Interaction between epithelial cells and immune cells in the intestine during aging:
Saved in:
| Main Author: | |
|---|---|
| Format: | Thesis Book |
| Language: | English |
| Published: |
Jena
[2023]
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis Inhaltsverzeichnis |
| Physical Description: | 140 Seiten Illustrationen, Diagramme 30 cm |
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| 100 | 1 | |a Lu, Jing |d 1988- |e Verfasser |0 (DE-588)1298801478 |4 aut | |
| 245 | 1 | 0 | |a Interaction between epithelial cells and immune cells in the intestine during aging |c by M.Sc., Jing Lu |
| 264 | 1 | |a Jena |c [2023] | |
| 300 | |a 140 Seiten |b Illustrationen, Diagramme |c 30 cm | ||
| 336 | |b txt |2 rdacontent | ||
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| 502 | |b Dissertation |c Friedrich Schiller University Jena |d 2023 | ||
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Record in the Search Index
| _version_ | 1804186447970828288 |
|---|---|
| adam_text | TABLE
OF
CONTENTS
ABSTRACT
................................................................................................................................................
5
ZUSAMMENFASSUNG
.............................................................................................................................
6
ABBREVIATIONS
......................................................................................................................................
7
GRAPHICAL
ABSTRACT
.............................................................................................................................
8
1
INTRODUCTION
......................................................................................................................................
9
1.1
AGING
............................................................................................................................................
9
1.1.1
AGING
CHARACTERIZATION
........................................................................................................................
9
1.1.2
AGING
MECHANISM
................................................................................................................................
9
1.2
INTESTINE
.....................................................................................................................................
10
1.2.1
INTESTINAL
EPITHELIUM
..........................................................................................................................
10
1.2.2
INTESTINAL
STEM
CELLS
IN
AGING
..............................................................................................................
11
1.3
INTESTINAL
ORGANOIDS
(RELATED
TO
MANUSCRIPT
2.1)
......................................................................
12
1.3.1
INTESTINAL
ORGANOID
STRUCTURE
.............................................................................................................
12
1.3.2
INTESTINAL
ORGANOID
HOMEOSTASIS
........................................................................................................
12
1.3.3
ORGANOID
CULTURING
.............................................................................................................................
13
1.4
INTESTINAL
IMMUNE
SYSTEM
........................................................................................................
14
1.4.1
OVERVIEW
OF
THE
IMMUNE
SYSTEM
.......................................................................................................
14
1.4.2
IMMUNE
RESPONSE
DURING
AGING
.........................................................................................................
15
1.4.3
INFLAMMAGING
.....................................................................................................................................
17
1.4.4
THE
INTESTINAL
IMMUNE
SYSTEM
...........................................................................................................
17
1.4.5
THE
INTESTINAL
IMMUNE
HOMEOSTASIS
..................................................................................................
18
1.5
INTERACTION
BETWEEN
EPITHELIAL
CELLS
AND
IMMUNE
CELLS
IN
THE
INTESTINE
.................................
18
1.5.1
1
FN-Y
AXIS:
AN
AGING
MECHANISM
BASED
ON
EPITHELIUM-IMMUNE
INTERACTION
IN
THE
SMALL
INTESTINE
(RELATED
TO
MANUSCRIPT
2.2)
.........................................................................................................................
18
1.5.2
AGING
ATLAS:
INTESTINAL
EPITHELIUM
AND
IMMUNITY
IN
THE
LARGE
INTESTINE
(RELATED
TO
MANUSCRIPT
2.3)
.19
1.5.3
COLON
TUMOR:
AN
AGING-RELEVANT
DISEASE
INVOLVED
WITH
THE
INTERACTION
OF
IMMUNE
CELLS
(RELATED
TO
MANUSCRIPT
2.4)
.........................................................................................................................................
20
2
MANUSCRIPTS
...................................................................................................................................
21
2.1
CHARACTERIZATION
OF
AN
IN
VITRO
3D
INTESTINAL
ORGANOID
MODEL
BY
USING
MASSIVE
RNASEQ-BASED
TRANSCRIPTOME
PROFILING
...................................................................................................................
21
2.2
IFNY-STATL
AXIS
DRIVES
AGING-ASSOCIATED
LOSS
OF
INTESTINAL
TISSUE
HOMEOSTASIS
AND
REGENERATION
....................................................................................................................................
36
2.3
SINGLE-CELL
ATLAS
OF
THE
AGING
MOUSE
COLON
...............................................................................
77
2.4
ESTABLISHMENT
AND
EVALUATION
OF
MODULE-BASED
IMMUNE-ASSOCIATED
GENE
SIGNATURE
TO
PREDICT
OVERALL
SURVIVAL
IN
PATIENTS
OF
COLON
ADENOCARCINOMA
....................................................
