Optogenetics.:
Optogenetics combines genetic engineering with optics to observe and control the function of cells using light, with clinical implications for restoration of vision and treatment of neurological diseases. As a new discipline much of the basic science and methods are currently under investigation and...
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| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Berlin :
De Gruyter,
2013.
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| Schriftenreihe: | Dahlem workshop reports.
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| Schlagworte: | |
| Online-Zugang: | Volltext |
| Zusammenfassung: | Optogenetics combines genetic engineering with optics to observe and control the function of cells using light, with clinical implications for restoration of vision and treatment of neurological diseases. As a new discipline much of the basic science and methods are currently under investigation and active development, thus there is a strong need for introductory literature in this field. This graduate level textbook provides an overview of the field of optogenetics in 5 concise chapters: Optogenetic tools, Applications in cellular systems, Mapping neuronal networks, Clinical applications and. |
| Beschreibung: | 6.5.1 Closed-loop optogenetic control and optical feedback from behavior and individual neurons. |
| Beschreibung: | 1 online resource (240 pages) |
| ISBN: | 9783110270723 3110270722 |
Internformat
MARC
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| 505 | 0 | |a List of contributing authors; Introduction; 1 The biophysics and engineering of signaling photoreceptors; 1.1 Photoreceptors; 1.1.1 Novel photoreceptors; 1.1.2 Biophysics of photoreceptors and signal transduction; 1.2 Engineering of photoreceptors; 1.2.1 Approaches to designing light-regulated biological processes; 1.3 Case study -- transcriptional control in cells by light; 1.4 Conclusion; Acknowledgements; References; 2 Current challenges in optogenetics; 2.1 Introduction; 2.2 Background: current functionality of tools. | |
| 505 | 8 | |a 2.3 Unsolved problems and open questions: technology from cell biology, optics, and behavior2.4 Unsolved problems and open questions: genomics and biophysics; 2.5 Conclusion; References; 3 Challenges and opportunities for optochemical genetics; 3.1 Introduction; 3.2 Photosensitizing receptors; 3.3 PCL and PTL development and applications; 3.4 Advantages and disadvantages of PCLs and PTLs; 3.5 Conclusion; References; 4 Optogenetic imaging of neural circuit dynamics using voltage-sensitive fluorescent proteins: potential, challenges and perspectives; 4.1 Introduction; 4.2 The biological problem. | |
| 505 | 8 | |a 4.3 The large scale challenge of circuit neurosciences4.4 The current approach to the large-scale integration problem; 4.5 Large-scale recordings of neuronal activities using optogenetic approaches; 4.6 Genetically encoded voltage indicators: state of development and application; 4.7 Unsolved methodological / technical challenges; References; 5 Why optogenetic "control" is not (yet) control; Acknowledgments; References; 6 Optogenetic actuation, inhibition, modulation and readout for neuronal networks generating behavior in the nematode Caenorhabditis elegans. | |
| 505 | 8 | |a 6.1 Introduction -- the nematode as a genetic model in systems neurosciencesystems neuroscience6.2 Imaging of neural activity in the nematode; 6.2.1 Genetically encoded Ca2+ indicators (GECIs); 6.2.2 Imaging populations of neurons in immobilized animals; 6.2.3 Imaging neural activity in freely moving animals; 6.2.4 Other genetically encoded indicators of neuronal function; 6.3 Optogenetic tools established in the nematode; 6.3.1 Channelrhodopsin (ChR2) and ChR variants with different functional properties for photodepolarization. | |
