Nonviral vectors for gene therapy /:
Gene transfer within humans has been an obstacle until about 10 years ago. At that time, it was found that viral vectors were effective carriers of "healthy genes" into patients' cells. The problem, however, was that viral vectors proved unnecessarily harmful to humans: subjects exper...
Gespeichert in:
| Weitere Verfasser: | , , |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
San Diego, CA :
Academic Press,
©1999.
|
| Schlagworte: | |
| Online-Zugang: | Volltext Volltext |
| Zusammenfassung: | Gene transfer within humans has been an obstacle until about 10 years ago. At that time, it was found that viral vectors were effective carriers of "healthy genes" into patients' cells. The problem, however, was that viral vectors proved unnecessarily harmful to humans: subjects experienced inflamatory activity and negative immunological responses to the genes. Viral vectors were also unable to meet the needs of the pharmaceutical community: they were not reproducible in large-scale proportions in cost-effective ways. Thus, research was undertaken to find a safer way to transfer genes to patients without jeopardizing the safety of the patient. And so non-viral vectors were discovered. This volume presents the various non-viral vectors currently under development. Although not methodologically oriented, it will provide the necessary details behind the development of the vectors. This information will prove useful to both researchers and clinicians. Key Features * Presents state-of-the art developments of nonviral vectors as tools for modern molecular medicine * Covers all types of nonviral vectors, from molecular structure to therapeutic application Provides a comprehensive review of synthetic vectors * Includes contributions from major investigators and leading experts in the field |
| Beschreibung: | 1 online resource (xxv, 442 pages) : illustrations (some color) |
| Bibliographie: | Includes bibliographical references and index. |
| ISBN: | 9780123584656 0123584655 9780080479774 0080479774 |
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| 520 | |a Gene transfer within humans has been an obstacle until about 10 years ago. At that time, it was found that viral vectors were effective carriers of "healthy genes" into patients' cells. The problem, however, was that viral vectors proved unnecessarily harmful to humans: subjects experienced inflamatory activity and negative immunological responses to the genes. Viral vectors were also unable to meet the needs of the pharmaceutical community: they were not reproducible in large-scale proportions in cost-effective ways. Thus, research was undertaken to find a safer way to transfer genes to patients without jeopardizing the safety of the patient. And so non-viral vectors were discovered. This volume presents the various non-viral vectors currently under development. Although not methodologically oriented, it will provide the necessary details behind the development of the vectors. This information will prove useful to both researchers and clinicians. Key Features * Presents state-of-the art developments of nonviral vectors as tools for modern molecular medicine * Covers all types of nonviral vectors, from molecular structure to therapeutic application Provides a comprehensive review of synthetic vectors * Includes contributions from major investigators and leading experts in the field | ||
