Multidimensional pharmacochemistry: design of safer drugs
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Orlando u.a.
Acad. Pr.
1984
|
| Schriftenreihe: | Medicinal chemistry
20 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XIV, 418 S. |
| ISBN: | 0124650201 |
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Datensatz im Suchindex
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| adam_text | - 06? O MULTIDIMENSIONAL PHARMACOCHEMISTRY DESIGN OF SAFER DRUGS PETER
P. MAGER RESEARCH GROUP FOR PHARMACOCHEMISTRY THE MEDICINAL BRANCH OF
THE KARL MARX UNIVERSITY LEIPZIG, GERMAN DEMOCRATIC REPUBLIC
UNIVERSITATS- BIBL^IOTHEK 1984 ACADEMIC PRESS, INC. (HARCOURT BRACE
JOVANOVICH, PUBLISHERS) ORLANDO SAN DIEGO NEW YORK LONDON TORONTO
MONTREAL SYDNEY TOKYO CONTENTS PREFACE XI INTRODUCTORY REMARKS XIII /
SOME ASPECTS OF MEDICINAL CHEMISTRY TODAY I. THE SCIENTIFIC ASPECT 1 II.
THE MULTIDIMENSIONAL VIEW 3 III. INNOVATION PROBLEMS IN DRUG DESIGN AND
PUBLIC OPINION 4 2 BIOCHEMICAL-PHARMACOLOGICAL DESIGN I. ARIENS S THREE
PHASES OF DRUG ACTION 6 II. SPANNING BIOSYSTEM-PARAMETER SPACE . 7 III.
INFLUENCING THE PHARMACOKINETIC-TOXOKINETIC PHASE THROUGH MOLECULAR
MANIPULATION 9 IV. THE PHARMACODYNAMIC-TOXODYNAMIC PHASE 47 V.
PHARMACOLOGICAL-TOXICOLOGICAL DATA BANKS 58 VI. CONCLUDING REMARKS . 59
3 UNDERLYING THEORY OF MULTIVARIATE STATISTICS I. DEFINITION OF
STATISTICAL TERMS 60 II. THE STRUCTURE OF A MULTIVARIATE DESIGN 62 III.
THE MASCA APPROACH 66 VII VLLL CONTENTS IV. IF MANY BIOLOGICAL RESPONSES
MUST BE ANALYZED, WHY CAN MANY UNIVARIATE APPROACHES NOT BE EMPLOYED? 69
V. MULTIVARIATE TEST CRITERIA AND SIGNIFICANCE POINTS 71 VI.
REQUIREMENTS AND ROBUSTNESS OF MULTIVARIATE APPROACHES 78 VII. OPERATOR
EQUATIONS 80 VIII. RECOGNITION AND PREDICTABILITY 81 IX. CONCLUDING
REMARKS 82 4 MULTIVARIATE BIOASSAY I. GENERAL REMARKS 83 II. ONE-GROUP
CASE: REPEATED MEASUREMENTS 84 III. TEST ON OUTLIERS 90 IV. ONE-GROUP
CASE: PROBABILISTIC PRINCIPAL COMPONENT ANALYSIS (PRINCO) 91 V.
TWO-GROUP CASE: FIXED FACTORS 126 VI. TWO-GROUP CASE: REPEATED
MEASUREMENTS 145 VII. ONE-WAY CLASSIFICATION OF MULTIVARIATE VARIANCE
ANALYSIS (MANOVA) 146 VIII. TWO-WAY CLASSIFICATION OF MANOVA 167 IX.
MULTIVARIATE CORRELATION AND REGRESSION ANALYSIS (KANORA) 183 X.
MULTIVARIATE COVARIANCE ANALYSIS (MACOVA) 206 XI. MULTIVARIATE
AUTOCORRELATION (MARA) 213 XII. ANALYSIS OF DISCRETE DATA 215 XIII.
CONCLUDING REMARKS 218 5 UNITY THROUGH DIVERSITY I. II. III. IV. V. GOAL
OF THE PRINCO KANORA MANOVA CLASCA ANALYSIS AND DISCRA 220 221 224 228
230 6 PHYSICOCHEMICAL PARAMETERS I. SYNTHESIS DESIGN 234 II. MOLECULAR
STRUCTURE CODING 242 CONTENTS IX III. MULTIDIMENSIONALITY IN
DESCRIBING SUBSTITUENT EFFECTS 246 IV. PHYSICOCHEMICAL DATA BANKS 280 V.