| 505 | 8 | |a 6.3.2 Halorhodopsin and light-triggered proton pumps for photohyperpolarization6.3.3 Photoactivated Adenylyl Cyclase (PAC) for phototriggered cAMPdependent effects that facilitate neuronal transmission; 6.3.4 Other optogenetic approaches; 6.3.5 Stimulation of single neurons by optogenetics in freely behaving C. elegans; 6.4 Examples for optogenetic applications in C. elegans; 6.4.1 Optical control of synaptic transmission at the neuromuscular junction and between neurons; 6.4.2 Optical control of neural network activity in the generation of behavior; 6.5 Future challenges. | |
| 500 | |a 6.5.1 Closed-loop optogenetic control and optical feedback from behavior and individual neurons. | ||
| 520 | |a Optogenetics combines genetic engineering with optics to observe and control the function of cells using light, with clinical implications for restoration of vision and treatment of neurological diseases. As a new discipline much of the basic science and methods are currently under investigation and active development, thus there is a strong need for introductory literature in this field. This graduate level textbook provides an overview of the field of optogenetics in 5 concise chapters: Optogenetic tools, Applications in cellular systems, Mapping neuronal networks, Clinical applications and. | ||
| 588 | 0 | |a Print version record. | |
| 650 | 0 | |a Neural transmission. |0 http://id.loc.gov/authorities/subjects/sh85091095 | |
| 650 | 0 | |a Neural networks (Neurobiology) |0 http://id.loc.gov/authorities/subjects/sh93002348 | |
| 650 | 0 | |a Electrooptical devices. |0 http://id.loc.gov/authorities/subjects/sh85042432 | |
| 650 | 0 | |a Physiological optics. |0 http://id.loc.gov/authorities/subjects/sh85095188 | |
| 650 | 6 | |a Transmission nerveuse. | |
| 650 | 6 | |a Réseaux neuronaux (Neurobiologie) | |
| 650 | 6 | |a Dispositifs électro-optiques. | |
| 650 | 6 | |a Optique physiologique. | |
| 650 | 7 | |a Biophysics. |2 bicssc | |
| 650 | 7 | |a Genetics (non-medical) |2 bicssc | |
| 650 | 7 | |a Human biology. |2 bicssc | |
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| 650 | 7 | |a SCIENCE |x Life Sciences |x Zoology |x General. |2 bisacsh | |
| 650 | 7 | |a Electrooptical devices |2 fast | |
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| 776 | 0 | 8 | |i Print version: |a Hegemann, Peter. |t Optogenetics. |d Berlin : De Gruyter, ©2013 |z 9783110270716 |
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Datensatz im Suchindex
| DE-BY-FWS_katkey | ZDB-4-EBA-ocn858761864 |
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| author2 | Sigrist, Stephan |
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| contents | List of contributing authors; Introduction; 1 The biophysics and engineering of signaling photoreceptors; 1.1 Photoreceptors; 1.1.1 Novel photoreceptors; 1.1.2 Biophysics of photoreceptors and signal transduction; 1.2 Engineering of photoreceptors; 1.2.1 Approaches to designing light-regulated biological processes; 1.3 Case study -- transcriptional control in cells by light; 1.4 Conclusion; Acknowledgements; References; 2 Current challenges in optogenetics; 2.1 Introduction; 2.2 Background: current functionality of tools. 2.3 Unsolved problems and open questions: technology from cell biology, optics, and behavior2.4 Unsolved problems and open questions: genomics and biophysics; 2.5 Conclusion; References; 3 Challenges and opportunities for optochemical genetics; 3.1 Introduction; 3.2 Photosensitizing receptors; 3.3 PCL and PTL development and applications; 3.4 Advantages and disadvantages of PCLs and PTLs; 3.5 Conclusion; References; 4 Optogenetic imaging of neural circuit dynamics using voltage-sensitive fluorescent proteins: potential, challenges and perspectives; 4.1 Introduction; 4.2 The biological problem. 4.3 The large scale challenge of circuit neurosciences4.4 The current approach to the large-scale integration problem; 4.5 Large-scale recordings of neuronal activities using optogenetic approaches; 4.6 Genetically encoded voltage indicators: state of development and application; 4.7 Unsolved methodological / technical challenges; References; 5 Why optogenetic "control" is not (yet) control; Acknowledgments; References; 6 Optogenetic actuation, inhibition, modulation and readout for neuronal networks generating behavior in the nematode Caenorhabditis elegans. 