Sterols and bile acids:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Amsterdam [u.a.]
Elsevier
1985
|
| Schriftenreihe: | New comprehensive biochemistry
12 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XV, 447 S. Ill., graph. Darst. |
| ISBN: | 0444806709 |
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| 245 | 1 | 0 | |a Sterols and bile acids |c ed. Henry Danielsson ... |
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| 490 | 1 | |a New comprehensive biochemistry |v 12 | |
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| 650 | 4 | |a Stérols - Métabolisme | |
| 650 | 4 | |a Bile Acids and Salts |x metabolism | |
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| adam_text | IMAGE 1
H. DANIELSSON AND J. SJOVALL (EDS.), STEROLS AND BILE ACIDS
0 1985 ELSEVIER SCIENCE PUBLISHERS B.V. (BIOMEDICAL DIVISION)
CONTENTS
PREFACE V
CHAPTER I BIOSYNTHESIS OF CHOLESTEROL HANS C. RILLING AND LILIANE T.
CHAYET (SALT LAKE CITY AND SANTIAGO) 1
I. INTRODUCTION * 1
II. SOURCE OF ACETYL-COA 2
III. ACETYL-COA ACETYL TRANSFERASE (EC 2.3.1.9) 3
1. CELLULAR LOCATION 3
2. ENZYMOLOGY 4
3. MECHANISM 4
IV. 3-HYDROXY-3-METHYLGLUTARYL-COA SYNTHETASE (EC 4.1.3.5) 5
1. CELLULAR LOCATION 5
2. ENZYMOLOGY 6
3. MECHANISM 7
V. 3-HYDROXY-3-METHYLGLUTARYL-COA REDUCTASE (EC 1.1.1.34) 8
1. ENZYMOLOGY 9
2. MECHANISM 9
3. REGULATION 11
VI. MEVALONATE-5-PHOSPHOTRANSFERASE(EC 2.7.1.36) 12
VII. PHOSPHOMEVALONATE KINASE (EC 2.7.4.2) 12
VIII. PYROPHOSPHOMEVALONATE DECARBOXYLASE (EC 4.1.1.33) 13
IX. ISOPENTENYL PYROPHOSPHATE ISOMERASE (EC 5.3.3.2) 14
1. ENZYMOLOGY 14
2. SUBSTRATE SPECIFICITY 15
3. MECHANISM 16
X. PRENYLTRANSFERASE (EC 2.5.1.1) 17
1. ENZYMOLOGY 17
2. SUBSTRATE BINDING 18
3. MECHANISM 19
4. KINETICS 20
5. TERMINATION 21
6. ANALOGS 22
XI. SQUALENE SYNTHETASE 23
1. ENZYMOLOGY 23
2. KINETICS 24
3. ANALOGS 24
4. MECHANISM 25
XII. SQUALENE EPOXIDASE AND CYCLASE 27
1. ENZYMOLOGY 27
2. MECHANISM 28
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XIII. THE CONVERSION OF LANOSTEROL TO CHOLESTEROL 31
1. STEROL FUNCTION 31
2. GENERAL ASPECTS OF ENZYMOLOGY 31
3. THE PATHWAY 32
4. DECARBONYLATION AT C-14 32
5. DECARBOXYLATION AT C-4 34
6. INTRODUCTION OF A 5 36
ACKNOWLEDGEMENT 37
REFERENCES 37
CHAPTER 2 CONTROL MECHANISMS IN STEROL UPTAKE AND BIOSYNTHESIS JOHN F.
GILL JR., PETER J. KENNELLY AND VICTOR W. RODWELL (WEST LAFAYETTE) . 41
I. CONTROL OF STEROL UPTAKE 41
1. PLASMA LIPOPROTEINS 41
A. NORMAL PLASMA LIPOPROTEINS, 41 - B. ABNORMAL PLASMA LIPOPROTEINS, 44
- C. CHEMICALLY MODIFIED LIPOPROTEINS, 44 - 2. CELLULAR MECHANISMS OF
CHOLESTEROL UPTAKE 44
A. THE LDL RECEPTOR AND RECEPTOR-MEDIATED ENDOCYTOSIS, 45 - B. OTHER
RECEPTOR-MEDIA- TED LIPOPROTEIN UPTAKE MECHANISMS, 48 - C.
