Radiation-protective drugs and their reaction mechanisms:
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Park Ridge, NJ
Noyes
1985
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XII, 146 S. |
| ISBN: | 0815510519 |
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| adam_text | SO G RADIATION-PROTECTIVE DRUGS AND THEIR REACTION MECHANISMS BY J.C.
LIVESEY D.J. REED LF. ADAMSON OREGON STATE UNIVERSITY DEPARTMENT OF
BIOCHEMISTRY AND BIOPHYSICS AND ENVIRONMENTAL HEALTH SCIENCES CENTER
CORVALLIS, OREGON NP NOYES PUBLICATIONS PARK RIDGE, NEW JERSEY, U.S.A.
CONTENTS AND SUBJECT INDEX I. EFFECTS OF RADIATION ON BIOLOGICAL SYSTEMS
1 A. INTRODUCTION 1 B. TYPES OF RADIATION 1 C. EFFECTS OF IONIZING
RADIATION AT THE ATOMIC AND MOLECULAR LEVELS. . . .1 1. MODES OF ENERGY
TRANSFER 2 LONIZATION 2 EXCITATION 3 COLLISION 3 INDIRECT ENERGY
TRANSFER 3 2. SIGNIFICANT VARIABLES 4 TYPE OF RADIATION 4 PARTICLE
VELOCITY 4 WAVELENGTH 4 LET/RBE / 4 DOSE 5 DOSE RATE 5 TISSUE AND FIELD
5 MODIFIERS 6 3. CRITICAL RADIATION TARGETS 6 NUCLEIC ACIDS .6 MEMBRANES
7 ENZYMES 8 D. EFFECTS OF IONIZING RADIATION AT THE FUNCTIONAL AND
SYSTEMIC LEVELS 9 1. CELL SURVIVAL CURVES AND MODELS OF CELLULAR
INACTIVATION 9 TARGET THEORY 9 REPAIR THEORY 9 2. EFFECTS ON CELL
DIVISION AND DIFFERENTIATION 10 CHROMOSOMAL ABBERRATIONS 10 IX X
CONTENTS AND SUBJECT INDEX MUTATION 10 TERATOGENESIS 11 CARCINOGENESIS
11 3. ACUTE RADIATION SYNDROMES 11 BONE MARROW SYNDROME 11
GASTROINTESTINAL SYNDROME 12 CNS SYNDROME 12 4. SUMMARY OF EFFECTS OF
IONIZING RADIATION ON BIOLOGICAL SYSTEMS 12 E. EFFECTS OF ULTRAVIOLET
RADIATION ON BIOLOGICAL SYSTEMS 12 F. EFFECTS OF NONIONIZING RADIATION
ON BIOLOGICAL SYSTEMS 13 1. TYPES OF NONIONIZING RADIATION 13 2.
CONTRASTS BETWEEN EFFECTS OF IONIZING AND NONIONIZING RADIATION 14 II.
ENDOGENOUS FACTORS WHICH INFLUENCE RADIO- RESISTANCE 16 A. WATER 16 B.
THE OXYGEN EFFECT 19 1. DEFINITION AND HISTORICAL NOTES 19 2. THE OXYGEN
ENHANCEMENT RATIO 20 3. CHARACTERISTICS OF OXYGEN ENHANCEMENT 21 A.
