Dynamic cortical representation of sounds in autism-related and auditory processing-impaired mouse models:
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| Main Author: | |
|---|---|
| Format: | Thesis Book |
| Language: | English |
| Published: |
Kaiserslautern
2023
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis Inhaltsverzeichnis |
| Item Description: | Literature: Seite 110-125 |
| Physical Description: | VIII, 133 Seiten Illustrationen, Diagramme 21 cm |
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MARC
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| 100 | 1 | |a Wadle, Simon Lothar |d 1991- |e Verfasser |0 (DE-588)1297755138 |4 aut | |
| 245 | 1 | 0 | |a Dynamic cortical representation of sounds in autism-related and auditory processing-impaired mouse models |c vorgelegt von Simon Lothar Wadle, M. Sc. |
| 264 | 1 | |a Kaiserslautern |c 2023 | |
| 300 | |a VIII, 133 Seiten |b Illustrationen, Diagramme |c 21 cm | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 500 | |a Literature: Seite 110-125 | ||
| 502 | |b Dissertation |c Rheinland-Pfälzische Technische Universität Kaiserslautern-Landau |d 2023 | ||
| 655 | 7 | |0 (DE-588)4113937-9 |a Hochschulschrift |2 gnd-content | |
| 856 | 4 | 2 | |m B:DE-101 |q application/pdf |u https://d-nb.info/1315351641/04 |3 Inhaltsverzeichnis |
| 856 | 4 | 2 | |m DNB Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=034928066&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-034928066 | ||
| 883 | 0 | |8 1\p |a emakn |c 0,47254 |d 20240116 |q DE-101 |u https://d-nb.info/provenance/plan#emakn | |
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| 883 | 2 | |8 3\p |a dnb |d 20240123 |q DE-101 |u https://d-nb.info/provenance/plan#dnb | |
Record in the Search Index
| _version_ | 1804186450164449280 |
|---|---|
| adam_text | INDEX
OF
CONTENTS
INDEX
OF
CONTENTS
...........................................................................................................................................
I
INDEX
OF
FIGURES
.............................................................................................................................................
V
INDEX
OF
TABLES
.............................................................................................................................................
VII
SUMMARY
....................................................................................................................................................
VIII
1.
INTRODUCTION
..............................................................................................................................................
1
1.1.
FUNCTIONAL
ORGANIZATION
OF
THE
AC
....................................................................................................
1
1.1.1.
PT
RECEPTIVE
FIELDS
......................................................................................................................
1
1.1.2.
TONOTOPY
AND
SUBFIELDS
IN
THE
AC
.............................................................................................
2
1.1.3.
FUNCTIONAL
NETWORKS
IN
THE
AC
..................................................................................................
3
1.2.
FUNCTION
OF
THE
CACNA2D3
GENE
AND
IMPLICATIONS
OF
ITS
LOSS..........................................................
5
1.2.1.
MOLECULAR
FUNCTIONS
OF
A263
.....................................................................................................
5
1.2.2.
NEURONAL
IMPAIRMENTS
UPON
FUNCTIONAL
LOSS
OF
A263
................................................................
5
1.3.
FUNCTION
OF
THE
FMR1
GENE
AND
ITS
ROLE
IN
ASD
..............................................................................
8
1.3.1.
FMR1
AND
ITS
ROLE
IN
ASD
...........................................................................................................
8
1.3.2.
MOLECULAR
AND
FUNCTIONAL
ALTERATIONS
IN
FMR1
KO
MICE
......................................................
8
1.3.3.
AUDITORY
PROCESSING
DEFICITS
IN
ASD
AND
FMR1
KO
MICE
......................................................
10
1.4.
AIMS
OF
THE
STUDY
............................................................................................................................
11
2.
MATERIALS
AND
METHODS
..........................................................................................................................
12
2.1.
ANIMALS
.............................................................................................................................................
12
2.1.1.
FMR1
KO
MICE
..........................................................................................................................
12
2.1.2.
A
2
63
KO
MICE
............................................................................................................................
12
2.2.
GENOTYPING
OF
KO
MICE
...................................................................................................................
