Molecular biology of DNA methylation:
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
New York [u.a.]
Springer
1985
|
| Schriftenreihe: | Springer series in molecular biology
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XIV, 247 S. Ill. |
| ISBN: | 0387961615 3540961615 |
Internformat
MARC
| LEADER | 00000nam a2200000 c 4500 | ||
|---|---|---|---|
| 001 | BV000437363 | ||
| 003 | DE-604 | ||
| 005 | 20020529 | ||
| 007 | t | ||
| 008 | 870612s1985 a||| |||| 00||| eng d | ||
| 020 | |a 0387961615 |9 0-387-96161-5 | ||
| 020 | |a 3540961615 |9 3-540-96161-5 | ||
| 035 | |a (OCoLC)12053421 | ||
| 035 | |a (DE-599)BVBBV000437363 | ||
| 040 | |a DE-604 |b ger |e rakwb | ||
| 041 | 0 | |a eng | |
| 049 | |a DE-12 |a DE-355 |a DE-703 |a DE-83 |a DE-188 |a DE-B768 | ||
| 050 | 0 | |a QP624 | |
| 050 | 0 | |a QU58 | |
| 082 | 0 | |a 574.87/3282 |2 19 | |
| 084 | |a WD 5360 |0 (DE-625)148202: |2 rvk | ||
| 100 | 1 | |a Adams, Roger L. P. |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Molecular biology of DNA methylation |c Roger L. P. Adams ; Roy H. Burdon |
| 264 | 1 | |a New York [u.a.] |b Springer |c 1985 | |
| 300 | |a XIV, 247 S. |b Ill. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 0 | |a Springer series in molecular biology | |
| 650 | 4 | |a ADN - Métabolisme | |
| 650 | 4 | |a Méthylation | |
| 650 | 4 | |a DNA |x Methylation | |
| 650 | 4 | |a DNA |x metabolism | |
| 650 | 4 | |a Methylation | |
| 650 | 0 | 7 | |a Molekularbiologie |0 (DE-588)4039983-7 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Methylierung |0 (DE-588)4123751-1 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a DNS |0 (DE-588)4070512-2 |2 gnd |9 rswk-swf |
| 689 | 0 | 0 | |a DNS |0 (DE-588)4070512-2 |D s |
| 689 | 0 | 1 | |a Methylierung |0 (DE-588)4123751-1 |D s |
| 689 | 0 | 2 | |a Molekularbiologie |0 (DE-588)4039983-7 |D s |
| 689 | 0 | |5 DE-604 | |
| 689 | 1 | 0 | |a DNS |0 (DE-588)4070512-2 |D s |
| 689 | 1 | 1 | |a Methylierung |0 (DE-588)4123751-1 |D s |
| 689 | 1 | |5 DE-604 | |
| 700 | 1 | |a Burdon, Roy H. |e Verfasser |4 aut | |
| 856 | 4 | 2 | |m HEBIS Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000270903&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-000270903 | ||
Datensatz im Suchindex
| _version_ | 1804114897696456704 |
|---|---|
| adam_text | Roger L P Adams
Roy H Burdon
Molecular Biology
of DNA Methylation
With 88 Figures
Springer-Verlag
New York Berlin Heidelberg Tokyo
Contents
1 Introduction I
1 1 Introducing DNA Methylation : 1
1 2 Methyl Bases in DNA 3
1 3 Distribution of Methylated Bases 4
2 DNA Methylation in the Cell 9
2 1 The Synthetic Reaction 9
2 2a Timing of Methylation in Prokaryotes 10
2 2b Timing of Methylation in Eukaryotes 10
2 3 De Novo and Maintenance Methylation 13
2 4 Demethylation 16
2 5 Methylation in Isolated Nuclei 17
3DNAStructureandtheEffectofMethylation19
31 Structure of DNA 19
3 2 Z-DNA and Supercoiling 21
3 3 Cytosine Methylation and Z-DNA in Vivo 22
3 4 Z-DNA in Vertebrates 24
3 5 Othc Effects of Cytosine Methylation on DNA Structure 26
3 6 Effect of Adenine Methylation on DNA Structure 28
4 S-Adenosyl-L-methionine—Donor of Methyl Groups 31
4 1 Intracellular Role and Metabolic Cost 31
4 2 Biosynthesis 32
Contents
4 3 Adenosyltransferase and Regulation of Intracellular
Concentration 34
4 4 Stability and Its Significance 35
4 5 Analogues 37
4 6 Catabolism 38
5 The Methylation Machinery: DNA Methyltransferases 43
5 1 Prokaryote Methylases 43
5 2 Mammalian DNA Methyltransferases 53
5 3 DNA Methyltransferases in Other Eukaryotes 63
5 4 Inhibitors of DNA Methylation 64
6 The Function of DNA Methylation in Bacteria
and Phage 73
6 1 Restriction Modification 73
6 2 dcm and dam Methylation 77
6 3 Modification in Phage mu 85
7 Methylation in Higher Eukaryotes 89
7 1 The Sequence Methylated 89
7 2 Deaminat ion of Methylcytosine 95
7 3 Locat ion of Methylcytosine in Different Compar tments 103
7 4 Methylat ion and Recombinat ion in Eukaryo tes 113
8 Methylation and Its Relationship with Transcription 115
8 1 Tissue Variation in the Overall Level of DNA Methylation 117
8 2 Changes in DNA Methylcytosine Content During Embryonic
Development 121
8 3 What Really Is the Evidence, for an Inverse Correlation
Between Methylation and Gene Expression? 123
8 4 Methylation and Expression of Genes Transferred into
Animal Cells 148
9 X-Chromosome Inactivation 163
9 1 The Phenomenon 163
9 2 Two Models to Explain X-Chromosome Inactivation 164