DEPENDENCE ON OXYGEN CONCENTRATION 21 B. TIME SCALE OF THE OXYGEN EFFECT
23 I. PREIRRADIATION OXYGEN EFFECTS 23 II. POST-IRRADIATION OXYGEN
EFFECTS 24 4. MECHANISMS OF THE OXYGEN EFFECT 24 C. ENDOGENOUS
RADIOPROTECTIVE SUBSTANCES 26 1. THIOLS 26 A. GLUTATHIONE-BIOSYNTHESIS
AND REGULATION 26 B. THIOLS AND FREE RADICAL REACTIONS 31 I. FORMATION
OF SULFUR-CENTERED RADICALS 31 II. REACTIONS OF SULFUR-CENTERED RADICALS
34 C. OVERALL SCHEME OF SULFUR-CENTERED RADICAL REACTIONS/, . . . . 36
2. VITAMINS AND ANTIOXIDANTS 38 D. THE COMPETITION MODEL 40 III.
CHEMICAL RADIOPROTECTION 43 A. PHYSIOLOGICAL RESPONSES TO CHEMICAL
MODULATION OF CELLULAR RADIOPROTECTION SYSTEMS 43 1. GENERAL CONCEPTS 43
2. CELLULAR ASPECTS OF RADIOPROTECTION SYSTEMS 45 A. COMPARTMENTATION 45
B. REDOX CYCLING 46 B. THEORIES OF RADIOPROTECTION 51 1. RADICAL
SCAVENGING 51 2. HYDROGEN DONATION TO TARGET RADICALS 52 3. MIXED
DISULFIDE FORMATION 52 CONTENTS AND SUBJECT INDEX XI 4. RELEASE OF
ENDOGENOUS RADIOPROTECTORS 53 5. BIOCHEMICAL SHOCK 54 6. HYPOXIA 55 7.
HYPOTHERMIA 56 C. BIOCHEMICAL MECHANISMS OF RADIOPROTECTOR ACTION 57 1 .
PREVENTION OR REDUCTION OF RADIATION DOSE 57 A. PHYSICAL SHIELDING OF
BIOLOGICAL TISSUE 57 B. ADMINISTRATION OF BLOCKING DRUGS OR CHELATORS 57
2. SUPPRESSION OF THE FORMATION OF REACTIVE SPECIES 57 A. CARDIOVASCULAR
HYPOXIA 57 B. CHEMICAL/BIOCHEMICAL HYPOXIA 59 3. DETOXICATION OF
RADIATION-INDUCED REACTIVE SPECIES 62 A. FREE RADICAL SCAVENGING 63 B.
HYDROGEN DONATION TO TARGET RADICALS 64 C. ENHANCED PROTECTION FROM
OXIDATIVE STRESS 66 4. TARGET STABILIZATION 67 A. BINDING TO DNA 67 B.
MIXED DISULFIDE FORMATION 69 5. ENHANCEMENT OR PROTECTION OF RECOVERY OR
REPAIR PROCESSES. . .71 A. RECOVERY FROM RADIATION DAMAGE 71 B. REPAIR
OF RADIATION-DAMAGED STRUCTURES 72 IV. THERAPY OF RADIATION DAMAGE 74 A.
TREATMENT OF GASTROINTESTINAL FAILURE 74 B. PHYSIOLOGICAL SUPPORT DURING
RECOVERY OF HEMOPOIETIC FUNCTIONS 75 INTERFERON 75 TISSUE EXTRACTS 75
ENDOTOXIN AND ENDOTOXIN POLYSACCHARIDES 76 HORMONES 76 OTHER AGENTS 77
C. REINFORCEMENT OF NORMAL DNA REPAIR PROCESSES 78 THIOLS 79 EXOGENOUS
ENZYMES 79 OTHER AGENTS 80 D. GENERAL PRINCIPLES 80 E. SUMMARY 80 V.
RECOMMENDATIONS FOR FUTURE WORK 82 1. PULSE RADIOLYSIS . . .82 2.