13
2.2.1.
DNA
ISOLATION
...........................................................................................................................
13
2.2.2.
PCR
PROTOCOLS
...........................................................................................................................
13
2.3.
SOLUTIONS
...........................................................................................................................................
16
2.3.1.
PREPARATION
SOLUTION
FOR
IN
VITRO
EXPERIMENTS
.......................................................................
16
2.3.2.
ARTIFICIAL
CEREBROSPINAL
FLUID
FOR
IN
VITRO
EXPERIMENTS
...........................................................
17
2.3.3.
INTERNAL
SOLUTION
.......................................................................................................................
17
2.3.4.
FORMULATION
BUFFER
...................................................................................................................
18
2.3.5.
CORTEX
BUFFER
............................................................................................................................
18
2.4.
VIRAL
INJECTIONS
................................................................................................................................
19
2.4.1.
VIRAL
VECTORS
.............................................................................................................................
19
2.4.2.
INJECTION
PROCEDURE
..................................................................................................................
19
2.5.
HABITUATION
PROCEDURE
....................................................................................................................
21
2.6.
CRANIAL
WINDOW
IMPLANTATION
.........................................................................................................
21
2.7.
ACOUSTIC
STIMULATION
AND
AMBIENT
NOISE
ATTENUATION
...................................................................
22
2.8.
IN
VIVO
CA
2+
IMAGING
.........................................................................................................................
25
2.8.1.
TWO-PHOTON
IMAGING
................................................................................................................
26
2.8.2.
WF
IMAGING
..............................................................................................................................
27
2.9.
HISTOLOGY
..........................................................................................................................................
28
2.10.
PREPARATION
OF
ACUTE
AC
SLICES
....................................................................................................
29
2.11.
ELECTROPHYSIOLOGICAL
RECORDINGS
AND
IN
VITRO
CA2T
IMAGING
...........................................................
29
2.11.1.
SINGLE-CELL
CA
2+
IMAGING
.........................................................................................................
30
2.11.2.
SLICE
CA
2+
IMAGING
...................................................................................................................
30
2.12.
DATA
ANALYSIS
.................................................................................................................................
31
2.12.1.
WF
IN
VIVO
CA
2+
IMAGING
ANALYSIS
...........................................................................................
31
2.12.2.
TWO-PHOTON
IN
VIVO
CA
2+
ACTIVITY
EXTRACTION
.........................................................................
32
2.12.3.
TWO-PHOTON
PT
ANALYSIS
........................................................................................................
35
2.12.4.
COMPLEX
SOUND
ANALYSIS
........................................................................................................
36
2.12.5.
IN
VITRO
CA
2+
IMAGING
ANALYSIS
................................................................................................
37
2.12.6.
DATA
VISUALIZATION
AND
STATISTICS
............................................................................................
38
3.
RESULTS
.....................................................................................................................................................
39
3.1.
RESPONSE
PROPERTIES
OF
AC
NEURONS
IN
A
2
63
KO
UPON
PT
STIMULATION
.........................................
39
3.1.1.
SUBFIELD
PARCELLATION
OF
AC
IN
A
2
63
KO
.................................................................................
39
II
3.1.2.
NEURONS
IN
0263
KO
ARE
SENSITIVE
TO
PTS
................................................................................
40
3.1.3.
SIMILAR
TUNING
PROPERTIES
IN
NEURONS
OF
A
2
63
KO
...................................................................
43
3.1.4.
SINGLE-PEAK
NEURONS
ARE
OVERREPRESENTED
IN
AAF
AND
A2
OF
A263
KO
.................................
45
3.1.5.
AAF
AND
A2
OF
A263
KO
EXHIBIT
A
SHIFT
TOWARDS
MID
FREQUENCIES
IN
BF
DISTRIBUTIONS
........
48
3.I.6.
INVERSE
LINEAR
TONOTOPIC
GRADIENT
ON
SINGLE-CELL
LEVEL
IN
AAF
AND
A2
OF
A263
KO
...............
49
3.I.7.
