PERSONALIZED IMMUNOTHERAPY FOR TUMOR DISEASES AND BEYOND /:
This book introduces personalized immunotherapy with multi-dimensional models of analysis to determine the best plan for immunotherapy of patients. The book introduces readers to some basic concepts which lay the foundation for personalized immunotherapy: the development of a major histocompatibilit...
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| Weitere Verfasser: | , , |
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| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Singapore :
BENTHAM Science PUBLISHER,
2020.
|
| Schlagworte: | |
| Online-Zugang: | DE-862 DE-863 |
| Zusammenfassung: | This book introduces personalized immunotherapy with multi-dimensional models of analysis to determine the best plan for immunotherapy of patients. The book introduces readers to some basic concepts which lay the foundation for personalized immunotherapy: the development of a major histocompatibility complex (MHC), the genome profile of T cells and tumor cells, and genome-wide association studies. Chapters also cover special topics such as new immunoassay methods related to personalized immunotherapy and targeted immunotherapy which are geared towards familiarizing readers with current research practices. Focusing on the central theme of personalized immunotherapy, the authors provide a wealth of information about T-cell screening, tumor neoantigen cloning, primary tumor cell culture for T-cell cloning, bioinformatics strategies for understanding T-cell and primary tumor cell biology and function, and new developments in research on adoptive T-cell immunotherapy. These developments include T-cell gene therapy and T-cell gene editing, transgenic T-cells for increasing affinity to tumor cells such as CAR T-cells and TCR T-cells, and the systematic modeling of polyclonal specific T-cells and biobank technology. Key Features:- Introduces readers to basic concepts in personalized medicine and immunotherapy- Presents current information about immunological assays used in research- Presents an overview of T cell immunotherapy and cloning techniques- Presents an overview of tumor cell bioinformatics and its role in immunotherapy- Includes new developments and references for personalized immunotherapy techniques (T-cell gene therapy and T-cell gene editing, transgenic T-cells which target CAR T-cells and TCR T-cells, and polyclonal T-cell modeling) - Includes a section on biobanking- Presents information in an easy-to-read format for a wide range of readers- Brings contributions from experts with over 30 years of experience in personalized immunotherapy Personalized Immunotherapy for Tumor Diseases and Beyond is an ideal handbook for medical professionals and students involved in personalized medicine, immunology and oncology. General readers interested in the new developments in these fields will also benefit from the information provided. |
| Beschreibung: | 1 online resource |
| ISBN: | 9811482756 9789811482755 |
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| 245 | 0 | 0 | |a PERSONALIZED IMMUNOTHERAPY FOR TUMOR DISEASES AND BEYOND / |c editors, Biaoru Li, Alan Larson, Shen Li. |
