Bioprocess intensification:
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| Format: | Book |
| Language: | English |
| Published: |
Berlin ; Boston
De Gruyter
[2024]
|
| Edition: | 1. Auflage |
| Series: | De Gruyter STEM
|
| Subjects: | |
| Online Access: | https://www.degruyter.com/isbn/9783110760323 Inhaltsverzeichnis |
| Physical Description: | XIV, 372 Seiten Illustrationen, Diagramme 24 cm x 17 cm |
| ISBN: | 9783110760323 |
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| 245 | 1 | 0 | |a Bioprocess intensification |c edited by Dirk Holtmann |
| 264 | 1 | |a Berlin ; Boston |b De Gruyter |c [2024] | |
| 300 | |a XIV, 372 Seiten |b Illustrationen, Diagramme |c 24 cm x 17 cm | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 0 | |a De Gruyter STEM | |
| 650 | 0 | 7 | |a Prozessoptimierung |0 (DE-588)4176074-8 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Bioverfahrenstechnik |0 (DE-588)4307166-1 |2 gnd |9 rswk-swf |
| 653 | |a Biotechnologie | ||
| 653 | |a Biotechnology | ||
| 653 | |a Chemical Engineering | ||
| 653 | |a Chemieingenieurwesen | ||
| 653 | |a Process Engineering | ||
| 653 | |a Technical Chemistry | ||
| 653 | |a Technische Chemie | ||
| 653 | |a Verfahrenstechnik | ||
| 689 | 0 | 0 | |a Bioverfahrenstechnik |0 (DE-588)4307166-1 |D s |
| 689 | 0 | 1 | |a Prozessoptimierung |0 (DE-588)4176074-8 |D s |
| 689 | 0 | |5 DE-604 | |
| 700 | 1 | |a Holtmann, Dirk |d 1970- |0 (DE-588)130505641 |4 edt | |
| 710 | 2 | |a Walter de Gruyter GmbH & Co. KG |0 (DE-588)10095502-2 |4 pbl | |
| 776 | 0 | 8 | |i Erscheint auch als |n Online-Ausgabe, PDF |z 978-3-11-076033-0 |
| 776 | 0 | 8 | |i Erscheint auch als |n Online-Ausgabe, EPUB |z 978-3-11-076037-8 |
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CONTENTS
LIST
OF
CONTRIBUTING
AUTHORS
-
XI
LUKAS
HARTMANN,
THOMAS
KRIEG
AND
DIRK
HOLTMANN
1
INTENSIFICATION
OF
BIOPROCESSES
-
DEFINITION,
EXAMPLES,
CHALLENGES
AND
FUTURE
DIRECTIONS
-
1
1.1
1.2
1.3
DEFINING
OF
PI
IN
BIOTECHNOLOGY
-
1
EXAMPLES
OF
PI
IN
BIOTECHNOLOGY
-
2
CURRENT
CHALLENGES
AND
FUTURE
DIRECTION
OF
PI
IMPLEMENTATION
IN
BIOTECHNOLOGY
-
5
REFERENCES
-
7
EDUARDO
J.
S.