REDUCED
LOCAL
BF
HETEROGENEITY
IN
A263
KO
..........................................................................
51
3.2.
RESPONSE
PROPERTIES
OF
AC
NEURONS
IN
A263
KO
UPON
COMPLEX
SOUND
STIMULATION
...................
52
3.2.1.
PCA
COULD
NOT
DETECT
DIFFERENCES
IN
AC
BETWEEN
A
2
63
KO
AND WT
IN
PROCESSING
OF
AM
TONES
52
3.2.2.
SMALL
CHANGES
OF
NEURONAL
CELL
CLUSTER
PROPERTIES
IN
A
2
63
KO
..............................................
55
3.2.3.
CELL
CLUSTERS
IN
0263
KO
DISPLAY
HIGHER
NOISE
CORRELATION
IN
AAF
AND
A2
BUT
REDUCED
RELIABILITY
IN
A2
..................................................................................................................................
58
3.3.
CA
2+
INFLUX
CONTROL
EXPERIMENTS
....................................................................................................
60
3.3.I.
NO
DIFFERENCE
IN
SINGLE
AP
TRIGGERED
CA
2+
FLUORESCENCE
IN
A
2
63
KO
.....................................
60
3.3.2.
HIGHER
POPULATION
CA
2+
ACTIVITY
AT
LOW
INTENSITY
STIMULATIONS
IN
01263
KO
...........................
61
3.4.
SUMMARY
OF
NEURONAL
RESPONSE
PATTERNS
IN
A
2
63
KO
...................................................................
63
3.5.
RESPONSE
PROPERTIES
OF
AC
NEURONS
IN
FMR1
KO
UPON
PT
STIMULATION
.......................................
64
3.5.I.
SUBFIELD
PARCELLATION
OF
AC
IN
FMR1
KO
.................................................................................64
3.5.2.
SMALL
REDUCTION
IN
PT-RESPONSIVENESS
AND
SINGLE-PEAK
NEURON
ABUNDANCE
IN
FMR1
KO...
64
3.5.3.
REDUCED
TUNING
BW
IN
SINGLE-PEAK
NEURONS
IN
AL
AND
AAF
OF
FMR1
KO
...........................
67
3.5.4.
LESS
NEURONS
IN
A2
OF
FMR1
KO
ARE
TUNED
TO
HIGH
FREQUENCIES
..........................................
69
3.5.5.
LINEAR
TONOTOPIC
GRADIENT
ON
SINGLE-CELL
LEVEL
ONLY
FOUND
IN
AL
OF
HIGHLY-TUNED
NEURONS
IN
WT
AND
FMR1
KO
...............................................................................................................................
72
3.5.6.
SUBFIELD-SPECIFIC
ALTERATIONS
OF
LOCAL
BF
HETEROGENEITY
IN
AC
OF
FMR1
KO
.........................
74
3.6.
RESPONSE
PROPERTIES
OF
AC
NEURONS
IN
FMR1
KO
UPON
COMPLEX
SOUND
STIMULATION
.................
76
3.6.I.
PCA
COULD
NOT
DETECT
DIFFERENCES
IN
AC
BETWEEN
FMR1
KO
AND
WT
IN
PROCESSING
OF
AM
TONES
76
3.6.2.
CELL
CLUSTER
ANALYSIS
REVEALS
SMALL
DIFFERENCES
IN
FMR1
KO
IN
COMPLEX
SOUND
PROCESSING.
79
4.
DISCUSSION...............................................................................................................................................84
III
4.1.
ALTERATIONS
IN
NEURONAL
ACTIVITY
UPON
PT
STIMULATION
IN
A263
KO
MICE
......................................
85
4.1.1.
ALTERATIONS
OF
PT
PROCESSING
IN
A
2
63
KO
................................................................................
85
4.1.2.
DIFFERENCES
IN
TONOTOPIC
ORGANIZATION
OF
A
2
63
KO.................................................................
88
4.2.
PROCESSING
DEFICITS
IN
A
2
63
KO
MICE
UPON
COMPLEX
SOUND
STIMULATION
......................................90
4.2.1.