| 505 | 0 | |a Introduction, L. Huang and E. Viroonhatapan. -- Cationic Liposomes: -- Progress in Gene Delivery Research and Development, P. Felgner. -- Cationic Lipid-Mediated Gene Delivery to the Airways, J. Marshall, N. Yew, S. Eastman, C. Jiang, R. Scheule, S. Cheng. -- Structure and Structure-Activity Relationship of Lipid-Based Gene Delivery Systems, D. Lasic. -- Self-Assembled Structures of Lipid/DNA Nonviral Gene Delivery Systems from Synchorotron X-Ray Diffraction, C. Safinya, I. Koltover. -- Sites of Uptake and Expression of Cationic Liposome/DNA Complexes Injected Intravenously, J. McLean, G. Thurston, D. McDonald. -- Other Vectors: -- Nuclear Transport of Exogenous DNA, M. Sebestyén and J. Wolff. -- Particle-Mediated Gene Delivery: Applications to Canine and Other Larger Animal Systems, N.-S. Yang, G. Hogge, E.G. MacEwen. -- Polyethylenimines: A Family of Potent Polymers for Nucleic Acid Delivery, A. Kichler, J.-P. Behr, P. Erbacher. -- Ligand-Polycation Conjugates for Receptor-Targeted Gene Transfer, E. Wagner. -- The Perplexing Delivery Mechanism of Lipoplexes, L. Barron and F. Szoka, Jr. -- Biopolymer-DNA Nanospheres, K. Leong. -- Novel Lipidic Vectors for Gene Transfer, S. Li, L. Huang. -- Animal Models and Clinical Trials: -- Mechanisms of Cationic Liposome-Mediated Transfection of the Lung Endothelium, D. Liu, J. Knapp, Y. Song. -- Cystic Fibrosis Gene Therapy, U. Griesenbach, D. Geddes, E. Alton. -- Targeting HER-2/neu-Overexpressing Cancer Cells with Transcriptional Repressor Genes Delivered by Cationic Liposome, M.-C. Hung, S.-C. Wang, G. Hortobagyi. -- Immune Pathways Used in Nucleic Acid Vaccination, G. Rhodes. -- A Novel Gene Regulatory System, S. Chua, M. Burcin, Y. Wang, S. Tsai. -- Index. | |
| 504 | |a Includes bibliographical references and index. | ||
| 588 | 0 | |a Print version record. | |
| 650 | 0 | |a Gene therapy. |0 http://id.loc.gov/authorities/subjects/sh85053738 | |
| 650 | 0 | |a Genetic vectors. |0 http://id.loc.gov/authorities/subjects/sh85053875 | |
| 650 | 0 | |a DNA-ligand interactions. |0 http://id.loc.gov/authorities/subjects/sh89006999 | |
| 650 | 0 | |a Liposomes. |0 http://id.loc.gov/authorities/subjects/sh85077311 | |
| 650 | 0 | |a Drug targeting. |0 http://id.loc.gov/authorities/subjects/sh88005350 | |
| 650 | 1 | 2 | |a Genetic Vectors |x therapeutic use |
| 650 | 2 | 2 | |a Genetic Therapy |x methods |
| 650 | 2 | 2 | |a Gene Transfer Techniques |
| 650 | 2 | 2 | |a Transformation, Genetic |
| 650 | 2 | |a Genetic Therapy |0 https://id.nlm.nih.gov/mesh/D015316 | |
| 650 | 2 | |a Genetic Vectors |0 https://id.nlm.nih.gov/mesh/D005822 | |
| 650 | 2 | |a Liposomes |0 https://id.nlm.nih.gov/mesh/D008081 | |
| 650 | 2 | |a Drug Delivery Systems |0 https://id.nlm.nih.gov/mesh/D016503 | |
| 650 | 6 | |a Thérapie génique. | |
| 650 | 6 | |a Vecteurs de clonage. | |
| 650 | 6 | |a Interactions ADN-ligand. | |
| 650 | 6 | |a Liposomes. | |
| 650 | 6 | |a Médicaments |x Ciblage. | |
| 650 | 7 | |a HEALTH & FITNESS |x Diseases |x Genetic. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Genetics. |2 bisacsh | |
| 650 | 7 | |a DNA-ligand interactions |2 fast | |
| 650 | 7 | |a Drug targeting |2 fast | |
| 650 | 7 | |a Gene therapy |2 fast | |
| 650 | 7 | |a Genetic vectors |2 fast | |
| 650 | 7 | |a Liposomes |2 fast | |
| 653 | 0 | 0 | |a gentherapie |
| 653 | 0 | 0 | |a gene therapy |
| 653 | 0 | 0 | |a genetische vectoren |
| 653 | 0 | 0 | |a genetic vectors |
| 653 | 0 | 0 | |a gentransfer |
| 653 | 0 | 0 | |a gene transfer |
| 653 | 0 | 0 | |a moleculaire biologie |
| 653 | 0 | 0 | |a molecular biology |
| 653 | 0 | 0 | |a medische behandeling |
| 653 | 0 | 0 | |a medical treatment |
| 653 | 0 | 0 | |a genetische modificatie |
| 653 | 0 | 0 | |a genetic engineering |
