Drug resistance in mycobacteria:
Gespeichert in:
| 1. Verfasser: | |
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| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Boca Raton, Fla.
CRC Pr.
1984
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | 167 S. |
| ISBN: | 0849365740 |
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| 650 | 4 | |a Drug resistance in microorganisms | |
| 650 | 4 | |a Microbial Sensitivity Tests |x methods | |
| 650 | 4 | |a Mycobacteria | |
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| adam_text | 2&30 O DRUG RESISTANCE IN MYCOBACTERIA AUTHOR PATTISAPU RAMA JOGI
GANGADHARAM, PH.D. DIRECTOR, MYCOBACTERIOLOGY RESEARCH NATIONAL JEWISH
HOSPITAL AND RESEARCH CENTER/ NATIONAL ASTHMA CENTER DENVER, COLORADO
UNIVERSITATS- BIBLIOTH! CRC PRESS, INC. BOCA RATON, FLORIDA TABLE OF
CONTENTS CHAPTER 1 INTRODUCTION 1 REFERENCES 5 CHAPTER 2 DEFINITIONS OF
DRUG RESISTANCE 7 REFERENCES 8 CHAPTER 3 ORIGIN OF DRUG RESISTANCE 9 I.
MUTATION-SELECTION THEORY 9 II. BASIC GENETIC STUDIES 9 III. INCREASE IN
THE PROPORTION OF MUTANTS WITH TIME 12 IV. SPEED OF DEVELOPMENT OF
RESISTANT MUTANTS 13 V. PROPORTION OF NATURALLY OCCURRING RESISTANT
MUTANTS IN WILD STRAINS OF TUBERCLE BACILLI 16 VI. STABILITY OF THE
RESISTANCE PATTERN OF THE MUTANTS 16 VII. INDIRECT SELECTION OF MUTANTS
16 VIII. IN VITRO AND CLINICAL EVIDENCE SUPPORTING THE MUTATION THEORY
18 A. IN VITRO EVIDENCE 18 B. FALL AND RISE PHENOMENON 18 C. CLINICAL
EVIDENCE 18 IX. GENETIC TRANSFER MECHANISMS 21 A. CONJUGATION 21 B.
TRANSFORMATION 21 C. TRANSDUCTION 21 D. RESISTANCE FACTORS 22 E.
PLASMIDS 22 F. ADAPTATION THEORY 23 REFERENCES 24 CHAPTER 4 MECHANISM OF
DRUG RESISTANCE 27 I. MECHANISM OF DEVELOPMENT OF RESISTANCE TO
ISONIAZID : 27 II. MECHANISM OF DEVELOPMENT OF RESISTANCE TO
STREPTOMYCIN AND OTHER AMINOGLY- COSIDE ANTIBIOTICS _ 28 III. EARLIER
LITERATURE ON NONMYCOBACTERIAL SYSTEMS 28 IV. MECHANISM OF DEVELOPMENT
OF RESISTANCE TO AMINOGLYCOSIDE ANTIBIOTICS IN MYCOBACTERIAL SYSTEMS 29
V. MECHANISMS OF DEVELOPMENT OF RESISTANCE TO RIFAMPIN 30 VI. MECHANISM
OF RESISTANCE TO PAS 30 VII. MECHANISM OF RESISTANCE TO CYCLOSERINE 31
VIII. MECHANISM OF RESISTANCE TO PYRAZINAMIDE 31 REFERENCES 31 CHAPTER 5
BIOLOGICAL VARIATIONS CONSEQUENT TO DRUG RESISTANCE 35 I. NUTRITIONAL
REQUIREMENTS 35 II. ENZYME ACTIVITIES 35 III. VIRULENCE TO THE
EXPERIMENTAL ANIMALS 35 REFERENCES 39 CHAPTER 6 SPECIAL ASPECTS OF DRUG
RESISTANCE 41 I. NATURAL RESISTANCE TO PAS 41 II. NATURAL RESISTANCE TO
THIACETAZONE 42 III. CROSS RESISTANCE 45 IV. MICROBIAL PERSISTENCE 48
REFERENCES 49 CHAPTER 7 EMERGENCE OF DRUG RESISTANCE 51 I. FACTORS
RESPONSIBLE FOR THE DEVELOPMENT OF DRUG RESISTANCE 52 II. METHODS OF
AVOIDING DRUG RESISTANCE IN PATIENTS 53 REFERENCES 54 CHAPTER 8
TECHNIQUES FOR DRUG SUSCEPTIBILITY TESTING 55 I. DIRECT SUSCEPTIBILITY
METHODS 57 II. METHOD OF MIDDLEBROOK AND COHN 59 III. GRADIENT PLATE
METHOD OF BRYSON AND SZYBALSKI 59 IV. OTHER DIRECT PROCEDURES 60 A.
METHOD USED BY HOBBY AND WICHELHAUSEN IN VA-AF COOPERATIVE STUDIES 60 B.
METHOD OF MACKEY 60 C. METHOD USED BY THE AUTHOR AND ASSOCIATES 61 V.