PCA
ANALYSIS
REVEALS
NO
ALTERATIONS
IN
AM
TONE
PROCESSING
.................................................
91
4.2.2.
ALTERED
RESPONSE
PROPERTIES
TO
ANIMAL
VOCALIZATIONS
IN
A
2
63
KO
........................................
92
4.3.
RESPONSE
PROPERTIES
OF
FMR1
KO
MICE
UPON
PT
STIMULATION
......................................................
97
4.3.1.
CHANGES
IN
PT
PROCESSING
IN
FMR1
KO
...................................................................................
97
4.3.2.
ALTERED
TONOTOPIC
ORGANIZATION
IN
THE
AC
OF
FMR1
KO
MICE
................................................
98
4.4.
RESPONSE
PROPERTIES
OF
NEURONS
IN
FMR1
KO
MICE
UPON
COMPLEX
SOUND
STIMULATION
............
100
4.4.1.
SUBFIELD-SPECIFIC
CHANGES
IN
CLUSTER
PROPERTIES
UPON
STIMULATION
WITH
ANIMAL
VOCALIZATIONS
101
4.5.
COMPARISON
OF
PROCESSING
DEFICITS
IN
A
2
63
KO
AND
FMR1
KO
....................................................
103
4.6. TECHNICAL
AND
ANALYTICAL
CONSIDERATIONS
......................................................................................
105
4.7.
OUTLOOK
..........................................................................................................................................
107
4.8.
CONCLUDING
REMARKS
......................................................................................................................
109
5.
LITERATURE
..............................................................................................................................................
110
6.
APPENDIX
...............................................................................................................................................
126
7.
INDEX
OF
ABBREVIATIONS
.........................................................................................................................
129
8.
CURRICULUM
VITAE
...................................................................................................................................
131
9.
ACKNOWLEDGEMENT
...............................................................................................................................
133
IV
|
| adam_txt |
INDEX
OF
CONTENTS
INDEX
OF
CONTENTS
.
I
INDEX
OF
FIGURES
.
V
INDEX
OF
TABLES
.
VII
SUMMARY
.
VIII
1.
INTRODUCTION
.
1
1.1.
FUNCTIONAL
ORGANIZATION
OF
THE
AC
.
1
1.1.1.
PT
RECEPTIVE
FIELDS
.
1
1.1.2.
TONOTOPY
AND
SUBFIELDS
IN
THE
AC
.
2
1.1.3.
FUNCTIONAL
NETWORKS
IN
THE
AC
.
3
1.2.
FUNCTION
OF
THE
CACNA2D3
GENE
AND
IMPLICATIONS
OF
ITS
LOSS.
5
1.2.1.
MOLECULAR
FUNCTIONS
OF
A263
.
5
1.2.2.
NEURONAL
IMPAIRMENTS
UPON
FUNCTIONAL
LOSS
OF
A263
.
5
1.3.
FUNCTION
OF
THE
FMR1
GENE
AND
ITS
ROLE
IN
ASD
.
8
1.3.1.
FMR1
AND
ITS
ROLE
IN
ASD
.
8
1.3.2.
MOLECULAR
AND
FUNCTIONAL
ALTERATIONS
IN
FMR1
KO
MICE
.
8
1.3.3.
AUDITORY
PROCESSING
DEFICITS
IN
ASD
AND
FMR1
KO
MICE
.
10
1.4.
AIMS
OF
THE
STUDY
.
11
2.
MATERIALS
AND
METHODS
.
12
2.1.
ANIMALS
.
12
2.1.1.
FMR1
KO
MICE
.
12
2.1.2.
A
2
63
KO
MICE
.
12
2.2.
GENOTYPING
OF
KO
MICE
.
13
2.2.1.
DNA
ISOLATION
.
13
2.2.2.
PCR
PROTOCOLS
.
13
2.3.
SOLUTIONS
.
16
2.3.1.
PREPARATION
SOLUTION
FOR
IN
VITRO
EXPERIMENTS
.
16
2.3.2.
ARTIFICIAL
CEREBROSPINAL
FLUID
FOR
IN
VITRO
EXPERIMENTS
.