| 653 | 0 | 0 | |a supramoleculaire chemie |
| 653 | 0 | 0 | |a supramolecular chemistry |
| 653 | 1 | 0 | |a Medicine (General) |
| 653 | 2 | 0 | |a Genetic Engineering |
| 653 | 1 | 0 | |a Geneeskunde (algemeen) |
| 653 | 2 | 0 | |a Genetische modificatie |
| 700 | 1 | |a Huang, Leaf. |0 http://id.loc.gov/authorities/names/nb99048144 | |
| 700 | 1 | |a Hung, Mien-chie. |0 http://id.loc.gov/authorities/names/nb99048145 | |
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Datensatz im Suchindex
| DE-BY-FWS_katkey | ZDB-4-EBA-ocn162572823 |
|---|---|
| _version_ | 1816881651353911296 |
| adam_text | |
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| author2 | Huang, Leaf Hung, Mien-chie Wagner, Ernst, 1960- |
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| author_GND | http://id.loc.gov/authorities/names/nb99048144 http://id.loc.gov/authorities/names/nb99048145 http://id.loc.gov/authorities/names/nb91094891 |
| author_facet | Huang, Leaf Hung, Mien-chie Wagner, Ernst, 1960- |
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| contents | Introduction, L. Huang and E. Viroonhatapan. -- Cationic Liposomes: -- Progress in Gene Delivery Research and Development, P. Felgner. -- Cationic Lipid-Mediated Gene Delivery to the Airways, J. Marshall, N. Yew, S. Eastman, C. Jiang, R. Scheule, S. Cheng. -- Structure and Structure-Activity Relationship of Lipid-Based Gene Delivery Systems, D. Lasic. -- Self-Assembled Structures of Lipid/DNA Nonviral Gene Delivery Systems from Synchorotron X-Ray Diffraction, C. Safinya, I. Koltover. -- Sites of Uptake and Expression of Cationic Liposome/DNA Complexes Injected Intravenously, J. McLean, G. Thurston, D. McDonald. -- Other Vectors: -- Nuclear Transport of Exogenous DNA, M. Sebestyén and J. Wolff. -- Particle-Mediated Gene Delivery: Applications to Canine and Other Larger Animal Systems, N.-S. Yang, G. Hogge, E.G. MacEwen. -- Polyethylenimines: A Family of Potent Polymers for Nucleic Acid Delivery, A. Kichler, J.-P. Behr, P. Erbacher. -- Ligand-Polycation Conjugates for Receptor-Targeted Gene Transfer, E. Wagner. -- The Perplexing Delivery Mechanism of Lipoplexes, L. Barron and F. Szoka, Jr. -- Biopolymer-DNA Nanospheres, K. Leong. -- Novel Lipidic Vectors for Gene Transfer, S. Li, L. Huang. -- Animal Models and Clinical Trials: -- Mechanisms of Cationic Liposome-Mediated Transfection of the Lung Endothelium, D. Liu, J. Knapp, Y. Song. -- Cystic Fibrosis Gene Therapy, U. Griesenbach, D. Geddes, E. Alton. -- Targeting HER-2/neu-Overexpressing Cancer Cells with Transcriptional Repressor Genes Delivered by Cationic Liposome, M.-C. Hung, S.-C. Wang, G. Hortobagyi. -- Immune Pathways Used in Nucleic Acid Vaccination, G. Rhodes. -- A Novel Gene Regulatory System, S. Chua, M. Burcin, Y. Wang, S. Tsai. -- Index. |
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| dewey-ones | 616 - Diseases |
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| dewey-search | 616/.042 |
| dewey-sort | 3616 242 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| format | Electronic eBook |
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| id | ZDB-4-EBA-ocn162572823 |
| illustrated | Illustrated |
| indexdate | 2024-11-27T13:16:06Z |
| institution | BVB |
| isbn | 9780123584656 0123584655 9780080479774 0080479774 |
| language | English |
| oclc_num | 162572823 |
| open_access_boolean | |
| owner | MAIN DE-863 DE-BY-FWS |
| owner_facet | MAIN DE-863 DE-BY-FWS |
| physical | 1 online resource (xxv, 442 pages) : illustrations (some color) |
| psigel | ZDB-4-EBA |
| publishDate | 1999 |
| publishDateSearch | 1999 |
| publishDateSort | 1999 |