BRAS
AND
PEDRO
CARLOS
DE
BARROS
FERNANDES
2
MINIATURIZATION
AND
MICROFLUIDIC
DEVICES:
AN
OVERVIEW
OF
BASIC
CONCEPTS,
FABRICATION
TECHNIQUES,
AND
APPLICATIONS
-
17
2.1
2.2
2.2.1
2.2.2
2.2.3
2.2.4
2.2.5
2.3
2.3.1
2.3.2
2.3.3
2.3.4
2.3.5
2.3.6
2.4
2.4.1
2.4.2
2.4.3
2.4.4
2.5
INTRODUCTION
-
17
MICROFABRICATION
TECHNIQUES:
ADVANTAGES
AND
LIMITATIONS
-
19
THERMOPLASTIC
PATTERNING
TECHNIQUES
-
20
GLASS
PATTERNING
TECHNIQUES
-
22
LASER
ABLATION
-
22
PDMS
PATTERNING
----
23
ADDITIVE
MANUFACTURING
-
24
FLUID
DYNAMICS
AND
THE
MICROFLUIDIC
ENVIRONMENT
-
24
CHARACTERISTIC
DIMENSION
-
24
REYNOLDS
NUMBER
-
25
PECLET
NUMBER
-
26
SCHMIDT
AND
PRANDTL
NUMBERS
-
26
CAPILLARY
NUMBER
-
26
DAMKOHLER
NUMBER
-
27
BIOPROCESS
DEVELOPMENT
THROUGH
MICROFLUIDICS
-
27
SCREENING
SYSTEMS
-
27
UPSTREAM
PROCESSING
-
BIOCATALYSIS
-
28
UPSTREAM
PROCESSING
-
CELL-BASED
APPROACHES
-
31
DOWNSTREAM
PROCESSING
-
33
CONCLUSIONS-----
37
REFERENCES
-
37
VI
-
CONTENTS
YUNTING
LIU,
SHIQI
GAO,
PENGBO
LIU,
WEIXI
KONG,
JIANQIAO
LIU
AND
YANJUN
JIANG
3
INTEGRATION
OF
CHEMO
AND
BIO-CATALYSIS
TO
INTENSIFY
BIOPROCESSES
-
45
3.1
INTRODUCTION
------
45
3.2
TEMPORAL
COMPARTMENTALIZATION
STRATEGY
-
46
3.3
SPATIAL
COMPARTMENTALIZATION
STRATEGY
-
50
3.3.1
BIPHASIC
SYSTEMS
-----
50
3.3.2
AQUEOUS
MICELLAR
SOLUTIONS
-----
52
3.3.3
ENCAPSULATION
-----
54
3.3.4
SEMI-PERMEABLE
MEMBRANE
SEPARATION
-
55
3.4
NANOREACTORS
-
56
3.4.1
CHEMICAL
OR
ENZYME-NANOREACTORS
------
56
3.4.2
METAL-ENZYME
CO-IMMOBILIZATION
-
59
3.4.3
BIOCONJUGATION
-----
63
3.5
DISCUSSION
AND
CONCLUSIONS
-----
64
REFERENCES
-
66
ANDRE
DELAVAULT,
KATRIN
OCHSENREITHER
AND
CHRISTOPH
SYLDATK
4
INTENSIFICATION
OF
BIOCATALYTIC
PROCESSES
BY
USING
ALTERNATIVE
REACTION
MEDIA
-
71
4.1
INTRODUCTION
-
71
4.2
ORGANIC
SOLVENTS
AS
MEDIA
-
73
4.2.1
ANHYDROUS
OR
NEARLY
ANHYDROUS
NEAT
ORGANIC
SOLVENT
SYSTEMS
-----
77
4.2.2
ORGANIC
SOLVENTS
MIXED
WITH
AQUEOUS
BUFFERS:
ONE-PHASE
AND
TWO-PHASE
SYSTEMS
-
79
4.3
LOW-TRANSITION-TEMPERATURE
MIXTURES
(LTTMS)
-
81
4.3.1
GENERAL
PRINCIPLES
AND
DEFINITIONS
-----
81
4.3.2
IONIC
LIQUIDS
(ILS)
-----
82
4.3.3
DEEP
EUTECTIC
SOLUTIONS
(DES)
AND
NATURALLY
DEEP
EUTECTIC
SOLUTIONS
(NADES)
-----
83
4.3.4
USE
OF
LTTMS
FOR
BIOCATALYSIS
----
84
4.4
DIVERSE
REACTION
SYSTEMS
FOR
BIOCATALYSIS
-
88
4.4.1
SUPERCRITICAL
FLUIDS
-----
88
4.4.2
GAS,
LIQUID
AND
SOLID
SOLVENT
FREE
APPROACHES
-
89
4.5
CONCLUSIONS
-----
90
REFERENCES
-
91
JOHANNES
MOLLER,
KIM
B.