108
3
DISCUSSION
.....................................................................................................................................
124
3.1
EVALUATION
OF
ORGANOIDS
AT
TRANSCRIPTOME-WIDE
LEVEL
REVEALED
A
SIGNIFICANT
INTERACTION
BETWEEN
INTESTINAL
EPITHELIAL
CELLS
AND
IMMUNE
CELLS
..................................................................
124
3.2
ANALYSIS
OF
THE
INTERACTION
BETWEEN
EPITHELIAL
AND
IMMUNE
CELLS
IDENTIFIED
THE
IMPORTANT
ROLE
OF
INTERFERON-GAMMA
IN
DRIVING
THE
AGING
PHENOTYPE
OF
THE
SMALL
INTESTINE
......................
125
3
3.3
INTERACTION
ATLAS
REVEALED
A
COMPREHENSIVE
COMMUNICATION
BETWEEN
EPITHELIAL
CELLS
AND
IMMUNE
CELLS
IN
LARGE
INTESTINAL
AGING
..........................................................................................
126
3.4
A
RISK
MODEL
BASED
ON
THE
INTERACTION
BETWEEN
TUMOR
CELLS
WITH
IMMUNE
CELLS
IN
THE
TUMOR
MICROENVIRONMENT
IS
INVESTIGATED
AS
A
PROGNOSIS
PARAMETER
FOR
COAD
.....................................
127
4
REFERENCES
....................................................................................................................................
129
5
ACKNOWLEDGEMENT
......................................................................................................................
139
6
DECLARATION
OF
HONOR
...................................................................................................................
140
7
CURRICULUM
VITAE
...........................................................................................................................
140
8
APPENDIX
FORMS
AND
TABLES
.......................................................................................................
140
|
| adam_txt |
TABLE
OF
CONTENTS
ABSTRACT
.
5
ZUSAMMENFASSUNG
.
6
ABBREVIATIONS
.
7
GRAPHICAL
ABSTRACT
.
8
1
INTRODUCTION
.
9
1.1
AGING
.
9
1.1.1
AGING
CHARACTERIZATION
.
9
1.1.2
AGING
MECHANISM
.
9
1.2
INTESTINE
.
10
1.2.1
INTESTINAL
EPITHELIUM
.
10
1.2.2
INTESTINAL
STEM
CELLS
IN
AGING
.
11
1.3
INTESTINAL
ORGANOIDS
(RELATED
TO
MANUSCRIPT
2.1)
.
12
1.3.1
INTESTINAL
ORGANOID
STRUCTURE
.
12
1.3.2
INTESTINAL
ORGANOID
HOMEOSTASIS
.
12
1.3.3
ORGANOID
CULTURING
.
13
1.4
INTESTINAL
IMMUNE
SYSTEM
.
14
1.4.1
OVERVIEW
OF
THE
IMMUNE
SYSTEM
.
14
1.4.2
IMMUNE
RESPONSE
DURING
AGING
.
15
1.4.3
INFLAMMAGING
.
17
1.4.4
THE
INTESTINAL
IMMUNE
SYSTEM
.
17
1.4.5
THE
INTESTINAL
IMMUNE
HOMEOSTASIS
.
18
1.5
INTERACTION
BETWEEN
EPITHELIAL
CELLS
AND
IMMUNE
CELLS
IN
THE
INTESTINE
.
18
1.5.1
1
FN-Y
AXIS:
AN
AGING
MECHANISM
BASED
ON
EPITHELIUM-IMMUNE
INTERACTION
IN
THE
SMALL
INTESTINE
(RELATED
TO
MANUSCRIPT
2.2)
.
18
1.5.2
AGING
ATLAS:
INTESTINAL
EPITHELIUM
AND
IMMUNITY
IN
THE
LARGE
INTESTINE
(RELATED
TO
MANUSCRIPT
2.3)
.19
1.5.3
COLON
TUMOR:
AN
AGING-RELEVANT
DISEASE
INVOLVED
WITH
THE
INTERACTION
OF
IMMUNE
CELLS
(RELATED
TO
MANUSCRIPT
2.4)
.
20
2
MANUSCRIPTS
.
21
2.1
CHARACTERIZATION
OF
AN
IN
VITRO
3D
INTESTINAL
ORGANOID
MODEL
BY
USING
MASSIVE
RNASEQ-BASED
TRANSCRIPTOME
PROFILING
.
21
2.2
IFNY-STATL
AXIS
DRIVES
AGING-ASSOCIATED
LOSS
OF
INTESTINAL
TISSUE
HOMEOSTASIS
AND
REGENERATION
.