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| 505 | 0 | |a Cover -- Title -- Copyright -- End User License Agreement -- Contents -- Preface -- REFERENCES -- List of Contributors -- INTRODUCTION -- MHC and Cancer Immunotherapy -- Li-Hua Jiang1,* and Wei-Hua Yan2 -- OVERVIEW OF MHC GENES AND MOLECULES -- 1. Characteristics of the HLA Gene Complex -- 2. HLA Molecule Structure -- 3. Distribution and Function of HLA Molecules -- 4. MHC Allele Detection -- MHC CLASS I MOLECULAR LOSS AND CANCER IMMUNOTHERAPY -- 1. Loss of Class I HLA Expression in Tumor Tissues -- 2. Types of Class I HLA Deletion. | |
| 505 | 8 | |a 3. Expression of Class I HLA Molecules and Efficiency of Immunotherapy -- 4. The Relation Between Selective Pressure of Immunocyte and Changes of Class-I HLA Expression Pattern in Tumor Cells -- EXPRESSION LEVELS OF NONCLASSICAL MHC CLASS I AND TUMOR IMMUNE ESCAPE -- 1. The HLA Class I Antigen Expression and Cancer -- 2. Roles of HLA Ib Antigens in Immune Modulation -- 3. Clinical Relevance of HLA Ib Expression in Cancers -- 4. Prospective of HLA-E and HLA-G Targeted Cancer Immunotherapy -- MHC FOR T-CELL EPITOPE AND ACTIVE IMMUNE VACCINES -- MHC FOR ADOPTIVE IMMUNE CELL THERAPY -- CONCLUSION | |
| 505 | 8 | |a CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- Immune Cells Signaling-Pathway and Genomic Profiles for Personalized Immunotherapy -- Wei Zhang1, Yan Qu1, Meihua Lin1, Amit Datta1, George E. Liu1,2 and Biaoru Li1,3,* -- INTRODUCTION -- T-CELL MEMBRANE SIGNALING -- T-CELLS PATHWAY AND NETWORKS -- GENOMIC EXPRESSION PROFILE OF T-CELLS -- 1. Genomic Expression Profiles of TIL -- 2. Genomic Expression Profiles from Peripheral Blood Immune Cells -- GENOMIC EXPRESSION PROFILE OF B-CELL -- 1. Genomic Expression Profiles of B-Lymphocyte -- 2. Network of B-lymphocyte | |
| 505 | 8 | |a GENOMIC EXPRESSION PROFILE AND NETWORK OF NK-CELL -- 1. NK-Lymphocyte -- 2. Genomic Expression Profiles of NK-Lymphocyte -- 3. Network of NK-Lymphocyte -- GENOMIC EXPRESSION PROFILE OF NKT-CELL -- 1. NKT-Lymphocyte -- 2. Genomic Expression Profiles and Network of NKT-Lymphocyte -- GENOMIC EXPRESSION PROFILE OF MACROPHAGE -- 1. Macrophage -- 2. Genomic Expression Profiles and Network of Macrophages -- CONCLUSION -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- Immunoassay of Personalized Immunotherapy -- Li-Hua Jiang1 and Biaoru Li1,2,* -- INTRODUCTION | |
| 505 | 8 | |a BASIC RECORD OF IMMUNE FUNCTION AND RESPONSE -- Delayed-Type Hypersensitivity In Vivo -- Measures of Immune Function Ex Vivo -- 1. Detection of T-cell Number with Intracellular Cytokines by Flow Cytometry -- 2. Detection of Secreted Cytokines by ELISA Assays -- 3. Lymphoproliferation Assay -- 4. CTL and Quantifying CTL -- Measures of Antigen-Specific Immune Responses In Vitro/Ex Vivo -- 1. Peptide MHC Tetramers -- 2. TCR Complementarity Determining Region -- Measurement of Cytokine mRNA -- Measurement of Tumor Antibodies -- MEASUREMENT OF IMMUNE TARGETS FOR IMMUNOTHERAPY | |
| 520 | |a This book introduces personalized immunotherapy with multi-dimensional models of analysis to determine the best plan for immunotherapy of patients. The book introduces readers to some basic concepts which lay the foundation for personalized immunotherapy: the development of a major histocompatibility complex (MHC), the genome profile of T cells and tumor cells, and genome-wide association studies. Chapters also cover special topics such as new immunoassay methods related to personalized immunotherapy and targeted immunotherapy which are geared towards familiarizing readers with current research practices. Focusing on the central theme of personalized immunotherapy, the authors provide a wealth of information about T-cell screening, tumor