KUCHEMULLER
AND
RALF
PORTNER
5
BIOPROCESS
INTENSIFICATION
WITH
MODEL-ASSISTED
DOE-STRATEGIES
FOR
THE
PRO
DUCTION
OF
BIOPHARMACEUTICALS
-
95
5.1
INTRODUCTION
-----
95
5.2
MODEL
ASSISTED
PROCESS
DEVELOPMENT
-----
97
CONTENTS
-
-
VII
5.2.1
5.2.2
5.3
MATHEMATICAL
MODELS
FOR
MODEL-ASSISTED
PROCESS
DESIGN
-
97
STRATEGIES
FOR
MODEL-ASSISTED
PROCESS
DEVELOPMENT
-
99
CRITICAL
ASPECTS
OF
DATA
GENERATION
FOR
SETTING
UP
MECHANISTIC
MATHEMATICAL
MODELS
-
100
5.3.1
5.3.2
5.3.3
PROBLEMS
RELATED
TO
THE
DETERMINATION
OF
METABOLIC
VALUES
-
101
IMPACT
OF
CULTURE
CONDITIONS
AND
SCALE
ON
MODEL
PARAMETERS
-
101
ADVANCED
EXPERIMENTAL
STRATEGIES
FOR
DATA
GENERATION
AND
EVALUATION
USED
FOR
MODEL-SET
UP
-
103
5.4
CASE
STUDY:
APPLICATION
OF
MODEL-ASSISTED
DOE
WITHIN
A
KNOWLEDGE-DRIVEN
WORKFLOW
----
103
5.5
APPLICATION
POTENTIAL
OF
MDOE
METHODS
-
109
REFERENCES
-
112
AXEL
SCHMIDT,
ALINA
HENGELBROCK
AND
JOCHEN
STRUBE
6
CONTINUOUS
BIOMANUFACTURING
IN
UPSTREAM
AND
DOWNSTREAM
PROCESSING
-
117
6.1
6.1.1
6.1.2
6.2
6.2.1
6.2.2
6.2.3
6.2.4
6.2.5
6.2.6
6.3
INTRODUCTION
-
117
BIOPHARMA
4.0
AND
SUSTAINABILITY
-
119
CHALLENGES
AND
OPPORTUNITIES
IN
CONTINUOUS
MANUFACTURING
-
121
CASE
STUDIES
-----
122
MONOCLONAL
ANTIBODIES
-
122
FRAGMENTS
----
129
PEPTIDES
-
133
VIRUS-LIKE-PARTICLES
-
142
PDNA
TO
MRNA
----
148
CELL
THERAPIES
-
158
CONCLUSIONS
-
161
REFERENCES
-
162
MARKUS
STOCKL,
ANDRE
GEMUNDE
AND
DIRK
HOLTMANN
7
MICROBIAL
ELECTROTECHNOLOGY
-
INTENSIFICATION
OF
BIOPROCESSES
THROUGH
THE
COMBINATION
OF
ELECTROCHEMISTRY
AND
BIOTECHNOLOGY
-
173
7.1
INTRODUCTION
-
HOW
CAN
ELECTROCHEMISTRY
BE
USED
TO
INTENSIFY
BIOPROCESSES?
-
173
7.2
7.3
7.3.1
7.3.2
7.3.3
7.3.4
7.3.5
FUNDAMENTAL
MECHANISMS
OF
THE
MICROBIAL
ELECTROTECHNOLOGY
(MET)
-
174
APPLICATIONS
OF
MICROORGANISM
IN
BES
-
177
MICROBIAL
FUEL
CELLS
-
177
CATHODIC
MICROBIAL
ELECTROSYNTHESIS
-----
178
ANODIC
MICROBIAL
ELECTROSYNTHESIS
-
179
ELECTROFERMENTATION
-
180
PAIRED
ELECTROLYSIS
CELLS
OR
MICROBIAL
ELECTROLYSIS
CELLS
-
180
VIII
-
CONTENTS
7.3.6
7.4
7.5
7.6
SECONDARY
MICROBIAL
ELECTROCHEMICAL
TECHNOLOGIES
-
181
KEY
PERFORMANCE
INDICATORS
DESCRIBING
THE
MET
-
182
CASE
STUDY
-
SECONDARY
MICROBIAL
ELECTROSYNTHESIS
BASED
IN
FORMIC
ACID
-
185
CONCLUSIONS
----
186
REFERENCES
-
187
MICHAEL
E.
