On physiological closed-loop control for lung-protective mechanical ventilation:
Saved in:
| Main Author: | |
|---|---|
| Format: | Thesis Book |
| Language: | English |
| Published: |
Düren
Shaker
2024
|
| Edition: | 1. Auflage |
| Series: | Aachener Beiträge zur Medizintechnik
78 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | 188 Seiten 81 Illustrationen 21 cm x 14.8 cm, 315 g |
| ISBN: | 9783844096583 3844096582 |
Staff View
MARC
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| 100 | 1 | |a Platen, Philip von |d 1990- |e Verfasser |0 (DE-588)1345867735 |4 aut | |
| 245 | 1 | 0 | |a On physiological closed-loop control for lung-protective mechanical ventilation |c Philip von Platen |
| 250 | |a 1. Auflage | ||
| 263 | |a 202410 | ||
| 264 | 1 | |a Düren |b Shaker |c 2024 | |
| 300 | |a 188 Seiten |b 81 Illustrationen |c 21 cm x 14.8 cm, 315 g | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Aachener Beiträge zur Medizintechnik |v 78 | |
| 502 | |b Dissertation |c RWTH Aachen University |d 2024 | ||
| 650 | 0 | 7 | |a Künstliche Beatmung |0 (DE-588)4033439-9 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Atemgeräusch |0 (DE-588)4268541-2 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a ARDS |0 (DE-588)4221275-3 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Regler |0 (DE-588)4140088-4 |2 gnd |9 rswk-swf |
| 653 | |a Mechanical Ventilation | ||
| 653 | |a Closed-Loop Control | ||
| 653 | |a Robust Control | ||
| 653 | |a Physiological Modelling | ||
| 653 | |a Hysteresis Modelling | ||
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Record in the Search Index
| _version_ | 1828133957531598848 |
|---|---|
| adam_text |
CONTENTS
ACKNOWLEDGMENT
V
ABSTRACT
VII
ABBREVIATIONS
AND
SYMBOLS
XIII
1
INTRODUCTION
1
1.1
AIM
OF
THE
THESIS
.
3
1.2
STRUCTURE
OF
THE
THESIS
.
4
2
BACKGROUND
5
2.1
MEDICAL
FUNDAMENTALS
.
5
2.1.1
ANATOMY
OF
THE
RESPIRATORY
SYSTEM
.
5
2.1.2
VENTILATION
AND
CIRCULATION
.
6
2.1.3
GAS
EXCHANGE
.
8
2.1.4
BLOOD
GAS
TRANSPORT
.
8
2.2
ACUTE
LUNG
INJURY
.
12
2.2.1
PATHOGENESIS
AND
DEFINITION
.
12
2.2.2
CHARACTERISTICS
OF
AN
ACUTE
LUNG
INJURY
.
13
2.2.3
EXPERIMENTAL
MODEL
OF
ACUTE
LUNG
INJURY
.
14
2.3
MECHANICAL
VENTILATION
FUNDAMENTALS
.
15
2.3.1
BASICS
OF
MECHANICAL
VENTILATION
.
15
2.3.2
CLINICAL
MEASUREMENTS
.
17
2.3.3
VENTILATOR-INDUCED
LUNG
INJURY
.
20
2.3.4
LUNG-PROTECTIVE
VENTILATION
STRATEGIES
.
21
2.4
COMPUTERISED
SYSTEMS
FOR
MECHANICAL
VENTILATION
.
22
2.4.1
LITERATURE
REVIEW
.
23
2.5
TECHNICAL
FUNDAMENTALS
.
25
2.5.1
SYSTEM
IDENTIFICATION
.
25
2.5.2
PHYSIOLOGICAL
MODELLING
.
27
2.5.3
PARAMETER
ESTIMATION
.
27
2.5.4
ROBUST
CONTROL
THEORY
.
32
3
MODELLING
AND
IDENTIFICATION
OF
THE
RESPIRATORY
SYSTEM
37
3.1
INTRODUCTION
.
37
3.2
THE
HYSTERESIS
PHENOMENON
.
38
3.3
MATHEMATICAL
HYSTERESIS
MODELLING
.
40
3.3.1
DIFFERENTIAL
EQUATION
MODELS
.
41
3.3.2
OPERATOR-BASED
MODELS
.
42
CONTENTS
3.4
REVIEW
OF
HYSTERESIS
MODELS
OF
THE
RESPIRATORY
SYSTEM
.
47
3.5
SMALL-SIGNAL
BEHAVIOUR
OF
THE
RESPIRATORY
SYSTEM
.
50
3.5.1
COMPARTMENT
MODELS
.
50
3.5.2
ESTIMATION
OF
MODEL
PARAMETERS
.