6.1 Introduction -- the nematode as a genetic model in systems neurosciencesystems neuroscience6.2 Imaging of neural activity in the nematode; 6.2.1 Genetically encoded Ca2+ indicators (GECIs); 6.2.2 Imaging populations of neurons in immobilized animals; 6.2.3 Imaging neural activity in freely moving animals; 6.2.4 Other genetically encoded indicators of neuronal function; 6.3 Optogenetic tools established in the nematode; 6.3.1 Channelrhodopsin (ChR2) and ChR variants with different functional properties for photodepolarization. 6.3.2 Halorhodopsin and light-triggered proton pumps for photohyperpolarization6.3.3 Photoactivated Adenylyl Cyclase (PAC) for phototriggered cAMPdependent effects that facilitate neuronal transmission; 6.3.4 Other optogenetic approaches; 6.3.5 Stimulation of single neurons by optogenetics in freely behaving C. elegans; 6.4 Examples for optogenetic applications in C. elegans; 6.4.1 Optical control of synaptic transmission at the neuromuscular junction and between neurons; 6.4.2 Optical control of neural network activity in the generation of behavior; 6.5 Future challenges. |
| ctrlnum | (OCoLC)858761864 |
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| discipline | Biologie |
| format | Electronic eBook |
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| id | ZDB-4-EBA-ocn858761864 |
| illustrated | Not Illustrated |
| indexdate | 2024-11-27T13:25:32Z |
| institution | BVB |
| isbn | 9783110270723 3110270722 |
| language | English |
| oclc_num | 858761864 |
| open_access_boolean | |
| owner | MAIN DE-863 DE-BY-FWS |
| owner_facet | MAIN DE-863 DE-BY-FWS |
| physical | 1 online resource (240 pages) |
| psigel | ZDB-4-EBA |
| publishDate | 2013 |
| publishDateSearch | 2013 |
| publishDateSort | 2013 |
| publisher | De Gruyter, |
| record_format | marc |
| series | Dahlem workshop reports. |
| series2 | Dahlem Workshop Reports |
| spelling | Hegemann, Peter. Optogenetics. Berlin : De Gruyter, 2013. 1 online resource (240 pages) text txt rdacontent computer c rdamedia online resource cr rdacarrier Dahlem Workshop Reports List of contributing authors; Introduction; 1 The biophysics and engineering of signaling photoreceptors; 1.1 Photoreceptors; 1.1.1 Novel photoreceptors; 1.1.2 Biophysics of photoreceptors and signal transduction; 1.2 Engineering of photoreceptors; 1.2.1 Approaches to designing light-regulated biological processes; 1.3 Case study -- transcriptional control in cells by light; 1.4 Conclusion; Acknowledgements; References; 2 Current challenges in optogenetics; 2.1 Introduction; 2.2 Background: current functionality of tools. 2.3 Unsolved problems and open questions: technology from cell biology, optics, and behavior2.4 Unsolved problems and open questions: genomics and biophysics; 2.5 Conclusion; References; 3 Challenges and opportunities for optochemical genetics; 3.1 Introduction; 3.2 Photosensitizing receptors; 3.3 PCL and PTL development and applications; 3.4 Advantages and disadvantages of PCLs and PTLs; 3.5 Conclusion; References; 4 Optogenetic imaging of neural circuit dynamics using voltage-sensitive fluorescent proteins: potential, challenges and perspectives; 4.1 Introduction; 4.2 The biological problem. 4.3 The large scale challenge of circuit neurosciences4.4 The current approach to the large-scale integration problem; 4.5 Large-scale recordings of neuronal activities using optogenetic approaches; 4.6 Genetically encoded voltage indicators: state of development and application; 4.7 Unsolved methodological / technical challenges; References; 5 Why optogenetic "control" is not (yet) control; Acknowledgments; References; 6 Optogenetic actuation, inhibition, modulation and readout for neuronal networks generating behavior in the nematode Caenorhabditis elegans. 6.1 Introduction -- the nematode as a genetic model in systems neurosciencesystems neuroscience6.2 Imaging of neural activity in the nematode; 6.2.1 Genetically encoded Ca2+ indicators (GECIs); 6.2.2 Imaging populations of neurons in immobilized animals; 6.2.3 Imaging neural activity in freely moving animals; 6.2.4 Other genetically encoded indicators of neuronal function; 6.3 Optogenetic tools established in the nematode; 6.3.1 Channelrhodopsin (ChR2) and ChR variants with different functional properties for photodepolarization. 