17
2.3.3.
INTERNAL
SOLUTION
.
17
2.3.4.
FORMULATION
BUFFER
.
18
2.3.5.
CORTEX
BUFFER
.
18
2.4.
VIRAL
INJECTIONS
.
19
2.4.1.
VIRAL
VECTORS
.
19
2.4.2.
INJECTION
PROCEDURE
.
19
2.5.
HABITUATION
PROCEDURE
.
21
2.6.
CRANIAL
WINDOW
IMPLANTATION
.
21
2.7.
ACOUSTIC
STIMULATION
AND
AMBIENT
NOISE
ATTENUATION
.
22
2.8.
IN
VIVO
CA
2+
IMAGING
.
25
2.8.1.
TWO-PHOTON
IMAGING
.
26
2.8.2.
WF
IMAGING
.
27
2.9.
HISTOLOGY
.
28
2.10.
PREPARATION
OF
ACUTE
AC
SLICES
.
29
2.11.
ELECTROPHYSIOLOGICAL
RECORDINGS
AND
IN
VITRO
CA2T
IMAGING
.
29
2.11.1.
SINGLE-CELL
CA
2+
IMAGING
.
30
2.11.2.
SLICE
CA
2+
IMAGING
.
30
2.12.
DATA
ANALYSIS
.
31
2.12.1.
WF
IN
VIVO
CA
2+
IMAGING
ANALYSIS
.
31
2.12.2.
TWO-PHOTON
IN
VIVO
CA
2+
ACTIVITY
EXTRACTION
.
32
2.12.3.
TWO-PHOTON
PT
ANALYSIS
.
35
2.12.4.
COMPLEX
SOUND
ANALYSIS
.
36
2.12.5.
IN
VITRO
CA
2+
IMAGING
ANALYSIS
.
37
2.12.6.
DATA
VISUALIZATION
AND
STATISTICS
.
38
3.
RESULTS
.
39
3.1.
RESPONSE
PROPERTIES
OF
AC
NEURONS
IN
A
2
63
KO
UPON
PT
STIMULATION
.
39
3.1.1.
SUBFIELD
PARCELLATION
OF
AC
IN
A
2
63
KO
.
39
II
3.1.2.
NEURONS
IN
0263
KO
ARE
SENSITIVE
TO
PTS
.
40
3.1.3.
SIMILAR
TUNING
PROPERTIES
IN
NEURONS
OF
A
2
63
KO
.
43
3.1.4.
SINGLE-PEAK
NEURONS
ARE
OVERREPRESENTED
IN
AAF
AND
A2
OF
A263
KO
.
45
3.1.5.
AAF
AND
A2
OF
A263
KO
EXHIBIT
A
SHIFT
TOWARDS
MID
FREQUENCIES
IN
BF
DISTRIBUTIONS
.
48
3.I.6.
INVERSE
LINEAR
TONOTOPIC
GRADIENT
ON
SINGLE-CELL
LEVEL
IN
AAF
AND
A2
OF
A263
KO
.
49
3.I.7.
REDUCED
LOCAL
BF
HETEROGENEITY
IN
A263
KO
.
51
3.2.
RESPONSE
PROPERTIES
OF
AC
NEURONS
IN
A263
KO
UPON
COMPLEX
SOUND
STIMULATION
.
52
3.2.1.
PCA
COULD
NOT
DETECT
DIFFERENCES
IN
AC
BETWEEN
A
2
63
KO
AND WT
IN
PROCESSING
OF
AM
TONES
52
3.2.2.
SMALL
CHANGES
OF
NEURONAL
CELL
CLUSTER
PROPERTIES
IN
A
2
63
KO
.
55
3.2.3.
CELL
CLUSTERS
IN
0263
KO
DISPLAY
HIGHER
NOISE
CORRELATION
IN
AAF
AND
A2
BUT
REDUCED
RELIABILITY
IN
A2
.
58
3.3.
CA
2+
INFLUX
CONTROL
EXPERIMENTS
.
60
3.3.I.