53
3.5.3
RESULTS
.
54
3.6
PREISACH
MODEL
OF
THE
RESPIRATORY
SYSTEM
.
58
3.6.1
IMPLEMENTATION
AND
IDENTIFICATION
.
59
3.6.2
EXPERIMENTS
AND
DATA
.
63
3.6.3
IDENTIFICATION
RESULTS
.
66
3.6.4
MODEL
APPLICATION
TO
CLINICAL
MANOEUVRES
.
68
3.7
DISCUSSION
.
71
3.8
SUMMARY
.
76
4
CLOSED-LOOP
CONTROL
OF
SYSTEMIC
OXYGENATION
77
4.1
INTRODUCTION
.
77
4.2
MODELS
OF
RESPIRATION
IN
ACUTE
LUNG
INJURY
.
79
4.2.1
COMPARTMENT
MODEL
OF
OXYGEN
EXCHANGE
AND
TRANSPORT
81
4.2.2
STATIC
MODELS
FOR
THE
INJURED
LUNG
.
84
4.2.3
VARIATION
OF
INPUTS
AND
PARAMETERS
.
89
4.3
SYSTEM
IDENTIFICATION
OF
SYSTEMIC
OXYGENATION
.
92
4.3.1
HAMMERSTEIN
MODEL
.
92
4.3.2
PARAMETER
ESTIMATION
OF
THE
STATIC
NON-LINEARITY
.
93
4.3.3
PARAMETER
ESTIMATION
OF
THE
DYNAMIC
LINEAR
SYSTEM
.
95
4.4
UNCERTAINTY
MODELLING
.
97
4.4.1
GAIN
UNCERTAINTY
.
98
4.4.2
DYNAMIC
UNCERTAINTY
.
100
4.5
CONTROLLER
DESIGN
.
101
4.5.1
RULE-BASED
CONTROL
.
102
4.5.2
ROBUST
CONTROL
.
104
4.6
CONTROL
RESULTS
.
105
4.6.1
SIMULATION
RESULTS
.
105
4.6.2
IN
VIVO
RESULTS
OF
THE
ROBUST
CONTROL
.
108
4.7
DISCUSSION
.
109
4.8
SUMMARY
.
113
5
CLOSED-LOOP
SYSTEM
FOCUSED
ON
PROTECTIVE
MECHANICAL
VENTILATION
115
5.1
INTRODUCTION
.
115
5.2
ADAPTIVE
LUNG-PROTECTIVE
OPERATING
SPACES
.
117
5.2.1
ONLINE
ESTIMATION
OF
RESPIRATORY
SYSTEM
PARAMETERS
.
117
5.2.2
OPERATING
SPACE
FOR
DRIVING
PRESSURE
AND
TIDAL
VOLUME
118
5.2.3
OPERATING
SPACE
FOR
RESPIRATORY
RATE
.
119
CONTENTS
5.3
AUTOMATED
PEEP
TITRATION
MANOEUVRE
.
120
5.3.1
CLINICAL
BEST
PEEP
METHODS
.
120
5.3.2
FINDING
MAXIMUM
COMPLIANCE
.
121
5.3.3
AUTOMATION
ALGORITHMS
.
123
5.4
CLOSED-LOOP
CONTROL
OF
SPO2
.
125
5.4.1
COUPLING
PEEP
AND
INSPIRED
OXYGEN
.
125
5.4.2
A
PERSONALISED
COUPLING
OF
PEEP
AND
INSPIRED
OXYGEN
126
5.5
PETCO2
CONTROL
AND
PRESSURE-REGULATED
VOLUME
CONTROL
.
.
.
129
5.6
IMPLEMENTATION
AND
TESTING
.
131
5.7
PILOT
STUDY
RESULTS
.
131
5.7.1
SYSTEM
SETUP
.
131
5.7.2
PILOT
STUDY
PROTOCOL
.
132
5.7.3
SPO2
CONTROL
.
133
5.7.4
PRVC
AND
PETCO2
CONTROL
.
135
5.8
VALIDATION
STUDY
RESULTS
.
140
5.8.1
SYSTEM
SETUP
.
140
5.8.2
VALIDATION
STUDY
PROTOCOL
.
140
5.8.3
AUTOMATED
PEEP
TITRATION
RESULTS
.
142
5.8.4
OVERALL
VALIDATION
STUDY
RESULTS
.
143
5.9
DISCUSSION
.
146
5.9.1
AUTOMATED
PEEP
TITRATIONS
.
146
5.9.2
SPO2
CONTROL
.
147
5.9.3
PETCO2
AND
PRVC
CONTROL
.
147
5.9.4
STUDY
LIMITATIONS
.
149
5.10
SUMMARY
.
