Extracellular matrix :: pathobiology and signaling /
Over the last decades cell biology and biological chemistry have increasingly turned their attention to the space between cells and revealed an elaborate network of macromolecules essential for structural support, cell migration, adhesion and signaling. This comprehensive handbook of the extracellul...
Gespeichert in:
| Weitere Verfasser: | |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Berlin :
Walter de Gruyter,
[2012]
|
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Zusammenfassung: | Over the last decades cell biology and biological chemistry have increasingly turned their attention to the space between cells and revealed an elaborate network of macromolecules essential for structural support, cell migration, adhesion and signaling. This comprehensive handbook of the extracellular matrix is organized into seven thematic sections, giving an overview of the current state of knowledge of matrix components (structure and function), their roles in health and disease (matrix pathobiology) as well as new concepts of pharmacological targeting. |
| Beschreibung: | 1 online resource (l, 888 pages) : illustrations, portraits |
| Bibliographie: | Includes bibliographical references and index. |
| ISBN: | 9783110258776 3110258773 |
Internformat
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| 245 | 0 | 0 | |a Extracellular matrix : |b pathobiology and signaling / |c edited by Nikos K. Karamanos. |
| 264 | 1 | |a Berlin : |b Walter de Gruyter, |c [2012] | |
| 264 | 4 | |c ©2012 | |
| 300 | |a 1 online resource (l, 888 pages) : |b illustrations, portraits | ||
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| 504 | |a Includes bibliographical references and index. | ||
| 505 | 0 | |a An introduction to the extracellular matrix molecules and their importance in pathobiology and signaling / Achilleas Theocharis [and others] -- Insights into the function of glycans / Paraskevi Heldin -- Proteoglycans : structure, pathobiology, and signaling / Liliana Schaefer -- ECM cell surface receptors / Donald Gullberg -- Extracellular proteinases / Jan-Olof Winberg -- Collagen : not just mechanics, for the high degree of connectivity grounded on the apparently simple triple helix / Ruggero Tenni -- Emerging aspects in extracellular matrix pathobiology / Achilleas Theocharis -- Targeting tumor microenvironment at the ECM level / Nikos K. Karamanos. | |
| 520 | |a Over the last decades cell biology and biological chemistry have increasingly turned their attention to the space between cells and revealed an elaborate network of macromolecules essential for structural support, cell migration, adhesion and signaling. This comprehensive handbook of the extracellular matrix is organized into seven thematic sections, giving an overview of the current state of knowledge of matrix components (structure and function), their roles in health and disease (matrix pathobiology) as well as new concepts of pharmacological targeting. | ||
| 546 | |a In English. | ||
| 588 | 0 | |a Online resource; title from PDF title page (de Gruyter, viewed November 6, 2018). | |
| 650 | 0 | |a Extracellular matrix. |0 http://id.loc.gov/authorities/subjects/sh85057464 | |
| 650 | 0 | |a Cellular signal transduction. |0 http://id.loc.gov/authorities/subjects/sh89002397 | |
| 650 | 2 | 2 | |a Extracellular Matrix |x pathology |
| 650 | 2 | 2 | |a Signal Transduction |x physiology |
| 650 | 2 | |a Extracellular Matrix |0 https://id.nlm.nih.gov/mesh/D005109 | |
| 650 | 2 | |a Signal Transduction |0 https://id.nlm.nih.gov/mesh/D015398 | |
| 650 | 4 | |a Biochemie. | |
| 650 | 4 | |a Glykane. | |
| 650 | 4 | |a Kollagene. | |
| 650 | 4 | |a Matrix. | |
| 650 | 4 | |a Metalloproteinasen. | |
| 650 | 6 | |a Substance fondamentale (Histologie) | |
| 650 | 6 | |a Transduction du signal cellulaire. | |
| 650 | 7 | |a MEDICAL |x Histology. |2 bisacsh | |
| 650 | 7 | |a Extracellular matrix |2 fast | |
| 650 | 7 | |a Cellular signal transduction |2 fast | |
| 650 | 7 | |a Pathophysiologie |2 gnd |0 http://d-nb.info/gnd/4044898-8 | |
| 650 | 7 | |a Signaltransduktion |2 gnd |0 http://d-nb.info/gnd/4318717-1 | |
| 650 | 7 | |a Extrazelluläre Matrix |2 gnd |0 http://d-nb.info/gnd/7530993-2 | |