neoantigen cloning, primary tumor cell culture for T-cell cloning, bioinformatics strategies for understanding T-cell and primary tumor cell biology and function, and new developments in research on adoptive T-cell immunotherapy. These developments include T-cell gene therapy and T-cell gene editing, transgenic T-cells for increasing affinity to tumor cells such as CAR T-cells and TCR T-cells, and the systematic modeling of polyclonal specific T-cells and biobank technology. Key Features:- Introduces readers to basic concepts in personalized medicine and immunotherapy- Presents current information about immunological assays used in research- Presents an overview of T cell immunotherapy and cloning techniques- Presents an overview of tumor cell bioinformatics and its role in immunotherapy- Includes new developments and references for personalized immunotherapy techniques (T-cell gene therapy and T-cell gene editing, transgenic T-cells which target CAR T-cells and TCR T-cells, and polyclonal T-cell modeling) - Includes a section on biobanking- Presents information in an easy-to-read format for a wide range of readers- Brings contributions from experts with over 30 years of experience in personalized immunotherapy Personalized Immunotherapy for Tumor Diseases and Beyond is an ideal handbook for medical professionals and students involved in personalized medicine, immunology and oncology. General readers interested in the new developments in these fields will also benefit from the information provided. | ||
| 650 | 0 | |a Cancer |x Immunological aspects. |0 http://id.loc.gov/authorities/subjects/sh85019512 | |
| 650 | 0 | |a Cancer |x Immunotherapy. |0 http://id.loc.gov/authorities/subjects/sh87002642 | |
| 650 | 0 | |a Tumors |x Immunological aspects. |0 http://id.loc.gov/authorities/subjects/sh85138558 | |
| 650 | 6 | |a Cancer |x Immunologie. | |
| 650 | 6 | |a Cancer |x Immunothérapie. | |
| 650 | 6 | |a Tumeurs |x Immunologie. | |
| 650 | 7 | |a Immunology. |2 bisacsh/2013 | |
| 650 | 7 | |a MEDICAL. |2 bisacsh/2013 | |
| 650 | 7 | |a Cancer |x Immunological aspects |2 fast | |
| 650 | 7 | |a Cancer |x Immunotherapy |2 fast | |
| 650 | 7 | |a Tumors |x Immunological aspects |2 fast | |
| 655 | 0 | |a Electronic books. | |
| 655 | 4 | |a Electronic book. | |
| 700 | 1 | |a Li, Biaoru. | |
| 700 | 1 | |a Larson, Alan. | |
| 700 | 1 | |a Li, Shen. | |
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| contents | Cover -- Title -- Copyright -- End User License Agreement -- Contents -- Preface -- REFERENCES -- List of Contributors -- INTRODUCTION -- MHC and Cancer Immunotherapy -- Li-Hua Jiang1,* and Wei-Hua Yan2 -- OVERVIEW OF MHC GENES AND MOLECULES -- 1. Characteristics of the HLA Gene Complex -- 2. HLA Molecule Structure -- 3. Distribution and Function of HLA Molecules -- 4. MHC Allele Detection -- MHC CLASS I MOLECULAR LOSS AND CANCER IMMUNOTHERAPY -- 1. Loss of Class I HLA Expression in Tumor Tissues -- 2. Types of Class I HLA Deletion. 