PROTEIN THIOLS AND MIXED DISULFIDES 82 3. METABOLISM AND DISTRIBUTION OF
RADIOPROTECTIVE COMPOUNDS. . .83 4. DNA REPAIR INDUCTION 84 5. THE
EFFECT OF RADICAL ACCEPTORS ON THE YIELD OF GLUTATHIONE RADIOLYSIS
PRODUCTS 84 6. TOXICITY OF THIOL RADIOPROTECTORS 85 XII CONTENTS AND
SUBJECT INDEX VI. APPENDIX A: CHEMICAL RADIOPROTECTION-RESEARCH IN
PROGRESS 87 A. MAJOR TOPICS AND CURRENT PRINCIPAL INVESTIGATORS 87
RADIATION DAMAGE: BASIC NATURE AND MECHANISMS 87 RADIATION
RESISTANCE/SENSITIVITY: BASIC NATURE AND MECHANISMS 87 RADIATION
RESISTANCE/SENSITIVITY: TEMPERATURE EFFECT 87 RADIATION
RESISTANCE/SENSITIVITY: OXYGEN EFFECT 87 RADIATION
RESISTANCE/SENSITIVITY: OTHER CHEMICAL MODULATION 87 RADIATION
REPAIR/RECOVERY PROCESSES: BASIC NATURE AND MECHANISMS 88 RADIATION
REPAIR/RECOVERY PROCESSES: CHEMICAL MODULATION . . .88 RESEARCH ON
METHODOLOGY FOR USE IN RADIOPROTECTION STUDIES 88 B. RESEARCH PROJECTS
IN AREAS RELEVANT TO CHEMICAL RADIO- PROTECTION 88 VII. APPENDIX B: SOME
COMPOUNDS SHOWING RADIO- PROTECTIVE ACTIVITY 104 A. STRUCTURE-ACTIVITY
RELATIONSHIPS 105 1. THE CARBON CHAIN 105 2. THE THIOL GROUP 106 3. THE
AMINO GROUP 107 4. OTHER COMPOUNDS 108 B. COMPOUND LIST 109 VIII.
REFERENCES 119
|
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| spelling | Livesey, J. C. Verfasser aut Radiation-protective drugs and their reaction mechanisms by J. C. Livesey ; D. J. Reed ; L. F. Adamson Park Ridge, NJ Noyes 1985 XII, 146 S. txt rdacontent n rdamedia nc rdacarrier Cancer Radiotherapy Complications Prevention Radiation-Protective Agents pharmacokinetics Radiation-protective agents Arzneimittel (DE-588)4003115-9 gnd rswk-swf Strahlenschutz (DE-588)4057826-4 gnd rswk-swf Strahlenbiologie (DE-588)4057819-7 gnd rswk-swf Strahlenschutz (DE-588)4057826-4 s Arzneimittel (DE-588)4003115-9 s DE-604 Strahlenbiologie (DE-588)4057819-7 s Reed, D. J. Verfasser aut Adamson, L. F. Verfasser aut GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000271342&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Livesey, J. C. Reed, D. J. Adamson, L. F. Radiation-protective drugs and their reaction mechanisms Cancer Radiotherapy Complications Prevention Radiation-Protective Agents pharmacokinetics Radiation-protective agents Arzneimittel (DE-588)4003115-9 gnd Strahlenschutz (DE-588)4057826-4 gnd Strahlenbiologie (DE-588)4057819-7 gnd |
| subject_GND | (DE-588)4003115-9 (DE-588)4057826-4 (DE-588)4057819-7 |
| title | Radiation-protective drugs and their reaction mechanisms |
| title_auth | Radiation-protective drugs and their reaction mechanisms |
| title_exact_search | Radiation-protective drugs and their reaction mechanisms |
| title_full | Radiation-protective drugs and their reaction mechanisms by J. C. Livesey ; D. J. Reed ; L. F. Adamson |
| title_fullStr | Radiation-protective drugs and their reaction mechanisms by J. C. Livesey ; D. J. Reed ; L. F. Adamson |
| title_full_unstemmed | Radiation-protective drugs and their reaction mechanisms by J. C. Livesey ; D. J. Reed ; L. F. Adamson |
| title_short | Radiation-protective drugs and their reaction mechanisms |
| title_sort | radiation protective drugs and their reaction mechanisms |
| topic | Cancer Radiotherapy Complications Prevention Radiation-Protective Agents pharmacokinetics Radiation-protective agents Arzneimittel (DE-588)4003115-9 gnd Strahlenschutz (DE-588)4057826-4 gnd Strahlenbiologie (DE-588)4057819-7 gnd |
| topic_facet | Cancer Radiotherapy Complications Prevention Radiation-Protective Agents pharmacokinetics Radiation-protective agents Arzneimittel Strahlenschutz Strahlenbiologie |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000271342&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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