RUNDA
AND
SANDY
SCHMIDT
8
8.1
8.2
8.3
LIGHT-DRIVEN
BIOPROCESSES
-
193
INTRODUCTION
-
193
BASIC
PRINCIPLES
AND
TERMS
IN
LIGHT-DRIVEN
BIOPROCESSES
-
195
PHOTOCATALYTIC
REGENERATION
CASCADES
VIA
DIRECT
OR
INDIRECT
ACTIVATION
OF
REDOX
ENZYMES
-
198
8.3.1
8.3.2
8.3.3
8.3.4
8.4
INDIRECT
PHOTOACTIVATION
OF
REDOX
ENZYMES
-
199
DIRECT
PHOTOACTIVATION
OF
REDOX
ENZYMES
-
202
LIGHT-DRIVEN
COFACTOR
SUPPLY
USING
PHOTOAUTOTROPHS
-
204
PHOTOCATALYTIC
GENERATION
OF
HYDROGEN
PEROXIDE
IN
SITU
-
206
NATURAL
AND
ARTIFICIAL
PHOTOENZYMES
FOR
(NON-NATURAL)
PHOTO-BIOCATALYTIC
REACTIONS
-
207
8.4.1
8.4.2
8.4.3
8.5
NATURAL
PHOTOENZYMES
-
207
ARTIFICIAL
PHOTOENZYMES
-
208
PHOTOINDUCED
ENZYME
PROMISCUITY
-
211
PHOTOENZYMATIC
CASCADES
COMBINING
PHOTO
AND
BIOCATALYTIC
TRANSFORMATIONS
-
212
8.5.1
8.5.2
8.6
8.7
SIMULTANEOUS
AND
SEQUENTIAL
PHOTOCHEMOENZYMATIC
CASCADES
-
214
PHOTOENZYMES
IN
BIOCATALYTIC
CASCADES
-
216
CURRENT
CHALLENGES
OF
APPLYING
LIGHT
IN
BIOPROCESSES
-
217
CONCLUSIONS
-
219
REFERENCES
-
219
SERA
BOLAT,
RAPHAEL
GREIFENSTEIN,
MATTHIAS
FRANZREB
AND
DIRK
HOLTMANN
9
9.1
9.2
9.3
9.3.1
9.3.2
9.3.3
9.4
PROCESS
INTENSIFICATION
USING
IMMOBILIZED
ENZYMES
-
227
INTRODUCTION
-
227
SHORT
INTRODUCTION
IN
ENZYME
IMMOBILIZATION
PROCEDURES
-
229
SUPPORTS
FOR
ENZYME
IMMOBILIZATION
-
233
WHOLE
CELL
BIOCATALYSTS
-
235
PERFORMANCE
INDICATORS
-
236
CASE
STUDY
-
IMMOBILIZATION
OF
UNSPECIFIC
PEROXYGENASES
-
237
CONCLUSIONS
-
242
REFERENCES
-
242
CONTENTS
-
IX
ULISES
A.
SALAS-VILLALOBOS
AND
OSCAR
AGUILAR
10
IN
SITU
PRODUCT
REMOVAL
-
247
10.1
ISPR
CLASSIFICATION
-
251
10.2
SOLID-LIQUID
ISPR
-----
252
10.2.1
MEMBRANE
BIOREACTORS
-
252
10.2.2
ADSORPTION
-----
254
10.3
LIQUID-LIQUID
ISPR
------
256
10.3.1
AQUEOUS
TWO-PHASE
SYSTEMS
(ATPS)
-----
256
10.3.2
ORGANIC
SOLVENT
EXTRACTION
-
258
10.4
GAS-LIQUID
SYSTEM
(STRIPPING)
-
260
10.5
CONCLUSIONS
AND
FUTURE
TRENDS
-
261
REFERENCES
-
262
ANNA
DINIUS,
ZUZANNA
J.
KOZANECKA,
KEVIN
P.
