Spin labeling in pharmacology:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Orlando u.a.
Acad. Pr.
1984
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XII, 229 S. |
| ISBN: | 012354050X |
Internformat
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| 245 | 1 | 0 | |a Spin labeling in pharmacology |c ed. by Jordan L. Holtzman |
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| 650 | 4 | |a Marqueurs de spin | |
| 650 | 4 | |a Médicaments - Analyse | |
| 650 | 4 | |a Pharmacologie expérimentale - Technique | |
| 650 | 4 | |a Spectroscopie de résonance paramagnétique électronique | |
| 650 | 4 | |a Drugs |x Analysis | |
| 650 | 4 | |a Electron Spin Resonance Spectroscopy | |
| 650 | 4 | |a Electron paramagnetic resonance spectroscopy | |
| 650 | 4 | |a Enzymes |x Analysis | |
| 650 | 4 | |a Pharmacology | |
| 650 | 4 | |a Pharmacology, Experimental |x Technique | |
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Datensatz im Suchindex
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| adam_text | A SPIN LABELING IN PHARMACOLOGY EDITED BY JORDAN L. HOLTZMAN MEDICAL
SERVICE VETERANS ADMINISTRATION MEDICAL CENTER MINNEAPOLIS, MINNESOTA
1984 ACADEMIC PRESS, INC. (HARCOURT BRACE JOVANOVICH, PUBLISHERS)
ORLANDO SAN DIEGO NEW YORK LONDON TORONTO MONTREAL SYDNEY TOKYO
UNIVERSITATS- BIBLIOTHEK CONTENTS CONTRIBUTORS IX PREFACE XI 1.
SYNTHESIS AND CHEMISTRY OF NITROXIDE SPIN LABELS JOHN F. W. KEANA I.
INTRODUCTION 2 II. NITROXIDE NOMENCLATURE 5 III. STRUCTURAL FEATURES
CHARACTERISTIC OF A STABLE NITROXIDE 5 IV. X-RAY CRYSTALLOGRAPHIC, NMR,
IR, AND MASS SPECTRAL CHARACTERIZATION OF STABLE NITROXIDES 15 V.
ISOTOPIC SUBSTITUTION 20 VI. NITROXIDE SPIN-LABEL SYNTHESIS 22 VII.
NOVEL AMINES THAT ARE POTENTIAL STABLE NITROXIDE PRECURSORS 55 VIII.
CHEMICAL REACTIONS INVOLVING THE NITROXIDE GROUP 57 IX. CHEMICAL
REACTIONS ON NITROXIDES NOT INVOLVING THE NITROXIDE GROUP 63 X.
DIAMAGNETIC STRUCTURE ANALOGS OF DOXYL, PROXYL, PIPERIDINOXYL, AND
PYRROLINOXYL NITROXIDES 65 XI. DINITROXIDE SPIN LABELS 66 APPENDIX 67
REFERENCES * 67 2. SPIN TRAPPING FREE RADICAL METABOLITES OF TOXIC
CHEMICALS RONALD P. MASON I. THE EXPERIMENT 87 II. SPIN-TRAPPING REVIEWS
88 III. HEMOPROTEIN-ORGANIC HYDROPEROXIDE SYSTEMS 88 IV. LIPID
PEROXIDATION AND PROSTAGLANDIN FORMATION 92 V. CARBON TETRACHLORIDE AND
HALOTHANE 100 VI. SULFUR DIOXIDE, BISULFITE, AND SULFITE 103 VII.
HYDRAZINES 111 VIII. PYRIDINYL RADICALS 116 IX. THIYL FREE RADICALS 117
X. NITROGEN-CENTERED FREE RADICAL FROM 3-METHYLINDOLE 118 VI CONTENTS
XI. SPIN TRAPS AS ENZYME INHIBITORS XII. SPIN TRAPS AND SPIN ADDUCTS AS
SUBSTRATES FOR ENZYMES AND PHYSIOLOGICAL REDUCING AGENTS XIII. SPIN
TRAPS AS RADICAL SCAVENGERS XIV. SPIN-ADDUCT IDENTIFICATION XV.
SPIN-ADDUCT IMPOSTORS XVI. SUMMARY REFERENCES 118 119 120 121 122 124
124 3. USE OF SPIN LABELS AS ENZYME PROBES COLIN F. CHICNELL I.
INTRODUCTION 131 II. DESIGN OF SPIN LABELS AND PROBES 132 HI.
APPLICATION TO ENZYMES 136 IV. CONCLUSION 156 REFERENCES 156 4. USE OF
SPIN LABELS IN THE STUDY OF DRUG EFFECTS ON MEMBRANES JAMES R. TRUDELL
I. MEASUREMENT OF ORDER PARAMETER IN MEMBRANES 159 II. PHASE TRANSITIONS
AND PHASE SEPARATIONS IN MEMBRANES 166 III. PH AND ELECTROSTATIC
GRADIENTS ACROSS MEMBRANES 171 REFERENCES 173 5. ENZYMATIC REACTIONS OF
SPIN LABELS ELMER J. RAUCKMAN, GERALD M. ROSEN, AND LANDIS K. GRIFFETH
I. INTRODUCTION 175 II. DIRECT ENZYMATIC REACTIONS INVOLVING
NITROXIDES 178 III. INDIRECT ENZYMATIC REACTIONS OF NITROXIDES 180 IV.