RECEPTOR-INDEPENDENT CHOLESTEROL UPTAKE, 51 3. REGULATION OF
RECEPTOR-MEDIATED STEROL UPTAKE 52
4. DISEASES RELATED TO RECEPTOR-MEDIATED CHOLESTEROL UPTAKE 54
A. HOMOZYGOUS FH, RECEPTOR-NEGATIVE AND RECEPTOR-DEFECTIVE, 54 - B.
HETEROZYGOUS FH, 56 - C. HOMOZYGOUS FH, INTERNALIZATION-DEFECTIVE, 56 -
D. WOLMAN SYNDROME, 56 - E. CHOLESTEROL ESTER STORAGE DISEASE, 56 - II.
CONTROL OF STEROL BIOSYNTHESIS 57
1. MAMMALIAN HMG-COA REDUCTASE 57
A. RATE-LIMITING STEP IN STEROL BIOSYNTHESIS, 57 - B. DISTRIBUTION, 57 -
C. DIURNAL RHYTHM AND DEVELOPMENTAL PATTERN, 58 - D. REGULATION OF
HMG-COA REDUCTASE PROTEIN LEVEL, 59 - E. MODULATION OF HMG-COA REDUCTASE
ACTIVITY, 62 - 2. OTHER SITES OF CONTROL 65
A. EARLY SITES OF CONTROL, 65 - B. LATER SITES OF CONTROL, 66 -
ACKNOWLEDGEMENTS : 67
REFERENCES 67
CHAPTER 3 PARTICIPATION OF STEROL CARRIER PROTEINS IN CHOLESTEROL
BIOSYNTHESIS, UTILIZATION AND INTRACELLULAR TRANSFER TERENCE J. SCALLEN
AND GEORGE V. VAHOUNY (ALBUQUERQUE AND WASHINGTON) 73
I. INTRODUCTION 73
II. STEROL CARRIER PROTEIN, (SCP,) 74
1. PURIFICATION AND CHARACTERIZATION OF SCP, 74
2. SUBSTRATE SPECIFICITY R 74
3. PARTICIPATION OF SCP, IN THE CONVERSION OF ENZYMATICALLY GENERATED,
MICROSOME-BOUND SQUALENE TO STEROL 75
4. PROPERTIES OF SCP! 75
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IX
III. STEROL CARRIER PROTEIN-, (SCP 2) 77
1. PARTICIPATION OF SCP 2 IN CHOLESTEROL BIOSYNTHESIS 77
A. GENERAL REMARKS, 77 - B. PURIFICATION AND CHARACTERIZATION OF SCP 2,
77 - C. SUBSTRATE SPECIFICITY, 78 - D. KINETIC STUDIES, 78 - E. ANTI-SCP
2 IGG, 79- 2. PARTICIPATION OF SCP 2 IN CHOLESTEROL UTILIZATION 80
A. CHOLESTEROL ESTERIFICATION, 80 - B. CHOLESTEROL 7A-HYDROXYLASE, 81 -
3. PARTICIPATION OF SCP 2 IN INTRACELLULAR CHOLESTEROL TRANSFER 82
A. SCP 2 IS REQUIRED FOR CHOLESTEROL TRANSPORT FROM ADRENAL LIPID
DROPLETS TO MITOCHONDRIA, 82 - B. IDENTIFICATION OF ADRENAL SCP 2, 84 -
C. SCP2 FACILITATES THE TRANSLOCATION OF CHOLESTEROL FROM THE OUTER TO
THE INNER MITOCHONDRIAL MEMBRANE, 85 - 4. COMPARISON OF SCP 2 WITH OTHER
LOW MOLECULAR WEIGHT PROTEINS 87