CONCLUDING REMARKS 281 7 THE MULTIVARIATE QUANTITATIVE
STRUCTURE-ACTIVITY RELATIONSHIP I. INTRODUCTION TO UNIVARIATE QSAR 282
II. PRINCIPAL COMPONENT REGRESSION ANALYSIS (PCRA) 296 III.
OVERALL-RESPONSE (OR) PARAMETER ANALYSIS 315 IV. KANORA APPLIED TO QSAR
321 V. GENERALIZED PARABOLIC MODEL (RESPONSE SURFACE OPTIMIZATION) 346
VI. GROUPED OBSERVATIONS 352 VII. SUMMARY 373 8 DISCUSSIONS AND FUTURE
PERSPECTIVES IN MULTIDIMENSIONAL PHARMACOCHEMISTRY 376 REFERENCES 383
INDEX 403
|
| any_adam_object | 1 |
| author | Mager, Peter P. |
| author_facet | Mager, Peter P. |
| author_role | aut |
| author_sort | Mager, Peter P. |
| author_variant | p p m pp ppm |
| building | Verbundindex |
| bvnumber | BV000323654 |
| callnumber-first | Q - Science |
| callnumber-label | QV744 M192M 1984 |
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| dewey-full | 615/.19 |
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| dewey-ones | 615 - Pharmacology and therapeutics |
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| dewey-search | 615/.19 |
| dewey-sort | 3615 219 |
| dewey-tens | 610 - Medicine and health |
| discipline | Chemie / Pharmazie Medizin |
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| isbn | 0124650201 |
| language | English |
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| physical | XIV, 418 S. |
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| series | Medicinal chemistry |
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| spelling | Mager, Peter P. Verfasser aut Multidimensional pharmacochemistry design of safer drugs Orlando u.a. Acad. Pr. 1984 XIV, 418 S. txt rdacontent n rdamedia nc rdacarrier Medicinal chemistry 20 Chimie pharmaceutique Chimie pharmaceutique - Méthodes statistiques Farmacochemie gtt Geneesmiddelen gtt Variantieanalyse gtt Analysis of Variance Chemistry, Pharmaceutical Pharmaceutical Preparations standards Pharmaceutical chemistry Pharmaceutical chemistry Statistical methods Arzneimittelentwicklung (DE-588)4143176-5 gnd rswk-swf Struktur-Aktivitäts-Beziehung (DE-588)4183784-8 gnd rswk-swf Pharmazeutische Chemie (DE-588)4132158-3 gnd rswk-swf Pharmakologie (DE-588)4045687-0 gnd rswk-swf Pharmazeutische Chemie (DE-588)4132158-3 s DE-604 Struktur-Aktivitäts-Beziehung (DE-588)4183784-8 s Pharmakologie (DE-588)4045687-0 s Arzneimittelentwicklung (DE-588)4143176-5 s Medicinal chemistry 20 (DE-604)BV000893224 20 GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000199075&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Mager, Peter P. Multidimensional pharmacochemistry design of safer drugs Medicinal chemistry Chimie pharmaceutique Chimie pharmaceutique - Méthodes statistiques Farmacochemie gtt Geneesmiddelen gtt Variantieanalyse gtt Analysis of Variance Chemistry, Pharmaceutical Pharmaceutical Preparations standards Pharmaceutical chemistry Pharmaceutical chemistry Statistical methods Arzneimittelentwicklung (DE-588)4143176-5 gnd Struktur-Aktivitäts-Beziehung (DE-588)4183784-8 gnd Pharmazeutische Chemie (DE-588)4132158-3 gnd Pharmakologie (DE-588)4045687-0 gnd |
| subject_GND | (DE-588)4143176-5 (DE-588)4183784-8 (DE-588)4132158-3 (DE-588)4045687-0 |
| title | Multidimensional pharmacochemistry design of safer drugs |
| title_auth | Multidimensional pharmacochemistry design of safer drugs |
| title_exact_search | Multidimensional pharmacochemistry design of safer drugs |
| title_full | Multidimensional pharmacochemistry design of safer drugs |
| title_fullStr | Multidimensional pharmacochemistry design of safer drugs |
| title_full_unstemmed | Multidimensional pharmacochemistry design of safer drugs |
| title_short | Multidimensional pharmacochemistry |
| title_sort | multidimensional pharmacochemistry design of safer drugs |
| title_sub | design of safer drugs |
| topic | Chimie pharmaceutique Chimie pharmaceutique - Méthodes statistiques Farmacochemie gtt Geneesmiddelen gtt Variantieanalyse gtt Analysis of Variance Chemistry, Pharmaceutical Pharmaceutical Preparations standards Pharmaceutical chemistry Pharmaceutical chemistry Statistical methods Arzneimittelentwicklung (DE-588)4143176-5 gnd Struktur-Aktivitäts-Beziehung (DE-588)4183784-8 gnd Pharmazeutische Chemie (DE-588)4132158-3 gnd Pharmakologie (DE-588)4045687-0 gnd |
| topic_facet | Chimie pharmaceutique Chimie pharmaceutique - Méthodes statistiques Farmacochemie Geneesmiddelen Variantieanalyse Analysis of Variance Chemistry, Pharmaceutical Pharmaceutical Preparations standards Pharmaceutical chemistry Pharmaceutical chemistry Statistical methods Arzneimittelentwicklung Struktur-Aktivitäts-Beziehung Pharmazeutische Chemie Pharmakologie |
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