6.3.2 Halorhodopsin and light-triggered proton pumps for photohyperpolarization6.3.3 Photoactivated Adenylyl Cyclase (PAC) for phototriggered cAMPdependent effects that facilitate neuronal transmission; 6.3.4 Other optogenetic approaches; 6.3.5 Stimulation of single neurons by optogenetics in freely behaving C. elegans; 6.4 Examples for optogenetic applications in C. elegans; 6.4.1 Optical control of synaptic transmission at the neuromuscular junction and between neurons; 6.4.2 Optical control of neural network activity in the generation of behavior; 6.5 Future challenges. 6.5.1 Closed-loop optogenetic control and optical feedback from behavior and individual neurons. Optogenetics combines genetic engineering with optics to observe and control the function of cells using light, with clinical implications for restoration of vision and treatment of neurological diseases. As a new discipline much of the basic science and methods are currently under investigation and active development, thus there is a strong need for introductory literature in this field. This graduate level textbook provides an overview of the field of optogenetics in 5 concise chapters: Optogenetic tools, Applications in cellular systems, Mapping neuronal networks, Clinical applications and. Print version record. Neural transmission. http://id.loc.gov/authorities/subjects/sh85091095 Neural networks (Neurobiology) http://id.loc.gov/authorities/subjects/sh93002348 Electrooptical devices. http://id.loc.gov/authorities/subjects/sh85042432 Physiological optics. http://id.loc.gov/authorities/subjects/sh85095188 Transmission nerveuse. Réseaux neuronaux (Neurobiologie) Dispositifs électro-optiques. Optique physiologique. Biophysics. bicssc Genetics (non-medical) bicssc Human biology. bicssc Neurosciences. bicssc SCIENCE Life Sciences Zoology General. bisacsh Electrooptical devices fast Neural networks (Neurobiology) fast Neural transmission fast Physiological optics fast Nervennetz gnd http://d-nb.info/gnd/4041638-0 Optogenetik gnd http://d-nb.info/gnd/1043139133 Sigrist, Stephan. has work: Optogenetics (Text) https://id.oclc.org/worldcat/entity/E39PCGcGfWJKpXMXH3vpPqTq43 https://id.oclc.org/worldcat/ontology/hasWork Print version: Hegemann, Peter. Optogenetics. Berlin : De Gruyter, ©2013 9783110270716 Dahlem workshop reports. http://id.loc.gov/authorities/names/n42030044 FWS01 ZDB-4-EBA FWS_PDA_EBA https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=641741 Volltext |
| spellingShingle | Hegemann, Peter Optogenetics. Dahlem workshop reports. List of contributing authors; Introduction; 1 The biophysics and engineering of signaling photoreceptors; 1.1 Photoreceptors; 1.1.1 Novel photoreceptors; 1.1.2 Biophysics of photoreceptors and signal transduction; 1.2 Engineering of photoreceptors; 1.2.1 Approaches to designing light-regulated biological processes; 1.3 Case study -- transcriptional control in cells by light; 1.4 Conclusion; Acknowledgements; References; 2 Current challenges in optogenetics; 2.1 Introduction; 2.2 Background: current functionality of tools. 2.3 Unsolved problems and open questions: technology from cell biology, optics, and behavior2.4 Unsolved problems and open questions: genomics and biophysics; 2.5 Conclusion; References; 3 Challenges and opportunities for optochemical genetics; 3.1 Introduction; 3.2 Photosensitizing receptors; 3.3 PCL and PTL development and applications; 3.4 Advantages and disadvantages of PCLs and PTLs; 3.5 Conclusion; References; 4 Optogenetic imaging of neural circuit dynamics using voltage-sensitive fluorescent proteins: potential, challenges and perspectives; 4.1 Introduction; 4.2 The biological problem. 