A. FATTY-ACID-BINDING PROTEIN (FABP), 87 - B. NONSPECIFIC PHOSPHOLIPID
EXCHANGE PROTEIN, 90 - IV. THE PARTICIPATION OF STEROL CARRIER PROTEINS
IN INTRACELLULAR CHOLESTEROL METABOLISM 91
ACKNOWLEDGEMENTS 91
REFERENCES 91
CHAPTER 4 BIOSYNTHESIS, FUNCTION AND METABOLISM OF STEROL ESTERS ALAN
JONES AND JOHN GLOMSET (SEATTLE) 95
I. INTRODUCTION 95
II. DISTRIBUTION AND PHYSICAL PROPERTIES OF CHOLESTEROL ESTERS 95
III. ENZYMES AND PROTEINS THAT MEDIATE THE FORMATION, TRANSPORT, AND
HYDROLYSIS OF CHOLESTEROL ESTERS 98
1. ACYL-COA : CHOLESTEROL ACYLTRANSFERASE (EC 2.3.1.26) 98
2. CHOLESTEROL ESTER HYDROLASE (EC 3.1.1.13) 101
A. ACID CEH, 101 - B. NEUTRAL CEH, 102 - 3. LECITHIN: CHOLESTEROL
ACYLTRANSFERASE (EC 2.3.1.43) 103
4. PLASMA CHOLESTEROL ESTER TRANSFER PROTEIN 106
IV. PHYSIOLOGY OF CHOLESTEROL ESTERS 107
1. PLASMA LIPOPROTEIN CHOLESTEROL ESTERS 107
2. TISSUE CHOLESTEROL ESTERS 110
A. FIBROBLASTS, 111 - B. CELLS THAT FORM STEROID HORMONES, 112 - C.
MACROPHAGES, 112 - D. HEPATOCYTES, 113 - V. CHOLESTEROL SULFATE 113
VI. CHOLESTEROL ESTERS AND DISEASE 114
VII. CONCLUSION 116
REFERENCES 116
CHAPTER 5 CHOLESTEROL ABSORPTION AND METABOLISM BY THE INTESTINAL
EPITHELIUM EDUARD F. STANGE AND JOHN M. DIETSCHY (DALLAS) 121
I. INTRODUCTION 121
II. ABSORPTION OF CHOLESTEROL 123
III. INTESTINAL CHOLESTEROL SYNTHESIS 125
1. METHODOLOGY 125
2. LOCALIZATION 126
IMAGE 4
3. REGULATION 128
4. FUNCTION 132
IV. INTESTINAL LIPOPROTEIN UPTAKE 132
1. METHODOLOGY 132
2. LOCALIZATION 133
3. REGULATION 134
4. FUNCTION 135
V. INTESTINAL CHOLESTEROL ESTERIFICATION 136
1. ACYL-COA: CHOLESTEROL ACYLTRANSFERASE (ACAT) 136
A. METHODOLOGY, 136 - B. LOCALIZATION, 137 - C. REGULATION, 138 - D.
FUNCTION, 139 - 2. CHOLESTEROL ESTERASE OF PANCREATIC ORIGIN 140
A. METHODOLOGY, 140 - B. LOCALIZATION, 140 - C. REGULATION, 140 - D.
FUNCTION, 140 VI. ORIGIN OF THE CHOLESTEROL IN INTESTINAL LYMPH 141
1. TOTAL CHOLESTEROL MASS 141
2. NEWLY SYNTHESIZED CHOLESTEROL 142
VII. COMPARTMENTALIZATION OF CHOLESTEROL IN THE ENTEROCYTE 144
ACKNOWLEDGEMENTS 146
REFERENCES 146
CHAPTER 6 CHOLESTEROL AND BIOMEMBRANE STRUCTURES D. CHAPMAN, MARY T.C.