9 3 Differential Levels of Methylcytosine in X-Chromosomes 166
Contents xiii
9 4 Gene Transfer Experiments 167
9 5 Reactivation with Azacytidine 168
10 DNA Methylation and Cancer 171
10 1 DNA Damage and Methylation 171
10 2 Carcinogens and DNA Methylation 172
10 3 Changes in DNA Methylation Associated with Tumors and
Transformed Cells 173
11 Variations on a Theme: Patterns of Methylation in
Protista, Fungi, Plants, and Animals 175
11 1 Introduction 175
11 2 Protista 176
11 3 Fungi 177
11 4 Animals Excluding Deuterostomia 178
11 5 Plants 182
11 6 Methylation of Organelle DNA 185
12 Has DNA a Role in the Control of Transcription? 191
12 1 The Dilemma 191
12 2 The Relationship Between Undermethylation and
Expression 192
12 3 Three Classes of Genes 193
12 4 Ways in Which a Methylation Pattern May Be Established
and Changed 194
12 5 The Relevance of Z-DNA Formation to the Study of Gene
Expression 196
12 6 A Role in Determination 197
13 Other Possible Functions of Eukaryotic
DNA Methylation 201
13 1 Restriction/Modification 201
13 2 Mismatch Repair 202
13 3 Recombination 202
13 4 Biological Clocks 202
13 5 Initiation of DNA Replication 203
13 6 Chromosome Inactivation 205
xiv Contents
14 DNA Methylation in Perspective—A Summing Up 207
Appendix Methods of Estimation of Minor Bases in DNA 211
A I Introduction 211
A 2 Isolation and Hydrolysis of DNA 212
A31 Base Analysis 213
A32 Nucleoside and Nucleotide Analysis 214
A 4 Use of Antibodies to Methylcytosine 215
A 5 Restriction Enzyme Digestion 215
A 6 Nearest Neighbor Analysis 216
A 7 Maxam-Gilbert Sequencing 216
References 219
Index 243
|
| any_adam_object | 1 |
| author | Adams, Roger L. P. Burdon, Roy H. |
| author_facet | Adams, Roger L. P. Burdon, Roy H. |
| author_role | aut aut |
| author_sort | Adams, Roger L. P. |
| author_variant | r l p a rlp rlpa r h b rh rhb |
| building | Verbundindex |
| bvnumber | BV000437363 |
| callnumber-first | Q - Science |
| callnumber-label | QP624 |
| callnumber-raw | QP624 QU58 |
| callnumber-search | QP624 QU58 |
| callnumber-sort | QP 3624 |
| callnumber-subject | QP - Physiology |
| classification_rvk | WD 5360 |
| ctrlnum | (OCoLC)12053421 (DE-599)BVBBV000437363 |
| dewey-full | 574.87/3282 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 574 - [Unassigned] |
| dewey-raw | 574.87/3282 |
| dewey-search | 574.87/3282 |
| dewey-sort | 3574.87 43282 |
| dewey-tens | 570 - Biology |
| discipline | Biologie |
| format | Book |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01900nam a2200529 c 4500</leader><controlfield tag="001">BV000437363</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">20020529 </controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">870612s1985 a||| |||| 00||| eng d</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">0387961615</subfield><subfield code="9">0-387-96161-5</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">3540961615</subfield><subfield code="9">3-540-96161-5</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)12053421</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV000437363</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-12</subfield><subfield code="a">DE-355</subfield><subfield code="a">DE-703</subfield><subfield code="a">DE-83</subfield><subfield code="a">DE-188</subfield><subfield code="a">DE-B768</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">QP624</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">QU58</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">574.87/3282</subfield><subfield code="2">19</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">WD 5360</subfield><subfield code="0">(DE-625)148202:</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Adams, Roger L. P.</subfield><subfield code="e">Verfasser</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Molecular biology of DNA methylation</subfield><subfield code="c">Roger L. P. Adams ; Roy H. Burdon</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">New York [u.a.]</subfield><subfield code="b">Springer</subfield><subfield code="c">1985</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">XIV, 247 S.</subfield><subfield code="b">Ill.