Toxicology of inhaled materials: general principles of inhalation toxicology
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Berlin [u.a.]
Springer
1985
|
| Schriftenreihe: | Handbook of experimental pharmacology
75 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XVII, 553 S. Ill., graph. Darst. |
| ISBN: | 3540131094 0387131094 |
Internformat
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| 245 | 1 | 0 | |a Toxicology of inhaled materials |b general principles of inhalation toxicology |c contributors I. Y. R. Adamson ... Ed. H. P. Witschi ... |
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| 490 | 1 | |a Handbook of experimental pharmacology |v 75 | |
| 650 | 4 | |a Aérosols - Toxicologie | |
| 650 | 4 | |a Gaz asphyxiants et délétères | |
| 650 | 4 | |a Toxicologie expérimentale | |
| 650 | 4 | |a Aerosols |x Toxicology | |
| 650 | 4 | |a Environmental Pollutants |x toxicity | |
| 650 | 4 | |a Gases, Asphyxiating and poisonous | |
| 650 | 4 | |a Respiratory Tract Diseases |x chemically induced | |
| 650 | 4 | |a Toxicology | |
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Datensatz im Suchindex
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| adam_text | ZOO TOXICOLOGY OF INHALED MATERIALS GENERAL PRINCIPLES OF INHALATION
TOXICOLOGY CONTRIBUTORS I.Y. R. ADAMSON * B. D. BECK * M. R. BECKLAKE *
J. D. BRAIN J. D. CRAPO * R. T. DREW * D. L. DUNGWORTH * A. B. FISHER T.
E. GRAM * P J. HAKKINEN * J. A. LAST * M. LIPPMANN M. G. MUSTAFA * K.E.
PINKERTON * C. E. PLOPPER * K. M. REISER S. A. ROONEY * B.T. SMITH * J.
M. STURGESS * W. S. TYLER PA.VALBERGH.P.WITSCHI EDITORS H. P. WITSCHI
AND J. D. BRAIN UNIVERSITATS- BIBLIOTHEK SPRINGER-VERLAG BERLIN
HEIDELBERG NEW YORK TOKYO CONTENTS EXPOSURE TECHNIQUES CHAPTER 1 THE
DESIGN AND OPERATION OF SYSTEMS FOR INHALATION EXPOSURE OF ANIMALS R. T.
DREW. WITH 6 FIGURES A. INTRODUCTION 3 B. DESIGN 3 I. FACILITIES 3 II.
SIMPLE SYSTEMS 4 III. CURRENT CHAMBER DESIGN 5 IV. ROOMS AS CHAMBERS 7
V. ISOLATION SYSTEMS 8 VI. GENERAL DESIGN FEATURES 8 C. OPERATION . . 9
I. STATIC SYSTEMS 9 II. DYNAMIC SYSTEMS 10 III. CHAMBER CONCENTRATION 11
IV. AIRFLOW 12 V. STATIC PRESSURE 12 VI. TEMPERATURE AND HUMIDITY . 13
VII. EXPOSURE DURATION . 13 VIII. NOIS E *.. . 13 IX. ANIMAL LOADING 14
X. CAGES AND RACKS 14 D. LIMITED EXPOSURE SYSTEMS 15 E. SUMMARY 18
REFERENCES 18 CHAPTER 2 GASES AND VAPORS: GENERATION AND ANALYSIS. M.
LIPPMANN WITH 11 FIGURES A. INTRODUCTION 23 B. GENERATION AND
ATMOSPHERES 25 I.STATIC SYSTEMS 25 II. DYNAMIC SYSTEMS 27 X CONTENTS C.