INDIRECT DRUG SUSCEPTIBILITY TESTS 61 A. ABSOLUTE CONCENTRATION METHOD
61 B. RESISTANCE RATIO (RR) METHOD 62 1. STATISTICAL ASPECTS OF THE
RESISTANCE RATIO METHOD .. 64 A. STATISTICAL CONCEPT OF SUSCEPTIBLE AND
RESISTANT STRAINS ... 64 B. PROBABILITY OF THE STRAINS BEING RESISTANT
OR SUSCEPTIBLE .. 66 C. HOMOGENEITY AND HETEROGENEITY OF SENSITIVE
STRAIN 67 D. INFLUENCE OF THE STANDARD STRAIN H 37 RV OF M. TUBERCULOSIS
ON THE TEST : 68 C. PROPORTION METHOD 70 1. STATISTICAL ASPECTS OF THE
PROPORTION METHOD 71 D. RELATIVE MERITS AND BROAD RECOMMENDATIONS 72 1.
BROAD RECOMMENDATIONS OF THE WHO EXPERT PANEL 73 2. RELATIVE MERITS OF
THE THREE METHODS FOR INDIRECT SENSITIVITY TESTS 73 E. CRITIQUE OF THE
THREE DIFFERENT TESTS 74 VI. FACTORS INFLUENCING THE OUTCOME OF DRUG
SUSCEPTIBILITY TESTS 76 A. MEDIA 76 B. STABILITY OF DRUGS 78 C.
INCUBATION 80 D. INOCULUM 80 E. QUALITY CONTROL 85 VII. SIMPLE AND RAPID
SUSCEPTIBILITY TEST METHODS 86 A. SLIDE CULTURE METHOD 87 B. RUNYON S
METHOD 87 C. SWAB METHOD 89 D. DISK SUSCEPTIBILITY TESTS 90 E. RECENT
METHODS WITH DISK SUSCEPTIBILITY TESTS 92 F. RADIOMETRIC METHODS 94
VIII. DRUG SUSCEPTIBILITY TESTS FOR THE SECOND-LINE DRUGS 101 IX. DRUG
SUSCEPTIBILITY TESTS WITH NONTUBERCULOSIS MYCOBACTERIA 103 X. COMBINED
DRUG SUSCEPTIBILITY TESTS 103 XI. DRUG SUSCEPTIBILITY TESTS IN
DEVELOPING COUNTRIES 105 REFERENCES 106 CHAPTER 9 CLINICAL SIGNIFICANCE
OF DRUG RESISTANCE ILL I. CRITIQUE OF THE RECOMMENDATIONS OF THE HONG
KONG STUDIES 121 REFERENCES 123 CHAPTER 10 EPIDEMIOLOGICAL ASPECTS OF
DRUG RESISTANCE 127 I. PRIMARY DRUG RESISTANCE IN THE WORLD 128 II.
INITIAL DRUG RESISTANCE 148 HI. ACQUIRED DRUG RESISTANCE 151 IV.
EPIDEMIOLOGICAL SIGNIFICANCE OF DRUG RESISTANCE SURVEYS 155 REFERENCES
157 CHAPTER 11 DRUG RESISTANCE, PAST, PRESENT, AND FUTURE 159 INDEX 161
|
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| isbn | 0849365740 |
| language | English |
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| physical | 167 S. |
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| spelling | Gangadharam, Pattisapu R. Verfasser aut Drug resistance in mycobacteria author Pattisapu Rama Jogi Gangadharam Boca Raton, Fla. CRC Pr. 1984 167 S. txt rdacontent n rdamedia nc rdacarrier Micro-organismes - Résistance aux médicaments Mycobactéries Drug Resistance, Microbial Drug resistance in microorganisms Microbial Sensitivity Tests methods Mycobacteria Mycobacterium Arzneimittelresistenz (DE-588)4143180-7 gnd rswk-swf Mykobakterien (DE-588)4170927-5 gnd rswk-swf Mykobakterien (DE-588)4170927-5 s Arzneimittelresistenz (DE-588)4143180-7 s DE-604 GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000096502&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Gangadharam, Pattisapu R. Drug resistance in mycobacteria Micro-organismes - Résistance aux médicaments Mycobactéries Drug Resistance, Microbial Drug resistance in microorganisms Microbial Sensitivity Tests methods Mycobacteria Mycobacterium Arzneimittelresistenz (DE-588)4143180-7 gnd Mykobakterien (DE-588)4170927-5 gnd |
| subject_GND | (DE-588)4143180-7 (DE-588)4170927-5 |
| title | Drug resistance in mycobacteria |
| title_auth | Drug resistance in mycobacteria |
| title_exact_search | Drug resistance in mycobacteria |
| title_full | Drug resistance in mycobacteria author Pattisapu Rama Jogi Gangadharam |
| title_fullStr | Drug resistance in mycobacteria author Pattisapu Rama Jogi Gangadharam |
| title_full_unstemmed | Drug resistance in mycobacteria author Pattisapu Rama Jogi Gangadharam |
| title_short | Drug resistance in mycobacteria |
| title_sort | drug resistance in mycobacteria |
| topic | Micro-organismes - Résistance aux médicaments Mycobactéries Drug Resistance, Microbial Drug resistance in microorganisms Microbial Sensitivity Tests methods Mycobacteria Mycobacterium Arzneimittelresistenz (DE-588)4143180-7 gnd Mykobakterien (DE-588)4170927-5 gnd |
| topic_facet | Micro-organismes - Résistance aux médicaments Mycobactéries Drug Resistance, Microbial Drug resistance in microorganisms Microbial Sensitivity Tests methods Mycobacteria Mycobacterium Arzneimittelresistenz Mykobakterien |
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