NO
DIFFERENCE
IN
SINGLE
AP
TRIGGERED
CA
2+
FLUORESCENCE
IN
A
2
63
KO
.
60
3.3.2.
HIGHER
POPULATION
CA
2+
ACTIVITY
AT
LOW
INTENSITY
STIMULATIONS
IN
01263
KO
.
61
3.4.
SUMMARY
OF
NEURONAL
RESPONSE
PATTERNS
IN
A
2
63
KO
.
63
3.5.
RESPONSE
PROPERTIES
OF
AC
NEURONS
IN
FMR1
KO
UPON
PT
STIMULATION
.
64
3.5.I.
SUBFIELD
PARCELLATION
OF
AC
IN
FMR1
KO
.64
3.5.2.
SMALL
REDUCTION
IN
PT-RESPONSIVENESS
AND
SINGLE-PEAK
NEURON
ABUNDANCE
IN
FMR1
KO.
64
3.5.3.
REDUCED
TUNING
BW
IN
SINGLE-PEAK
NEURONS
IN
AL
AND
AAF
OF
FMR1
KO
.
67
3.5.4.
LESS
NEURONS
IN
A2
OF
FMR1
KO
ARE
TUNED
TO
HIGH
FREQUENCIES
.
69
3.5.5.
LINEAR
TONOTOPIC
GRADIENT
ON
SINGLE-CELL
LEVEL
ONLY
FOUND
IN
AL
OF
HIGHLY-TUNED
NEURONS
IN
WT
AND
FMR1
KO
.
72
3.5.6.
SUBFIELD-SPECIFIC
ALTERATIONS
OF
LOCAL
BF
HETEROGENEITY
IN
AC
OF
FMR1
KO
.
74
3.6.
RESPONSE
PROPERTIES
OF
AC
NEURONS
IN
FMR1
KO
UPON
COMPLEX
SOUND
STIMULATION
.
76
3.6.I.
PCA
COULD
NOT
DETECT
DIFFERENCES
IN
AC
BETWEEN
FMR1
KO
AND
WT
IN
PROCESSING
OF
AM
TONES
76
3.6.2.
CELL
CLUSTER
ANALYSIS
REVEALS
SMALL
DIFFERENCES
IN
FMR1
KO
IN
COMPLEX
SOUND
PROCESSING.
79
4.
DISCUSSION.84
III
4.1.
ALTERATIONS
IN
NEURONAL
ACTIVITY
UPON
PT
STIMULATION
IN
A263
KO
MICE
.
85
4.1.1.
ALTERATIONS
OF
PT
PROCESSING
IN
A
2
63
KO
.
85
4.1.2.
DIFFERENCES
IN
TONOTOPIC
ORGANIZATION
OF
A
2
63
KO.
88
4.2.
PROCESSING
DEFICITS
IN
A
2
63
KO
MICE
UPON
COMPLEX
SOUND
STIMULATION
.90
4.2.1.
PCA
ANALYSIS
REVEALS
NO
ALTERATIONS
IN
AM
TONE
PROCESSING
.
91
4.2.2.
ALTERED
RESPONSE
PROPERTIES
TO
ANIMAL
VOCALIZATIONS
IN
A
2
63
KO
.
92
4.3.
RESPONSE
PROPERTIES
OF
FMR1
KO
MICE
UPON
PT
STIMULATION
.
97
4.3.1.
CHANGES
IN
PT
PROCESSING
IN
FMR1
KO
.
97
4.3.2.
ALTERED
TONOTOPIC
ORGANIZATION
IN
THE
AC
OF
FMR1
KO
MICE
.
98
4.4.
RESPONSE
PROPERTIES
OF
NEURONS
IN
FMR1
KO
MICE
UPON
COMPLEX
SOUND
STIMULATION
.
100
4.4.1.
SUBFIELD-SPECIFIC
CHANGES
IN
CLUSTER
PROPERTIES
UPON
STIMULATION
WITH
ANIMAL
VOCALIZATIONS
101
4.5.
COMPARISON
OF
PROCESSING
DEFICITS
IN
A
2
63
KO
AND
FMR1
KO
.