KRAMERS AND C.J. RESTALL (LONDON) 151
I. INTRODUCTION 151
II. THE OCCURRENCE OF STEROLS 151
III. CHOLESTEROL-PHOSPHOLIPID INTERACTIONS 152
IV. THE EFFECTS OF CHOLESTEROL UPON MEMBRANE PROTEINS 159
V. THE EFFECTS OF CHOLESTEROL ON CELLULAR FUNCTIONS 161
VI. CHOLESTEROL EXCHANGE 162
VII. THE EXPERIMENTAL MANIPULATION OF CHOLESTEROL 163
VIII. CHOLESTEROL AND DISEASE 164
1. LIVER DISEASE 164
2. FAMILIAL HYPERCHOLESTEROLAEMIA 164
3. AGEING AND ATHEROSCLEROSIS 165
4. MUSCULAR DYSTROPHY 166
5. MALARIA * 166
6. CHOLESTEROL AND CANCER 166
IX. CHOLESTEROL EVOLUTION 168
X. CONCLUSIONS 169
ACKNOWLEDGEMENTS 170
REFERENCES 170
CHAPTER 7 BIOSYNTHESIS OF PLANT STEROLS T.W. GOODWIN (LIVERPOOL) 175
I. INTRODUCTION 175
II. FORMATION OF CYCLOARTENOL 175
III. ALKYLATION REACTIONS 178
IMAGE 5
XI
IV. STEPS OTHER THAN THOSE INVOLVING METHYLATION 184
1. DEMETHYLATION 184
2. ISOMERIZATION OF A 8 -» A5 187
3. INSERTION OF THE A 22 DOUBLE BOND 188
V. CHOLESTEROL 189
VI. STEROID HORMONES 190
VII. CARDIAC GLYCOSIDES 190
VIII. SAPOGENINS 192
IX. ECDYSTEROIDS 192
X. STEROID ALKALOIDS 193
XI. WITHANOLIDES 194
XII. BRASSINOSTEROIDS 194
XIII. STEROL ESTERS 196
XIV. STEROL GLYCOSIDES AND ACYLGLYCOSIDES 196
XV. FUNCTION OF STEROLS 196
1. IN MEMBRANES 196
2. AS HORMONES 197
REFERENCES 198
CHAPTER 8 STRUCTURES, BIOSYNTHESIS AND FUNCTION OF STEROLS IN
INVERTEBRATES NOBUO IKEKAWA (TOKYO) 199
I. STEROLS IN MARINE INVERTEBRATES 199
1. INTRODUCTION 199
2. STEROLS IN PORIFERA (SPONGES) 201
3. STEROLS IN COELENTERATA 204
4. STEROLS IN ECHINODERMATA (STARFISH) 207
5. STEROLS IN CRUSTACEANS 209
6. STEROLS IN MOLLUSCA AND OTHERS 210
7. SIDE CHAIN MODIFICATION OF STEROLS IN MARINE INVERTEBRATES 212
II. STEROL METABOLISM IN INSECTS 213
1. DEALKYLATION OF PHYTOSTEROL 213
2. INHIBITORS OF PHYTOSTEROL METABOLISM 217
3. STRUCTURE REQUIREMENT OF STEROL FOR GROWTH AND DEVELOPMENT 219
III. ECDYSTEROIDS IN INSECTS 219
1. INTRODUCTION 219
2. ECDYSTEROIDS ISOLATED FROM INSECTS AND THEIR BIOSYNTHESIS 220
3. ECDYSONE METABOLISM AND BIOLOGICAL ACTIVITY 222
ACKNOWLEDGEMENTS 225
REFERENCES 225
CHAPTER 9 MECHANISM OF BILE ACID BIOSYNTHESIS IN MAMMALIAN LIVER INGEMAR
BJORKHEM (STOCKHOLM) 231
I. INTRODUCTION 231
II. FORMULATION OF THE SEQUENCE OF REACTIONS IN THE BIOSYNTHESIS OF BILE
ACIDS 233
