Adverse Outcome Pathway on Protein Alkylation Leading to Liver Fibrosis:
Liver fibrosis is an important human health issue associated with chemical exposure. It is a typical result of chronic toxic injury and one of the considered endpoints for regulatory purposes. This AOP describes the linkage between hepatic injury caused by protein alkylation and the formation of liv...
Gespeichert in:
| 1. Verfasser: | |
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| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Paris
OECD Publishing
2016
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| Schriftenreihe: | OECD Series on Adverse Outcome Pathways
no.2 |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Zusammenfassung: | Liver fibrosis is an important human health issue associated with chemical exposure. It is a typical result of chronic toxic injury and one of the considered endpoints for regulatory purposes. This AOP describes the linkage between hepatic injury caused by protein alkylation and the formation of liver fibrosis. Fibrogenesis is a long-term and complex process for which an adequate cell model is not available and an in vitro evaluation of fibrogenic potential is therefore not feasible yet. This systematic and coherent display of currently available mechanistic-toxicological information can serve as a knowledge-based repository for identification/selection/development of in vitro methods suitable for measuring key events and their relationships along the AOP and to facilitate the use of alternative data for regulatory purposes. Identified uncertainties and knowledge gaps can indicate priorities for future research. |
| Beschreibung: | 1 Online-Ressource (72 p.) 21 x 29.7cm. |
| DOI: | 10.1787/5jlsvwl6g7r5-en |
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| 520 | |a Liver fibrosis is an important human health issue associated with chemical exposure. It is a typical result of chronic toxic injury and one of the considered endpoints for regulatory purposes. This AOP describes the linkage between hepatic injury caused by protein alkylation and the formation of liver fibrosis. Fibrogenesis is a long-term and complex process for which an adequate cell model is not available and an in vitro evaluation of fibrogenic potential is therefore not feasible yet. This systematic and coherent display of currently available mechanistic-toxicological information can serve as a knowledge-based repository for identification/selection/development of in vitro methods suitable for measuring key events and their relationships along the AOP and to facilitate the use of alternative data for regulatory purposes. Identified uncertainties and knowledge gaps can indicate priorities for future research. | ||
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| indexdate | 2024-11-26T14:55:54Z |
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| series2 | OECD Series on Adverse Outcome Pathways |
| spelling | Landesmann, Brigitte VerfasserIn aut Adverse Outcome Pathway on Protein Alkylation Leading to Liver Fibrosis Brigitte, Landesmann Paris OECD Publishing 2016 1 Online-Ressource (72 p.) 21 x 29.7cm. Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier OECD Series on Adverse Outcome Pathways no.2 Liver fibrosis is an important human health issue associated with chemical exposure. It is a typical result of chronic toxic injury and one of the considered endpoints for regulatory purposes. This AOP describes the linkage between hepatic injury caused by protein alkylation and the formation of liver fibrosis. Fibrogenesis is a long-term and complex process for which an adequate cell model is not available and an in vitro evaluation of fibrogenic potential is therefore not feasible yet. This systematic and coherent display of currently available mechanistic-toxicological information can serve as a knowledge-based repository for identification/selection/development of in vitro methods suitable for measuring key events and their relationships along the AOP and to facilitate the use of alternative data for regulatory purposes. Identified uncertainties and knowledge gaps can indicate priorities for future research. Environment Social Issues/Migration/Health FWS01 ZDB-13-SOC FWS_PDA_SOC https://doi.org/10.1787/5jlsvwl6g7r5-en Volltext |
| spellingShingle | Landesmann, Brigitte Adverse Outcome Pathway on Protein Alkylation Leading to Liver Fibrosis Environment Social Issues/Migration/Health |
| title | Adverse Outcome Pathway on Protein Alkylation Leading to Liver Fibrosis |
| title_auth | Adverse Outcome Pathway on Protein Alkylation Leading to Liver Fibrosis |
| title_exact_search | Adverse Outcome Pathway on Protein Alkylation Leading to Liver Fibrosis |
| title_full | Adverse Outcome Pathway on Protein Alkylation Leading to Liver Fibrosis Brigitte, Landesmann |
| title_fullStr | Adverse Outcome Pathway on Protein Alkylation Leading to Liver Fibrosis Brigitte, Landesmann |
| title_full_unstemmed | Adverse Outcome Pathway on Protein Alkylation Leading to Liver Fibrosis Brigitte, Landesmann |
| title_short | Adverse Outcome Pathway on Protein Alkylation Leading to Liver Fibrosis |
| title_sort | adverse outcome pathway on protein alkylation leading to liver fibrosis |
| topic | Environment Social Issues/Migration/Health |
| topic_facet | Environment Social Issues/Migration/Health |
| url | https://doi.org/10.1787/5jlsvwl6g7r5-en |
| work_keys_str_mv | AT landesmannbrigitte adverseoutcomepathwayonproteinalkylationleadingtoliverfibrosis |