HOFFMANN
AND
RAINER
KRULL
11
INTENSIFICATION
OF
BIOPROCESSES
WITH
FILAMENTOUS
MICROORGANISMS
-
265
11.1
INTRODUCTION
-
266
11.2
CELLULAR
MORPHOLOGY
AND
ITS
INFLUENCE
ON
PRODUCTIVITY
-
268
11.2.1
MICRO-MORPHOLOGY
------269
11.2.2
MACRO-MORPHOLOGY
-----
272
11.2.3
PRODUCT
FORMATION
-
277
11.3
METHODS
FOR
STRUCTURE
ELUCIDATION
-
281
11.3.1
IMAGE
ANALYSIS
-
281
11.3.2
PARTICLE
SIZE
ANALYSIS
BY
LASER
LIGHT
DIFFRACTION
-
283
11.3.3
PELLET
SLICING
AND
CONFOCAL
LASER
SCANNING
MICROSCOPY
-
284
11.3.4
FLOW
CYTOMETRY
-----
285
11.3.5
X-RAY
MICROTOMOGRAPHY
-
287
11.3.6
PELLET
SEDIMENTATION
-
288
11.3.7
PELLET
MECHANICS
-
289
11.3.8
OXYGEN
MICROELECTRODE
TECHNIQUE
-
289
11.4
BIO-INTENSIFICATION
STRATEGIES
IN
FILAMENTOUS
MICROORGANISMS
-
291
11.4.1
MICROPARTICLE
SUPPLEMENTATION
-
292
11.4.2
MACROPARTICLE
SUPPLEMENTATION
-
294
11.4.3
SALT
SUPPLEMENTATION
-
296
11.4.4
SUPPLEMENTATION
OF
SURFACE-ACTIVE
AGENTS
-
297
11.4.5
COMBINATION
OF
MULTIPLE
MORPHOLOGY
ENGINEERING
APPROACHES
-
301
11.5
CONCLUSIONS
-----
302
REFERENCES
-
304
X
-
-
CONTENTS
JOCHEN
SCHAUB,
ANDREAS
ANKENBAUER,
TOBIAS
HABICHER,MICHAEL
LOFFLER,
NICOLAS
MAGUIRE,
DOMINIQUE
MONTEIL,
SEBASTIAN
PUNGEL,
LISA
STEPPER,
FABIAN
STIEFEL,
JUDITH
THOMA,
ANDREAS
UNSOLD,
JULIA
WALTHER,
CHRISTOPHER
WAYNE
AND
THOMAS
WUCHERPFENNIG
12
PROCESS
INTENSIFICATION
IN
BIOPHARMACEUTICAL
PROCESS
DEVELOPMENT
AND
PRODUCTION
-
AN
INDUSTRIAL
PERSPECTIVE
-
313
12.1
INTRODUCTION
-----
314
12.2
BASIC
CONCEPTS
FOR
PROCESS
INTENSIFICATION
-
321
12.3
TECHNICAL
ASPECTS
AND
ENGINEERING
PRINCIPLES
FOR
PROCESS
INTENSIFICATION
-----
325
12.3.1
UPSTREAM
-----
326
12.3.2
DOWNSTREAM
-----
327
12.4
CHEMICALLY
DEFINED
CELL
CULTURE
MEDIA
FOR
INTENSIFIED
CHO
PROCESSES
-
331
12.4.1
GENERAL
REQUIREMENTS
-
331
12.4.2
MEDIA
FOR
PRE-STAGE
PERFUSION
-
331
12.4.3
MEDIA
FOR
HSD
FED
BATCH
PROCESSES-----
332
12.5
SCIENTIFIC
APPROACHES
SUPPORTING
PROCESS
INTENSIFICATION
-
333
12.5.1
SYSTEMS
BIOTECHNOLOGY
-
333
12.5.2
ADVANCED
DATA
ANALYSIS
AND
MODELING
-
334
12.6
PAT
TOOLS
-----
335
12.6.1
UPSTREAM
-----336
12.6.2
DOWNSTREAM
-----
340
12.7
EXAMPLES
FOR
-
INTENSIFIED
CHO
CELL
CULTURE
PROCESSES
PRODUCING
THERAPEUTIC
ANTIBODIES
340
12.7.1
HSD
FED
BATCH
PROCESS
IN
STAINLESS
STEEL
BIOREACTOR
-
340
12.7.2
CONTINUOUS
PERFUSION
PROCESS
IN
SINGLE-USE
BIOREACTOR
-
342
12.8
CELL
LINE
AND
CLONE
SELECTION
ASPECTS
-
342
12.9
ECONOMIC
CONSIDERATIONS
-----
345
12.9.1
FACILITY
MODELING
------346
12.9.2
COST
OF
GOODS
MODELING
-----
347
12.10
SUSTAINABILITY
ASPECTS
-----
351
12.11
SUMMARY
AND
FUTURE
PERSPECTIVES
-
353
REFERENCES----
354
INDEX
----
367 |
| adam_txt | |
| any_adam_object | 1 |
| any_adam_object_boolean | |
| author2 | Holtmann, Dirk 1970- |
| author2_role | edt |
| author2_variant | d h dh |
| author_GND | (DE-588)130505641 |
| author_facet | Holtmann, Dirk 1970- |
| building | Verbundindex |
| bvnumber | BV049611002 |
| classification_rvk | VN 7320 |