III. CHOLESTEROL 7 *-HYDROXYLASE 237
1. ASSAY OF CHOLESTEROL 7 X-HYDROXYLASE IN LIVER MICROSOMES 237
2. SUBSTRATE SPECIFICITY AND PHYSIOLOGICAL SUBSTRATE FOR CHOLESTEROL
7A-HYDROXYLASE 239
IMAGE 6
XLL
3. MECHANISM OF 7A-HYDROXYLATION OF CHOLESTEROL AND EXPERIMENTS WITH
PURIFIED ENZYME COMPONENTS 240
IV. CONVERSION OF 7A-HYDROXYCHOLESTEROL INTO
7A-HYDROXY-4-CHOLESTEN-3-ONE 244
V. 12A-HYDROXYLATION 245
VI. SATURATION OF THE A 4 DOUBLE BOND 246
VII. REDUCTION OF THE 3-OXO GROUP 247
VIII. 26-HYDROXYLATION 247
1. MICROSOMAL 26-HYDROXYLATION 248
2. MITOCHONDRIAL 26-HYDROXYLATION 249
IX. CONVERSION OF 5/6-CHOLESTANE-3A,7A,12A,26-TETROL INTO
3A,7A,12A-TRIHYDROXY-5/8-CHOLESTANOIC ACID 251
X. CONVERSION OF 3A,7A,12A-TRIHYDROXY-5/J-CHOLESTANOIC ACID INTO CHOLIC
ACID 252
XI. CONJUGATION OF THE CARBOXYLIC GROUP 253
XII. FORMATION OF ALLO BILE ACIDS IN THE LIVER 255
1. CONVERSION OF 5/3-BILE ACIDS TO ALLO BILE ACIDS 255
2. CONVERSION OF CHOLESTANOL INTO ALLO BILE ACIDS 255
3. CONVERSION OF 7A-HYDROXY-4-CHOLESTEN-3-ONE INTO ALLO BILE ACIDS 257
XIII. SPECIES DIFFERENCES AND ALTERNATIVE PATHWAYS IN THE BIOSYNTHESIS
OF BILE ACIDS 257
XIV. INBORN ERRORS OF METABOLISM IN BILE ACID BIOSYNTHESIS 261
1. CEREBROTENDINOUS XANTHOMATOSIS 261
2. ZELLWEGER S DISEASE 263
XV. REGULATION OF THE OVERALL BIOSYNTHESIS OF BILE ACIDS 264
1. FEEDBACK REGULATION OF BILE ACID BIOSYNTHESIS 264
2. RELATION BETWEEN CHOLESTEROL 7A-HYDROXYLASE AND HMG-COA REDUCTASE 266
3. POSSIBLE MECHANISMS FOR REGULATION OF CHOLESTEROL 7A-HYDROXYLASE
ACTIVITY 268
XVI. REGULATION OF THE RATIO BETWEEN CHOLIC ACID AND CHENODEOXYCHOLIC
ACID 270
ACKNOWLEDGEMENTS 272
REFERENCES 272
CHAPTER 10 BILE ALCOHOLS AND PRIMITIVE BILE ACIDS TAKAHIKO HOSHITA
(HIROSHIMA) 279
I. INTRODUCTION 279
II. OCCURRENCE AND STRUCTURE OF BILE ALCOHOLS IN LOWER VERTEBRATES 279
III. OCCURRENCE AND STRUCTURE OF PRIMITIVE BILE ACIDS IN LOWER
VERTEBRATES 285
IV. OCCURRENCE AND STRUCTURE OF BILE ALCOHOLS IN MAMMALS 289
V. OCCURRENCE AND STRUCTURE OF PRIMITIVE BILE ACIDS IN MAMMALS 291
VI. METABOLISM OF BILE ALCOHOLS AND PRIMITIVE BILE ACIDS IN MAMMALS 293
VII. METABOLISM OF BILE ALCOHOLS AND PRIMITIVE BILE ACIDS IN LOWER
VERTEBRATES 296
REFERENCES 299
CHAPTER 11
METABOLISM OF BILE ACIDS IN LIVER AND EXTRAHEPATIC TISSUES WILLIAM H.