103
4.6. TECHNICAL
AND
ANALYTICAL
CONSIDERATIONS
.
105
4.7.
OUTLOOK
.
107
4.8.
CONCLUDING
REMARKS
.
109
5.
LITERATURE
.
110
6.
APPENDIX
.
126
7.
INDEX
OF
ABBREVIATIONS
.
129
8.
CURRICULUM
VITAE
.
131
9.
ACKNOWLEDGEMENT
.
133
IV |
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| author | Wadle, Simon Lothar 1991- |
| author_GND | (DE-588)1297755138 |
| author_facet | Wadle, Simon Lothar 1991- |
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| bvnumber | BV049583177 |
| ctrlnum | (OCoLC)1408826195 (DE-599)KXP1867609754 |
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| genre | (DE-588)4113937-9 Hochschulschrift gnd-content |
| genre_facet | Hochschulschrift |
| id | DE-604.BV049583177 |
| illustrated | Illustrated |
| index_date | 2024-07-03T23:32:17Z |
| indexdate | 2024-07-10T10:11:19Z |
| institution | BVB |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-034928066 |
| oclc_num | 1408826195 |
| open_access_boolean | |
| owner | DE-29T |
| owner_facet | DE-29T |
| physical | VIII, 133 Seiten Illustrationen, Diagramme 21 cm |
| publishDate | 2023 |
| publishDateSearch | 2023 |
| publishDateSort | 2023 |
| record_format | marc |
| spelling | Wadle, Simon Lothar 1991- Verfasser (DE-588)1297755138 aut Dynamic cortical representation of sounds in autism-related and auditory processing-impaired mouse models vorgelegt von Simon Lothar Wadle, M. Sc. Kaiserslautern 2023 VIII, 133 Seiten Illustrationen, Diagramme 21 cm txt rdacontent n rdamedia nc rdacarrier Literature: Seite 110-125 Dissertation Rheinland-Pfälzische Technische Universität Kaiserslautern-Landau 2023 (DE-588)4113937-9 Hochschulschrift gnd-content B:DE-101 application/pdf https://d-nb.info/1315351641/04 Inhaltsverzeichnis DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=034928066&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p emakn 0,47254 20240116 DE-101 https://d-nb.info/provenance/plan#emakn 2\p dnb 20240123 DE-101 https://d-nb.info/provenance/plan#dnb 3\p dnb 20240123 DE-101 https://d-nb.info/provenance/plan#dnb |
| spellingShingle | Wadle, Simon Lothar 1991- Dynamic cortical representation of sounds in autism-related and auditory processing-impaired mouse models |
| subject_GND | (DE-588)4113937-9 |
| title | Dynamic cortical representation of sounds in autism-related and auditory processing-impaired mouse models |
| title_auth | Dynamic cortical representation of sounds in autism-related and auditory processing-impaired mouse models |
| title_exact_search | Dynamic cortical representation of sounds in autism-related and auditory processing-impaired mouse models |
| title_exact_search_txtP | Dynamic cortical representation of sounds in autism-related and auditory processing-impaired mouse models |
| title_full | Dynamic cortical representation of sounds in autism-related and auditory processing-impaired mouse models vorgelegt von Simon Lothar Wadle, M. Sc. |
| title_fullStr | Dynamic cortical representation of sounds in autism-related and auditory processing-impaired mouse models vorgelegt von Simon Lothar Wadle, M. Sc. |
| title_full_unstemmed | Dynamic cortical representation of sounds in autism-related and auditory processing-impaired mouse models vorgelegt von Simon Lothar Wadle, M. Sc. |
| title_short | Dynamic cortical representation of sounds in autism-related and auditory processing-impaired mouse models |
| title_sort | dynamic cortical representation of sounds in autism related and auditory processing impaired mouse models |
| topic_facet | Hochschulschrift |
| url | https://d-nb.info/1315351641/04 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=034928066&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT wadlesimonlothar dynamiccorticalrepresentationofsoundsinautismrelatedandauditoryprocessingimpairedmousemodels |
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