Contents
Chapter 5
Role of antibody in the prevention and pathogenesis of endotoxin and
gram-negative septic shock
R A Proctor
1 Introduction 161
2 Historical perspective 162
3 Protective mechanisms mediated by endotoxin-specific antibody 164
3 1 Neutralization and/or clearance of endotoxin 164
3 2 Complement-mediated bacterial lysis 166
3 3 Opsonic activity 166
3 4 Nonspecific macrophage stimulation 167
4 Protective studies in animals 168
4 1 Bacteremia 168
4 2 Protection from endotoxin shock 169
4 3 Protection from fever 169
4 4 Protection from lethal gram-negative pneumonia 170
4 5 Prevention of local and systemic Shwartzman reaction 171
5 Protective studies in man 172
5 1 Protection from bacteremia, shock, and death 172
5 2 Reduced incidence of fever in neutropenic patients 173
5 3 Protection from gram-negative pneumonia 173
5 4 Protection in P aeruginosa infections 174
6 Adverse effects of endotoxin-specific antibodies 174
7 Summary and future studies 176
Acknowledgements 176
References 177
Chapter 6
Cardiqpulmonary dysfunction from sepsis: diagnosis and treatment
R H Demling
1 Introduction 185
2 Pulmonary dysfunction 186
3 Pulmonary membrane physiology 186
3 1 Microvascular membrane 186
3 2 Interstitium 190
Contents
3 3 Alveolar membrane 193
4 General physiology of respiration 193
4 2 Ventilation 193
4 2 Perfusion 196
5 Ventilation-perfusion matching 197
6 Definition of acute respiratory failure 197
7 Characterization of the adult respiratory distress syndrome 198
7 1 Early phase 198
7 2 Late phase (pulmonary fibrosis) 199
8 Pathophysiology of sepsis-induced adult respiratory stress
syndrome 200
8 1 Arachidonic acid metabolites 202
8 2 Cyclooxygenase pathway products 203
8 3 Lipoxygenase pathway 205
8 4 White cells 205
8 5 Platelets and the coagulation system 208
8 6 Depression of reticuloendothelial system and fibronectin
deficiency 210
9 Myocardial dysfunction 211
10 Abnormalities in the systemic circulation 212
11 General principles of prevention and treatment of sepsis-induced
cardiopulmonary dysfunction 213
11 1 Surgical treatment 213
11 2 Monitoring techniques 214
11 3 Maintenance of ventilation 217
11 4 Fluid management 221
11 5 Pharmacologic manipulation 223
12 Lung metabolism and sepsis-induced respiratory failure 228
13 Summary 229
References 229
Chapter 7
Role of antibiotics in endotoxin shock
S Gudmundsson and W A Craig
1 Introduction 238
2 Direct inhibitory effect of antimicrobials on endotoxin action 238
xi
Contents
2 1 In vitro effects 239
2 2 In vivo effects 242
2 3 Animal infection models 243
2 4 Human studies 244
3 Endotoxin release by antimicrobial agents 245
4 /Effects of endotoxin on antimicrobial pharmacokinetics 246
5 Antimicrobial therapy in gram-negative bacteremia and shock 247
5 1 Appropriate versus inappropriate therapy 248
5 2 Antimicrobial therapy in prevention of shock 250
5 3 Single agent versus combination therapy 250
5 4 Importance of synergy, serum levels and serum bactericidal
activity 252
6 Summary 256
References 256
Chapter 8
Role of glucocorticoids in the treatment of endotoxin shock
L S Young
1 Introduction 264
2 Reviews of earlier studies 265
3 The Schumer study 267
4 Recent developments 268
5 Outlook for the future 269
References 270
Subject index 273
xu
|
| any_adam_object | 1 |
| building | Verbundindex |
| bvnumber | BV000466354 |
| callnumber-first | R - Medicine |
| callnumber-label | RC182 |
| callnumber-raw | RC182.S4 |
| callnumber-search | RC182.S4 |
| callnumber-sort | RC 3182 S4 |
| callnumber-subject | RC - Internal Medicine |
| ctrlnum | (OCoLC)12975610 (DE-599)BVBBV000466354 |
| dewey-full | 615.9/5299 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 615 - Pharmacology and therapeutics |
| dewey-raw | 615.9/5299 |
| dewey-search | 615.9/5299 |
| dewey-sort | 3615.9 45299 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| format | Book |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01497nam a2200421 cb4500</leader><controlfield tag="001">BV000466354</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">00000000000000.0</controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">870612s1986 a||| |||| 00||| eng d</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">0444903909</subfield><subfield code="9">0-444-90390-9</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)12975610</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV000466354</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rakddb</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-12</subfield><subfield code="a">DE-19</subfield><subfield code="a">DE-29</subfield><subfield code="a">DE-188</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RC182.S4</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">615.9/5299</subfield><subfield code="2">19</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Clinical aspects of endotoxin shock</subfield><subfield code="c">ed.: R. A. Proctor</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Amsterdam u.a.