MONITORING AND CONTROL OF CONCENTRATIONS 30 I. BASIC CONSIDERATIONS IN
MONITORING 31 II. CONTROL OF CONCENTRATION 32 III. TYPES OF MONITORS 33
D. SAMPLING AND ANALYSIS 44 I. SAMPLING PROCEDURES 44 II. SAMPLING TRAIN
51 III. ANALYSIS OF GASES AND VAPORS 51 E. CALIBRATION AND RECORD
KEEPING 51 I. CALIBRATION TECHNIQUES 51 II. DATA HANDLING 54 F. SUMMARY
55 REFERENCES 55 CHAPTER 3 DETERMINATION OF RETAINED LUNG DOSE. P. A.
VALBERG. WITH 5 FIGURES A. GENERAL PRINCIPLES 57 I. TYPES OF AEROSOLS 57
II. DESCRIPTION OF THE AEROSOL 60 III. CHARACTERIZATION OF RETAINED DOSE
63 B. PREDICTING DOSE FROM EXPOSURE: DETERMINING FACTORS 64 I.
DEPOSITION AS RELATED TO PARTICLE PROPERTIES 65 II. PATTERN OF
VENTILATION 70 III. RESPIRATORY TRACT ANATOMY 72 IV. EFFECT OF DISEASE
AND AGE 72 V. MODELS OF LUNG DEPOSITION 73 C. DOSE BY MEASUREMENT OF
INSPIRED AND EXPIRED AEROSOL 75 I. MASS BALANCE MEASUREMENT 75 II.
WITHIN-BREATH ANALYSIS 75 D. INFECTIOUS PARTICLES 75 E. TECHNIQUES
UTILIZING RADIOACTIVITY 76 I. RADIOPACITY : . . . . 76 II. WHOLE BODY
COUNTING 76 III. COLLIMATED DETECTORS AND GAMMA CAMERAS 76 IV. TISSUE
SAMPLES AND DISSECTION 77 F. MORPHOLOGICAL METHODS 82 I. MEASUREMENT AT
AUTOPSY 82 II. LIGHT AND ELECTRON MICROSCOPY 82 III. MORPHOMETRY 82 G.
MAGNETOPNEUMOGRAPHY 83 I. RETENTION FROM OCCUPATIONAL EXPOSURE 83 II.
MEASUREMENT OF LUNG CLEARANCE 83 III. PARTICLE ENVIRONMENT MEASUREMENTS:
RELAXATION 83 H. TOMOGRAPHY: THE IMAGING PROBLEM 84 I. COMPUTED X-RAY
TRANSMISSION TOMOGRAPHY 84 II. EMISSION TOMOGRAPHY: Y-RAY AND POSITRON
84 III. NUCLEAR MAGNETIC RESONANCE 84 REFERENCES 85 CONTENTS XI GENERAL
ASSESSMENT OF TOXIC EFFECTS CHAPTER 4 ANIMAL MODELS. P. J. HAKKINEN AND
H. P. WITSCHI A. INTRODUCTION 95 B. ADVANTAGES AND DISADVANTAGES OF
DIFFERENT SPECIES 96 I. MICE 96 II. RATS 98 III. HAMSTERS 100 IV.
RABBITS 101 V. GUINEA PIGS 102 VI. DOGS 103 VII. CATS 104 VIII. SHEEP
104 IX. HORSES AND DONKEYS 105 X. GOATS 105 XI. PIGS 105 XII. CATTLE 106
XIII. NONHUMAN PRIMATES 106 C. CONCLUSIONS 106 REFERENCES 107 CHAPTER 5
EPIDEMIOLOGIC STUDIES IN HUMAN POPULATIONS. MARGARET R. BECKLAKE A.
INTRODUCTION 115 B. SCOPE 115 C. USES OF EPIDEMIOLOGY IN THE GENERAL
ASSESSMENT OF THE TOXIC EFFECTS OF INHALED MATERIALS .117 D. EXPOSURE
117 E. EPIDEMIOLOGIC STUDIES IN HUMAN POPULATIONS . . 119 I.
DEFINITIONS, SOME BASIC CONCEPTS, AND THE GENERAL ASSESSMENT OF A
PROBLEM .119 II. THE ELEMENTS OF A PLANNED STUDY 120 F. DESIGN 122 I.