</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="490" ind1="0" ind2=" "><subfield code="a">Springer series in molecular biology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">ADN - Métabolisme</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Méthylation</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">DNA</subfield><subfield code="x">Methylation</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">DNA</subfield><subfield code="x">metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Methylation</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Molekularbiologie</subfield><subfield code="0">(DE-588)4039983-7</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Methylierung</subfield><subfield code="0">(DE-588)4123751-1</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">DNS</subfield><subfield code="0">(DE-588)4070512-2</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">DNS</subfield><subfield code="0">(DE-588)4070512-2</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="1"><subfield code="a">Methylierung</subfield><subfield code="0">(DE-588)4123751-1</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="2"><subfield code="a">Molekularbiologie</subfield><subfield code="0">(DE-588)4039983-7</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="689" ind1="1" ind2="0"><subfield code="a">DNS</subfield><subfield code="0">(DE-588)4070512-2</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="1" ind2="1"><subfield code="a">Methylierung</subfield><subfield code="0">(DE-588)4123751-1</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="1" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Burdon, Roy H.</subfield><subfield code="e">Verfasser</subfield><subfield code="4">aut</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">HEBIS Datenaustausch</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000270903&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-000270903</subfield></datafield></record></collection> |
| id | DE-604.BV000437363 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T15:14:01Z |
| institution | BVB |
| isbn | 0387961615 3540961615 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-000270903 |
| oclc_num | 12053421 |
| open_access_boolean | |
| owner | DE-12 DE-355 DE-BY-UBR DE-703 DE-83 DE-188 DE-B768 |
| owner_facet | DE-12 DE-355 DE-BY-UBR DE-703 DE-83 DE-188 DE-B768 |
| physical | XIV, 247 S. Ill. |
| publishDate | 1985 |
| publishDateSearch | 1985 |
| publishDateSort | 1985 |
| publisher | Springer |
| record_format | marc |
| series2 | Springer series in molecular biology |
| spelling | Adams, Roger L. P. Verfasser aut Molecular biology of DNA methylation Roger L. P. Adams ; Roy H. Burdon New York [u.a.] Springer 1985 XIV, 247 S. Ill. txt rdacontent n rdamedia nc rdacarrier Springer series in molecular biology ADN - Métabolisme Méthylation DNA Methylation DNA metabolism Methylation Molekularbiologie (DE-588)4039983-7 gnd rswk-swf Methylierung (DE-588)4123751-1 gnd rswk-swf DNS (DE-588)4070512-2 gnd rswk-swf DNS (DE-588)4070512-2 s Methylierung (DE-588)4123751-1 s Molekularbiologie (DE-588)4039983-7 s DE-604 Burdon, Roy H. Verfasser aut HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000270903&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Adams, Roger L. P. Burdon, Roy H. Molecular biology of DNA methylation ADN - Métabolisme Méthylation DNA Methylation DNA metabolism Methylation Molekularbiologie (DE-588)4039983-7 gnd Methylierung (DE-588)4123751-1 gnd DNS (DE-588)4070512-2 gnd |
| subject_GND | (DE-588)4039983-7 (DE-588)4123751-1 (DE-588)4070512-2 |
| title | Molecular biology of DNA methylation |
| title_auth | Molecular biology of DNA methylation |
| title_exact_search | Molecular biology of DNA methylation |
| title_full | Molecular biology of DNA methylation Roger L. P. Adams ; Roy H. Burdon |
| title_fullStr | Molecular biology of DNA methylation Roger L. P. Adams ; Roy H. Burdon |
| title_full_unstemmed | Molecular biology of DNA methylation Roger L. P. Adams ; Roy H. Burdon |
| title_short | Molecular biology of DNA methylation |
| title_sort | molecular biology of dna methylation |
| topic | ADN - Métabolisme Méthylation DNA Methylation DNA metabolism Methylation Molekularbiologie (DE-588)4039983-7 gnd Methylierung (DE-588)4123751-1 gnd DNS (DE-588)4070512-2 gnd |
| topic_facet | ADN - Métabolisme Méthylation DNA Methylation DNA metabolism Methylation Molekularbiologie Methylierung DNS |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000270903&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT adamsrogerlp molecularbiologyofdnamethylation AT burdonroyh molecularbiologyofdnamethylation |