ELLIOTT (ST. LOUIS) 303
I. INTRODUCTION 303
1. ENTEROHEPATIC CIRCULATION 303
2. SUBCELLULAR LOCATION 304
3. TRANSPORT AND HEPATOCYTES 306
IMAGE 7
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II. CONJUGATION 306
1. AMINO ACIDS AND PROTEINS 306
A. PREPARATION AND ANALYSES OF COA DERIVATIVES, 307 - B. BILE ACID: COA
SYNTHETASE (BILE ACID COA LIGASE) AND BILE ACID COA:
GLYCINE/TAURINE-W-ACYLTRANSFERASE, 307 - C. METABOLISM, 308 - 2.
SULFATES 309
3. GLUCURONIDES 310
III. HYDROXYLATION OF THE STEROID NUCLEUS 310
1. 3A-HYDROXYLATION 311
2. 6/J- AND 6A-HYDROXYLATION 311
3. LA- AND 7/?-HYDROXYLATION 313
4. 12 A-HYDROXYLATION 315
5. 16-HYDROXYLATION 315
IV. HYDROXYLATION IN THE SIDE CHAIN 316
V. OXIDOREDUCTION 317
VI. EXTRAHEPATIC STUDIES 320
1. BRAIN 320
2. CECUM 320
3. URINE 321
4. MECONIUM 324
ACKNOWLEDGEMENT 324
REFERENCES 325
CHAPTER 12 METABOLISM OF BILE ACIDS IN INTESTINAL MICROFLORA PHILLIP B.
HYLEMON (RICHMOND) 331
I. INTRODUCTION 331
II. COMPOSITION OF INTESTINAL MICROFLORA 332
III. DECONJUGATION 333
IV. DESULFATION 334
V. EPIMERIZATION OF HYDROXYL GROUPS 334
1. 3A- AND 3/8-HYDROXYSTEROID DEHYDROGENASE 335
2. 6A- AND 6/?-HYDROXYSTEROID DEHYDROGENASE 335
3. 7A-HYDROXYSTEROID DEHYDROGENASE 336
4. 7/J-HYDROXYSTEROID DEHYDROGENASE 336
5. 12A-HYDROXYSTEROID DEHYDROGENASE 337
VI. 7A- AND 7,6-DEHYDROXYLASE 338
ACKNOWLEDGEMENT 341
REFERENCES 342
CHAPTER 13 PHYSICAL-CHEMICAL PROPERTIES OF BILE ACIDS AND THEIR SALTS
MARTIN C. CAREY (BOSTON)
I. INTRODUCTION 345
II. MOLECULAR STRUCTURES 345
1. CHEMISTRY 345
2. HYDROPHILIC-HYDROPHOBIC BALANCE 348
3. MISCELLANEOUS PHYSICAL CONSTANTS 349
III. CRYSTALLINE STRUCTURES 352
1. BILE ACIDS AND THEIR DERIVATIVES 352
IMAGE 8
XIV
2. BILE SALT HYDRATES 352
3. CHOLEIC ACIDS 358
IV. SURFACE PHYSICAL CHEMISTRY 359
1. BILE ACIDS 359
2. BILE SALTS 360
3. MIXED MONOLAYERS 362
V. BULK AQUEOUS PHYSICAL CHEMISTRY 364
1. PH-SOLUBILITY RELATIONS 365
2. BILE ACIDS - SOLUBILITY BEHAVIOR 369
3. TEMPERATURE-SOLUBILITY RELATIONS 370
VI. MICELLE FORMATION IN AQUEOUS SOLVENTS 372
1. CRITICAL MICELLAR CONCENTRATIONS 372
A. METHODS OF DETERMINING BILE SALT CMC VALUES, 372 - B. INFLUENCE OF
VARIATION IN PHYSICAL-CHEMICAL CONDITIONS, 372 - C. INVENTORY OF
PUBLISHED DATA, 373 - 2. MICELLAR SIZE AND POLYDISPERSITY 373
A. UNCONJUGATED BILE SALTS, 374 - B. GLYCINE-CONJUGATED BILE SALTS, 374
- C. TAURINE- CONJUGATED BILE SALTS, 375 - D. POLYDISPERSITY, 375 - 3.