EXPERIMENTAL DESIGNS 122 II. NONEXPERIMENTAL DESIGNS .123 G. TYPES OF
SURVEY 123 H. POPULATION 126 J. VARIABLES . . . 127 K. MEASUREMENT 129 ,
I. HEALTH MEASUREMENTS 129 II. MEASUREMENTS UNDERLYING THE EXPOSURE
VARIABLE 133 L. ANALYSIS AND INFERENCE 135 M. USES OF EPIDEMIOLOGIC
STUDIES IN THE GENERAL ASSESSMENT OF TOXIC EFFECTS OF INHALED AGENTS 136
I. IDENTIFICATION 136 XII CONTENTS II. ETIOLOGIC STUDIES 138 III.
EVALUATION 140 N. SUMMARY 141 REFERENCES 142 CHAPTER 6 THE ISOLATED
PERFUSED LUNG. A. B. FISHER. WITH 5 FIGURES A. PERSPECTIVE 149 I.
HISTORICAL DEVELOPMENTS 149 II. LUNG PERFUSION SYSTEMS 150 HI. MERITS OF
THE PERFUSED LUNG PREPARATION 150 B. TECHNIQUE OF LUNG PERFUSION 151 I.
INTRODUCTION 151 II. ISOLATION OF THE LUNG FOR PERFUSION 151 III. LUNG
PERFUSION APPARATUS 152 IV. VENTILATION OF THE LUNG 154 V. PERFUSION OF
THE LUNG 156 C. PROPERTIES OF THE PERFUSED LUNG 161 I. MONITORS OF LUNG
STABILITY 161 II. LUNG TISSUE COMPARTMENTS 163 III. PULMONARY EDEMA 164
IV. DISTRIBUTION OF PULMONARY PERFUSATE 166 V. VIABILITY OF THE PERFUSED
LUNG 167 D. METABOLIC FUNCTION OF THE PERFUSED LUNG 168 I. INTERMEDIARY
METABOLISM AND ENERGY STATE 168 II. BIOSYNTHESIS 169 III. METABOLISM OF
HORMONES AND XENOBIOTICS 170 E. LUNG TOXICOLOGY . . 171 I. EXPOSURE
REGIMENS 171 II. PULMONARY RESPONSES TO HYPEROXIA 172 F. CONCLUSIONS 173
REFERENCES 173 CHAPTER 7 PULMONARY CELL AND TISSUE CULTURES. B. T. SMITH
A. INTRODUCTION 181 B. LUNG CELL AND TISSUE CULTURE SYSTEMS 181 I.
STRENGTHS AND WEAKNESSES 181 II. PURE CULTURES OF INDIVIDUAL CELL TYPES
183 III. ISOLATED CELLS IN HETEROGENEOUS SYSTEMS 192 IV. ORGAN CULTURES
192 C. SUMMARY AND FUTURE DIRECTIONS 194 REFERENCES 195 CONTENTS XIII
CHAPTER 8 BRONCHOALVEOLAR LAVAGE. J. D. BRAIN AND BARBARA D. BECK. WITH
6 FIGURES A. INTRODUCTION 203 B. TECHNIQUES OF LUNG LAVAGE 203 C.
COMPOSITION OF BAL 206 I. CELLS 206 II. SMALL MOLECULES 208 III.
MACROMOLECULES 208 D. RELATIONSHIP BETWEEN BAL AND PULMONARY PATHOLOGY
212 E. THE USE OF BAL AS A BIOASSAY TOOL 213 F. BAL AND DISEASE
PROGRESSION 218 G. BAL ASSESSMENTS OF EXPOSURE TO TOXIC AGENTS 219 H.
CONCLUSION 220 REFERENCES 220 MORPHOLOGIC TECHNIQUES CHAPTER 9
MORPHOLOGICAL METHODS FOR GROSS AND MICROSCOPIC PATHOLOGY D. L.