| 700 | 1 | |a Karamanos, Nikos K., |e editor. |0 http://id.loc.gov/authorities/names/n2012184533 | |
| 776 | 0 | 8 | |i Print version: |t Extracellular matrix. |d Berlin ; Boston : Walter de Gruyter, ©2012 |z 9783110258769 |w (DLC) 2012019181 |w (OCoLC)793503505 |
| 856 | 4 | 0 | |l FWS01 |p ZDB-4-EBA |q FWS_PDA_EBA |u https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=494252 |3 Volltext |
| 880 | 0 | |6 505-00/(S |a Intro -- Preface -- Comments on the book Extracellular Matrix: Pathobiology & Signaling by Dick Heinegård -- About the Editor/Section Editors -- List of contributing authors -- Abbreviations and acronyms used -- 1 An introduction to the extracellular matrix molecules and their importance in pathobiology and signaling -- 1.1 Extracellular matrix: a functional scaffold -- 1.1.1 ECM components: structural and functional properties -- 1.1.2 Matrix remodeling is accomplished by proteolytic enzymes -- 1.1.3 Cell surface receptors mediate cell-cell and cell-matrix interactions -- 1.1.4 Take-home message -- 2 Insights into the function of glycans -- 2.1 Introduction -- 2.2 Metabolic control of hyaluronan synthesis -- 2.2.1 Introduction -- 2.2.2 Transcription of hyaluronan synthases -- 2.2.3 UDP-sugar substrates as limiting factors in hyaluronan synthesis -- 2.2.4 Posttranslational processing of HAS -- 2.2.5 Challenges and future prospects -- 2.2.6 Take-home message -- 2.3 Multiple roles of hyaluronan as a target and modifier of the inflammatory response -- 2.3.1 Introduction -- 2.3.2 Endothelial permeability -- 2.3.3 Angiogenesis -- 2.3.4 Mechanisms of hyaluronan degradation -- 2.3.5 Consequences of hyaluronan fragmentation -- 2.3.6 Hyaluronan cross-talk with leukocytes -- 2.3.7 Adhesion of leukocytes to hyaluronan -- 2.3.8 Hyaluronan removal in the late phase of inflammation -- 2.3.9 Local clearance of hyaluronan -- 2.3.10 Chronic inflammation -- 2.3.11 Hyaluronan increase in wounds -- 2.3.12 Support of migration and proliferation -- 2.3.13 TGF-β and myofibroblasts -- 2.3.14 Therapeutic applications -- 2.3.15 Future perspectives -- 2.3.16 Take-home message -- 2.4 Roles of sulfated and nonsulfated glycosaminoglycans in cancer growth and progression-therapeutic implications -- 2.4.1 Introduction. | |
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Datensatz im Suchindex
| DE-BY-FWS_katkey | ZDB-4-EBA-on1042881631 |
|---|---|
| _version_ | 1816882464489996288 |
| adam_text | |
| any_adam_object | |
| author2 | Karamanos, Nikos K. |
| author2_role | edt |
| author2_variant | n k k nk nkk |
| author_GND | http://id.loc.gov/authorities/names/n2012184533 |
| author_facet | Karamanos, Nikos K. |
| building | Verbundindex |
| bvnumber | localFWS |
| callnumber-first | Q - Science |
| callnumber-label | QP88 |
| callnumber-raw | QP88.23 .E98 2012 |
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| callnumber-subject | QP - Physiology |
| classification_rvk | WE 3900 |
| collection | ZDB-4-EBA |
| contents | An introduction to the extracellular matrix molecules and their importance in pathobiology and signaling / Achilleas Theocharis [and others] -- Insights into the function of glycans / Paraskevi Heldin -- Proteoglycans : structure, pathobiology, and signaling / Liliana Schaefer -- ECM cell surface receptors / Donald Gullberg -- Extracellular proteinases / Jan-Olof Winberg -- Collagen : not just mechanics, for the high degree of connectivity grounded on the apparently simple triple helix / Ruggero Tenni -- Emerging aspects in extracellular matrix pathobiology / Achilleas Theocharis -- Targeting tumor microenvironment at the ECM level / Nikos K. Karamanos. |
| ctrlnum | (OCoLC)1042881631 |
| dewey-full | 611/.0182 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 611 - Human anatomy, cytology, histology |
| dewey-raw | 611/.0182 |
| dewey-search | 611/.0182 |
| dewey-sort | 3611 3182 |
| dewey-tens | 610 - Medicine and health |
| discipline | Biologie Medizin |
| format | Electronic eBook |
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| id | ZDB-4-EBA-on1042881631 |
| illustrated | Illustrated |
| indexdate | 2024-11-27T13:29:02Z |
| institution | BVB |
| isbn | 9783110258776 3110258773 |
| language | English |
| oclc_num | 1042881631 |