MICELLAR SHAPE AND HYDRATION 375
4. MICELLAR STRUCTURES 377
5. MICELLAR CHARGE AND COUNTERION BINDING 378
6. RATES OF EXCHANGE OF MICELLAR AND INTERMICELLAR COMPONENTS 379
7. CRITICAL AND NON-CRITICAL SELF-ASSOCIATION 379
VII. REVERSE MICELLE FORMATION IN NON-AQUEOUS MEDIA 382
1. BILE ACID ESTERS 382
2. BILE ACIDS AND SALTS 383
3. BILE SALTS WITHIN THE HYDROPHOBIC DOMAINS OF LIPOSOMES AND MEMBRANES
384
VIII. MIXED MICELLE FORMATION 388
1. BILE SALT-HYDROCARBON MICELLES 388
2. BILE SALT-INSOLUBLE AMPHIPHILE MICELLES 389
3. BILE SALT-SWELLING AMPHIPHILE MICELLES 390
4. BILE SALT-SOLUBLE AMPHIPHILE MICELLES 393
5. BILE SALT-SWELLING AMPHIPHILE-INSOLUBLE AMPHIPHILE MICELLES 394
6. MIXED MICELLE-UNILAMELLAR VESICLE TRANSITION 395
7. NATIVE BILE AND INTESTINAL CONTENT 396
ACKNOWLEDGEMENTS 397
REFERENCES 397
CHAPTER 14
ROLES OF BILE ACIDS IN INTESTINAL LIPID DIGESTION AND ABSORPTION B.
BORGSTROM, J.A. BARROWMAN AND M. LINDSTROM (LUND) 405
I. INTRODUCTION 405
1. HISTORICAL REMARKS 405
2. BRIEF OUTLINE OF INTESTINAL LIPID DIGESTION AND ABSORPTION 405
II. ROLES OF BILE SALTS IN THE INTESTINAL LUMEN 406
1. WHAT IS THE PHYSICAL STATE OF THE LIPIDS IN THE INTESTINAL CONTENTS?
406
2. BILE SALTS ARE BAD EMULSIFIERS! 407
3. WHAT IS THE IMPORTANCE OF BILE SALTS FOR THE FUNCTION OF THE
LIPOLYTIC ENZYMES? 407
4. WHAT IS THE COMPOSITION OF THE LUMINAL CONTENTS AFTER A FAT MEAL? 409
III. ROLES OF BILE SALTS IN TRANSPORT OF LIPOLYTIC PRODUCTS FROM LUMEN
OF CYTOSOL THROUGH MUCOSAL DIFFUSION BARRIERS AND PLASMA MEMBRANE 410
1. METHODS EMPLOYED IN THE STUDY OF LIPID ABSORPTION 410
IMAGE 9
2. WHICH ARE THE BARRIERS FOR LIPID TRANSPORT FROM LUMEN TO CYTOSOL? 411
3. WHAT FACTORS DETERMINE THE RATE OF TRANSPORT ACROSS THE INTESTINAL
DIFFUSION BARRIERS? . . .. 413 4. WHAT IS THE ROLE OF MICELLAR
SOLUBILIZATION FOR INTESTINAL LIPID ABSORPTION? 414
5. ABSORPTION OF LIPIDS FROM NON-MICELLAR PHASES 416
IV. ROLES OF BILE SALTS IN INTRACELLULAR EVENTS IN LIPID ABSORPTION 417
V. ROLES OF BILE SALTS IN THE ABSORPTION OF SPECIFIC LIPID CLASSES 419
1. TRIGLYCERIDES 419
2. PHOSPHOLIPIDS 419
3. CHOLESTEROL 419
4. FAT-SOLUBLE VITAMINS 420
5. OTHER NONPOLAR COMPOUNDS 421
VI. ARE BILE SALTS NECESSARY FOR LIPID ABSORPTION? 421
REFERENCES 422
SUBJECT INDEX 427
|
| any_adam_object | 1 |
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| callnumber-search | QD415 QP752.S75 |
| callnumber-sort | QD 3415 |
| callnumber-subject | QD - Chemistry |
| classification_rvk | VK 8540 WD 4000 |
| classification_tum | CHE 697f CHE 889f CHE 840f |
| ctrlnum | (OCoLC)12614074 (DE-599)BVBBV000394555 |
| dewey-full | 574.19/2 574.19/2431 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 574 - [Unassigned] |
| dewey-raw | 574.19/2 574.19/2431 |
| dewey-search | 574.19/2 574.19/2431 |
| dewey-sort | 3574.19 12 |
| dewey-tens | 570 - Biology |
| discipline | Chemie / Pharmazie Biologie Chemie |
| format | Book |