DUNGWORTH, W. S. TYLER, AND C. E. PLOPPER. WITH 6 FIGURES A.
INTRODUCTION 229 B. ROUTINE EXAMINATION 229 I. NASOPHARYNGEAL REGION 229
II. TRACHEOBRONCHIAL TREE AND PULMONARY PARENCHYMA 229 C. SPECIAL
METHODS .240 I. SUBGROSS SURVEY OF LARGE LUNGS 240 II. MORPHOLOGY AND
MORPHOMETRY OF AIRWAYS 241 III. VASCULAR PATTERN 243 IV. STRUCTURE OF
PULMONARY VESSELS AND ALVEOLAR WALLS . . . : . . 244 V. CRYOTECHNIQUES
FOR ANALYSIS OF STRUCTURE AND FUNCTION . . . . . 245 VI. MORPHOLOGICAL
ASSESSMENT OF CELLULAR FUNCTION 247 D. CONCLUSIONS 250 REFERENCES 251
CHAPTER 10 MORPHOMETRY OF THE ALVEOLAR REGION OF THE LUNG K. E.
PINKERTON AND J. D. CRAPO. WITH 9 FIGURES A. WHAT IS MORPHOMETRY? 259 B.
WHY DO MORPHOMETRY? 259 C. TYPES OF DATA OBTAINED BY MORPHOMETRY 259 D.
DESIGN STRATEGY FOR A MORPHOMETRIC STUDY OF LUNG TISSUE 260 I. LIGHT
MICROSCOPY OR ELECTRON MICROSCOPY 260 II. ANIMAL SELECTION AND OPTIMAL
SAMPLE DENSITY 262 XIV CONTENTS E. DETAILED METHODOLOGY 263 I. LUNG
FIXATION 263 ^ II. LUNG VOLUME MEASUREMENT 266 HI. DETERMINATION OF THE
FRACTION OF LUNG THAT IS PARENCHYMA . . . 267 IV. LIGHT MICROSCOPY
ANALYSIS 269 V. ELECTRON MICROSCOPY ANALYSIS 270 VI. EQUIPMENT 283
REFERENCES 283 BIOLOGICAL AND BIOCHEMICAL ANALYSIS CHAPTER 11 CELLULAR
KINETICS OF THE LUNG. I. Y. R. ADAMSON. WITH 8 FIGURES A. INTRODUCTION
289 B. USE OF CYTOKINETICS IN PULMONARY TOXICOLOGY 290 C. METHODS TO
DETERMINE CELL TURNOVER 291 I. AUTORADIOGRAPHY 291 II. MITOTIC ARREST
299 III. OTHER METHODS 301 D. KINETICS OF SPECIFIC LUNG CELLS 302 I.
TRACHEOBRONCHIAL CELLS 302 II. BRONCHIOLAR CELLS 303 III. ALVEOLAR CELLS
305 E. FACTORS AFFECTING CELL TURNOVER 311 I. SEX, STRAIN, AND CIRCADIAN
RHYTHM 311 II. AGE OF ANIMAL 311 III. NUTRITION 312 F. CYTOKINETICS OF
IN VITRO SYSTEMS 313 G. CONCLUSIONS 313 REFERENCES 314 CHAPTER 12
MUCOCILIARY CLEARANCE AND MUCUS SECRETION IN THE LUNG JENNIFER M.