| publisher | Academic Press, |
| record_format | marc |
| spelling | Nonviral vectors for gene therapy / edited by Leaf Huang, Mien-chie Hung, Ernst Wagner. San Diego, CA : Academic Press, ©1999. 1 online resource (xxv, 442 pages) : illustrations (some color) text txt rdacontent computer c rdamedia online resource cr rdacarrier Gene transfer within humans has been an obstacle until about 10 years ago. At that time, it was found that viral vectors were effective carriers of "healthy genes" into patients' cells. The problem, however, was that viral vectors proved unnecessarily harmful to humans: subjects experienced inflamatory activity and negative immunological responses to the genes. Viral vectors were also unable to meet the needs of the pharmaceutical community: they were not reproducible in large-scale proportions in cost-effective ways. Thus, research was undertaken to find a safer way to transfer genes to patients without jeopardizing the safety of the patient. And so non-viral vectors were discovered. This volume presents the various non-viral vectors currently under development. Although not methodologically oriented, it will provide the necessary details behind the development of the vectors. This information will prove useful to both researchers and clinicians. Key Features * Presents state-of-the art developments of nonviral vectors as tools for modern molecular medicine * Covers all types of nonviral vectors, from molecular structure to therapeutic application Provides a comprehensive review of synthetic vectors * Includes contributions from major investigators and leading experts in the field Introduction, L. Huang and E. Viroonhatapan. -- Cationic Liposomes: -- Progress in Gene Delivery Research and Development, P. Felgner. -- Cationic Lipid-Mediated Gene Delivery to the Airways, J. Marshall, N. Yew, S. Eastman, C. Jiang, R. Scheule, S. Cheng. -- Structure and Structure-Activity Relationship of Lipid-Based Gene Delivery Systems, D. Lasic. -- Self-Assembled Structures of Lipid/DNA Nonviral Gene Delivery Systems from Synchorotron X-Ray Diffraction, C. Safinya, I. Koltover. -- Sites of Uptake and Expression of Cationic Liposome/DNA Complexes Injected Intravenously, J. McLean, G. Thurston, D. McDonald. -- Other Vectors: -- Nuclear Transport of Exogenous DNA, M. Sebestyén and J. Wolff. -- Particle-Mediated Gene Delivery: Applications to Canine and Other Larger Animal Systems, N.-S. Yang, G. Hogge, E.G. MacEwen. -- Polyethylenimines: A Family of Potent Polymers for Nucleic Acid Delivery, A. Kichler, J.-P. Behr, P. Erbacher. -- Ligand-Polycation Conjugates for Receptor-Targeted Gene Transfer, E. Wagner. -- The Perplexing Delivery Mechanism of Lipoplexes, L. Barron and F. Szoka, Jr. -- Biopolymer-DNA Nanospheres, K. Leong. -- Novel Lipidic Vectors for Gene Transfer, S. Li, L. Huang. -- Animal Models and Clinical Trials: -- Mechanisms of Cationic Liposome-Mediated Transfection of the Lung Endothelium, D. Liu, J. Knapp, Y. Song. -- Cystic Fibrosis Gene Therapy, U. Griesenbach, D. Geddes, E. Alton. -- Targeting HER-2/neu-Overexpressing Cancer Cells with Transcriptional Repressor Genes Delivered by Cationic Liposome, M.-C. Hung, S.