REACTIONS RESULTING IN THE FORMATION OF NITROXIDES 182 V. NITROXIDES AS
ENZYME INHIBITORS 186 VI. POTENTIAL IN VIVO USE OF NITROXIDES 186 VII.
CONCLUSION . 188 REFERENCES 189 CONTENTS VII 6. APPLICATION OF SPIN
LABELING TO THE STUDY OF PROTEIN BINDING OF DRUGS JORDAN L. HOLTZMAN I.
INTRODUCTION 191 II. TECHNIQUES FOR THE STUDY OF BINDING 192 III. BASIC
CONSIDERATIONS IN THE APPLICATION OF SPIN LABELING TO BINDING STUDIES
195 IV. APPLICATION OF SPIN LABELING TO BINDING STUDIES 202 V. EXAMPLES
OF THE STUDY OF THE BINDING OF SPIN-LABELED DRUGS TO SERUM PROTEINS 208
VI. STUDIES ON THE ESR SPECTRUM OF PHENYTOIN BOUND TO BOVINE SERUM
ALBUMIN 219 VII. CONCLUSIONS 220 APPENDIX I. ANALYSIS OF THE BINDING OF
DRUGS THAT DO NOT SATURATE THE BINDING PROTEIN 221 APPENDIX II. BINDING
ANALYSIS OF DRUGS THAT SATURATE THE BINDING SITES . 222 REFERENCES 223
INDEX 225
|
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| language | English |
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| spelling | Spin labeling in pharmacology ed. by Jordan L. Holtzman Orlando u.a. Acad. Pr. 1984 XII, 229 S. txt rdacontent n rdamedia nc rdacarrier Enzymes - Analyse Marqueurs de spin Médicaments - Analyse Pharmacologie expérimentale - Technique Spectroscopie de résonance paramagnétique électronique Drugs Analysis Electron Spin Resonance Spectroscopy Electron paramagnetic resonance spectroscopy Enzymes Analysis Pharmacology Pharmacology, Experimental Technique Spin Labels Spin labels Pharmakologie (DE-588)4045687-0 gnd rswk-swf Elektronenspinresonanzspektroskopie (DE-588)4151888-3 gnd rswk-swf Enzym (DE-588)4014988-2 gnd rswk-swf Spinmarkierung (DE-588)4182318-7 gnd rswk-swf Spinmarkierung (DE-588)4182318-7 s Pharmakologie (DE-588)4045687-0 s DE-604 Enzym (DE-588)4014988-2 s Elektronenspinresonanzspektroskopie (DE-588)4151888-3 s Holtzman, Jordan L. Sonstige oth GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000199512&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Spin labeling in pharmacology Enzymes - Analyse Marqueurs de spin Médicaments - Analyse Pharmacologie expérimentale - Technique Spectroscopie de résonance paramagnétique électronique Drugs Analysis Electron Spin Resonance Spectroscopy Electron paramagnetic resonance spectroscopy Enzymes Analysis Pharmacology Pharmacology, Experimental Technique Spin Labels Spin labels Pharmakologie (DE-588)4045687-0 gnd Elektronenspinresonanzspektroskopie (DE-588)4151888-3 gnd Enzym (DE-588)4014988-2 gnd Spinmarkierung (DE-588)4182318-7 gnd |
| subject_GND | (DE-588)4045687-0 (DE-588)4151888-3 (DE-588)4014988-2 (DE-588)4182318-7 |
| title | Spin labeling in pharmacology |
| title_auth | Spin labeling in pharmacology |
| title_exact_search | Spin labeling in pharmacology |
| title_full | Spin labeling in pharmacology ed. by Jordan L. Holtzman |
| title_fullStr | Spin labeling in pharmacology ed. by Jordan L. Holtzman |
| title_full_unstemmed | Spin labeling in pharmacology ed. by Jordan L. Holtzman |
| title_short | Spin labeling in pharmacology |
| title_sort | spin labeling in pharmacology |
| topic | Enzymes - Analyse Marqueurs de spin Médicaments - Analyse Pharmacologie expérimentale - Technique Spectroscopie de résonance paramagnétique électronique Drugs Analysis Electron Spin Resonance Spectroscopy Electron paramagnetic resonance spectroscopy Enzymes Analysis Pharmacology Pharmacology, Experimental Technique Spin Labels Spin labels Pharmakologie (DE-588)4045687-0 gnd Elektronenspinresonanzspektroskopie (DE-588)4151888-3 gnd Enzym (DE-588)4014988-2 gnd Spinmarkierung (DE-588)4182318-7 gnd |
| topic_facet | Enzymes - Analyse Marqueurs de spin Médicaments - Analyse Pharmacologie expérimentale - Technique Spectroscopie de résonance paramagnétique électronique Drugs Analysis Electron Spin Resonance Spectroscopy Electron paramagnetic resonance spectroscopy Enzymes Analysis Pharmacology Pharmacology, Experimental Technique Spin Labels Spin labels Pharmakologie Elektronenspinresonanzspektroskopie Enzym Spinmarkierung |
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