STURGESS. WITH 11 FIGURES A. INTRODUCTION 319 B. BRONCHIAL MUCOSA:
NORMAL STRUCTURE AND FUNCTIONAL ORGANIZATION . 320 I. BASAL AND
INTERMEDIATE CELLS 322 II. CILIATED CELLS 323 III. EPITHELIAL
MUCUS-SECRETING CELLS 326 *IV. BRUSH CELLS 328 V. SUBMUCOSAL GLANDS 328
VI. NEUROENDOCRINE CELLS 329 C. RESPIRATORY SECRETIONS: SOURCE,
COMPOSITION, AND PHYSICOCHEMICAL CHARACTERISTICS 329 I. EXTRACELLULAR
FLUID LINING OF AIRWAYS 329 CONTENTS XV II. CHEMICAL COMPOSITION OF
MUCOUS SECRETIONS 333 III. RHEOLOGICAL PROPERTIES OF MUCOUS SECRETIONS
336 D. FUNDAMENTAL ASPECTS OF MUCOCILIARY CLEARANCE 337 I. DYNAMICS OF
CILIARY MOVEMENT 337 II. RELATIONSHIP OF CILIARY BEAT AND IN VIVO
MUCOCILIARY CLEARANCE 339 E. MUCOCILIARY CLEARANCE: ASSESSMENT AND FLOW
RATES 340 I. MEASUREMENT OF MUCOCILIARY CLEARANCE IN VIVO 341 II. IN
VITRO ASSESSMENT OF MUCOCILIARY FUNCTION 345 F. FACTORS AFFECTING
MUCOCILIARY TRANSPORT 346 I. PHYSIOLOGIC FACTORS 346 II. PHARMACOLOGIC
AGENTS 347 III. ENVIRONMENTAL FACTORS AND POLLUTANTS 352 IV. INFECTION
354 REFERENCES 355 CHAPTER 13 GENERAL ENZYMOLOGY OF THE LUNG. M. G.
MUSTAFA. WITH 2 FIGURES A. INTRODUCTION 369 B. TISSUE PREPARATION 370 I.
ISOLATION OF LUNG 370 II. ISOLATION OF CELLS 371 III. PREPARATION OF
TISSUE SLICES 373 IV. PREPARATION OF SUBCELLULAR FRACTIONS 374 C.
BIOCHEMICAL AND ENZYMATIC DETERMINATIONS 381 I. BODY WEIGHT AND LUNG
WEIGHT 381 II. LUNG PROTEIN AND DNA CONTENT 382 III. OXYGEN CONSUMPTION
AND ENERGY METABOLISM 383 IV. GLUCOSE METABOLISM 389 V. LIPID METABOLISM
391 VI. PROTEIN METABOLISM . . 394 VII. NUCLEIC ACID METABOLISM . 395
VIII. SULFHYDRYL METABOLISM 395 IX. LIPID PEROXIDATION 399 X. OTHER
ENZYME ACTIVITIES AND METABOLIC PATHWAYS 401 D. CONCLUSIONS 403
REFERENCES .403 CHAPTER 14 THE PULMONARY MIXED-FUNCTION OXIDASE SYSTEM
T. E. GRAM. WITH 10 FIGURES A. INTRODUCTION 421 B. CELL TYPES OF LUNG
421 C. DRUG OXIDATION BY LUNG 422 I. PULMONARY CELL FRACTIONATION AND
THE PREPARATION OF MICROSOMES 423 XVI CONTENTS II. PRAGMATIC
CONSIDERATIONS IN THE PREPARATION OF PULMONARY * MICROSOMES 425 III. THE
MICROSOMAL MONOOXYGENASE SYSTEM OF MAMMALIAN LUNG . 425 D.
MIXED-FUNCTION OXIDASE ACTIVITY IN SPECIFIC PULMONARY CELL TYPES . 431
I. PULMONARY ALVEOLAR MACROPHAGE 431 II. DISPERSED SINGLE CELLS ISOLATED
FROM WHOLE LUNG 432 III. TYPE I PNEUMOCYTES 432 IV. TYPE II PNEUMOCYTES
432 V. NONCILIATED BRONCHIOLAR (CLARA) CELLS 433 E. INDUCTION OF THE
PULMONARY MIXED-FUNCTION OXIDASE SYSTEM . . . . 435 I. PHENOBARBITAL 435
II. 3-METHYLCHOLANTHRENE AND OTHER POLYCYCLIC AROMATIC HYDROCARBONS:
TOBACCO SMOKE, CANNABIS 435 III. FLAVONES 439 IV. BENZOTHIAZOLES 439 V.