| open_access_boolean | |
| owner | MAIN DE-863 DE-BY-FWS |
| owner_facet | MAIN DE-863 DE-BY-FWS |
| physical | 1 online resource (l, 888 pages) : illustrations, portraits |
| psigel | ZDB-4-EBA |
| publishDate | 2012 |
| publishDateSearch | 2012 |
| publishDateSort | 2012 |
| publisher | Walter de Gruyter, |
| record_format | marc |
| spelling | Extracellular matrix : pathobiology and signaling / edited by Nikos K. Karamanos. Berlin : Walter de Gruyter, [2012] ©2012 1 online resource (l, 888 pages) : illustrations, portraits text txt rdacontent computer c rdamedia online resource cr rdacarrier text file Includes bibliographical references and index. An introduction to the extracellular matrix molecules and their importance in pathobiology and signaling / Achilleas Theocharis [and others] -- Insights into the function of glycans / Paraskevi Heldin -- Proteoglycans : structure, pathobiology, and signaling / Liliana Schaefer -- ECM cell surface receptors / Donald Gullberg -- Extracellular proteinases / Jan-Olof Winberg -- Collagen : not just mechanics, for the high degree of connectivity grounded on the apparently simple triple helix / Ruggero Tenni -- Emerging aspects in extracellular matrix pathobiology / Achilleas Theocharis -- Targeting tumor microenvironment at the ECM level / Nikos K. Karamanos. Over the last decades cell biology and biological chemistry have increasingly turned their attention to the space between cells and revealed an elaborate network of macromolecules essential for structural support, cell migration, adhesion and signaling. This comprehensive handbook of the extracellular matrix is organized into seven thematic sections, giving an overview of the current state of knowledge of matrix components (structure and function), their roles in health and disease (matrix pathobiology) as well as new concepts of pharmacological targeting. In English. Online resource; title from PDF title page (de Gruyter, viewed November 6, 2018). Extracellular matrix. http://id.loc.gov/authorities/subjects/sh85057464 Cellular signal transduction. http://id.loc.gov/authorities/subjects/sh89002397 Extracellular Matrix pathology Signal Transduction physiology Extracellular Matrix https://id.nlm.nih.gov/mesh/D005109 Signal Transduction https://id.nlm.nih.gov/mesh/D015398 Biochemie. Glykane. Kollagene. Matrix. Metalloproteinasen. Substance fondamentale (Histologie) Transduction du signal cellulaire. MEDICAL Histology. bisacsh Extracellular matrix fast Cellular signal transduction fast Pathophysiologie gnd http://d-nb.info/gnd/4044898-8 Signaltransduktion gnd http://d-nb.info/gnd/4318717-1 Extrazelluläre Matrix gnd http://d-nb.info/gnd/7530993-2 Karamanos, Nikos K., editor. http://id.loc.gov/authorities/names/n2012184533 Print version: Extracellular matrix. Berlin ; Boston : Walter de Gruyter, ©2012 9783110258769 (DLC) 2012019181 (OCoLC)793503505 FWS01 ZDB-4-EBA FWS_PDA_EBA https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=494252 Volltext 505-00/(S Intro -- Preface -- Comments on the book Extracellular Matrix: Pathobiology & Signaling by Dick Heinegård -- About the Editor/Section Editors -- List of contributing authors -- Abbreviations and acronyms used -- 1 An introduction to the extracellular matrix molecules and their importance in pathobiology and signaling -- 1.1 Extracellular matrix: a functional scaffold -- 1.1.1 ECM components: structural and functional properties -- 1.1.2 Matrix remodeling is accomplished by proteolytic enzymes -- 1.1.3 Cell surface receptors mediate cell-cell and cell-matrix interactions -- 1.1.4 Take-home message -- 2 Insights into the function of glycans -- 2.1 Introduction -- 2.2 Metabolic control of hyaluronan synthesis -- 2.2.1 Introduction -- 2.2.2 Transcription of hyaluronan synthases -- 2.2.3 UDP-sugar substrates as limiting factors in hyaluronan synthesis -- 2.2.4 Posttranslational processing of HAS -- 2.2.5 Challenges and future prospects -- 2.2.6 Take-home message -- 2.3 Multiple roles of hyaluronan as a target and modifier of the inflammatory response -- 2.3.1 Introduction -- 2.3.2 Endothelial permeability -- 2.3.3 Angiogenesis -- 2.3.4 Mechanisms of hyaluronan degradation -- 2.3.5 Consequences of hyaluronan fragmentation -- 2.3.6 Hyaluronan cross-talk with leukocytes -- 2.3.7 Adhesion of leukocytes to hyaluronan -- 2.3.8 Hyaluronan removal in the late phase of inflammation -- 2.3.9 Local clearance of hyaluronan -- 2.3.10 Chronic inflammation -- 2.3.11 Hyaluronan increase in wounds -- 2.3.12 Support of migration and proliferation -- 2.3.13 TGF-β and myofibroblasts -- 2.3.14 Therapeutic applications -- 2.3.15 Future perspectives -- 2.3.16 Take-home message -- 2.4 Roles of sulfated and nonsulfated glycosaminoglycans in cancer growth and progression-therapeutic implications -- 2.4.1 Introduction. |