3. Expression of Class I HLA Molecules and Efficiency of Immunotherapy -- 4. The Relation Between Selective Pressure of Immunocyte and Changes of Class-I HLA Expression Pattern in Tumor Cells -- EXPRESSION LEVELS OF NONCLASSICAL MHC CLASS I AND TUMOR IMMUNE ESCAPE -- 1. The HLA Class I Antigen Expression and Cancer -- 2. Roles of HLA Ib Antigens in Immune Modulation -- 3. Clinical Relevance of HLA Ib Expression in Cancers -- 4. Prospective of HLA-E and HLA-G Targeted Cancer Immunotherapy -- MHC FOR T-CELL EPITOPE AND ACTIVE IMMUNE VACCINES -- MHC FOR ADOPTIVE IMMUNE CELL THERAPY -- CONCLUSION CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- Immune Cells Signaling-Pathway and Genomic Profiles for Personalized Immunotherapy -- Wei Zhang1, Yan Qu1, Meihua Lin1, Amit Datta1, George E. Liu1,2 and Biaoru Li1,3,* -- INTRODUCTION -- T-CELL MEMBRANE SIGNALING -- T-CELLS PATHWAY AND NETWORKS -- GENOMIC EXPRESSION PROFILE OF T-CELLS -- 1. Genomic Expression Profiles of TIL -- 2. Genomic Expression Profiles from Peripheral Blood Immune Cells -- GENOMIC EXPRESSION PROFILE OF B-CELL -- 1. Genomic Expression Profiles of B-Lymphocyte -- 2. Network of B-lymphocyte GENOMIC EXPRESSION PROFILE AND NETWORK OF NK-CELL -- 1. NK-Lymphocyte -- 2. Genomic Expression Profiles of NK-Lymphocyte -- 3. Network of NK-Lymphocyte -- GENOMIC EXPRESSION PROFILE OF NKT-CELL -- 1. NKT-Lymphocyte -- 2. Genomic Expression Profiles and Network of NKT-Lymphocyte -- GENOMIC EXPRESSION PROFILE OF MACROPHAGE -- 1. Macrophage -- 2. Genomic Expression Profiles and Network of Macrophages -- CONCLUSION -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- Immunoassay of Personalized Immunotherapy -- Li-Hua Jiang1 and Biaoru Li1,2,* -- INTRODUCTION BASIC RECORD OF IMMUNE FUNCTION AND RESPONSE -- Delayed-Type Hypersensitivity In Vivo -- Measures of Immune Function Ex Vivo -- 1. Detection of T-cell Number with Intracellular Cytokines by Flow Cytometry -- 2. Detection of Secreted Cytokines by ELISA Assays -- 3. Lymphoproliferation Assay -- 4. CTL and Quantifying CTL -- Measures of Antigen-Specific Immune Responses In Vitro/Ex Vivo -- 1. Peptide MHC Tetramers -- 2. TCR Complementarity Determining Region -- Measurement of Cytokine mRNA -- Measurement of Tumor Antibodies -- MEASUREMENT OF IMMUNE TARGETS FOR IMMUNOTHERAPY |
| ctrlnum | (OCoLC)1204607283 |
| dewey-full | 616.99/4079 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
| dewey-raw | 616.99/4079 |
| dewey-search | 616.99/4079 |
| dewey-sort | 3616.99 44079 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| format | Electronic eBook |
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NK-Lymphocyte -- 2. Genomic Expression Profiles of NK-Lymphocyte -- 3. Network of NK-Lymphocyte -- GENOMIC EXPRESSION PROFILE OF NKT-CELL -- 1. NKT-Lymphocyte -- 2. Genomic Expression Profiles and Network of NKT-Lymphocyte -- GENOMIC EXPRESSION PROFILE OF MACROPHAGE -- 1. Macrophage -- 2. Genomic Expression Profiles and Network of Macrophages -- CONCLUSION -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- Immunoassay of Personalized Immunotherapy -- Li-Hua Jiang1 and Biaoru Li1,2,* -- INTRODUCTION</subfield></datafield><datafield tag="505" ind1="8" ind2=" "><subfield code="a">BASIC RECORD OF IMMUNE FUNCTION AND RESPONSE -- Delayed-Type Hypersensitivity In Vivo -- Measures of Immune Function Ex Vivo -- 1. Detection of T-cell Number with Intracellular Cytokines by Flow Cytometry -- 2. Detection of Secreted Cytokines by ELISA Assays -- 3. Lymphoproliferation Assay -- 4. CTL and Quantifying CTL -- Measures of Antigen-Specific Immune Responses In Vitro/Ex Vivo -- 1. Peptide MHC Tetramers -- 2. TCR Complementarity Determining Region -- Measurement of Cytokine mRNA -- Measurement of Tumor Antibodies -- MEASUREMENT OF IMMUNE TARGETS FOR IMMUNOTHERAPY</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">This book introduces personalized immunotherapy with multi-dimensional models of analysis to