-C. Wang, G. Hortobagyi. -- Immune Pathways Used in Nucleic Acid Vaccination, G. Rhodes. -- A Novel Gene Regulatory System, S. Chua, M. Burcin, Y. Wang, S. Tsai. -- Index. Includes bibliographical references and index. Print version record. Gene therapy. http://id.loc.gov/authorities/subjects/sh85053738 Genetic vectors. http://id.loc.gov/authorities/subjects/sh85053875 DNA-ligand interactions. http://id.loc.gov/authorities/subjects/sh89006999 Liposomes. http://id.loc.gov/authorities/subjects/sh85077311 Drug targeting. http://id.loc.gov/authorities/subjects/sh88005350 Genetic Vectors therapeutic use Genetic Therapy methods Gene Transfer Techniques Transformation, Genetic Genetic Therapy https://id.nlm.nih.gov/mesh/D015316 Genetic Vectors https://id.nlm.nih.gov/mesh/D005822 Liposomes https://id.nlm.nih.gov/mesh/D008081 Drug Delivery Systems https://id.nlm.nih.gov/mesh/D016503 Thérapie génique. Vecteurs de clonage. Interactions ADN-ligand. Liposomes. Médicaments Ciblage. HEALTH & FITNESS Diseases Genetic. bisacsh MEDICAL Genetics. bisacsh DNA-ligand interactions fast Drug targeting fast Gene therapy fast Genetic vectors fast Liposomes fast gentherapie gene therapy genetische vectoren genetic vectors gentransfer gene transfer moleculaire biologie molecular biology medische behandeling medical treatment genetische modificatie genetic engineering supramoleculaire chemie supramolecular chemistry Medicine (General) Genetic Engineering Geneeskunde (algemeen) Genetische modificatie Huang, Leaf. http://id.loc.gov/authorities/names/nb99048144 Hung, Mien-chie. http://id.loc.gov/authorities/names/nb99048145 Wagner, Ernst, 1960- https://id.oclc.org/worldcat/entity/E39PCjvDrhQHC6wWFj3gchk3Bd http://id.loc.gov/authorities/names/nb91094891 has work: Nonviral vectors for gene therapy (Text) https://id.oclc.org/worldcat/entity/E39PCGH3b69dvHwmbfFFRp3WQm https://id.oclc.org/worldcat/ontology/hasWork Print version: Nonviral vectors for gene therapy. San Diego, CA : Academic Press, ©1999 0123584655 9780123584656 (DLC) 99063092 (OCoLC)41464932 FWS01 ZDB-4-EBA FWS_PDA_EBA https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=196127 Volltext FWS01 ZDB-4-EBA FWS_PDA_EBA https://www.sciencedirect.com/science/book/9780123584656 Volltext |
| spellingShingle | Nonviral vectors for gene therapy / Introduction, L. Huang and E. Viroonhatapan. -- Cationic Liposomes: -- Progress in Gene Delivery Research and Development, P. Felgner. -- Cationic Lipid-Mediated Gene Delivery to the Airways, J. Marshall, N. Yew, S. Eastman, C. Jiang, R. Scheule, S. Cheng. -- Structure and Structure-Activity Relationship of Lipid-Based Gene Delivery Systems, D. Lasic. -- Self-Assembled Structures of Lipid/DNA Nonviral Gene Delivery Systems from Synchorotron X-Ray Diffraction, C. Safinya, I. Koltover. -- Sites of Uptake and Expression of Cationic Liposome/DNA Complexes Injected Intravenously, J. McLean, G. Thurston, D. McDonald. -- Other Vectors: -- Nuclear Transport of Exogenous DNA, M. Sebestyén and J. Wolff. -- Particle-Mediated Gene Delivery: Applications to Canine and Other Larger Animal Systems, N.-S. Yang, G. Hogge, E.G. MacEwen. -- Polyethylenimines: A Family of Potent Polymers for Nucleic Acid Delivery, A. Kichler, J.-P. Behr, P. Erbacher. -- Ligand-Polycation Conjugates for Receptor-Targeted Gene Transfer, E. Wagner. -- The Perplexing Delivery Mechanism of Lipoplexes, L. Barron and F. Szoka, Jr. -- Biopolymer-DNA Nanospheres, K. Leong. -- Novel Lipidic Vectors for Gene Transfer, S. Li, L. Huang. -- Animal Models and Clinical Trials: -- Mechanisms of Cationic Liposome-Mediated Transfection of the Lung Endothelium, D. Liu, J. Knapp, Y. Song. -- Cystic Fibrosis Gene Therapy, U. Griesenbach, D. Geddes, E. Alton. -- Targeting HER-2/neu-Overexpressing Cancer Cells with Transcriptional Repressor Genes Delivered by Cationic Liposome, M.-C. Hung, S.