Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation:
This Adverse Outcome Pathway (AOP) describes the linkage between Deiodinase 2 inhibition and increased mortality via reduced anterior swim bladder inflation. The swim bladder is a gas-filled organ found in many bony fish species and typically consists of two gas-filled chambers. The posterior chambe...
Gespeichert in:
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| Weitere Verfasser: | , , |
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Paris
OECD Publishing
2022
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| Schriftenreihe: | OECD Series on Adverse Outcome Pathways
no.23 |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Zusammenfassung: | This Adverse Outcome Pathway (AOP) describes the linkage between Deiodinase 2 inhibition and increased mortality via reduced anterior swim bladder inflation. The swim bladder is a gas-filled organ found in many bony fish species and typically consists of two gas-filled chambers. The posterior chamber inflates during early development (embryo), while the anterior chamber inflates during late development (larva). Both chambers are important for fish to control buoyancy and the anterior chamber has an additional role in hearing. This AOP is part of a network of 5 AOPs describing how disruption of the thyroid hormone system can affect developmental processes involved in swim bladder inflation. The network includes three molecular initiating events representing the inhibition of enzymes that are important for thyroid hormone synthesis and activation. It describes how inhibition of thyroperoxidase and/or deiodinase, leads to reduced swim bladder inflation, resulting in reduced swimming performance, increased mortality and ultimately, decreased population trajectory in fish. This AOP network is currently mainly based on experimental evidence from studies on fish species with a two-chambered swim bladder. This AOP is referred to as AOP 156 in the Collaborative Adverse Outcome Pathway Wiki (AOP-Wiki). |
| Beschreibung: | 1 Online-Ressource (66 p.) 21 x 28cm. |
| DOI: | 10.1787/b1bf0bea-en |
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| 520 | |a This Adverse Outcome Pathway (AOP) describes the linkage between Deiodinase 2 inhibition and increased mortality via reduced anterior swim bladder inflation. The swim bladder is a gas-filled organ found in many bony fish species and typically consists of two gas-filled chambers. The posterior chamber inflates during early development (embryo), while the anterior chamber inflates during late development (larva). Both chambers are important for fish to control buoyancy and the anterior chamber has an additional role in hearing. This AOP is part of a network of 5 AOPs describing how disruption of the thyroid hormone system can affect developmental processes involved in swim bladder inflation. The network includes three molecular initiating events representing the inhibition of enzymes that are important for thyroid hormone synthesis and activation. It describes how inhibition of thyroperoxidase and/or deiodinase, leads to reduced swim bladder inflation, resulting in reduced swimming performance, increased mortality and ultimately, decreased population trajectory in fish. This AOP network is currently mainly based on experimental evidence from studies on fish species with a two-chambered swim bladder. This AOP is referred to as AOP 156 in the Collaborative Adverse Outcome Pathway Wiki (AOP-Wiki). | ||
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| spelling | Vergauwen, Lucia VerfasserIn aut Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation Lucia, Vergauwen ... [et al] Paris OECD Publishing 2022 1 Online-Ressource (66 p.) 21 x 28cm. Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier OECD Series on Adverse Outcome Pathways no.23 This Adverse Outcome Pathway (AOP) describes the linkage between Deiodinase 2 inhibition and increased mortality via reduced anterior swim bladder inflation. The swim bladder is a gas-filled organ found in many bony fish species and typically consists of two gas-filled chambers. The posterior chamber inflates during early development (embryo), while the anterior chamber inflates during late development (larva). Both chambers are important for fish to control buoyancy and the anterior chamber has an additional role in hearing. This AOP is part of a network of 5 AOPs describing how disruption of the thyroid hormone system can affect developmental processes involved in swim bladder inflation. The network includes three molecular initiating events representing the inhibition of enzymes that are important for thyroid hormone synthesis and activation. It describes how inhibition of thyroperoxidase and/or deiodinase, leads to reduced swim bladder inflation, resulting in reduced swimming performance, increased mortality and ultimately, decreased population trajectory in fish. This AOP network is currently mainly based on experimental evidence from studies on fish species with a two-chambered swim bladder. This AOP is referred to as AOP 156 in the Collaborative Adverse Outcome Pathway Wiki (AOP-Wiki). Environment Stinckens, Evelyn MitwirkendeR ctb Villeneuve, Daniel L... MitwirkendeR ctb Knapen, Dries MitwirkendeR ctb FWS01 ZDB-13-SOC FWS_PDA_SOC https://doi.org/10.1787/b1bf0bea-en Volltext |
| spellingShingle | Vergauwen, Lucia Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation Environment |
| title | Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation |
| title_auth | Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation |
| title_exact_search | Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation |
| title_full | Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation Lucia, Vergauwen ... [et al] |
| title_fullStr | Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation Lucia, Vergauwen ... [et al] |
| title_full_unstemmed | Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation Lucia, Vergauwen ... [et al] |
| title_short | Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation |
| title_sort | deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation |
| topic | Environment |
| topic_facet | Environment |
| url | https://doi.org/10.1787/b1bf0bea-en |
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