determine the best plan for immunotherapy of patients. The book introduces readers to some basic concepts which lay the foundation for personalized immunotherapy: the development of a major histocompatibility complex (MHC), the genome profile of T cells and tumor cells, and genome-wide association studies. Chapters also cover special topics such as new immunoassay methods related to personalized immunotherapy and targeted immunotherapy which are geared towards familiarizing readers with current research practices. Focusing on the central theme of personalized immunotherapy, the authors provide a wealth of information about T-cell screening, tumor neoantigen cloning, primary tumor cell culture for T-cell cloning, bioinformatics strategies for understanding T-cell and primary tumor cell biology and function, and new developments in research on adoptive T-cell immunotherapy. These developments include T-cell gene therapy and T-cell gene editing, transgenic T-cells for increasing affinity to tumor cells such as CAR T-cells and TCR T-cells, and the systematic modeling of polyclonal specific T-cells and biobank technology. Key Features:- Introduces readers to basic concepts in personalized medicine and immunotherapy- Presents current information about immunological assays used in research- Presents an overview of T cell immunotherapy and cloning techniques- Presents an overview of tumor cell bioinformatics and its role in immunotherapy- Includes new developments and references for personalized immunotherapy techniques (T-cell gene therapy and T-cell gene editing, transgenic T-cells which target CAR T-cells and TCR T-cells, and polyclonal T-cell modeling) - Includes a section on biobanking- Presents information in an easy-to-read format for a wide range of readers- Brings contributions from experts with over 30 years of experience in personalized immunotherapy Personalized Immunotherapy for Tumor Diseases and Beyond is an ideal handbook for medical professionals and students involved in personalized medicine, immunology and oncology. 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| genre | Electronic books. Electronic book. |
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| id | ZDB-4-EBA-on1204607283 |
| illustrated | Not Illustrated |
| indexdate | 2025-04-11T08:47:31Z |
| institution | BVB |
| isbn | 9811482756 9789811482755 |
| language | English |
| oclc_num | 1204607283 |
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| publishDate | 2020 |
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| publisher | BENTHAM Science PUBLISHER, |
| record_format | marc |
| spelling | PERSONALIZED IMMUNOTHERAPY FOR TUMOR DISEASES AND BEYOND / editors, Biaoru Li, Alan Larson, Shen Li. Singapore : BENTHAM Science PUBLISHER, 2020. 1 online resource text txt rdacontent computer c rdamedia online resource cr rdacarrier Cover -- Title -- Copyright -- End User License Agreement -- Contents -- Preface -- REFERENCES -- List of Contributors -- INTRODUCTION -- MHC and Cancer Immunotherapy -- Li-Hua Jiang1,* and Wei-Hua Yan2 -- OVERVIEW OF MHC GENES AND MOLECULES -- 1. Characteristics of the HLA Gene Complex -- 2. HLA Molecule Structure -- 3. Distribution and Function of HLA Molecules -- 4. MHC Allele Detection -- MHC CLASS I MOLECULAR LOSS AND CANCER IMMUNOTHERAPY -- 1. Loss of Class I HLA Expression in Tumor Tissues -- 2. Types of Class I HLA Deletion. 