-C. Wang, G. Hortobagyi. -- Immune Pathways Used in Nucleic Acid Vaccination, G. Rhodes. -- A Novel Gene Regulatory System, S. Chua, M. Burcin, Y. Wang, S. Tsai. -- Index. Gene therapy. http://id.loc.gov/authorities/subjects/sh85053738 Genetic vectors. http://id.loc.gov/authorities/subjects/sh85053875 DNA-ligand interactions. http://id.loc.gov/authorities/subjects/sh89006999 Liposomes. http://id.loc.gov/authorities/subjects/sh85077311 Drug targeting. http://id.loc.gov/authorities/subjects/sh88005350 Genetic Vectors therapeutic use Genetic Therapy methods Gene Transfer Techniques Transformation, Genetic Genetic Therapy https://id.nlm.nih.gov/mesh/D015316 Genetic Vectors https://id.nlm.nih.gov/mesh/D005822 Liposomes https://id.nlm.nih.gov/mesh/D008081 Drug Delivery Systems https://id.nlm.nih.gov/mesh/D016503 Thérapie génique. Vecteurs de clonage. Interactions ADN-ligand. Liposomes. Médicaments Ciblage. HEALTH & FITNESS Diseases Genetic. bisacsh MEDICAL Genetics. bisacsh DNA-ligand interactions fast Drug targeting fast Gene therapy fast Genetic vectors fast Liposomes fast |
| subject_GND | http://id.loc.gov/authorities/subjects/sh85053738 http://id.loc.gov/authorities/subjects/sh85053875 http://id.loc.gov/authorities/subjects/sh89006999 http://id.loc.gov/authorities/subjects/sh85077311 http://id.loc.gov/authorities/subjects/sh88005350 https://id.nlm.nih.gov/mesh/D015316 https://id.nlm.nih.gov/mesh/D005822 https://id.nlm.nih.gov/mesh/D008081 https://id.nlm.nih.gov/mesh/D016503 |
| title | Nonviral vectors for gene therapy / |
| title_auth | Nonviral vectors for gene therapy / |
| title_exact_search | Nonviral vectors for gene therapy / |
| title_full | Nonviral vectors for gene therapy / edited by Leaf Huang, Mien-chie Hung, Ernst Wagner. |
| title_fullStr | Nonviral vectors for gene therapy / edited by Leaf Huang, Mien-chie Hung, Ernst Wagner. |
| title_full_unstemmed | Nonviral vectors for gene therapy / edited by Leaf Huang, Mien-chie Hung, Ernst Wagner. |
| title_short | Nonviral vectors for gene therapy / |
| title_sort | nonviral vectors for gene therapy |
| topic | Gene therapy. http://id.loc.gov/authorities/subjects/sh85053738 Genetic vectors. http://id.loc.gov/authorities/subjects/sh85053875 DNA-ligand interactions. http://id.loc.gov/authorities/subjects/sh89006999 Liposomes. http://id.loc.gov/authorities/subjects/sh85077311 Drug targeting. http://id.loc.gov/authorities/subjects/sh88005350 Genetic Vectors therapeutic use Genetic Therapy methods Gene Transfer Techniques Transformation, Genetic Genetic Therapy https://id.nlm.nih.gov/mesh/D015316 Genetic Vectors https://id.nlm.nih.gov/mesh/D005822 Liposomes https://id.nlm.nih.gov/mesh/D008081 Drug Delivery Systems https://id.nlm.nih.gov/mesh/D016503 Thérapie génique. Vecteurs de clonage. Interactions ADN-ligand. Liposomes. Médicaments Ciblage. HEALTH & FITNESS Diseases Genetic. bisacsh MEDICAL Genetics. bisacsh DNA-ligand interactions fast Drug targeting fast Gene therapy fast Genetic vectors fast Liposomes fast |
| topic_facet | Gene therapy. Genetic vectors. DNA-ligand interactions. Liposomes. Drug targeting. Genetic Vectors therapeutic use Genetic Therapy methods Gene Transfer Techniques Transformation, Genetic Genetic Therapy Genetic Vectors Liposomes Drug Delivery Systems Thérapie génique. Vecteurs de clonage. Interactions ADN-ligand. Médicaments Ciblage. HEALTH & FITNESS Diseases Genetic. MEDICAL Genetics. DNA-ligand interactions Drug targeting Gene therapy Genetic vectors |
| url | https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=196127 https://www.sciencedirect.com/science/book/9780123584656 |
| work_keys_str_mv | AT huangleaf nonviralvectorsforgenetherapy AT hungmienchie nonviralvectorsforgenetherapy AT wagnerernst nonviralvectorsforgenetherapy |