| ctrlnum | (OCoLC)1442943128 (DE-599)DNB1300897511 |
| discipline | Chemie / Pharmazie |
| edition | 1. Auflage |
| format | Book |
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| id | DE-604.BV049611002 |
| illustrated | Illustrated |
| index_date | 2024-07-03T23:36:13Z |
| indexdate | 2024-11-22T11:04:48Z |
| institution | BVB |
| institution_GND | (DE-588)10095502-2 |
| isbn | 9783110760323 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-034955217 |
| oclc_num | 1442943128 |
| open_access_boolean | |
| owner | DE-29T DE-703 |
| owner_facet | DE-29T DE-703 |
| physical | XIV, 372 Seiten Illustrationen, Diagramme 24 cm x 17 cm |
| publishDate | 2024 |
| publishDateSearch | 2024 |
| publishDateSort | 2024 |
| publisher | De Gruyter |
| record_format | marc |
| series2 | De Gruyter STEM |
| spelling | Bioprocess intensification edited by Dirk Holtmann Berlin ; Boston De Gruyter [2024] XIV, 372 Seiten Illustrationen, Diagramme 24 cm x 17 cm txt rdacontent n rdamedia nc rdacarrier De Gruyter STEM Prozessoptimierung (DE-588)4176074-8 gnd rswk-swf Bioverfahrenstechnik (DE-588)4307166-1 gnd rswk-swf Biotechnologie Biotechnology Chemical Engineering Chemieingenieurwesen Process Engineering Technical Chemistry Technische Chemie Verfahrenstechnik Bioverfahrenstechnik (DE-588)4307166-1 s Prozessoptimierung (DE-588)4176074-8 s DE-604 Holtmann, Dirk 1970- (DE-588)130505641 edt Walter de Gruyter GmbH & Co. KG (DE-588)10095502-2 pbl Erscheint auch als Online-Ausgabe, PDF 978-3-11-076033-0 Erscheint auch als Online-Ausgabe, EPUB 978-3-11-076037-8 X:MVB https://www.degruyter.com/isbn/9783110760323 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=034955217&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p vlb 20230904 DE-101 https://d-nb.info/provenance/plan#vlb |
| spellingShingle | Bioprocess intensification Prozessoptimierung (DE-588)4176074-8 gnd Bioverfahrenstechnik (DE-588)4307166-1 gnd |
| subject_GND | (DE-588)4176074-8 (DE-588)4307166-1 |
| title | Bioprocess intensification |
| title_auth | Bioprocess intensification |
| title_exact_search | Bioprocess intensification |
| title_exact_search_txtP | Bioprocess Intensification |
| title_full | Bioprocess intensification edited by Dirk Holtmann |
| title_fullStr | Bioprocess intensification edited by Dirk Holtmann |
| title_full_unstemmed | Bioprocess intensification edited by Dirk Holtmann |
| title_short | Bioprocess intensification |
| title_sort | bioprocess intensification |
| topic | Prozessoptimierung (DE-588)4176074-8 gnd Bioverfahrenstechnik (DE-588)4307166-1 gnd |
| topic_facet | Prozessoptimierung Bioverfahrenstechnik |
| url | https://www.degruyter.com/isbn/9783110760323 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=034955217&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT holtmanndirk bioprocessintensification AT walterdegruytergmbhcokg bioprocessintensification |