3. Expression of Class I HLA Molecules and Efficiency of Immunotherapy -- 4. The Relation Between Selective Pressure of Immunocyte and Changes of Class-I HLA Expression Pattern in Tumor Cells -- EXPRESSION LEVELS OF NONCLASSICAL MHC CLASS I AND TUMOR IMMUNE ESCAPE -- 1. The HLA Class I Antigen Expression and Cancer -- 2. Roles of HLA Ib Antigens in Immune Modulation -- 3. Clinical Relevance of HLA Ib Expression in Cancers -- 4. Prospective of HLA-E and HLA-G Targeted Cancer Immunotherapy -- MHC FOR T-CELL EPITOPE AND ACTIVE IMMUNE VACCINES -- MHC FOR ADOPTIVE IMMUNE CELL THERAPY -- CONCLUSION CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- Immune Cells Signaling-Pathway and Genomic Profiles for Personalized Immunotherapy -- Wei Zhang1, Yan Qu1, Meihua Lin1, Amit Datta1, George E. Liu1,2 and Biaoru Li1,3,* -- INTRODUCTION -- T-CELL MEMBRANE SIGNALING -- T-CELLS PATHWAY AND NETWORKS -- GENOMIC EXPRESSION PROFILE OF T-CELLS -- 1. Genomic Expression Profiles of TIL -- 2. Genomic Expression Profiles from Peripheral Blood Immune Cells -- GENOMIC EXPRESSION PROFILE OF B-CELL -- 1. Genomic Expression Profiles of B-Lymphocyte -- 2. Network of B-lymphocyte GENOMIC EXPRESSION PROFILE AND NETWORK OF NK-CELL -- 1. NK-Lymphocyte -- 2. Genomic Expression Profiles of NK-Lymphocyte -- 3. Network of NK-Lymphocyte -- GENOMIC EXPRESSION PROFILE OF NKT-CELL -- 1. NKT-Lymphocyte -- 2. Genomic Expression Profiles and Network of NKT-Lymphocyte -- GENOMIC EXPRESSION PROFILE OF MACROPHAGE -- 1. Macrophage -- 2. Genomic Expression Profiles and Network of Macrophages -- CONCLUSION -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- Immunoassay of Personalized Immunotherapy -- Li-Hua Jiang1 and Biaoru Li1,2,* -- INTRODUCTION BASIC RECORD OF IMMUNE FUNCTION AND RESPONSE -- Delayed-Type Hypersensitivity In Vivo -- Measures of Immune Function Ex Vivo -- 1. Detection of T-cell Number with Intracellular Cytokines by Flow Cytometry -- 2. Detection of Secreted Cytokines by ELISA Assays -- 3. Lymphoproliferation Assay -- 4. CTL and Quantifying CTL -- Measures of Antigen-Specific Immune Responses In Vitro/Ex Vivo -- 1. Peptide MHC Tetramers -- 2. TCR Complementarity Determining Region -- Measurement of Cytokine mRNA -- Measurement of Tumor Antibodies -- MEASUREMENT OF IMMUNE TARGETS FOR IMMUNOTHERAPY This book introduces personalized immunotherapy with multi-dimensional models of analysis to determine the best plan for immunotherapy of patients. The book introduces readers to some basic concepts which lay the foundation for personalized immunotherapy: the development of a major histocompatibility complex (MHC), the genome profile of T cells and tumor cells, and genome-wide association studies. Chapters also cover special topics such as new immunoassay methods related to personalized immunotherapy and targeted immunotherapy which are geared towards familiarizing readers with current research practices. Focusing on the central theme of personalized immunotherapy, the authors provide a wealth of information about T-cell screening, tumor neoantigen cloning, primary tumor cell culture for T-cell cloning, bioinformatics strategies for understanding T-cell and primary tumor cell biology and function, and new developments in research on adoptive T-cell immunotherapy. These developments include T-cell gene therapy and T-cell gene editing, transgenic T-cells for increasing affinity to tumor cells such as CAR T-cells and TCR T-cells, and the systematic modeling of polyclonal specific T-cells and biobank technology. Key Features:- Introduces