Oxidative DNA damage leading to chromosomal aberrations and mutations:
This Adverse Outcome Pathway (AOP) describes the linkage between oxidative DNA damage and irreversible genomic damage (chromosomal aberrations and mutations). DNA damage is considered an important contributor to the adverse health effects of many environmental toxicants and this AOP may thus be of w...
Gespeichert in:
| 1. Verfasser: | |
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| Weitere Verfasser: | , , , , , , , , , , , |
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Paris
OECD Publishing
2023
|
| Schriftenreihe: | OECD Series on Adverse Outcome Pathways
no.29 |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Zusammenfassung: | This Adverse Outcome Pathway (AOP) describes the linkage between oxidative DNA damage and irreversible genomic damage (chromosomal aberrations and mutations). DNA damage is considered an important contributor to the adverse health effects of many environmental toxicants and this AOP may thus be of widespread use to the regulatory community. Although increase in oxidative DNA damage is the molecular initiating event for this AOP, there are numerous upstream key events that can also lead to DNA oxidation. Thus, this AOP may be expanded upstream, and could be incorporated into a variety of AOP networks. Furthermore, the AOP points to critical research gaps required to establish the quantitative associations and modulating factors that connect KEs across the AOP, and highlights the utility of novel test methods in understanding and evaluating the implications of oxidative DNA damage. This AOP is referred to as AOP 296 in the Collaborative Adverse Outcome Pathway Wiki (AOP-Wiki). |
| Beschreibung: | 1 Online-Ressource (154 p.) 21 x 28cm. |
| DOI: | 10.1787/399d2c34-en |
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| author | Cho, Eunnara |
| author2 | Allemang, Ashley Audebert, Marc Chauhan, Vinita Dertinger, Stephen Hendriks, Giel Luijten, Mirjam Marchetti, Francesco Minocherhomji, Sheroy Pfuhler, Stefan Roberts, Daniel J.. Trenz, Kristina Yauk, Carole L.. |
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| author_facet | Cho, Eunnara Allemang, Ashley Audebert, Marc Chauhan, Vinita Dertinger, Stephen Hendriks, Giel Luijten, Mirjam Marchetti, Francesco Minocherhomji, Sheroy Pfuhler, Stefan Roberts, Daniel J.. Trenz, Kristina Yauk, Carole L.. |
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| author_sort | Cho, Eunnara |
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| ctrlnum | (DE-627-1)098549707 (DE-599)KEP098549707 (FR-PaOEC)399d2c34-en (EBP)098549707 |
| discipline | Wirtschaftswissenschaften |
| doi_str_mv | 10.1787/399d2c34-en |
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| id | ZDB-13-SOC-098549707 |
| illustrated | Not Illustrated |
| indexdate | 2024-11-26T14:55:35Z |
| institution | BVB |
| language | English |
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| physical | 1 Online-Ressource (154 p.) 21 x 28cm. |
| psigel | ZDB-13-SOC |
| publishDate | 2023 |
| publishDateSearch | 2023 |
| publishDateSort | 2023 |
| publisher | OECD Publishing |
| record_format | marc |
| series2 | OECD Series on Adverse Outcome Pathways |
| spelling | Cho, Eunnara VerfasserIn aut Oxidative DNA damage leading to chromosomal aberrations and mutations Eunnara, Cho ... [et al] Paris OECD Publishing 2023 1 Online-Ressource (154 p.) 21 x 28cm. Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier OECD Series on Adverse Outcome Pathways no.29 This Adverse Outcome Pathway (AOP) describes the linkage between oxidative DNA damage and irreversible genomic damage (chromosomal aberrations and mutations). DNA damage is considered an important contributor to the adverse health effects of many environmental toxicants and this AOP may thus be of widespread use to the regulatory community. Although increase in oxidative DNA damage is the molecular initiating event for this AOP, there are numerous upstream key events that can also lead to DNA oxidation. Thus, this AOP may be expanded upstream, and could be incorporated into a variety of AOP networks. Furthermore, the AOP points to critical research gaps required to establish the quantitative associations and modulating factors that connect KEs across the AOP, and highlights the utility of novel test methods in understanding and evaluating the implications of oxidative DNA damage. This AOP is referred to as AOP 296 in the Collaborative Adverse Outcome Pathway Wiki (AOP-Wiki). Environment Allemang, Ashley MitwirkendeR ctb Audebert, Marc MitwirkendeR ctb Chauhan, Vinita MitwirkendeR ctb Dertinger, Stephen MitwirkendeR ctb Hendriks, Giel MitwirkendeR ctb Luijten, Mirjam MitwirkendeR ctb Marchetti, Francesco MitwirkendeR ctb Minocherhomji, Sheroy MitwirkendeR ctb Pfuhler, Stefan MitwirkendeR ctb Roberts, Daniel J... MitwirkendeR ctb Trenz, Kristina MitwirkendeR ctb Yauk, Carole L... MitwirkendeR ctb FWS01 ZDB-13-SOC FWS_PDA_SOC https://doi.org/10.1787/399d2c34-en Volltext |
| spellingShingle | Cho, Eunnara Oxidative DNA damage leading to chromosomal aberrations and mutations Environment |
| title | Oxidative DNA damage leading to chromosomal aberrations and mutations |
| title_auth | Oxidative DNA damage leading to chromosomal aberrations and mutations |
| title_exact_search | Oxidative DNA damage leading to chromosomal aberrations and mutations |
| title_full | Oxidative DNA damage leading to chromosomal aberrations and mutations Eunnara, Cho ... [et al] |
| title_fullStr | Oxidative DNA damage leading to chromosomal aberrations and mutations Eunnara, Cho ... [et al] |
| title_full_unstemmed | Oxidative DNA damage leading to chromosomal aberrations and mutations Eunnara, Cho ... [et al] |
| title_short | Oxidative DNA damage leading to chromosomal aberrations and mutations |
| title_sort | oxidative dna damage leading to chromosomal aberrations and mutations |
| topic | Environment |
| topic_facet | Environment |
| url | https://doi.org/10.1787/399d2c34-en |
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