150
6
CONCLUSION
151
A
APPENDIX
153
B
PUBLICATIONS
163
BIBLIOGRAPHY
169 |
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| author | Platen, Philip von 1990- |
| author_GND | (DE-588)1345867735 |
| author_facet | Platen, Philip von 1990- |
| author_role | aut |
| author_sort | Platen, Philip von 1990- |
| author_variant | p v p pv pvp |
| building | Verbundindex |
| bvnumber | BV049926844 |
| classification_rvk | XC 4000 |
| ctrlnum | (OCoLC)1494748467 (DE-599)DNB1341089045 |
| discipline | Medizin |
| edition | 1. Auflage |
| format | Thesis Book |
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| genre_facet | Hochschulschrift |
| id | DE-604.BV049926844 |
| illustrated | Illustrated |
| indexdate | 2025-03-31T18:06:41Z |
| institution | BVB |
| institution_GND | (DE-588)1064118135 |
| isbn | 9783844096583 3844096582 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-035265291 |
| oclc_num | 1494748467 |
| open_access_boolean | |
| owner | DE-83 |
| owner_facet | DE-83 |
| physical | 188 Seiten 81 Illustrationen 21 cm x 14.8 cm, 315 g |
| publishDate | 2024 |
| publishDateSearch | 2024 |
| publishDateSort | 2024 |
| publisher | Shaker |
| record_format | marc |
| series | Aachener Beiträge zur Medizintechnik |
| series2 | Aachener Beiträge zur Medizintechnik |
| spelling | Platen, Philip von 1990- Verfasser (DE-588)1345867735 aut On physiological closed-loop control for lung-protective mechanical ventilation Philip von Platen 1. Auflage 202410 Düren Shaker 2024 188 Seiten 81 Illustrationen 21 cm x 14.8 cm, 315 g txt rdacontent n rdamedia nc rdacarrier Aachener Beiträge zur Medizintechnik 78 Dissertation RWTH Aachen University 2024 Künstliche Beatmung (DE-588)4033439-9 gnd rswk-swf Atemgeräusch (DE-588)4268541-2 gnd rswk-swf ARDS (DE-588)4221275-3 gnd rswk-swf Regler (DE-588)4140088-4 gnd rswk-swf Mechanical Ventilation Closed-Loop Control Robust Control Physiological Modelling Hysteresis Modelling (DE-588)4113937-9 Hochschulschrift gnd-content Künstliche Beatmung (DE-588)4033439-9 s ARDS (DE-588)4221275-3 s Regler (DE-588)4140088-4 s Atemgeräusch (DE-588)4268541-2 s DE-604 Shaker Verlag (DE-588)1064118135 pbl Aachener Beiträge zur Medizintechnik 78 (DE-604)BV039843840 78 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=035265291&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p vlb 20240905 DE-101 https://d-nb.info/provenance/plan#vlb |
| spellingShingle | Platen, Philip von 1990- On physiological closed-loop control for lung-protective mechanical ventilation Aachener Beiträge zur Medizintechnik Künstliche Beatmung (DE-588)4033439-9 gnd Atemgeräusch (DE-588)4268541-2 gnd ARDS (DE-588)4221275-3 gnd Regler (DE-588)4140088-4 gnd |
| subject_GND | (DE-588)4033439-9 (DE-588)4268541-2 (DE-588)4221275-3 (DE-588)4140088-4 (DE-588)4113937-9 |
| title | On physiological closed-loop control for lung-protective mechanical ventilation |
| title_auth | On physiological closed-loop control for lung-protective mechanical ventilation |
| title_exact_search | On physiological closed-loop control for lung-protective mechanical ventilation |
| title_full | On physiological closed-loop control for lung-protective mechanical ventilation Philip von Platen |
| title_fullStr | On physiological closed-loop control for lung-protective mechanical ventilation Philip von Platen |
| title_full_unstemmed | On physiological closed-loop control for lung-protective mechanical ventilation Philip von Platen |
| title_short | On physiological closed-loop control for lung-protective mechanical ventilation |
| title_sort | on physiological closed loop control for lung protective mechanical ventilation |
| topic | Künstliche Beatmung (DE-588)4033439-9 gnd Atemgeräusch (DE-588)4268541-2 gnd ARDS (DE-588)4221275-3 gnd Regler (DE-588)4140088-4 gnd |
| topic_facet | Künstliche Beatmung Atemgeräusch ARDS Regler Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=035265291&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV039843840 |
| work_keys_str_mv | AT platenphilipvon onphysiologicalclosedloopcontrolforlungprotectivemechanicalventilation AT shakerverlag onphysiologicalclosedloopcontrolforlungprotectivemechanicalventilation |