readers to basic concepts in personalized medicine and immunotherapy- Presents current information about immunological assays used in research- Presents an overview of T cell immunotherapy and cloning techniques- Presents an overview of tumor cell bioinformatics and its role in immunotherapy- Includes new developments and references for personalized immunotherapy techniques (T-cell gene therapy and T-cell gene editing, transgenic T-cells which target CAR T-cells and TCR T-cells, and polyclonal T-cell modeling) - Includes a section on biobanking- Presents information in an easy-to-read format for a wide range of readers- Brings contributions from experts with over 30 years of experience in personalized immunotherapy Personalized Immunotherapy for Tumor Diseases and Beyond is an ideal handbook for medical professionals and students involved in personalized medicine, immunology and oncology. General readers interested in the new developments in these fields will also benefit from the information provided. Cancer Immunological aspects. http://id.loc.gov/authorities/subjects/sh85019512 Cancer Immunotherapy. http://id.loc.gov/authorities/subjects/sh87002642 Tumors Immunological aspects. http://id.loc.gov/authorities/subjects/sh85138558 Cancer Immunologie. Cancer Immunothérapie. Tumeurs Immunologie. Immunology. bisacsh/2013 MEDICAL. bisacsh/2013 Cancer Immunological aspects fast Cancer Immunotherapy fast Tumors Immunological aspects fast Electronic books. Electronic book. Li, Biaoru. Larson, Alan. Li, Shen. has work: Personalized immunotherapy for tumor diseases and beyond (Text) https://id.oclc.org/worldcat/entity/E39PCFpFByVQtxHXkFK8BycCKm https://id.oclc.org/worldcat/ontology/hasWork |
| spellingShingle | PERSONALIZED IMMUNOTHERAPY FOR TUMOR DISEASES AND BEYOND / Cover -- Title -- Copyright -- End User License Agreement -- Contents -- Preface -- REFERENCES -- List of Contributors -- INTRODUCTION -- MHC and Cancer Immunotherapy -- Li-Hua Jiang1,* and Wei-Hua Yan2 -- OVERVIEW OF MHC GENES AND MOLECULES -- 1. Characteristics of the HLA Gene Complex -- 2. HLA Molecule Structure -- 3. Distribution and Function of HLA Molecules -- 4. MHC Allele Detection -- MHC CLASS I MOLECULAR LOSS AND CANCER IMMUNOTHERAPY -- 1. Loss of Class I HLA Expression in Tumor Tissues -- 2. Types of Class I HLA Deletion. 3. Expression of Class I HLA Molecules and Efficiency of Immunotherapy -- 4. The Relation Between Selective Pressure of Immunocyte and Changes of Class-I HLA Expression Pattern in Tumor Cells -- EXPRESSION LEVELS OF NONCLASSICAL MHC CLASS I AND TUMOR IMMUNE ESCAPE -- 1. The HLA Class I Antigen Expression and Cancer -- 2. Roles of HLA Ib Antigens in Immune Modulation -- 3. Clinical Relevance of HLA Ib Expression in Cancers -- 4. Prospective of HLA-E and HLA-G Targeted Cancer Immunotherapy -- MHC FOR T-CELL EPITOPE AND ACTIVE IMMUNE VACCINES -- MHC FOR ADOPTIVE IMMUNE CELL THERAPY -- CONCLUSION CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- Immune Cells Signaling-Pathway and Genomic Profiles for Personalized Immunotherapy -- Wei Zhang1, Yan Qu1, Meihua Lin1, Amit Datta1, George E. Liu1,2 and Biaoru Li1,3,* -- INTRODUCTION -- T-CELL MEMBRANE SIGNALING -- T-CELLS PATHWAY AND NETWORKS -- GENOMIC EXPRESSION PROFILE OF T-CELLS -- 1. Genomic Expression Profiles of TIL -- 2. Genomic Expression Profiles from Peripheral Blood Immune Cells -- GENOMIC EXPRESSION PROFILE OF B-CELL -- 1. Genomic Expression Profiles of B-Lymphocyte -- 