PHENOTHIAZINES 439 F. THE ROLE OF THE LUNG IN WHOLE BODY DRUG CLEARANCE
439 G. THE ROLE OF PULMONARY XENOBIOTIC METABOLISM IN CHEMICALLY INDUCED
LUNG DAMAGE 441 I. POLYCYCLIC AROMATIC HYDROCARBONS 441 II. FURANS 445
III. CARBON TETRACHLORIDE 448 IV. BUTYLATED HYDROXYTOLUENE 448 V.
PARAQUAT 449 VI. MISCELLANEOUS COMPOUNDS 453 REFERENCES 460 CHAPTER 15
THE SURFACTANT SYSTEM OF THE LUNG. S. A. ROONEY. WITH 1 FIGURE A.
INTRODUCTION 471 B. SURFACTANT COMPOSITION 472 C. BIOSYNTHESIS OF
SURFACTANT PHOSPHOLIPIDS 473 I. CELLULAR SITE OF SURFACTANT SYNTHESIS
473 II. ROLE OF LAMELLAR BODIES IN SURFACTANT PRODUCTION 473 III.
SYNTHESIS OF PHOSPHATIDYLCHOLINE 474 IV. SYNTHESIS OF
PHOSPHATIDYLGLYCEROL 476 D. CONTROL OF SURFACTANT SECRETION 477 E.
TURNOVER AND REMOVAL OF SURFACTANT 478 F. METHODS OF MEASURING
SURFACTANT 480 I. GENERAL COMMENTS 480 II. PHYSICAL METHODS 481 III.
BIOCHEMICAL METHODS 482 IV. OTHER METHODS 485 G. THE FETAL LUNG AS AN
EXAMPLE OF ALTERED SURFACTANT PRODUCTION . .485 H. ALTERED SURFACTANT
DUE TO TOXICANTS IN THE AIRWAYS 486 REFERENCES 491 CONTENTS XVII CHAPTER
16 EFFECTS OF PNEUMOTOXINS ON LUNG CONNECTIVE TISSUE J. A. LAST AND K.
M. REISER A. INTRODUCTION 503 B. PNEUMOTOXINS AND LUNG COLLAGEN 503 I.
HISTOLOGIC STUDIES 504 II. MORPHOMETRIC STUDIES 504 III. ELECTRON
MICROSCOPY 505 IV. IMMUNOFLUORESCENT STUDIES 505 V. PHYSIOLOGIC STUDIES
505 VI. BIOCHEMICAL STUDIES 506 VII. SPECIFIC FIBROTIC AGENTS 507 C.
PNEUMOTOXINS AND LUNG ELASTIN 508 D. MECHANISMS OF PNEUMOTOXIN-INDUCED
DAMAGE TO CONNECTIVE TISSUE . 509 I. CENTRAL ROLE OF FREE RADICALS IN
FIBROSIS 510 II. CENTRAL ROLE OF FIBROGENIC FACTORS 510 III. CENTRAL
ROLE OF IMMUNOLOGIC FACTORS ....511 IV. SYNERGISM IN PNEUMOTOXIN-INDUCED
LUNG INJURY 511 V. MECHANISMS OF INJURY IN EXPERIMENT EMPHYSEMA 512
REFERENCES 521 SUBJECT INDEX 537
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| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV000321740 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T15:12:16Z |
| institution | BVB |
| isbn | 3540131094 0387131094 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-000197823 |
| oclc_num | 11159078 |
| open_access_boolean | |
| owner | DE-12 DE-19 DE-BY-UBM DE-355 DE-BY-UBR DE-20 DE-11 DE-188 DE-578 |
| owner_facet | DE-12 DE-19 DE-BY-UBM DE-355 DE-BY-UBR DE-20 DE-11 DE-188 DE-578 |
| physical | XVII, 553 S. Ill., graph. Darst. |
| publishDate | 1985 |
| publishDateSearch | 1985 |
| publishDateSort | 1985 |
| publisher | Springer |
| record_format | marc |
| series | Handbook of experimental pharmacology |
| series2 | Handbook of experimental pharmacology |
| spelling | Toxicology of inhaled materials general principles of inhalation toxicology contributors I. Y. R. Adamson ... Ed. H. P. Witschi ... Berlin [u.a.] Springer 1985 XVII, 553 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Handbook of experimental pharmacology 75 Aérosols - Toxicologie Gaz asphyxiants et délétères Toxicologie expérimentale Aerosols Toxicology Environmental Pollutants toxicity Gases, Asphyxiating and poisonous Respiratory Tract Diseases chemically