4.3 The large scale challenge of circuit neurosciences4.4 The current approach to the large-scale integration problem; 4.5 Large-scale recordings of neuronal activities using optogenetic approaches; 4.6 Genetically encoded voltage indicators: state of development and application; 4.7 Unsolved methodological / technical challenges; References; 5 Why optogenetic "control" is not (yet) control; Acknowledgments; References; 6 Optogenetic actuation, inhibition, modulation and readout for neuronal networks generating behavior in the nematode Caenorhabditis elegans. 6.1 Introduction -- the nematode as a genetic model in systems neurosciencesystems neuroscience6.2 Imaging of neural activity in the nematode; 6.2.1 Genetically encoded Ca2+ indicators (GECIs); 6.2.2 Imaging populations of neurons in immobilized animals; 6.2.3 Imaging neural activity in freely moving animals; 6.2.4 Other genetically encoded indicators of neuronal function; 6.3 Optogenetic tools established in the nematode; 6.3.1 Channelrhodopsin (ChR2) and ChR variants with different functional properties for photodepolarization. 6.3.2 Halorhodopsin and light-triggered proton pumps for photohyperpolarization6.3.3 Photoactivated Adenylyl Cyclase (PAC) for phototriggered cAMPdependent effects that facilitate neuronal transmission; 6.3.4 Other optogenetic approaches; 6.3.5 Stimulation of single neurons by optogenetics in freely behaving C. elegans; 6.4 Examples for optogenetic applications in C. elegans; 6.4.1 Optical control of synaptic transmission at the neuromuscular junction and between neurons; 6.4.2 Optical control of neural network activity in the generation of behavior; 6.5 Future challenges. Neural transmission. http://id.loc.gov/authorities/subjects/sh85091095 Neural networks (Neurobiology) http://id.loc.gov/authorities/subjects/sh93002348 Electrooptical devices. http://id.loc.gov/authorities/subjects/sh85042432 Physiological optics. http://id.loc.gov/authorities/subjects/sh85095188 Transmission nerveuse. Réseaux neuronaux (Neurobiologie) Dispositifs électro-optiques. Optique physiologique. Biophysics. bicssc Genetics (non-medical) bicssc Human biology. bicssc Neurosciences. bicssc SCIENCE Life Sciences Zoology General. bisacsh Electrooptical devices fast Neural networks (Neurobiology) fast Neural transmission fast Physiological optics fast Nervennetz gnd http://d-nb.info/gnd/4041638-0 Optogenetik gnd http://d-nb.info/gnd/1043139133 |
| subject_GND | http://id.loc.gov/authorities/subjects/sh85091095 http://id.loc.gov/authorities/subjects/sh93002348 http://id.loc.gov/authorities/subjects/sh85042432 http://id.loc.gov/authorities/subjects/sh85095188 http://d-nb.info/gnd/4041638-0 http://d-nb.info/gnd/1043139133 |
| title | Optogenetics. |
| title_auth | Optogenetics. |
| title_exact_search | Optogenetics. |
| title_full | Optogenetics. |
| title_fullStr | Optogenetics. |
| title_full_unstemmed | Optogenetics. |
| title_short | Optogenetics. |
| title_sort | optogenetics |
| topic | Neural transmission. http://id.loc.gov/authorities/subjects/sh85091095 Neural networks (Neurobiology) http://id.loc.gov/authorities/subjects/sh93002348 Electrooptical devices. http://id.loc.gov/authorities/subjects/sh85042432 Physiological optics. http://id.loc.gov/authorities/subjects/sh85095188 Transmission nerveuse. Réseaux neuronaux (Neurobiologie) Dispositifs électro-optiques. Optique physiologique. Biophysics. bicssc Genetics (non-medical) bicssc Human biology. bicssc Neurosciences. bicssc SCIENCE Life Sciences Zoology General. bisacsh Electrooptical devices fast Neural networks (Neurobiology) fast Neural transmission fast Physiological optics fast Nervennetz gnd http://d-nb.info/gnd/4041638-0 Optogenetik gnd http://d-nb.info/gnd/1043139133 |
| topic_facet | Neural transmission. Neural networks (Neurobiology) Electrooptical devices. Physiological optics. Transmission nerveuse. Réseaux neuronaux (Neurobiologie) Dispositifs électro-optiques. Optique physiologique. Biophysics. Genetics (non-medical) Human biology. Neurosciences. SCIENCE Life Sciences Zoology General. Electrooptical devices Neural transmission Physiological optics Nervennetz Optogenetik |
| url | https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=641741 |
| work_keys_str_mv | AT hegemannpeter optogenetics AT sigriststephan optogenetics |