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| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV000394555 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T15:13:21Z |
| institution | BVB |
| isbn | 0444806709 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-000244998 |
| oclc_num | 12614074 |
| open_access_boolean | |
| owner | DE-12 DE-19 DE-BY-UBM DE-703 DE-355 DE-BY-UBR DE-29 DE-83 DE-11 DE-188 |
| owner_facet | DE-12 DE-19 DE-BY-UBM DE-703 DE-355 DE-BY-UBR DE-29 DE-83 DE-11 DE-188 |
| physical | XV, 447 S. Ill., graph. Darst. |
| publishDate | 1985 |
| publishDateSearch | 1985 |
| publishDateSort | 1985 |
| publisher | Elsevier |
| record_format | marc |
| series | New comprehensive biochemistry |
| series2 | New comprehensive biochemistry |
| spelling | Sterols and bile acids ed. Henry Danielsson ... Amsterdam [u.a.] Elsevier 1985 XV, 447 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier New comprehensive biochemistry 12 Acides biliaires - Métabolisme Stérols - Métabolisme Bile Acids and Salts metabolism Bile acids Metabolism Sterols Metabolism Sterols metabolism Stoffwechsel (DE-588)4057699-1 gnd rswk-swf Sterine (DE-588)4126502-6 gnd rswk-swf Gallensäuren (DE-588)4155851-0 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Sterine (DE-588)4126502-6 s DE-604 Gallensäuren (DE-588)4155851-0 s Stoffwechsel (DE-588)4057699-1 s Danielsson, Henry Sonstige oth New comprehensive biochemistry 12 (DE-604)BV000003914 12 SWB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000244998&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Sterols and bile acids New comprehensive biochemistry Acides biliaires - Métabolisme Stérols - Métabolisme Bile Acids and Salts metabolism Bile acids Metabolism Sterols Metabolism Sterols metabolism Stoffwechsel (DE-588)4057699-1 gnd Sterine (DE-588)4126502-6 gnd Gallensäuren (DE-588)4155851-0 gnd |
| subject_GND | (DE-588)4057699-1 (DE-588)4126502-6 (DE-588)4155851-0 (DE-588)4143413-4 |
| title | Sterols and bile acids |
| title_auth | Sterols and bile acids |
| title_exact_search | Sterols and bile acids |
| title_full | Sterols and bile acids ed. Henry Danielsson ... |
| title_fullStr | Sterols and bile acids ed. Henry Danielsson ... |
| title_full_unstemmed | Sterols and bile acids ed. Henry Danielsson ... |
| title_short | Sterols and bile acids |
| title_sort | sterols and bile acids |
| topic | Acides biliaires - Métabolisme Stérols - Métabolisme Bile Acids and Salts metabolism Bile acids Metabolism Sterols Metabolism Sterols metabolism Stoffwechsel (DE-588)4057699-1 gnd Sterine (DE-588)4126502-6 gnd Gallensäuren (DE-588)4155851-0 gnd |
| topic_facet | Acides biliaires - Métabolisme Stérols - Métabolisme Bile Acids and Salts metabolism Bile acids Metabolism Sterols Metabolism Sterols metabolism Stoffwechsel Sterine Gallensäuren Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000244998&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000003914 |
| work_keys_str_mv | AT danielssonhenry sterolsandbileacids |