2. Network of B-lymphocyte GENOMIC EXPRESSION PROFILE AND NETWORK OF NK-CELL -- 1. NK-Lymphocyte -- 2. Genomic Expression Profiles of NK-Lymphocyte -- 3. Network of NK-Lymphocyte -- GENOMIC EXPRESSION PROFILE OF NKT-CELL -- 1. NKT-Lymphocyte -- 2. Genomic Expression Profiles and Network of NKT-Lymphocyte -- GENOMIC EXPRESSION PROFILE OF MACROPHAGE -- 1. Macrophage -- 2. Genomic Expression Profiles and Network of Macrophages -- CONCLUSION -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- Immunoassay of Personalized Immunotherapy -- Li-Hua Jiang1 and Biaoru Li1,2,* -- INTRODUCTION BASIC RECORD OF IMMUNE FUNCTION AND RESPONSE -- Delayed-Type Hypersensitivity In Vivo -- Measures of Immune Function Ex Vivo -- 1. Detection of T-cell Number with Intracellular Cytokines by Flow Cytometry -- 2. Detection of Secreted Cytokines by ELISA Assays -- 3. Lymphoproliferation Assay -- 4. CTL and Quantifying CTL -- Measures of Antigen-Specific Immune Responses In Vitro/Ex Vivo -- 1. Peptide MHC Tetramers -- 2. TCR Complementarity Determining Region -- Measurement of Cytokine mRNA -- Measurement of Tumor Antibodies -- MEASUREMENT OF IMMUNE TARGETS FOR IMMUNOTHERAPY Cancer Immunological aspects. http://id.loc.gov/authorities/subjects/sh85019512 Cancer Immunotherapy. http://id.loc.gov/authorities/subjects/sh87002642 Tumors Immunological aspects. http://id.loc.gov/authorities/subjects/sh85138558 Cancer Immunologie. Cancer Immunothérapie. Tumeurs Immunologie. Immunology. bisacsh/2013 MEDICAL. bisacsh/2013 Cancer Immunological aspects fast Cancer Immunotherapy fast Tumors Immunological aspects fast |
| subject_GND | http://id.loc.gov/authorities/subjects/sh85019512 http://id.loc.gov/authorities/subjects/sh87002642 http://id.loc.gov/authorities/subjects/sh85138558 |
| title | PERSONALIZED IMMUNOTHERAPY FOR TUMOR DISEASES AND BEYOND / |
| title_auth | PERSONALIZED IMMUNOTHERAPY FOR TUMOR DISEASES AND BEYOND / |
| title_exact_search | PERSONALIZED IMMUNOTHERAPY FOR TUMOR DISEASES AND BEYOND / |
| title_full | PERSONALIZED IMMUNOTHERAPY FOR TUMOR DISEASES AND BEYOND / editors, Biaoru Li, Alan Larson, Shen Li. |
| title_fullStr | PERSONALIZED IMMUNOTHERAPY FOR TUMOR DISEASES AND BEYOND / editors, Biaoru Li, Alan Larson, Shen Li. |
| title_full_unstemmed | PERSONALIZED IMMUNOTHERAPY FOR TUMOR DISEASES AND BEYOND / editors, Biaoru Li, Alan Larson, Shen Li. |
| title_short | PERSONALIZED IMMUNOTHERAPY FOR TUMOR DISEASES AND BEYOND / |
| title_sort | personalized immunotherapy for tumor diseases and beyond |
| topic | Cancer Immunological aspects. http://id.loc.gov/authorities/subjects/sh85019512 Cancer Immunotherapy. http://id.loc.gov/authorities/subjects/sh87002642 Tumors Immunological aspects. http://id.loc.gov/authorities/subjects/sh85138558 Cancer Immunologie. Cancer Immunothérapie. Tumeurs Immunologie. Immunology. bisacsh/2013 MEDICAL. bisacsh/2013 Cancer Immunological aspects fast Cancer Immunotherapy fast Tumors Immunological aspects fast |
| topic_facet | Cancer Immunological aspects. Cancer Immunotherapy. Tumors Immunological aspects. Cancer Immunologie. Cancer Immunothérapie. Tumeurs Immunologie. Immunology. MEDICAL. Cancer Immunological aspects Cancer Immunotherapy Tumors Immunological aspects Electronic books. Electronic book. |
| work_keys_str_mv | AT libiaoru personalizedimmunotherapyfortumordiseasesandbeyond AT larsonalan personalizedimmunotherapyfortumordiseasesandbeyond AT lishen personalizedimmunotherapyfortumordiseasesandbeyond |