</subfield><subfield code="b">Elsevier</subfield><subfield code="c">1986</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">XVI, 274 S.</subfield><subfield code="b">Ill.</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="490" ind1="1" ind2=" "><subfield code="a">Handbook of endotoxin</subfield><subfield code="v">4</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Choc infectieux</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Endotoxines - Effets physiologiques</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Endotoxins</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Endotoxins</subfield><subfield code="x">Physiological effect</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Septic shock</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Shock, Septic</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Endotoxinschock</subfield><subfield code="0">(DE-588)4152196-1</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">Endotoxinschock</subfield><subfield code="0">(DE-588)4152196-1</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Proctor, Richard A.</subfield><subfield code="e">Sonstige</subfield><subfield code="4">oth</subfield></datafield><datafield tag="830" ind1=" " ind2="0"><subfield code="a">Handbook of endotoxin</subfield><subfield code="v">4</subfield><subfield code="w">(DE-604)BV000018178</subfield><subfield code="9">4</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">HEBIS Datenaustausch</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000287359&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-000287359</subfield></datafield></record></collection> |
| id | DE-604.BV000466354 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T15:14:22Z |
| institution | BVB |
| isbn | 0444903909 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-000287359 |
| oclc_num | 12975610 |
| open_access_boolean | |
| owner | DE-12 DE-19 DE-BY-UBM DE-29 DE-188 |
| owner_facet | DE-12 DE-19 DE-BY-UBM DE-29 DE-188 |
| physical | XVI, 274 S. Ill. |
| publishDate | 1986 |
| publishDateSearch | 1986 |
| publishDateSort | 1986 |
| publisher | Elsevier |
| record_format | marc |
| series | Handbook of endotoxin |
| series2 | Handbook of endotoxin |
| spelling | Clinical aspects of endotoxin shock ed.: R. A. Proctor Amsterdam u.a. Elsevier 1986 XVI, 274 S. Ill. txt rdacontent n rdamedia nc rdacarrier Handbook of endotoxin 4 Choc infectieux Endotoxines - Effets physiologiques Endotoxins Endotoxins Physiological effect Septic shock Shock, Septic Endotoxinschock (DE-588)4152196-1 gnd rswk-swf Endotoxinschock (DE-588)4152196-1 s DE-604 Proctor, Richard A. Sonstige oth Handbook of endotoxin 4 (DE-604)BV000018178 4 HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000287359&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Clinical aspects of endotoxin shock Handbook of endotoxin Choc infectieux Endotoxines - Effets physiologiques Endotoxins Endotoxins Physiological effect Septic shock Shock, Septic Endotoxinschock (DE-588)4152196-1 gnd |
| subject_GND | (DE-588)4152196-1 |
| title | Clinical aspects of endotoxin shock |
| title_auth | Clinical aspects of endotoxin shock |
| title_exact_search | Clinical aspects of endotoxin shock |
| title_full | Clinical aspects of endotoxin shock ed.: R. A. Proctor |
| title_fullStr | Clinical aspects of endotoxin shock ed.: R. A. Proctor |
| title_full_unstemmed | Clinical aspects of endotoxin shock ed.: R. A. Proctor |
| title_short | Clinical aspects of endotoxin shock |
| title_sort | clinical aspects of endotoxin shock |
| topic | Choc infectieux Endotoxines - Effets physiologiques Endotoxins Endotoxins Physiological effect Septic shock Shock, Septic Endotoxinschock (DE-588)4152196-1 gnd |
| topic_facet | Choc infectieux Endotoxines - Effets physiologiques Endotoxins Endotoxins Physiological effect Septic shock Shock, Septic Endotoxinschock |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000287359&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000018178 |
| work_keys_str_mv | AT proctorricharda clinicalaspectsofendotoxinshock |