| spellingShingle | Extracellular matrix : pathobiology and signaling / An introduction to the extracellular matrix molecules and their importance in pathobiology and signaling / Achilleas Theocharis [and others] -- Insights into the function of glycans / Paraskevi Heldin -- Proteoglycans : structure, pathobiology, and signaling / Liliana Schaefer -- ECM cell surface receptors / Donald Gullberg -- Extracellular proteinases / Jan-Olof Winberg -- Collagen : not just mechanics, for the high degree of connectivity grounded on the apparently simple triple helix / Ruggero Tenni -- Emerging aspects in extracellular matrix pathobiology / Achilleas Theocharis -- Targeting tumor microenvironment at the ECM level / Nikos K. Karamanos. Extracellular matrix. http://id.loc.gov/authorities/subjects/sh85057464 Cellular signal transduction. http://id.loc.gov/authorities/subjects/sh89002397 Extracellular Matrix pathology Signal Transduction physiology Extracellular Matrix https://id.nlm.nih.gov/mesh/D005109 Signal Transduction https://id.nlm.nih.gov/mesh/D015398 Biochemie. Glykane. Kollagene. Matrix. Metalloproteinasen. Substance fondamentale (Histologie) Transduction du signal cellulaire. MEDICAL Histology. bisacsh Extracellular matrix fast Cellular signal transduction fast Pathophysiologie gnd http://d-nb.info/gnd/4044898-8 Signaltransduktion gnd http://d-nb.info/gnd/4318717-1 Extrazelluläre Matrix gnd http://d-nb.info/gnd/7530993-2 |
| subject_GND | http://id.loc.gov/authorities/subjects/sh85057464 http://id.loc.gov/authorities/subjects/sh89002397 https://id.nlm.nih.gov/mesh/D005109 https://id.nlm.nih.gov/mesh/D015398 http://d-nb.info/gnd/4044898-8 http://d-nb.info/gnd/4318717-1 http://d-nb.info/gnd/7530993-2 |
| title | Extracellular matrix : pathobiology and signaling / |
| title_auth | Extracellular matrix : pathobiology and signaling / |
| title_exact_search | Extracellular matrix : pathobiology and signaling / |
| title_full | Extracellular matrix : pathobiology and signaling / edited by Nikos K. Karamanos. |
| title_fullStr | Extracellular matrix : pathobiology and signaling / edited by Nikos K. Karamanos. |
| title_full_unstemmed | Extracellular matrix : pathobiology and signaling / edited by Nikos K. Karamanos. |
| title_short | Extracellular matrix : |
| title_sort | extracellular matrix pathobiology and signaling |
| title_sub | pathobiology and signaling / |
| topic | Extracellular matrix. http://id.loc.gov/authorities/subjects/sh85057464 Cellular signal transduction. http://id.loc.gov/authorities/subjects/sh89002397 Extracellular Matrix pathology Signal Transduction physiology Extracellular Matrix https://id.nlm.nih.gov/mesh/D005109 Signal Transduction https://id.nlm.nih.gov/mesh/D015398 Biochemie. Glykane. Kollagene. Matrix. Metalloproteinasen. Substance fondamentale (Histologie) Transduction du signal cellulaire. MEDICAL Histology. bisacsh Extracellular matrix fast Cellular signal transduction fast Pathophysiologie gnd http://d-nb.info/gnd/4044898-8 Signaltransduktion gnd http://d-nb.info/gnd/4318717-1 Extrazelluläre Matrix gnd http://d-nb.info/gnd/7530993-2 |
| topic_facet | Extracellular matrix. Cellular signal transduction. Extracellular Matrix pathology Signal Transduction physiology Extracellular Matrix Signal Transduction Biochemie. Glykane. Kollagene. Matrix. Metalloproteinasen. Substance fondamentale (Histologie) Transduction du signal cellulaire. MEDICAL Histology. Extracellular matrix Cellular signal transduction Pathophysiologie Signaltransduktion Extrazelluläre Matrix |
| url | https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=494252 |
| work_keys_str_mv | AT karamanosnikosk extracellularmatrixpathobiologyandsignaling |