36
2.3
SINGLE-CELL
ATLAS
OF
THE
AGING
MOUSE
COLON
.
77
2.4
ESTABLISHMENT
AND
EVALUATION
OF
MODULE-BASED
IMMUNE-ASSOCIATED
GENE
SIGNATURE
TO
PREDICT
OVERALL
SURVIVAL
IN
PATIENTS
OF
COLON
ADENOCARCINOMA
.
108
3
DISCUSSION
.
124
3.1
EVALUATION
OF
ORGANOIDS
AT
TRANSCRIPTOME-WIDE
LEVEL
REVEALED
A
SIGNIFICANT
INTERACTION
BETWEEN
INTESTINAL
EPITHELIAL
CELLS
AND
IMMUNE
CELLS
.
124
3.2
ANALYSIS
OF
THE
INTERACTION
BETWEEN
EPITHELIAL
AND
IMMUNE
CELLS
IDENTIFIED
THE
IMPORTANT
ROLE
OF
INTERFERON-GAMMA
IN
DRIVING
THE
AGING
PHENOTYPE
OF
THE
SMALL
INTESTINE
.
125
3
3.3
INTERACTION
ATLAS
REVEALED
A
COMPREHENSIVE
COMMUNICATION
BETWEEN
EPITHELIAL
CELLS
AND
IMMUNE
CELLS
IN
LARGE
INTESTINAL
AGING
.
126
3.4
A
RISK
MODEL
BASED
ON
THE
INTERACTION
BETWEEN
TUMOR
CELLS
WITH
IMMUNE
CELLS
IN
THE
TUMOR
MICROENVIRONMENT
IS
INVESTIGATED
AS
A
PROGNOSIS
PARAMETER
FOR
COAD
.
127
4
REFERENCES
.
129
5
ACKNOWLEDGEMENT
.
139
6
DECLARATION
OF
HONOR
.
140
7
CURRICULUM
VITAE
.
140
8
APPENDIX
FORMS
AND
TABLES
.
140 |
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| author_GND | (DE-588)1298801478 |
| author_facet | Lu, Jing 1988- |
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| id | DE-604.BV049582054 |
| illustrated | Illustrated |
| index_date | 2024-07-03T23:32:06Z |
| indexdate | 2024-07-10T10:11:17Z |
| institution | BVB |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-034926975 |
| oclc_num | 1393128899 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR |
| owner_facet | DE-355 DE-BY-UBR |
| physical | 140 Seiten Illustrationen, Diagramme 30 cm |
| publishDate | 2023 |
| publishDateSearch | 2023 |
| publishDateSort | 2023 |
| record_format | marc |
| spelling | Lu, Jing 1988- Verfasser (DE-588)1298801478 aut Interaction between epithelial cells and immune cells in the intestine during aging by M.Sc., Jing Lu Jena [2023] 140 Seiten Illustrationen, Diagramme 30 cm txt rdacontent n rdamedia nc rdacarrier Dissertation Friedrich Schiller University Jena 2023 (DE-588)4113937-9 Hochschulschrift gnd-content B:DE-101 application/pdf https://d-nb.info/1298765978/04 Inhaltsverzeichnis DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=034926975&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p dnb 20240110 DE-101 https://d-nb.info/provenance/plan#dnb 2\p dnb 20240110 DE-101 https://d-nb.info/provenance/plan#dnb |
| spellingShingle | Lu, Jing 1988- Interaction between epithelial cells and immune cells in the intestine during aging |
| subject_GND | (DE-588)4113937-9 |
| title | Interaction between epithelial cells and immune cells in the intestine during aging |
| title_auth | Interaction between epithelial cells and immune cells in the intestine during aging |
| title_exact_search | Interaction between epithelial cells and immune cells in the intestine during aging |
| title_exact_search_txtP | Interaction between epithelial cells and immune cells in the intestine during aging |
| title_full | Interaction between epithelial cells and immune cells in the intestine during aging by M.Sc., Jing Lu |
| title_fullStr | Interaction between epithelial cells and immune cells in the intestine during aging by M.Sc., Jing Lu |
| title_full_unstemmed | Interaction between epithelial cells and immune cells in the intestine during aging by M.Sc., Jing Lu |
| title_short | Interaction between epithelial cells and immune cells in the intestine during aging |
| title_sort | interaction between epithelial cells and immune cells in the intestine during aging |
| topic_facet | Hochschulschrift |
| url | https://d-nb.info/1298765978/04 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=034926975&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT lujing interactionbetweenepithelialcellsandimmunecellsintheintestineduringaging |
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