induced Toxicology Toxicology, Experimental Toxikologie (DE-588)4060538-3 gnd rswk-swf Inhalationstoxizität (DE-588)4133542-9 gnd rswk-swf Inhalation (DE-588)4161727-7 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Inhalation (DE-588)4161727-7 s Toxikologie (DE-588)4060538-3 s DE-604 Inhalationstoxizität (DE-588)4133542-9 s Witschi, Hanspeter Sonstige oth Adamson, Ian Y. R. Sonstige oth Handbook of experimental pharmacology 75 (DE-604)BV002390716 75 GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000197823&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Toxicology of inhaled materials general principles of inhalation toxicology Handbook of experimental pharmacology Aérosols - Toxicologie Gaz asphyxiants et délétères Toxicologie expérimentale Aerosols Toxicology Environmental Pollutants toxicity Gases, Asphyxiating and poisonous Respiratory Tract Diseases chemically induced Toxicology Toxicology, Experimental Toxikologie (DE-588)4060538-3 gnd Inhalationstoxizität (DE-588)4133542-9 gnd Inhalation (DE-588)4161727-7 gnd |
| subject_GND | (DE-588)4060538-3 (DE-588)4133542-9 (DE-588)4161727-7 (DE-588)4143413-4 |
| title | Toxicology of inhaled materials general principles of inhalation toxicology |
| title_auth | Toxicology of inhaled materials general principles of inhalation toxicology |
| title_exact_search | Toxicology of inhaled materials general principles of inhalation toxicology |
| title_full | Toxicology of inhaled materials general principles of inhalation toxicology contributors I. Y. R. Adamson ... Ed. H. P. Witschi ... |
| title_fullStr | Toxicology of inhaled materials general principles of inhalation toxicology contributors I. Y. R. Adamson ... Ed. H. P. Witschi ... |
| title_full_unstemmed | Toxicology of inhaled materials general principles of inhalation toxicology contributors I. Y. R. Adamson ... Ed. H. P. Witschi ... |
| title_short | Toxicology of inhaled materials |
| title_sort | toxicology of inhaled materials general principles of inhalation toxicology |
| title_sub | general principles of inhalation toxicology |
| topic | Aérosols - Toxicologie Gaz asphyxiants et délétères Toxicologie expérimentale Aerosols Toxicology Environmental Pollutants toxicity Gases, Asphyxiating and poisonous Respiratory Tract Diseases chemically induced Toxicology Toxicology, Experimental Toxikologie (DE-588)4060538-3 gnd Inhalationstoxizität (DE-588)4133542-9 gnd Inhalation (DE-588)4161727-7 gnd |
| topic_facet | Aérosols - Toxicologie Gaz asphyxiants et délétères Toxicologie expérimentale Aerosols Toxicology Environmental Pollutants toxicity Gases, Asphyxiating and poisonous Respiratory Tract Diseases chemically induced Toxicology Toxicology, Experimental Toxikologie Inhalationstoxizität Inhalation Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000197823&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV002390716 |
| work_keys_str_mv | AT witschihanspeter toxicologyofinhaledmaterialsgeneralprinciplesofinhalationtoxicology AT adamsonianyr toxicologyofinhaledmaterialsgeneralprinciplesofinhalationtoxicology |